文献一覧: Koji KOBAYASHI (著者)

4 0 0 0 OA Urinary lipid production profile in canine patients with splenic mass

著者: Taiki KIDA Arisa YAMAZAKI Tatsuro NAKAMURA Koji KOBAYASHI Sho YOSHIMOTO Shingo MAEDA Takayuki NAKAGAWA Ryohei NISHIMURA Takahisa MURATA
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: pp.22-0355, (Released:2022-09-06)

Polyunsaturated fatty acids (PUFAs), including arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), are metabolized to various lipid mediators. The profile of these lipid metabolites excreted into the urine reflects inflammatory state of the body and disease conditions. In this study, we quantified 156 types of lipids in urine samples of dogs with splenic mass, using liquid chromatography-tandem mass spectrometry. We found that metabolites of prostaglandin (PG) E2, F2α, and D2, 8-iso-PGF3α, lyso-platelet activating factor, and 14,15-leukotrien C4 significantly increased in urine samples of dogs with splenic mass compared to that of healthy dogs. These observations may reflect general inflammatory responses and will help better understanding of the canine splenic mass.

2022-09-14 00:52:08
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3 0 0 0 OA Prevention Measures for COVID-19 and Changes in Kawasaki Disease Incidence

著者: Nobuyuki Katsumata Daisuke Harama Takako Toda Yuto Sunaga Masashi Yoshizawa Yosuke Kono Yohei Hasebe Keiichi Koizumi Minako Hoshiai Tomohiro Saito Sho Hokibara Koji Kobayashi Miwa Goto Tomoaki Sano Makoto Tsuruta Makoto Nakamura Sonoko Mizorogi Masanori Ohta Mie Mochizuki Hiroki Sato Hiroshi Yokomichi Takeshi Inukai
出版者: Japan Epidemiological Association
雑誌: Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日: vol.31, no.11, pp.573-580, 2021-11-05 (Released:2021-11-05)
参考文献数: 42
被引用文献数: 6

Background: Kawasaki disease is suspected to be triggered by previous infection. The prevention measures for coronavirus disease 2019 (COVID-19) have reportedly reduced transmission of certain infectious diseases. Under these circumstances, the prevention measures for COVID-19 may reduce the incidence of Kawasaki disease.Methods: We conducted a retrospective study using registration datasets of patients with Kawasaki disease who were diagnosed in all 11 inpatient pediatric facilities in Yamanashi Prefecture. The eligible cases were 595 cases that were diagnosed before the COVID-19 pandemic (from January 2015 through February 2020) and 38 cases that were diagnosed during the COVID-19 pandemic (from March through November 2020). Incidence of several infectious disease were evaluated using data from the Infectious Disease Weekly Report conducted by the National Institute of Infectious Diseases.Results: Epidemics of various infectious diseases generally remained at low levels during the first 9 months (March through November 2020) of the COVID-19 pandemic. Moreover, the incidence of COVID-19 was 50–80 times lower than the incidence in European countries and the United States. The total number of 38 cases with Kawasaki disease for the 9 months during the COVID-19 pandemic was 46.3% (−3.5 standard deviations [SDs] of the average [82.0; SD, 12.7 cases] for the corresponding 9 months of the previous 5 years. None of the 38 cases was determined to be triggered by COVID-19 based on their medical histories and negative results of severe acute respiratory syndrome coronavirus 2 testing at admission.Conclusion: These observations provide a new epidemiological evidence for the notion that Kawasaki disease is triggered by major infectious diseases in children.

