著者

月本 一郎 塙 嘉之 高久 史麿 浅野 茂隆 上田 一博 土田 昌宏 佐藤 武幸 大平 睦郎 星 順隆 西平 浩一 中畑 龍俊 今宿 晋作 秋山 祐一 櫻井 實 宮崎 澄雄 堺 薫 内海 治郎 黒梅 恭芳 古川 利温 山本 圭子 関根 勇夫 麦島 秀雄 矢田 純一 中沢 真平 小出 亮 加藤 俊一 金子 隆 松山 秀介 堀部 敬三 小西 省三郎 多和 昭雄 筒井 孟 高上 洋一 田坂 英子 植田 浩司

出版者

一般社団法人 日本血液学会

雑誌

臨床血液 (ISSN:04851439)

巻号頁・発行日

vol.31, no.10, pp.1647-1655, 1990 (Released:2009-03-12)

参考文献数

14

被引用文献数

3

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Recombinant human granulocyte colony-stimulating factor (rG-CSF), produced by Chinese hamster ovary cells, was administered in 69 chemotherapy-induced neutropenic pediatric patients (pts) with malignant tumors. Each pt received two cycles of the same chemotherapy and had neutropenia with absolute neutrophil counts (ANC) <500/μl in the first cycle. Initiating 72 hours after termination of chemotherapy in the second cycle, rG-CSF (2 μg/kg/day) was given subcutaneously or intravenously to each pt for 10 days. rG-CSF significantly increased ANC at nadir; 72±14 vs. 206±40/μl (data in the first cycle vs. data in the second cycle, respectively), and reduced the period of neutropenia with ANC<500/μl; 9.7±0.6 vs. 5.1±0.6 days, and the period for restoration to ANC≥1,000/μl after initiation of chemotherapy; 25.5±0.6 vs. 17.5±0.9 days. rG-CSF did not affect other components of peripheral blood. The number of days with fever ≥38°C was significantly reduced by rG-CSF treatment. Neck pain and lumbago were observed in one pt, polakysuria in one pt, and elevation of the serum levels of LDH and uric acid in one pt, however these were mild to moderate, transient, and resolved without any specific treatment. We concluded that rG-CSF was effective in neutropenia induced by intensive chemotherapy for malignant tumors without any serious side effects.

著者

中嶋 清雄 黒梅 恭芳 竹内 政夫

出版者

The Kitakanto Medical Society

雑誌

北関東医学 (ISSN:00231908)

巻号頁・発行日

vol.26, no.2, pp.161-173, 1976-03-30 (Released:2009-11-11)

参考文献数

29

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Six cases of abdominal epilepsy were studied from viewpoint of food allergy and the following results were obtained.1. Through elimination and trial ingestion, food allergens were confirmed in all six cases. They were soybean in 6, milk in 2 and egg in 1.2. Irregular slow dysrhythmia was evidently decreased five days to a month after eliminating food allergens.3. Diffuse irregular slow dysrhythmia with seizure discharge was markedly increased four to twenty-four hours after giving food allergens.4. Threshold of activating agents for the EEG was obviously reduced after administering food allergens. In this way close relationship between abdominal epilepsy and food allergy was demonstrated.