著者

Yukiko Kinjo Makoto Takahashi Naoto Hirose Masami Mizu De-Xing Hou Koji Wada

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.68, no.2, pp.183-191, 2019 (Released:2019-02-01)

参考文献数

35

被引用文献数

1 6

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Stress is a part of everyday life, but excessive stress can be related to diverse diseases. Recently, oral intake of a non-centrifuged cane sugar, Kokuto, was reported to produce potential anti-stress effects in humans. However, the molecular components associated with the anti-stress property of Kokuto remain mostly unknown. Therefore, we focused on the non-sugar component (NSC) fractions of Kokuto, and investigated how serum corticosterone level (used as a stress marker) and antioxidant activity were affected in restraint-stressed mice treated with NSC fractions obtained from the elusion on HP-20 resin with 25%, 50%, 75%, and 100% aqueous methanol (MeOH) solutions. Among the four NSC fractions, the 50% MeOH fraction showed a high content of phenolic compounds and high antioxidant activity. Moreover, oral administration of the 50% MeOH fraction suppressed both corticosterone secretion into the serum and reduction of antioxidant activity in serum and liver in restraint-stressed mice. Component analysis of the 50% MeOH fraction identified five antioxidative phenolic compounds: p-hydroxybenzaldehyde, p-hydroxyacetophenone, schaftoside, isoschaftoside, and p-coumaric acid. Phenolic compounds detected in the NSC fractions of Kokuto might contribute to the anti-stress property of Kokuto. In addition, this research provides more understanding of potential health benefits offered by the constituents of Kokuto.

著者

Makoto TAKAHASHI Yonathan ASIKIN Kensaku TAKARA Koji WADA

出版者

(社)日本農芸化学会

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

vol.76, no.12, pp.2317-2320, 2012-12-23 (Released:2012-12-23)

参考文献数

14

被引用文献数

3

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To identify plants with bioactive potential for skin care, methanol extracts of 56 plant parts from 47 medical and edible plants cultivated in Okinawa were tested for their proliferative effects on NB1RGB skin fibroblast cells. Extracts from six plants, Bischofia javanica, Colocasia esculenta, Melaleuca alternifolia, Piper angustifolia, Jasminum sambac, and Curcuma longa, showed higher NB1RGB cell proliferation activity (>10%) than the control, at various concentrations. Among the six extracts, only the C. longa extract caused an increase in collagen synthesis in NB1RGB cells, as compared to treatment with the positive control, ascorbic acid (AsA). Expression of the collagen synthesis marker, transforming growth factor-β1, was higher after treatment with the C. longa extract than with AsA.

著者

中村 友香 藤澤 憲 中西 裕子 西林 佳人 守谷 安津蓉 小河 理恵子 髙橋 真一郎 亀井 有美 高橋 眞琴 Yuka NAKAMURA Ken FUJISAWA Yuko NAKANISHI Yoshito NISHIBAYASHI Atsuyo MORIYA Rieko OGAWA Shinichiro TAKAHASHI Yumi KAMEI Makoto TAKAHASHI

出版者

鳴門教育大学地域連携センター

雑誌

鳴門教育大学学校教育研究紀要 = Bulletin of Center for Collaboration in Community Naruto University of Education (ISSN:18806864)

巻号頁・発行日

no.35, pp.29-38, 2021-02

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新型コロナウイルス感染症(以下,COVID-19)の対応に際して,緊急事態宣言発出後,筆者らが関与する教育関係,福祉関係,医療関係の最前線での実践現場においては,これまでの実践内容にない対応を求められた。本論文では,筆者らが関与している教育関係,福祉関係,医療関係の最前線での実践現場についての現状と課題を把握していくことを目的とした。現状として,実践現場での感染症予防対策以外にも教材作成や労務上の対応が求められており,課題として,児童・生徒,利用者の心のケアや実践者自身のバーンアウトへの対応必要性も示唆された。

著者

Hitoshi ARAKI Makoto TAKAHASHI Takuya GOTO Masashi IKEDA Nobuyuki IWAMA Masaya IGA Akiko IKEGUCHI Junya TATEMI

出版者

The Association of Japanese Geographers

雑誌

地理学評論 (ISSN:13479555)

巻号頁・発行日

vol.79, no.5, pp.267-271, 2006-04-01 (Released:2008-12-25)

著者

Makoto Takahashi Shigeyoshi Tanaka Reo Kimura Masatomo Umitsu Rokuro Tabuchi Tatsuaki Kuroda Masataka Ando Fumiaki Kimata

出版者

Japan Society for Natural Disaster Science

雑誌

Journal of Natural Disaster Science (ISSN:03884090)

巻号頁・発行日

vol.29, no.2, pp.53-61, 2007 (Released:2009-04-14)

参考文献数

16

被引用文献数

3 5

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This paper is based on the results of research by the Sumatra Earthquake Interdisciplinary or Integrated Research Team, Graduate School of Environmental Studies, Nagoya University. This research shows: (1) the Sumatra Earthquake tsunami disaster damage in Banda Aceh can be divided into four areas; (2) the tsunami action was directed left and right by the Banda Aceh topography; (3) within which District I saw total destruction of housing, a high death rate, and the collapse of families; (4) with the high death rate due to a lack of earthquake-tsunami association; (5) that even in the core of housing reconstruction, the pace is slow; (6) there are four main obstacles to housing reconstruction; (7) the slow pace of the reconstruction is a function of social causes related to the size of the tsunami, the lack of established adjustment mechanisms for aid groups, the slow pace of the reconstruction in society overall, and the failure of market functions; (8) that in the case of large scale disasters, with the loss of life and home, as well as infrastructure, the collapse of society as an entity occurs as well.

著者

Makoto Takahashi Dai Kitamoto Yonathan Asikin Kensaku Takara Koji Wada

出版者

公益社団法人 日本油化学会

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.58, no.12, pp.643-650, 2009 (Released:2009-11-14)

参考文献数

31

被引用文献数

8 43

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Aloe vela leaf gel extract (AGE) are widely used as cosmetic and pharmaceutical ingredients because of its versatile skin care properties. In order to enhance the bioavailability of AGE, liposomes encapsulating AGE were prepared and examined for their interfacial and biochemical properties. The liposomes prepared from a soybean lecithin (SLP-WHITE, 1.0 wt%) by the Bangham method gave relatively a good trapping efficiency up to the AGE concentration of 0.5 wt%. The stable liposomes were then prepared from 1.0 wt% of SLP-WHITE and different concentrations of AGE by the mechanochemical method using a homogenizer and microfluidizer. The liposomes obtained from 0.25 wt% of AGE were confirmed to be small unilamellar vesicles with a diameter of less than 200 nm, and remained well dispersed for at least two weeks. The obtained liposomes encapsulating AGE were further examined for the effects on proliferation and type I collagen synthesis in normal human neonatal skin fibroblasts, NB1RGB cells. Liposomal AGE clearly showed higher proliferation rate than that of AGE alone. In addition, compared to the control, liposomal AGE significantly increased the collagen synthesis by 23%, while AGE alone showed a small effect. Liposomal AGE was also assayed for the effect on proliferation in normal human epidermal keratinocytes, NHEK(F) cells. Interestingly, liposomal AGE fractions containing 4 and 20μg/mL of the extract considerably increased the proliferation rate by 77% and 101%, respectively. In contrast, AGE alone fractions containing 4 and 20μg/mL of the extract increased the rate by 41% and 60%, respectively. Accordingly, the bioavailability and skin care properties of AGE will be significantly enhanced by liposome encapsulation, and the present liposomal AGE should have a great potential as an effective skin care formulation.