2022-12-03 21:05:50
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2 0 0 0 OA The urinary lipid profile in cats with idiopathic cystitis

著者: Shinya TAKENOUCHI Yui KOBAYASHI Tatsuya SHINOZAKI Koji KOBAYASHI Tatsuro NAKAMURA Tomohiro YONEZAWA Takahisa MURATA
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: pp.22-0049, (Released:2022-04-05)

Although feline idiopathic cystitis (FIC) distresses of many cats, its pathogenesis is unknown and the diagnosis is challenging. Polyunsaturated fatty acids (PUFAs) are metabolized into various lipid mediators. Lipid mediators such as prostaglandins (PGs) modulate inflammation and many of them are excreted into the urine. Thus, the investigation of the urinary lipid profile may reveal pathogenesis and help diagnosis of FIC. We collected urine samples from five FIC cats by spontaneous urination and analyzed 158 types of lipid mediators in urines using liquid chromatography-mass spectrometry. The urinary levels of PUFAs were higher in FIC compared to those of the healthy group. The excretions of a major inflammatory mediator, PGD2, were less in FIC. Other well-known inflammatory mediators such as PGE2, PGI2, and their metabolites did not show a difference. In contrast, the levels of PGF2α and its 2 metabolites and PGF3α were higher in FIC. These results may provide new insights into the future management of cat FIC.

2022-04-07 23:21:07
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2 0 0 0 OA Family Behavior of Japanese and Slovak Populationsfferences

著者: Koji KOBAYASHI Jozef MLÁDEK Jana ŠIROCKOVÁ Tsukiko KOBAYASHI
出版者: The Association of Japanese Geographers
雑誌: 地理学評論 (ISSN:13479555)
巻号頁・発行日: vol.79, no.12, pp.644-663, 2006-10-01 (Released:2008-12-25)
参考文献数: 29
被引用文献数: 1 1 2

The purpose of this study is to recognize and illustrate the presentation of principal developmental trends, regional differences and causal implications of selected population processes, which characterize similar and different features of family behavior of populations in Japan and Slovakia. Our analysis reveals that in spite of a strong influence of family traditions, family behaviour has changed in Slovakia and in Japan. Changes of traditional family behaviour in Slovakia are characterised by a decrease in the marriage rate and a subsequent increase in the age of marriage, a slowly increasing divorce rate, a decrease in abortion levels, and a gradual spreading of informal partner bonds (cohabitations). The past model of early marriage has changed to a model of late marriage. The family in Japan had traditionally economic, cultural, reproductive and educational functions. In spite of certain changes in family behaviour, these functions have been preserved. Changes in family behaviour in Japan include an increasing age of marriage, and an increasing share of “single” households. On the other hand, the low level of the divorce rate, small number of cohabitations, and the low level of extra-marital fertility seems to confirm the conservatism of the family. Changes in family behaviour of inhabitants in Japan and Slovakia seem to have some similarities with those in the West European countries. Further analysis of the 2nd demographic transition is required.

2 0 0 0 OA Roles played by protein metabolism and myogenic progenitor cells in exercise-induced muscle hypertrophy and their relation to resistance training regimens

著者: Naokata Ishii Riki Ogasawara Koji Kobayashi Koichi Nakazato
出版者: 一般社団法人日本体力医学会
雑誌: The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)
巻号頁・発行日: vol.1, no.1, pp.83-94, 2012-05-25 (Released:2012-08-22)
参考文献数: 118
被引用文献数: 2 11 6

To learn the mechanisms underlying resistance exercise-induced muscle hypertrophy, recent studies on muscle protein metabolism and myogenic progenitor cells were reviewed. Numerous studies have suggested that activation of the translation process plays a major role in a resistance exercise-induced increase in muscle protein synthesis, and also in muscle hypertrophy after a prolonged period of training. Among regulators of the translational activity, the mTORC1 signaling pathway has been shown to be important, although the relation between its upstream regulation and exercise regimen remains unclear. In addition, the muscle satellite cells play a part, even if not indispensable, in exercise-induced muscle hypertrophy, by supplying muscle fibers with new myonuclei. Middle to high exercise intensity has been regarded as essential for gaining muscle mass, because it causes the recruitment of large motor units with fast, type II muscle fibers, which are readily hypertrophied through activation of mTORC1 signaling. However, several studies have shown that low-intensity resistance exercises with either large exercise volume or prolonged contraction time effectively activate protein synthesis and induce muscle hypertrophy. These findings suggest that various strategies are possible in exercise regimens, and exercise intensity is not necessarily a primary factor for gaining muscular size.

