著者

Li-Hua Li Hua-Yi Hsieh Cheng-Chih Hsu

出版者

The Mass Spectrometry Society of Japan

雑誌

Mass Spectrometry (ISSN:2187137X)

巻号頁・発行日

vol.6, no.2, pp.S0060-S0060, 2017-02-22 (Released:2017-02-24)

参考文献数

100

被引用文献数

31

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Ambient ionization allows mass spectrometry analysis directly on the sample surface under atmospheric pressure with almost zero sample pretreatment. Since the development of desorption electrospray ionization (DESI) in 2004, many other ambient ionization techniques were developed. Due to their simplicity and low operation cost, rapid and on-site clinical mass spectrometry analysis becomes real. In this review, we will highlight some of the most widely used ambient ionization mass spectrometry approaches and their applications in clinical study.

著者

Sha Tang Hua Li Lei Song Yucheng Zhou

出版者

International Heart Journal Association

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

vol.64, no.2, pp.203-212, 2023-03-31 (Released:2023-03-31)

参考文献数

34

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This study aimed to evaluate the changes in the left ventricular (LV) myocardial work (MW) in breast cancer patients following chemotherapy by left ventricular pressure-strain loop (LVPSL).A total of 50 patients with newly breast cancer undergoing postoperative adjuvant chemotherapy containing anthracycline were selected. Echocardiography was performed before the treatment (T0), the second (T2) and fourth (T4) cycles of chemotherapy, and 3 (P3 m) and 6 (P6 m) months after the end of chemotherapy. The standard dynamic images of the required sections were collected. After off-line analysis, the routine, global myocardial strain, and global MW parameters were obtained, and the average regional MW index (RMWI) and regional MW efficiency (RMWE) at three levels of LV were calculated.Compared with those at T0 and T2, the global work index (GWI), global constructive work (GCW), global work efficiency (GWE), and global longitudinal strain (GLS) gradually decreased and global wasted work (GWW) gradually increased at T4, P0, and P6 m. The mean RMWI and RMWE of the three levels of LV exhibited a gradually decreasing trend at T4, P0, and P6 m compared with those at T0 and T2. The GWI, GCW, GWE, mean RMWI, and RMWE (basal, medial, and apical) were negatively correlated with the GLS (r = −0.76, −0.66, −0.67, −0.76, −0.77, −0.66, −0.67, −0.59, and −0.61, respectively), whereas the GWW was positively correlated with the GLS (r = 0.55).The mean RMWI and RMWE are effective parameters to reflect the cardiotoxicity of LV, and LVPSL has certain value in the evaluation of the left ventricular myocardial work (LVMW) during anthracycline treatment and follow-up in breast cancer patients.

著者

李 光華 Guang-hua LI

出版者

創価大学日本語日本文学会

雑誌

日本語日本文学 (ISSN:09171762)

巻号頁・発行日

no.21, pp.69-82, 2011-03-20

著者

Tomoko Nakano Tomomi Kotani Yukio Mano Hiroyuki Tsuda Kenji Imai Takafumi Ushida Hua Li Rika Miki Seiji Sumigama Yoshiaki Sato Akira Iwase Akihiro Hirakawa Masato Asai Shinya Toyokuni Fumitaka Kikkawa

出版者

SOCIETY FOR FREE RADICAL RESEARCH JAPAN

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.57, no.3, pp.178-182, 2015 (Released:2015-11-01)

参考文献数

33

被引用文献数

12 11

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Fetal brain injury is often related to prenatal inflammation; however, there is a lack of effective therapy. Recently, molecular hydrogen (H2), a specific antioxidant to hydroxyl radical and peroxynitrite, has been reported to have anti-inflammatory properties. The aim of this study was to investigate whether maternal H2 administration could protect the fetal brain against inflammation. Pregnant C3H/HeN mice received an intraperitoneal injection of lipopolysaccharide (LPS) on gestational day 15.5 and were provided with H2 water for 24 h prior to LPS injection. Pup brain samples were collected on gestational day 16.5, and the levels of apoptosis and oxidative damage were evaluated using immunohistochemistry. Interleukin-6 (IL-6) levels were examined using real-time PCR. The levels of apoptosis and oxidative damage, as well as the levels of IL-6 mRNA, increased significantly when the mother was injected with LPS than that in the control group. However, these levels were significantly reduced when H2 was administered prior to the LPS-injection. Our results suggest that LPS-induced apoptosis, oxidative damage and inflammation in the fetal brain were ameliorated by maternal H2 administration. Antenatal H2 administration might protect the premature brain against maternal inflammation.

著者

Tatsuya Amano Mei-Hua Li Hoshiko Yoshida

出版者

The Ornithological Society of Japan

雑誌

ORNITHOLOGICAL SCIENCE (ISSN:13470558)

巻号頁・発行日

vol.9, no.1, pp.49-53, 2010-06-25 (Released:2010-07-10)

参考文献数

20

被引用文献数

8

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Many studies have reported population declines and range contractions of bird species in agricultural landscapes around the world. However, few studies have described population trends of bird species in rice-paddy areas or identified causes of decline in these areas as opposed to other types of farmland. The Greater Painted Snipe Rostratula benghalensis is strongly dependent on rice-paddy areas for habitat. This paper uses the results of local field surveys and national survey data to document the population trends of Greater Painted Snipe in Japan. Field surveys conducted in Ibaraki Prefecture indicated a severe decline over a recent 10-year period. Data from the National Surveys on the Natural Environment also showed that the distribution of the Greater Painted Snipe has decreased nationwide from the 1970s to the 1990s. This population decline might be due to (1) the introduction of an efficient drainage system in rice fields and/or (2) a reduction in the area of flooded fallow fields with short vegetation at both breeding and wintering sites. Further work on the conservation status of this species is urgently needed.