著者

小林 寛 金 河守 Hiroshi Kobayashi Ha-soo Kim

雑誌

研究紀要 = Bulletin of Tsukuba International University (ISSN:13412382)

巻号頁・発行日

vol.20, pp.63-76, 2014

著者

Hiroshi Kobayashi Masaru Yamaoka Makoto Hayashi Bunnai Ogiso

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.58, no.1, pp.93-99, 2016 (Released:2016-03-26)

参考文献数

27

被引用文献数

1 5

---

A non-contact electromagnetic vibration device (NEVD) was previously developed to monitor the condition of periodontal tissues by assessing mechanical parameters. This system requires placement of an accelerometer on the target tooth, to detect vibration. Using experimental tooth models, we evaluated the performance of an NEVD system with a laser displacement sensor (LDS), which does not need an accelerometer. Simulated teeth (polyacetal rods) were submerged at various depths in simulated bone (polyurethane or polyurethane foam) containing simulated periodontal ligament (tissue conditioner). Then, mechanical parameters (resonant frequency, elastic modulus, and viscosity coefficient) were assessed using the NEVD with the following detection methods: Group 1, measurement with an accelerometer; Group 2, measurement with an LDS in the presence of the accelerometer; and Group 3, measurement with an LDS in the absence of the accelerometer. Statistical analyses were performed using nonparametric methods (n = 5) (P < 0.05). The three mechanical parameters significantly increased with increasing depth. In addition, the mechanical parameters significantly differed between the polyurethane and polyurethane foam models. Although Groups 1 and 2 did not significantly differ, most all mechanical parameters in Group 3 were significantly larger and more distinguishable than those in Groups 1 and 2. The LDS was more accurate in measuring mechanical parameters and better able to differentiate periodontal tissue conditions. (J Oral Sci 58, 93-99, 2016)

著者

Hiroshi Kobayashi Hiromi Saito Tomohito Kakegawa

出版者

Applied Microbiology, Molecular and Cellular Biosciences Research Foundation

雑誌

The Journal of General and Applied Microbiology (ISSN:00221260)

巻号頁・発行日

vol.46, no.5, pp.235-243, 2000 (Released:2005-11-04)

参考文献数

73

被引用文献数

31 32

---

Bacteria can inhabit a wide range of environmental conditions, including extremes in pH ranging from 1 to 11. The primary strategy employed by bacteria in acidic environments is to maintain a constant cytoplasmic pH value. However, many data demonstrate that bacteria can grow under conditions in which pH values are out of the range in which cytoplasmic pH is kept constant. Based on these observations, a novel notion was proposed that bacteria have strategies to survive even if the cytoplasm is acidified by low external pH. Under these conditions, bacteria are obliged to use acid-resistant systems, implying that multiple systems having the same physiological role are operating at different cytoplasmic pH values. If this is true, it is quite likely that bacteria have genes that are induced by environmental stimuli under different pH conditions. In fact, acid-inducible genes often respond to another factor(s) besides pH. Furthermore, distinct genes might be required for growth or survival at acid pH under different environmental conditions because functions of many systems are dependent on external conditions. Systems operating at acid pH have been described to date, but numerous genes remain to be identified that function to protect bacteria from an acid challenge. Identification and analysis of these genes is critical, not only to elucidate bacterial physiology, but also to increase the understanding of bacterial pathogenesis.

著者

Kaho Ohta Yuna Motohira Yuki Maruishi Ikuko Minami Hiroshi Kobayashi Hiroya Ishikawa

出版者

Japanese Society for Food Science and Technology

雑誌

Food Science and Technology Research (ISSN:13446606)

巻号頁・発行日

pp.FSTR-D-23-00071, (Released:2023-07-31)

被引用文献数

1

---

Lipid oxidation in food can result in the generation of off-odor compounds. We investigated the combined effects of α-tocopherol with rosmarinic acid and various antioxidants on the prevention and inhibition of off-odor formation. We added these combined compounds in a linoleic acid emulsion, followed by an oxidation reaction with 2'2-Azobis (2-methylpropionamidine) Dihydrochloride at 37 ℃ for 5 h. The hydroperoxide was measured by the ferric thiocyanate method, and the off-odor components were measured by gas chromatography. Median effect analysis was used to assess the combined effects. The results showed that the combinations of α-tocopherol with rosmarinic acid and caffeic acid exhibited a synergistic effect on inhibition of lipid peroxidation and some off-odor components, likely attributable to the catechol structure in these compounds. Interestingly, the combination of α-tocopherol and rosmarinic acid showed a potent synergistic effect on (E)-2-nonenal and (E)-2-octenal, indicating that the formation process of off-odor components may influence the combined effect.