2016-03-08 01:02:11
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1 0 0 0 OA The urinary lipid profile in cats with idiopathic cystitis

著者: Shinya TAKENOUCHI Yui KOBAYASHI Tatsuya SHINOZAKI Koji KOBAYASHI Tatsuro NAKAMURA Tomohiro YONEZAWA Takahisa MURATA
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: vol.84, no.5, pp.689-693, 2022 (Released:2022-05-17)
参考文献数: 37

2023-07-30 10:17:47
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1 0 0 0 OA Comprehensive profiling of lipid metabolites in urine of canine patients with liver mass

著者: Taiki KIDA Arisa YAMAZAKI Tatsuro NAKAMURA Koji KOBAYASHI Sho YOSHIMOTO Shingo MAEDA Takayuki NAKAGAWA Ryohei NISHIMURA Takahisa MURATA
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: pp.22-0191, (Released:2022-06-08)
被引用文献数: 2

Fatty acids are an essential component of mammalian bodies. They go through different metabolic pathways depending on physiological states and inflammatory stimuli. In this study, we conducted a liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based comprehensive analysis of lipid metabolites in urine of canine patients with liver mass. There were significant differences in quantity of some lipid metabolites that may be closely associated with the disease and/or general inflammatory responses, including increased metabolites of PGE2 and/or PGF2α. We demonstrated that our approach of profiling lipid metabolites in the urine is useful in gaining insights into the disease. These findings may also have an application as a screening test or a diagnosis tool for canine liver mass.

2022-06-09 15:29:54
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1 0 0 0 OA The profile of urinary lipid metabolites in healthy dogs

著者: Taiki KIDA Arisa YAMAZAKI Koji KOBAYASHI Tatsuro NAKAMURA Takayuki NAKAGAWA Ryohei NISHIMURA Takahisa MURATA
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: pp.22-0020, (Released:2022-03-23)
被引用文献数: 2

Polyunsaturated fatty acids, including arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), are converted to hundreds of lipid mediators by cyclooxygenases (COX), lipoxygenases (LOX), and cytochrome P450 (CYP), or through non-enzymatic processes, and they reflect inflammatory states of the body. We comprehensively analyzed lipid metabolites in dog urine using a liquid chromatograph-mass spectrometry (LC-MS/MS) to describe their metabolic characteristics. We detected 31 AA-derived metabolites, four EPA-derived metabolites, and a DHA-derived metabolite in all urine samples. Among AA-derived metabolites, 15, 5, 3, and 8 were generated by COX, LOX, CYP, and non-enzymatic oxidation respectively. This study will be the first step to use profiles of urinary lipid metabolites for better understanding and diagnosis of canine diseases.

2022-03-25 02:44:40
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1 0 0 0 OA The profile of urinary lipid metabolites in cats with bacterial cystitis

著者: Yui KOBAYASHI Tatsuro NAKAMURA Tomohiro YONEZAWA Koji KOBAYASHI Takahisa MURATA
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: pp.21-0433, (Released:2021-11-05)
被引用文献数: 1

Bacterial cystitis is one of the feline lower urinary tract diseases (FLUTDs). Polyunsaturated fatty acids, such as arachidonic acid (ARA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), are oxidized into various lipid mediators that modulate inflammation. Since the profile of lipid metabolites excreted in urine is useful for assessing inflammatory body conditions, we analyzed 126 types of urinary lipid metabolites in cats with bacterial cystitis. Using LC-MS/MS, we found that the levels of 11 metabolites were higher in the urine of cystitis cats than in the urine of healthy cats. In detail, the urinary levels of ARA, EPA, and DHA and eight of their metabolites were increased in cystitis cats. Focusing on the lipid oxidation pathway, the urinary levels of four cyclooxygenase-, three lipoxygenase-, and one cytochrome p450-dependent oxidated metabolites were increased in bacterial cystitis. These urinary lipid profiles can provide some insight into the pathology and future diagnosis of bacterial cystitis.

