著者

Eizo NAKAMURA Katsura KOBAYASHI Ryoji TANAKA Tak KUNIHIRO Hiroshi KITAGAWA Christian POTISZIL Tsutomu OTA Chie SAKAGUCHI Masahiro YAMANAKA Dilan M. RATNAYAKE Havishk TRIPATHI Rahul KUMAR Maya-Liliana AVRAMESCU Hidehisa TSUCHIDA Yusuke YACHI Hitoshi MIURA Masanao ABE Ryota FUKAI Shizuho FURUYA Kentaro HATAKEDA Tasuku HAYASHI Yuya HITOMI Kazuya KUMAGAI Akiko MIYAZAKI Aiko NAKATO Masahiro NISHIMURA Tatsuaki OKADA Hiromichi SOEJIMA Seiji SUGITA Ayako SUZUKI Tomohiro USUI Toru YADA Daiki YAMAMOTO Kasumi YOGATA Miwa YOSHITAKE Masahiko ARAKAWA Atsushi FUJII Masahiko HAYAKAWA Naoyuki HIRATA Naru HIRATA Rie HONDA Chikatoshi HONDA Satoshi HOSODA Yu-ichi IIJIMA Hitoshi IKEDA Masateru ISHIGURO Yoshiaki ISHIHARA Takahiro IWATA Kosuke KAWAHARA Shota KIKUCHI Kohei KITAZATO Koji MATSUMOTO Moe MATSUOKA Tatsuhiro MICHIKAMI Yuya MIMASU Akira MIURA Tomokatsu MOROTA Satoru NAKAZAWA Noriyuki NAMIKI Hirotomo NODA Rina NOGUCHI Naoko OGAWA Kazunori OGAWA Chisato OKAMOTO Go ONO Masanobu OZAKI Takanao SAIKI Naoya SAKATANI Hirotaka SAWADA Hiroki SENSHU Yuri SHIMAKI Kei SHIRAI Yuto TAKEI Hiroshi TAKEUCHI Satoshi TANAKA Eri TATSUMI Fuyuto TERUI Ryudo TSUKIZAKI Koji WADA Manabu YAMADA Tetsuya YAMADA Yukio YAMAMOTO Hajime YANO Yasuhiro YOKOTA Keisuke YOSHIHARA Makoto YOSHIKAWA Kent YOSHIKAWA Masaki FUJIMOTO Sei-ichiro WATANABE Yuichi TSUDA

出版者

The Japan Academy

雑誌

Proceedings of the Japan Academy, Series B (ISSN:03862208)

巻号頁・発行日

vol.98, no.6, pp.227-282, 2022-06-10 (Released:2022-06-10)

参考文献数

245

被引用文献数

90

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Presented here are the observations and interpretations from a comprehensive analysis of 16 representative particles returned from the C-type asteroid Ryugu by the Hayabusa2 mission. On average Ryugu particles consist of 50% phyllosilicate matrix, 41% porosity and 9% minor phases, including organic matter. The abundances of 70 elements from the particles are in close agreement with those of CI chondrites. Bulk Ryugu particles show higher δ18O, Δ17O, and ε54Cr values than CI chondrites. As such, Ryugu sampled the most primitive and least-thermally processed protosolar nebula reservoirs. Such a finding is consistent with multi-scale H-C-N isotopic compositions that are compatible with an origin for Ryugu organic matter within both the protosolar nebula and the interstellar medium. The analytical data obtained here, suggests that complex soluble organic matter formed during aqueous alteration on the Ryugu progenitor planetesimal (several 10’s of km), <2.6 Myr after CAI formation. Subsequently, the Ryugu progenitor planetesimal was fragmented and evolved into the current asteroid Ryugu through sublimation.