著者

小林 寛 Hiroshi Kobayashi

出版者

つくば国際大学

雑誌

研究紀要 = Bulletin of Tsukuba International University (ISSN:13412078)

巻号頁・発行日

no.22, pp.89-102, 2016

著者

Akira Kido Shozo Yoshida Emiko Shimoda Yukako Ishida Masatoshi Hasegawa Hiroshi Kobayashi Kanya Honoki Hirosei Horikawa Yasuhito Tanaka

出版者

The Japanese Association of Rehabilitation Medicine

雑誌

Progress in Rehabilitation Medicine (ISSN:24321354)

巻号頁・発行日

vol.1, pp.20160009, 2016 (Released:2016-12-21)

参考文献数

15

被引用文献数

1

---

Objective: Radiotherapy is an essential component of curative or palliative therapy for patients with uterine cervical cancer. Although advances in radiotherapy have led to longer survival, survivors may consequently be at risk of pelvic insufficiency fracture (PIF). We retrospectively reviewed medical records and clinical outcomes to assess the impact of PIF on walking disability. Methods: Between January 2002 and December 2009, 145 uterine cancer patients treated with radiotherapy in our hospital were reviewed. Among these, 15 patients (10.3%) were diagnosed with PIF. The types of fractures were identified according to the AO/OTA classification system. Medical records were examined to establish the time to first diagnosis of PIF, the type of fracture, and clinical outcomes. Disability was assessed using Barthel index mobility scores. Results: The median time to PIF detection was 16 months. Of the 15 patients with PIF, 14 had type B fractures (7 cases of B2 and 7 cases of B3) and 1 had a type C fracture. Among 11 patients with pelvic pain, 6 achieved pain control but 5 patients with bilateral lesions in the posterior arch or lateral compression of the sacrum developed pain that finally resulted in walking disability and a lower performance status. Conclusions: PIF causes severe motor disturbance in patients with unstable fracture types. Routine imaging checkups were useful during the 5 years after completion of radiotherapy; in nine patients the fracture progressed for longer than 1 year. In cancer rehabilitation for PIF patients, continuous assessment is essential for predicting walking disability.

著者

Yusuke SUZUKI Makoto HAYASHI Takuya YASUKAWA Hiroshi KOBAYASHI Kosuke MAKINO Yoriyuki HIRANO Shozo TAKAGI Laurence C. CHOW Bunnai OGISO

出版者

日本歯科理工学会

雑誌

Dental Materials Journal (ISSN:02874547)

巻号頁・発行日

pp.2014-255, (Released:2015-02-25)

参考文献数

31

被引用文献数

5

---

Aim of this study was to develop a novel fluorapatite-forming calcium phosphate cement (FA-CPC) with tricalcium silicate (TCS) for endodontic applications and to examine its in vitro and in vivo characteristics. The FA-CPC powder consisted of 62.8% CaHPO4, 30.8% CaCO3, and 6.4% NaF. One part of TCS was combined with 9 parts of FA-CPC powder (FA-CPC with TCS). A 1.5 M phosphate solution was used as cement liquid. Setting time (ST), diametral tensile strength (DTS), phase composition by X-ray diffraction (XRD), and cement alkalinity were analyzed. Cement biocompatibility was assessed using rat subcutaneous model. Cement ST was 10.3±0.6 min and DTS was 3.89±0.76 MPa. XRD patterns showed that highly crystalline apatitic material was the only significant phase present and pH value was approximate 11.0. FA-CPC with TCS demonstrated similar biocompatibility as that of mineral trioxide aggregate control. These results suggest that FA-CPC with TCS may be useful for endodontic applications.