著者

長嶋 友美 東海 林徹 中村 郁子 遠藤 泰 米澤 裕司 竹野 敏彦 小松﨑 康文 山﨑 浩 鬼頭 健二 田中 秀弥 山根 理恵子 村井 久美 池田 幸 斎藤 義夫 遠山 邦子 花岡 平司 鵜飼 孝子 外尾 典子 上中 清隆

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.35, no.1, pp.16-26, 2016 (Released:2016-05-10)

参考文献数

18

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The purpose of the present study was to survey the use of antibacterial agents at 18 private dental college or university hospitals in Japan, as performed approximately every 10 years since 1983, and to identify the diseases treated with these medicines for longer than eight days at these dental hospitals. We first calculated the amount of antibacterial agents prescribed in October 2013. For internal and external preparations, almost all antibiotics comprised cephems (68%, 64%), penicillins (23%, 25%) and macrolides (7%, 8%), with values expressed in terms of percentage for outpatient and inpatient treatments, respectively, and these values were similar to previous surveys. The ratio of internal and external preparations was nearly six-fold higher when compared with injections. About 70% of oral cephems administrated to both outpatients and inpatients was cefcapene pivoxil hydrochloride. In contrast, the antibacterial injection administered to inpatients was primarily cefazolin sodium and that to outpatients was primarily ceftriaxone sodium hydrate. The ratio of carbapenems was less than 1%. Among the antibacterial agents administered for longer than eight days, clarithromycin was mainly used for the treatment of odontogenic chronic sinusitis. Our study suggested that clarithromycin was used appropriately in long-term treatment for chronic diseases. However, we found that a limited variety of oral cephems were heavily used for short-time administration, which might lead to the emergence of resistant bacteria. Pharmacist information and advice may be helpful for dentists to avoid it because proper pharmaceutical management of antibacterial agents is essential for the prevention of resistant bacteria.

著者

影向 範昭 山本 加代子 高橋 美枝子 岡田 道子 遠藤 泰 千葉 智子 遠藤 初恵 鬼頭 健二 鈴木 恵美子 森塚 光子 吉田 紀昭 遠山 邦子 大久保 幸子 大橋 恵 上中 清隆

出版者

一般社団法人 日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.27, no.1, pp.36-44, 2008-04-01 (Released:2010-06-08)

参考文献数

10

被引用文献数

2

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The present study surveyed the application of antimicrobials in dental practice in 17 private dental college or university hospitals in Japan, in order to investigate the actual conditions of using antimicrobials.According to the medicinal virtues, a drug list with percentage was prepared depending upon the number of actual use of internal medicine, injections provided in the prescription or instructions for the 10-day period from September 4 to 15, 2006. Furthermore, a survey of the kind of antimicrobials with consumption for each hospital was also done for the six-month period from April 1, 2006 to September 30, 2006.Classified by medicinal virtues by internal use medicines, the proportion of antibacterial and anti-inflammatory analgesic drugs accounted for 32% each, and gargle and gastrointestinal medicine for 12% and 10% respectively. Among the internal use antimicrobials, usage of the cephem system was 54% whereas penicillin and macrolide system were 23% and 21%, respectively. The largest consumption was cefcapene pivoxil hydrochloride for antibacterial medicines. This drug was widely used in 10 out of 17 hospitals. Erythromycin ethylsuccinate was in second position, followed by cefdinir, rifampicin and ampicillin.The method of marking order of each hospital and order of the total consumption were analyzed and some differences in consumption of different drugs were observed. Many hospitals suggested the use of clarithromycin, cefaclor and amoxicillin although consumption was low.According to the medicinal virtues of injectable medicines, the frequency of use of antimicrobials was the highest (34%) . Among the injectable antimicrobials, the cephem based system (60%) and penicillin system (33%) accounted for more than 90% of the total use. Cefazolin was the most consumed drug, followed by asoxicillin, flomoxef sodium and ceftriaxone.