著者

Jun KIMURA Hauke HUSSMANN Shunichi KAMATA Koji MATSUMOTO Jürgen OBERST Gregor STEINBRÜGGE Alexander STARK Klaus GWINNER Shoko OSHIGAMI Noriyuki NAMIKI Kay LINGENAUBER Keigo ENYA Kiyoshi KURAMOTO Sho SASAKI

出版者

THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES

雑誌

TRANSACTIONS OF THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES, AEROSPACE TECHNOLOGY JAPAN (ISSN:18840485)

巻号頁・発行日

vol.17, no.2, pp.234-243, 2019 (Released:2019-03-04)

参考文献数

50

被引用文献数

4

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Laser altimetry is a powerful tool for addressing the major objectives of planetary physics and geodesy. Through measurements of distances between a spacecraft and the surface of the planetary bodies, it can be used to determine the global shape and radius: global, regional, and local topography: tidal deformation: and rotational states including physical librations. Laser altimeters have been applied in planetary explorations of the Moon, Mars, Mercury, and the asteroids Eros, and Itokawa. The JUpiter Icy Moons Explorer (JUICE), led by European Space Agency (ESA), has started development to explore the emergence of habitable worlds around gas giants. The Ganymede Laser Altimeter (GALA) will be the first laser altimeter for icy bodies, and will measure the shape and topography of the large icy moons of Jupiter, (globally for Ganymede, and using flyby ground-tracks for Europa and Callisto). Such information is crucial for understanding the formation of surface features and can tremendously improve our understanding of the icy tectonics. In addition, the GALA will infer the presence or absence of a subsurface ocean by measuring the tidal and rotational responses. Furthermore, it also improves the accuracy of gravity field measurements reflecting the interior structure, collaborating with the radio science experiment. In addition to range measurements, the signal strength and the waveform of the laser pulses reflected from the moon's surface contain information about surface reflectance at the laser wavelength and small scale roughness. Therefore we can infer the degrees of chemical and physical alterations, e.g., erosion, space weathering, compaction and deposition of exogenous materials, through GALA measurements without being affected by illumination conditions. JUICE spacecraft carries ten science payloads including GALA. They work closely together in a synergistic way with GALA being one of the key instruments for understanding the evolution of the icy satellites Ganymede, Europa, and Callisto.

著者

Jun KIMURA Hauke HUSSMANN Shunichi KAMATA Koji MATSUMOTO Jürgen OBERST Gregor STEINBRÜGGE Alexander STARK Klaus GWINNER Shoko OSHIGAMI Noriyuki NAMIKI Kay LINGENAUBER Keigo ENYA Kiyoshi KURAMOTO Sho SASAKI

出版者

THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES

雑誌

TRANSACTIONS OF THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES, AEROSPACE TECHNOLOGY JAPAN (ISSN:18840485)

巻号頁・発行日

pp.17.234, (Released:2019-01-31)

参考文献数

50

被引用文献数

4

---

Laser altimetry is a powerful tool for addressing the major objectives of planetary physics and geodesy. Through measurements of distances between a spacecraft and the surface of the planetary bodies, it can be used to determine the global shape and radius: global, regional, and local topography: tidal deformation: and rotational states including physical librations. Laser altimeters have been applied in planetary explorations of the Moon, Mars, Mercury, and the asteroids Eros, and Itokawa. The JUpiter Icy Moons Explorer (JUICE), led by European Space Agency (ESA), has started development to explore the emergence of habitable worlds around gas giants. The Ganymede Laser Altimeter (GALA) will be the first laser altimeter for icy bodies, and will measure the shape and topography of the large icy moons of Jupiter, (globally for Ganymede, and using flyby ground-tracks for Europa and Callisto). Such information is crucial for understanding the formation of surface features and can tremendously improve our understanding of the icy tectonics. In addition, the GALA will infer the presence or absence of a subsurface ocean by measuring the tidal and rotational responses. Furthermore, it also improves the accuracy of gravity field measurements reflecting the interior structure, collaborating with the radio science experiment. In addition to range measurements, the signal strength and the waveform of the laser pulses reflected from the moon's surface contain information about surface reflectance at the laser wavelength and small scale roughness. Therefore we can infer the degrees of chemical and physical alterations, e.g., erosion, space weathering, compaction and deposition of exogenous materials, through GALA measurements without being affected by illumination conditions. JUICE spacecraft carries ten science payloads including GALA. They work closely together in a synergistic way with GALA being one of the key instruments for understanding the evolution of the icy satellites Ganymede, Europa, and Callisto.

