著者

Keisuke Kuwahara Toru Honda Tohru Nakagawa Shuichiro Yamamoto Takeshi Hayashi Tetsuya Mizoue

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.28, no.2, pp.94-98, 2018-02-05 (Released:2018-02-05)

参考文献数

24

被引用文献数

6 11

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Background: Data on the effect of physical activity intensity on depression is scarce. We investigated the prospective association between intensity of leisure-time exercise and risk of depressive symptoms among Japanese workers.Methods: The participants were 29,052 employees (24,653 men and 4,399 women) aged 20 to 64 years without psychiatric disease including depressive symptoms at health checkup in 2006–2007 and were followed up until 2014–2015. Details of leisure-time exercise were ascertained via a questionnaire. Depressive states were assessed using a 13-item questionnaire. Multivariable-adjusted hazard ratio of depressive symptoms was estimated using Cox regression analysis.Results: During a mean follow-up of 5.8 years with 168,203 person-years, 6,847 workers developed depressive symptoms. Compared with workers who engaged in no exercise during leisure-time (0 MET-hours per week), hazard ratios (95% confidence intervals) associated with >0 to <7.5, 7.5 to <15.0, and ≥15.0 MET-hours of leisure-time exercise were 0.88 (0.82–0.94), 0.85 (0.76–0.94), and 0.78 (0.68–0.88) among workers who engaged in moderate-intensity exercise alone; 0.93 (0.82–1.06), 0.82 (0.68–0.98), and 0.83 (0.71–0.98) among workers who engaged in vigorous-intensity exercise alone; and 0.96 (0.80–1.15), 0.80 (0.67–0.95), and 0.76 (0.66–0.87) among workers who engaged in both moderate- and vigorous-intensity exercise with adjustment for age, sex, lifestyles, work-related and socioeconomic factors, and body mass index. Additional adjustment for baseline depression score attenuated the inverse association, especially among those who engaged in moderate-intensity exercise alone.Conclusions: The results suggest that vigorous-intensity exercise alone or vigorous-intensity combined with moderate-intensity exercise would prevent depressive symptoms among Japanese workers.

著者

Hisashi HARADA Kazuhisa KITAZAKI Takeshi TSUJINO Yasuhiro WATARI Sachiyo IWATA Hidemi NONAKA Takeshi HAYASHI Tatsuya TAKESHITA Kanehisa MORIMOTO Mitsuhiro YOKOYAMA

出版者

The Japanese Society of Hypertension

雑誌

Hypertension Research (ISSN:09169636)

巻号頁・発行日

vol.23, no.3, pp.277-284, 2000 (Released:2006-08-10)

参考文献数

34

被引用文献数

20 26

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Taurine is known to lower blood pressure in essential hypertension and some experimental hypertensive models. Taurine has also been reported to activate aldehyde dehydrogenase and to inhibit the elevation of plasma acetaldehyde concentration after ethanol intake. Because acetaldehyde, the first metabolite of ethanol, is suspected to be responsible for many adverse effects of alcohol consumption, we examined the effect of taurine supplementation on ethanol-induced hypertension and abnormalities in the intracellular cation metabolism in Witar-Kyoto rats. In Study 1, systolic blood pressure and intraplatelet free calcium were significantly higher in rats who received 15% ethanol in drinking water than in control rats. Oral taurine supplementation (1% taurine and 15% ethanol in drinking water) completely prevented the development of ethanol-induced hypertension. Intraerythrocyte sodium and intraplatelet free calcium were significantly decreased in taurine-supplemented rats as compared with rats who received 15% ethanol only. In Study 2, hemoglobin-associated acetaldehyde (HbAA) was measured as a marker of protein-bound acetaldehyde. HbAA was significantly elevated in rats who received 5% ethanol in drinking water as compared with control rats. Taurine supplementation (1% taurine and 5% ethanol in drinking water) significantly decreased HbAA. Our findings suggest that the oral supplementation of taurine prevents ethanol-induced hypertension by decreasing protein bound acetaldehyde and altering the cation handling by the membrane. (Hypertens Res 2000; 23: 277-284)

