- 著者
- Kozo Okamoto Hiromi Owada Tadashi Fujita Masahiro Kazumori Michiko Otsuka Hiromu Seko Yoshifumi Ota Naotaka Uekiyo Hiroshi Ishimoto Masahiro Hayashi Haruma Ishida Akiyoshi Ando Masaya Takahashi Kotaro Bessho Hironobu Yokota
- 出版者
- Meteorological Society of Japan
- 雑誌
- SOLA (ISSN:13496476)
- 巻号頁・発行日
- vol.16, pp.162-168, 2020 (Released:2020-09-05)
- 参考文献数
- 21
- 被引用文献数
- 14
To discuss the feasibility of the Himawari follow-on program, impacts of a hyperspectral sounder on a geostationary satellite (GeoHSS) is assessed using an observing system simulation experiment. Hypothetical GeoHSS observations are simulated by using an accurate reanalysis dataset for a heavy rainfall event in western Japan in 2018. The global data assimilation experiment demonstrates that the assimilation of clear-sky radiances of the GeoHSS improves the forecasts of the representative meteorological field and slightly reduces the typhoon position error. The regional data assimilation experiment shows that assimilating temperature and relative humidity profiles derived from the GeoHSS improves the heavy rainfall in the Chugoku region of western Japan as a result of enhanced southwesterly moisture flow off the northwestern coast of the Kyushu Island. These results suggest that the GeoHSS provides valuable information on frequently available vertically resolved temperature and humidity and thus improves the forecasts of severe events.
- 著者
- Kozo Okamoto Hiromi Owada Tadashi Fujita Masahiro Kazumori Michiko Otsuka Hiromu Seko Yoshifumi Ota Naotaka Uekiyo Hiroshi Ishimoto Masahiro Hayashi Haruma Ishida Akiyoshi Ando Masaya Takahashi Kotaro Bessho Hironobu Yokota
- 出版者
- Meteorological Society of Japan
- 雑誌
- SOLA (ISSN:13496476)
- 巻号頁・発行日
- pp.2020-028, (Released:2020-07-10)
- 被引用文献数
- 14
To discuss the feasibility of the Himawari follow-on program, impacts of a hyperspectral sounder on a geostationary satellite (GeoHSS) is assessed using an observing system simulation experiment. Hypothetical GeoHSS observations are simulated by using an accurate reanalysis dataset for a heavy rainfall event in western Japan in 2018. The global data assimilation experiment demonstrates that the assimilation of clear-sky radiances of the GeoHSS improves the forecasts of the representative meteorological field and slightly reduces the typhoon position error. The regional data assimilation experiment shows that assimilating temperature and relative humidity profiles derived from the GeoHSS improves the heavy rainfall in the Chugoku region of western Japan as a result of enhanced southwesterly moisture flow off the northwestern coast of the Kyushu Island. These results suggest that the GeoHSS provides valuable information on frequently available vertically resolved temperature and humidity and thus improves the forecasts of severe events.
- 著者
- Tadashi Fujita Atsushi Kawase Toshiro Niwa Norimichi Tomohiro Megumi Masuda Hideaki Matsuda Masahiro Iwaki
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Biological and Pharmaceutical Bulletin (ISSN:09186158)
- 巻号頁・発行日
- vol.31, no.5, pp.925-930, 2008-05-01 (Released:2008-05-01)
- 参考文献数
- 45
- 被引用文献数
- 36 39
In a previous study we found that 50% ethanol extracts of immature fruits of Citrus unshiu (satsuma mandarin) have anti-allergic effects against the Type I, II and IV allergic reactions. However, many adverse interactions between citrus fruit, especially grapefruit juice, and drugs have been reported due to the inhibition of cytochrome P450 (CYP) activities. The purpose of this study was to examine the competitive inhibitory effects of extracts from immature citrus fruit on CYP activity. Extracts were prepared from 12 citrus species or cultivars, and were tested against three kinds of major CYPs, CYP2C9, CYP2D6 and CYP3A4, in human liver microsomes. We also estimated the amounts of flavonoids (narirutin, hesperidin, naringin and neohesperidin) and furanocoumarins (bergapten, 6′,7′-dihydroxybergamottin and bergamottin) in each extract using HPLC. Citrus paradisi (grapefruit) showed the greatest inhibition of CYP activities, while Citrus unshiu which has an antiallergic effect, showed relatively weak inhibitory effects. Extracts having relatively strong inhibitory effects for CYP3A4 tended to contain higher amounts of naringin, bergamottin and 6′,7′-dihydroxybergamottin. These results, providing comparative information on the inhibitory effects of citrus extracts on CYP isoforms, suggest that citrus extracts containing high levels of narirutin and hesperidin and lower levels of furanocoumarins such as C. unshiu are favorable as antiallergic functional ingredients.
- 著者
- Keisuke TSUTSUI Masato KAKU Masahide MOTOKAWA Yuiko TOHMA Toshitsugu KAWATA Tadashi FUJITA Shinya KOHNO Junji OHTANI Kaoru TENJOH Mao NAKANO Hiroko KAMADA Kazuo TANNE
- 出版者
- バイオメディカルリサーチプレス
- 雑誌
- Biomedical Research (ISSN:03886107)
- 巻号頁・発行日
- vol.28, no.1, pp.1-7, 2007 (Released:2007-03-13)
- 参考文献数
- 22
- 被引用文献数
- 29 59
It has been reported that reduction of masticatory afferent stimulation might influence learning and memory function. In order to clarify the influences of reduced masticatory sensory input on spatial memory/learning ability and neuropathological changes, we conducted the Morris water maze experiment and investigated the number of hippocampal neurons in association with the differences in masticatory afferent stimuli from hard- and soft-diet feeding in mice. The water maze experiment showed no significant difference in learning ability between 180-day-old solid- and powderdiet groups. Meanwhile, the ability was significantly reduced in the 360-day-old powder-diet group as compared with the age-matched solid-diet group. The total number of pyramidal cells in the hippocampal CA1 and CA3 regions was significantly smaller in 360-day-old powder-diet group than in the remaining groups. These results demonstrate that reduction of masticatory afferent stimuli due to long-term soft-diet feeding may induce neuron loss in the hippocampus and reduced memory/learning ability.