著者

Hiroshi ARAKI Ko ISHIBASHI Noriyuki NAMIKI Hirotomo NODA Masanori KOBAYASHI Keigo ENYA Masanobu OZAKI Takahide MIZUNO Yoshifumi SAITO Kazuyuki TOUHARA Shoko OSHIGAMI Shingo KASHIMA Jun KIMURA Shingo KOBAYASHI Gregor STEINBRUEGGE Alexander STARK Christian ALTHAUS Simone Del TOGNO Kay LINGENAUBER Hauke HUSSMANN

出版者

THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES

雑誌

TRANSACTIONS OF THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES, AEROSPACE TECHNOLOGY JAPAN (ISSN:18840485)

巻号頁・発行日

vol.17, no.2, pp.150-154, 2019 (Released:2019-03-04)

参考文献数

10

被引用文献数

1

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GALA (GAnymede Laser Altimeter) is one of the payload instruments of the JUICE (JUpiter ICy moons Explorer) project to be launched in 2022 to the Jovian icy moons Ganymede, Europa, and Callisto. GALA is developed through an international collaboration between Germany, Japan, Switzerland, and Spain. With the performance model of GALA, we have sought to create the interface conditions that satisfy the science requirements on the probability of false detection (PFD) and the range accuracy. The science requirements on GALA performance can be summarized as involving the following four criteria: [1] for Europa fly-by, PFD is less than 0.2 from an altitude of 1300 km or lower, [2] under the worst observation condition for albedo and surface slope of GCO500 (Ganymede Circular Orbit whose height is 500 km), the accuracy of ranging is less than 10 m and PFD is less than 0.2, [3] under the nominal observation condition of GCO500, the accuracy of ranging is less than 2 m and PFD is less than 0.1, and [4] under the best observation condition of GCO500, the accuracy of ranging is less than 1 m and PFD is less than 0.1. For the assessment, however, we had used literature data as the characteristics of the laser detector of GALA, avalanche photodiode (APD), which should be degraded due to the severe radiation environment around Jupiter. Then we carried out a more realistic model simulation of GALA by incorporating these degradation effects of APD. Characteristics of APD, such as gain, quantum efficiency, excess noise index, surface dark current, and bulk dark current, were re-evaluated through radiation tests using the data of dark and photo current of the APD irradiated with 2-MeV-electron and 50-MeV-proton beams, which are the radiation conditions assumed for JUICEGALA around Jupiter. These degraded characteristics of APD by radiation were introduced to our performance model of GALA. As a result, our performance simulation of GALA showed again that the science requirements are satisfied even after taking into account the degraded characteristics of APD. The remaining matter is the effect of noise or digitization in the Analog Electronics Module (AEM), which must be taken into account for the final specifications of GALA.

著者

Yasuharu Kashiwagura Shinya Uchida Shimako Tanaka Hiroshi Watanabe Masahiro Masuzawa Tadanori Sasaki Noriyuki Namiki

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.37, no.4, pp.666-670, 2014-04-01 (Released:2014-04-01)

参考文献数

12

被引用文献数

5 11

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This study aimed to elucidate the clinical efficacy and pharmacokinetics of levothyroxine (LT4) suppository, thus, we examined the pharmacokinetics of thyroxine (T4) after the administration of the suppository in thyroidectomized rats and examined dose and the levels of free T4 (FT4) in patients with hypothyroidism receiving suppositories. Thyroidectomized rats were administered with LT4 solution and LT4 suppository (30 µg/kg), and plasma T4 concentrations were measured using LC/MS. The AUC0–168 of T4 after rectal administration of the LT4 suppository was 64% lower than these values after oral administration. To evaluate clinical effect of LT4 suppository, we enrolled 6 Japanese patients with hypothyroidism (2 men and 4 women; age, 68.2±13.5 years) who were administered LT4 suppository at Kameda Medical Center from 2007 to 2013 in this case series. The FT4 level during the administration of suppositories was significantly lower than that during the administration of tablets (0.657±0.183 ng/dL vs. 1.25±0.51 ng/dL, p=0.034). The FT4/dose ratio for the suppository was significantly 44% lower than that for the tablet (p=0.020). In conclusion, although the bioavailability of LT4 is lower after administration of the suppository than after the oral formulation, it was suggested that T4 levels can be maintained in patients with hypothyroidism by administering LT4 suppositories at a dose 1.8 times higher than that of the tablet. Thus, the administration of LT4 suppository can be an alternative for treatment with oral medication in clinical practice.