著者

Rongjian Zhan Jing Zhang Xuanyu Chen Tong Liu Yangsheng He Shaozhao Zhang Xinxue Liao Xiaodong Zhuang Ting Tian Li Feng

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0037, (Released:2023-04-26)

参考文献数

43

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Background: Hypertensive patients show highly heterogeneous treatment effects (HTEs) and cardiovascular prognosis, and not all benefit from intensive blood pressure treatment.Methods and Results: We used the causal forest model to identify potential HTEs of patients in the Systolic Blood Pressure Intervention Trial (SPRINT). Cox regression was performed to assess hazard ratios (HRs) for cardiovascular disease (CVD) outcomes and to compare the effects of intensive treatment among groups. The model revealed 3 representative covariates and patients were partitioned into 4 subgroups: Group 1 (baseline body mass index [BMI] ≤28.32 kg/m2and estimated glomerular filtration rate [eGFR] ≤69.53 mL/min/1.73 m2); Group 2 (baseline BMI ≤28.32 kg/m2and eGFR >69.53 mL/min/1.73 m2); Group 3 (baseline BMI >28.32 kg/m2and 10-year CVD risk ≤15.8%); Group 4 (baseline BMI >28.32 kg/m2and 10-year CVD risk >15.8%). Intensive treatment was shown to be beneficial only in Group 2 (HR 0.54, 95% confidence interval [CI] 0.35–0.82; P=0.004) and Group 4 (HR 0.69, 95% CI 0.52–0.91; P=0.009).Conclusions: Intensive treatment was effective for patients with high BMI and 10-year CVD risk, or low BMI and normal eGFR, but not for those with low BMI and eGFR, or high BMI and low 10-year CVD risk. Our study could facilitate the categorization of hypertensive patients, ensuring individualized therapy.

著者

Zhaoyu Xing Wanma Pan Jing Zhang Xianlin Xu Xuemei Zhang Xiaozhou He Min Fan

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.40, no.5, pp.610-615, 2017-05-01 (Released:2017-05-01)

参考文献数

27

被引用文献数

13 19

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The current research was designed to study the role of hydrogen in renal fibrosis and the renal epithelial to mesenchymal transition (EMT) induced by transforming growth factor-β1 (TGF-β1). Hydrogen rich water (HW) was used to treat animal and cell models. Unilateral ureteral obstruction (UUO) was performed on Balb/c mice to create a model of renal fibrosis. Human kidney proximal tubular epithelial cells (HK-2 cells) were treated with TGF-β1 for 36 h to induce EMT. Serum creatinine (Scr) and blood urea nitrogen (BUN) were measured to test renal function, in addition, kidney histology and immunohistochemical staining of alpha-smooth muscle actin (α-SMA) positive cells was performed to examine the morphological changes. The treatment with UUO induced a robust fibrosis of renal interstitium, shrink of glomerulus and partial fracture of basement membrane. Renal function was also impaired in the experimental group with UUO, with an increase of Scr and BUN in serum. After that, Western-blot was performed to examine the expression of α-SMA, fibronectin, E-cadherin, Smad2 and Sirtuin-1 (Sirt1). The treatment with HW attenuated the development of fibrosis and deterioration of renal function in UUO model. In HK-2 cells, the pretreatment of HW abolished EMT induced by TGF-β1. The down-regulation the expression of Sirt1 induced by TGF-β1 which was dampened by the treatment with HW. Sirtinol, a Sirt1 inhibitor, reversed the effect of HW on EMT induced by TGF-β1. HW can inhibit the development of fibrosis in kidney and prevents HK-2 cells from undergoing EMT which is mediated through Sirt1, a downstream molecule of TGF-β1.

著者

張 静 Jing Zhang

雑誌

愛知県立大学大学院国際文化研究科論集

巻号頁・発行日

vol.11, pp.260-243, 2010

著者

Qing-hai Hu Jun-jie Xu Zhen-xing Chu Jing Zhang Yan-qiu Yu Huan Yu Hai-bo Ding Yong-jun Jiang Wen-qing Geng Ning Wang Hong Shang

出版者

国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

pp.JJID.2016.177, (Released:2016-10-31)

参考文献数

27

被引用文献数

8

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We aimed to assess the prevalence and determinants of herpes simplex virus type 2 (HSV-2) mono-infection and HSV-2/syphilis co-infection in human immunodeficiency virus (HIV)-positive men who have sex with men (MSM) in China. A cross-sectional study was conducted on 545 HIV-positive MSM in Shenyang between February 2009 and October 2014. Participants received physical examinations and serological tests for HSV-2 and syphilis. A multinomial logistic regression was used to identify risk factors associated with HSV-2/syphilis co-infection and HSV-2 mono-infection. The HSV-2 mono-infection, syphilis mono-infection, and HSV-2/syphilis co-infection prevalence (95% confidence interval) was 48.6% (44.4–52.8%), 34.3% (30.3–38.3%), and 22.9% (19.4–26.5%), respectively. In regression analysis, after controlling within HSV-2/syphilis-seronegative cases, related factors for HSV-2/syphilis co-infection were age (25–50 years vs. ≤24 years, aOR: 4.55; >50 years vs. ≤24 years, aOR: 43.02), having regular female sexual partner(s) in the past 6 months (aOR: 0.43) and age at first MSM experience (>18 years vs ⩽18 years, aOR: 2.59) (all P < 0.05).The high prevalence of HSV-2 infection and HSV-2/syphilis co-infection in HIV-positive MSM indicates high HIV secondary transmission risk. A campaign for detection and treatment of HSV-2 and syphilis is urgently required for HIV-positive MSM in China.