著者

Yuji Kato Takeshi Hayashi Noriko Arai Norio Tanahashi Koichi Takahashi Masaki Takao

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.2587-18, (Released:2019-05-22)

参考文献数

10

被引用文献数

13

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Postural tachycardia syndrome (POTS) can cause orthostatic headache. However, it is difficult to differentiate POTS from spontaneous intracranial hypotension (SIH) caused by cerebrospinal fluid (CSF) leaks. We herein report a 53-year-old woman who presented with SIH associated with POTS. A cervicothoracic and lumbar epidural blood patch rapidly improved not only the headache but also the orthostatic tachycardia, suggesting POTS secondary to SIH. This case suggests that a CSF leak can cause secondary POTS. Therefore, POTS should be considered in patients with orthostatic headaches, even in the presence of a CSF leak.

著者

Yasushi MOTOKI Toshikazu TAMURA Takeshi ISHIDA Takanobu SOTOME Takemi KOGURE Hiroshi SAWAGUCHI Kunio YOSHIKAWA Yasushi MOTOKI Kazuko UCHIDA Hiroki TAKAMURA Atsunao MARUI Akinobu MIYAKOSHI Takeshi HAYASHI Hiroshi KODAMA Nobuyuki KOMURO Naoyoshi SATO

出版者

The Association of Japanese Geographers

雑誌

地理学評論 (ISSN:13479555)

巻号頁・発行日

vol.79, no.12, pp.746-750, 2006-10-01 (Released:2008-12-25)

著者

Takeshi Hayashi

出版者

Research Institute forMathematical Sciences

雑誌

Publications of the Research Institute for Mathematical Sciences (ISSN:00345318)

巻号頁・発行日

vol.9, no.1, pp.61-92, 1973 (Released:2009-04-24)

参考文献数

6

被引用文献数

39

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In this paper, the uvwxy-theorem of context-free languages is extended to the case of indexed languages. Applying the extended theorem, it is shown that the finiteness problem for the indexed languages is solvable and certain languages such as {an!| n{≥}1} and {($ w)|w||w∈{a, b}*} are not indexed languages.

著者

Atsushi Imai Takeshi Kuniga Terutaka Yoshioka Keisuke Nonaka Nobuhito Mitani Hiroshi Fukamachi Naofumi Hiehata Masashi Yamamoto Takeshi Hayashi

出版者

一般社団法人 園芸学会

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.OKD-013, (Released:2016-09-24)

被引用文献数

12

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We analyzed the pedigree records (1995–2010) of the Kuchinotsu Citrus Breeding Program (KCBP) at the National Institute of Fruit Tree Science (NIFTS) in Japan, abbreviated as NIFTS-KCBP, to reveal the genetic background and current status of inbreeding and genetic uniformity of the parental cultivars/genotypes and their F1 breeding progenies. The founding genotypes mostly used for crossing in NIFTS-KCBP were satsuma mandarin (Citrus unshiu Marcow.), sweet orange (C. sinensis [L.] Osbeck), king mandarin (C. nobilis Lour.), clementine (C. clementina hort. ex Tanaka), mediterranean mandarin (C. deliciosa Ten.), dancy tangerine (C. tangerina hort. ex Tanaka), and ponkan (C. reticulata Blanco). The intensive use of these seven genotypes and their progenies as crossed parents has led to a high degree of inbreeding in the breeding population. Moreover, these seven genotypes have dominated about 80% of the genetic composition of the breeding population. Although further studies are needed to reveal the influence of inbreeding and genetic uniformity on agronomically important traits, these data offer useful information for the selection of cross combinations and breeding strategies in the ongoing NIFTS citrus breeding program, Japan.