2021-11-05 23:34:50
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1 0 0 0 OA Prevention Measures for COVID-19 and Changes in Kawasaki Disease Incidence

著者: Nobuyuki Katsumata Daisuke Harama Takako Toda Yuto Sunaga Masashi Yoshizawa Yosuke Kono Yohei Hasebe Keiichi Koizumi Minako Hoshiai Tomohiro Saito Sho Hokibara Koji Kobayashi Miwa Goto Tomoaki Sano Makoto Tsuruta Makoto Nakamura Sonoko Mizorogi Masanori Ohta Mie Mochizuki Hiroki Sato Hiroshi Yokomichi Takeshi Inukai
出版者: Japan Epidemiological Association
雑誌: Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日: pp.JE20210132, (Released:2021-09-04)
参考文献数: 42
被引用文献数: 6

2021-10-10 18:31:41
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1 0 0 0 OA Market Economy and Changing Regional Structures: The Case of Central Europe

著者: Koji KOBAYASHI Ewa TAYLOR
出版者: The Association of Japanese Geographers
雑誌: Geographical review of Japan, Series B (ISSN:02896001)
巻号頁・発行日: vol.73, no.2, pp.225-240, 2000-12-01 (Released:2008-12-25)
参考文献数: 4

2021-01-29 12:11:00
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1 0 0 0 OA Regional Planning and Regional Problems in the Former East Germany

著者: Koji KOBAYASHI
出版者: The Association of Japanese Geographers
雑誌: Geographical review of Japan, Series B (ISSN:02896001)
巻号頁・発行日: vol.70, no.2, pp.95-114, 1997-12-01 (Released:2008-12-25)
参考文献数: 26

This study has attempted to describe some of the regional planning issues that have been developed and executed as well as illustrating some regional problems that have arisen in the former East Germany. Features of regional planning achieved in the former East Germany includes the following: 1) a major effort has been made to provide efficient access between the former East and West Germany; 2) the resolution of many conflicts faced by the two former regions is being addressed in regional plans that have incorporated many of the unique, positive elements that still persist in the former East Germany; and, 3) major efforts are being taken to coordinate and integrate reciprocal regional planning issues with the neighboring East European nations. At the same time, however, various regional problems within the former East Germany have arisen. The main issues are a drastic decline in services in rural areas, the spread of urban sprawl in the cities and suburbs, delays in urban redevelopment projects, and the collapse of industrial areas.

2021-01-29 12:07:00
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1 0 0 0 OA Changing Regional Structure and Prospects in Central Europe

著者: Koji KOBAYASHI Satoshi NAKAGAWA Jozef MLAÁDEK Masahiro KAGAMI Peter MEUSBURGER Hiroshi SASAKI Koji KOBAYASHI Masaaki KUREHA Teresa CZYZ Ivan BICIK Martin HAMPL Antal AUBERT Jörg MATER Mitsuru YAMAMOTO Lidia SASAKI Shigeru YAMAMOTO
出版者: The Association of Japanese Geographers
雑誌: 地理学評論 (ISSN:13479555)
巻号頁・発行日: vol.76, no.5, pp.392-403, 2003-04-01 (Released:2008-12-25)

2021-01-29 09:20:00
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1 0 0 0 OA The profile of urinary lipid metabolites in cats

著者: Yui KOBAYASHI Tatsuro NAKAMURA Koji KOBAYASHI Takahisa MURATA
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: pp.20-0238, (Released:2020-06-05)
被引用文献数: 5

Polyunsaturated fatty acids including arachidonic acid (AA), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are converted to lipid mediators by oxidation. Unlike other mammals, cats cannot synthesize AA. Since their lipid metabolic features remain unknown, we qualitatively analyzed 118 types of urinary lipid metabolites in healthy neutered cats. Using LC-MS, we found 26 lipid metabolites in urines of all individuals. In detail, 20 AA-, 5 EPA- and 1 DHA-derived lipid mediators were detected. Focusing on oxidative pathway, 17 cyclooxygenase-metabolites and 5 metabolites produced by non-enzymatic pathway were detected. Of interest, few lipoxygenase- or cytochrome P450-metabolites were excreted. Thus, AA-derived cyclooxygenase-metabolites mainly composed the urinary lipid metabolites in cats.

2020-06-06 06:04:35
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