著者

Jing ZHANG Dan LI Hong-an LI Xuewen LI Lizhi ZHANG

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE TRANSACTIONS on Information and Systems (ISSN:09168532)

巻号頁・発行日

vol.E106-D, no.2, pp.229-239, 2023-02-01

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In order to solve the low-quality problems such as low brightness, poor contrast, noise interference and color imbalance in night images, a night image enhancement algorithm based on MDIFE-Net curve estimation is presented. This algorithm mainly consists of three parts: Firstly, we design an illumination estimation curve (IEC), which adjusts the pixel level of the low illumination image domain through a non-linear fitting function, maps to the enhanced image domain, and effectively eliminates the effect of illumination loss; Secondly, the DCE-Net is improved, replacing the original Relu activation function with a smoother Mish activation function, so that the parameters can be better updated; Finally, illumination estimation loss function, which combines image attributes with fidelity, is designed to drive the no-reference image enhancement, which preserves more image details while enhancing the night image. The experimental results show that our method can not only effectively improve the image contrast, but also make the details of the target more prominent, improve the visual quality of the image, and make the image achieve a better visual effect. Compared with four existing low illumination image enhancement algorithms, the NIQE and STD evaluation index values are better than other representative algorithms, verify the feasibility and validity of the algorithm, and verify the rationality and necessity of each component design through ablation experiments.

著者

Jiawei Xu Xingyu Liu Shuqin Wu Deju Zhang Xiao Liu Panpan Xia Jitao Ling Kai Zheng Minxuan Xu Yunfeng Shen Jing Zhang Peng Yu

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

BioScience Trends (ISSN:18817815)

巻号頁・発行日

pp.2022.01473, (Released:2023-01-22)

参考文献数

149

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Metabolic-associated fatty liver disease (MAFLD) is the most common chronic liver disease globally and seriously increases the public health burden, affecting approximately one quarter of the world population. Recently, RNA binding proteins (RBPs)-related pathogenesis of MAFLD has received increasing attention. RBPs, vividly called the gate keepers of MAFLD, play an important role in the development of MAFLD through transcription regulation, alternative splicing, alternative polyadenylation, stability and subcellular localization. In this review, we describe the mechanisms of different RBPs in the occurrence and development of MAFLD, as well as list some drugs that can improve MAFLD by targeting RBPs. Considering the important role of RBPs in the development of MAFLD, elucidating the RNA regulatory networks involved in RBPs will facilitate the design of new drugs and biomarkers discovery.

著者

Ze Li Jing Zhang Yunjia Yang Huilan Xu Jianwu Wang Yi Yang

出版者

The Japan Society for Analytical Chemistry

雑誌

Analytical Sciences (ISSN:09106340)

巻号頁・発行日

pp.20N013, (Released:2020-08-21)

被引用文献数

5

著者

JIAN ZHENG TATSUO AONO SHIGEO UCHIDA JING ZHANG MAKIO C. HONDA

出版者

GEOCHEMICAL SOCIETY OF JAPAN

雑誌

GEOCHEMICAL JOURNAL (ISSN:00167002)

巻号頁・発行日

vol.46, no.4, pp.361-369, 2012-08-20 (Released:2013-11-08)

参考文献数

52

被引用文献数

59 24

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The Fukushima Dai-ichi Nuclear Power Plant (DNPP) accident has caused serious contamination of the marine environment from atmospheric fallout deposition and the direct discharges of highly radioactive liquid wastes. In contrast to the immediate intensive studies on the distributions of released fission products, such as 131I, 134Cs and 137Cs, information on the possible contamination by actinides in the marine environment is quite limited. In this study, we report the first data-set on the distribution of Pu isotopes in surface sediments in the Pacific 30 km off Fukushima after the Fukushima DNPP accident. Activities of 239+240Pu and 241Pu, and atom ratios of 240Pu/239Pu and 241Pu/239Pu in surface sediments collected in July-August, 2011 were analyzed to make a quick assessment on the environmental impact of the possible Pu contamination. The observed 239+240Pu activities and 240Pu/239Pu atom ratios are comparable to those previously reported in marine sediments in the western North Pacific and its marginal seas, and in Japanese estuaries before the accident. The Pu contamination from the Fukushima DNPP accident was not observed in marine sediments outside the 30 km zone.