著者

藤盛 真樹 鳥谷部 純行 角 伸博 嶋﨑 康相 宮澤 政義 宮手 浩樹 北田 秀昭 佐藤 雄治 三澤 肇 山下 徹郎 中嶋 頼俊 針谷 靖史 小林 一三 西方 聡 太子 芳仁 杉浦 千尋 笠原 和恵 浅香 雄一郎 榊原 典幸 岡田 益彦 柴山 尚大 末次 博 鈴木 豊典 阿部 貴洋 谷村 晶広 工藤 章裕 道念 正樹 川口 泰 野島 正寛 牧野 修治郎

出版者

公益社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.68, no.4, pp.168-183, 2022-04-20 (Released:2022-06-20)

参考文献数

38

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Tooth extraction is reported as the main trigger of bisphosphonate (BP) -related osteonecrosis of the jaw (BRONJ). A method to prevent BRONJ has not been scientifically proven. The American Association of Oral and Maxillofacial Surgeons (AAOMS) differs from the International Task Force on Osteonecrosis of the Jaw with regard to the prevention of BRONJ via prophylactic withdrawal before tooth extraction. We performed a multicenter prospective study regarding the development of BRONJ after tooth extraction in BP-treated patients for the purpose of determining factors associated with the frequency of BRONJ. We extracted teeth from patients with a history of current or prior treatment with BP preparations; teeth were extracted using a common treatment protocol. The presence or absence of BRONJ and adverse events were evaluated. A total of 1,323 cases were targeted for this study; 2,371 teeth were extracted. The overall incidence of BRONJ was 1.74%; in the prophylactic withdrawal group it was 1.73%, whereas in the prophylactic non-withdrawal group it was 1.75%. Factors associated with the onset of BRONJ were sex, preparation adaptation classification, oral hygiene state, site of tooth extraction, and Denosumab usage. From analysis that considered the effect of confounding using the propensity score, prophylactic BP withdrawal did not result in a reduction of BRONJ (onset odds ratio with withdrawal: 1.13, 95%CI 0.36-3.57).

著者

久保 孝市 池田 敦 佐々木 雅彦 鳥谷部 純行 竹川 政範 松田 光悦 西村 泰一 北 進一 奈良 潤一郎 池畑 正宏

出版者

Japanese Society of Oral and Maxillofacial Surgeons

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.43, no.1, pp.45-47, 1997-01-20

参考文献数

6

被引用文献数

7 2

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We clinicostatistically studied 102 cases of external dental fistula at the Department of Oral and Maxillofacial Surgery, Asahikawa Medical College during the past 18 years (from 1977 through 1994). The following results were obtained:<BR>1) The 102 patients comprised 49 males and 53 females. As for age, patients, in their twenties and thirties were most frequently encountered.<BR>2) The period from the onset of disease until the first visit at our clinic tended to be relatively long. The longest period was 13 years and the shortest several days. The average period was 16.9 months.<BR>3) The cheek area (48.0%) was the commonest site of external dental fistulae.<BR>4) External dental fistula arose more often in the mandibular region than the maxillary region, and was especially frequent in the mandibular molars and incisors.<BR>5) In many patients the involved teeth and the fistula were concurrently treated by surgery.