著者

NAOMICHI OGIHARA HIDEKI AMANO TAKEO KIKUCHI YUSUKE MORITA KUNIHIRO HASEGAWA TAKANORI KOCHIYAMA HIROKI C. TANABE

出版者

日本人類学会

雑誌

Anthropological Science (ISSN:09187960)

巻号頁・発行日

vol.123, no.1, pp.57-68, 2015 (Released:2015-04-23)

参考文献数

33

被引用文献数

4 15 2

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In order to discuss possible differences in brain anatomy between Neanderthals and early modern humans, the original antemortem appearance of fossil crania that enclosed the brain must somehow be correctly restored, as soft tissues such as the brain are generally not fossilized. However, crania are typically fractured, fragmented, and deformed due to compaction and diagenesis. Furthermore, recovery of all component fragments of fossil crania is rare. Restoration of the brain morphology of fossil crania therefore necessitates correct assembly of the available fragments, eliminating distortions, and compensating for missing parts as a first step. This paper reviews the current status of computerized reconstruction methods, then provides an overview and future directions toward digital reconstruction of fossil crania and the associated brain morphology.

著者

Yusuke Morita Daisuke Matsubara Mitsuru Seki Daisuke Tamura Toshihiro Tajima

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.258, no.3, pp.177-182, 2022 (Released:2022-10-25)

参考文献数

14

被引用文献数

3

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Perimyocarditis is a rare and serious cardiac complication following COVID-19 vaccination. Young males are most at risk after the second dose. With the introduction of the booster (third) dose, some reports have focused on the risk of perimyocarditis after a booster dose. However, no currently available report in Japan has comprehensively described this phenomenon. A healthy 14-year-old Japanese male, who had completed a two-dose primary series of the BNT162b2 (Pfizer-BioNTech) vaccine six months prior, developed fever and chest pain within 24 hours after a homologous booster dose. He was transferred to our institute because of worsening chest pain. A multiplex PCR test showed no evidence of active viral infections, including SARS-CoV-2. Electrocardiography revealed ST-segment elevation in almost all leads, suggesting pericarditis. Echocardiography showed normal systolic function. Laboratory data demonstrated C-reactive protein levels of 8.8 mg/dL and elevated cardiac damage markers (troponin T, 1.9 ng/mL; creatine phosphokinase, 1527 U/L; MB isoenzyme, 120 U/L), suggesting myocarditis. He was diagnosed with perimyocarditis associated with the booster dose, which was confirmed by cardiac magnetic resonance imaging four days after initial symptoms. Chest pain improved spontaneously along with a resolution of electrocardiographic findings and laboratory data within several days. He was discharged eight days after admission. Perimyocarditis is less frequent after a booster dose than after primary doses. In this case, the patient with booster-dose-associated perimyocarditis showed favorable clinical course without severe sequelae. The patient’s clinical course was consistent with findings on previous large-scale reports on primary-dose-associated perimyocarditis and case series on booster-dose-associated perimyocarditis.

著者

Yuta Seko Takao Kato Masayuki Shiba Yusuke Morita Yuhei Yamaji Yoshizumi Haruna Eisaku Nakane Tetsuya Haruna Moriaki Inoko

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.1, no.12, pp.617-622, 2019-12-10 (Released:2019-12-10)

参考文献数

25

被引用文献数

4

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Background:The aim of this study was to evaluate the association of isolated tricuspid regurgitation (TR) with long-term outcome in patients with preserved left ventricular ejection fraction (LVEF).Methods and Results:We retrospectively analyzed 3,714 patients who had undergone both scheduled transthoracic echocardiography and electrocardiography in 2013 in a hospital-based population, after excluding severe and moderate left-side valvular disease and LVEF <50%. We classified patients into 2 groups: moderate to severe TR (n=53) and no moderate to severe TR (n=3,661). Next, we generated a propensity score (PS)-matched cohort: the moderate to severe TR group and the no moderate to severe TR group (n=41 in each group). The primary outcome was a composite of all-cause death and major adverse cardiac events. In the moderate to severe TR group, patients were older, and more likely to have higher left atrial volume index and E/e’ than those in the no moderate to severe TR group. In the PS-matched cohort, cumulative 3-year incidence of the primary outcome was 61.5% in the moderate to severe TR group and 24.3% in the no moderate to severe TR group (log-rank P=0.043; hazard ratio, 2.86; 95% CI: 1.37–6.37).Conclusions:Isolated moderate to severe TR is associated with poor clinical outcome in patients with preserved LVEF.

著者

Tomohiro TAKAKI Kazuya NAKAGAWA Yusuke MORITA Eiji NAKAMACHI

出版者

一般社団法人日本機械学会

雑誌

Mechanical Engineering Journal (ISSN:21879745)

巻号頁・発行日

vol.2, no.3, pp.15-00063-15-00063, 2015 (Released:2015-06-15)

参考文献数

61

被引用文献数

1 6

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In this study, we applied a modified Kobayashi-Warren-Carter (KWC) phase-field model to the neurite growth process. To confirm the applicability of this model, we observed axonal extension of PC-12D cells cultured with nerve growth factor (NGF). Based on our observations, we defined three stages of nerve cell axonal extension: neurite generation, neurite contraction, and axon extension. We further determined the parameters in the phase-field equations to express the three extension stages. Finally, our results show that the modified KWC phase-field model reasonably expresses the morphologies of nerve cells and predicts the three stages of nerve cell axonal extension. Although, we employed the binary alloy solidification model as a sample model in the present phase-field simulations, this work will be extensible to relatively more realistic models for nerve cell growth.

著者

Tomohiro TAKAKI Kazuya NAKAGAWA Yusuke MORITA Eiji NAKAMACHI

出版者

一般社団法人日本機械学会

雑誌

Mechanical Engineering Journal (ISSN:21879745)

巻号頁・発行日

pp.15-00063, (Released:2015-05-22)

参考文献数

61

被引用文献数

1 6

---

In this study, we applied a modified Kobayashi-Warren-Carter (KWC) phase-field model to the neurite growth process. To confirm the applicability of this model, we observed axonal extension of PC-12D cells cultured with nerve growth factor (NGF). Based on our observations, we defined three stages of nerve cell axonal extension: neurite generation, neurite contraction, and axon extension. We further determined the parameters in the phase-field equations to express the three extension stages. Finally, our results show that the modified KWC phase-field model reasonably expresses the morphologies of nerve cells and predicts the three stages of nerve cell axonal extension. Although, we employed the binary alloy solidification model as a sample model in the present phase-field simulations, this work will be extensible to relatively more realistic models for nerve cell growth.

著者

NAOMICHI OGIHARA HIDEKI AMANO TAKEO KIKUCHI YUSUKE MORITA KUNIHIRO HASEGAWA TAKANORI KOCHIYAMA HIROKI C. TANABE

出版者

日本人類学会

雑誌

Anthropological Science (ISSN:09187960)

巻号頁・発行日

pp.141109, (Released:2015-01-29)

被引用文献数

4 15

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In order to discuss possible differences in brain anatomy between Neanderthals and early modern humans, the original antemortem appearance of fossil crania that enclosed the brain must somehow be correctly restored, as soft tissues such as the brain are generally not fossilized. However, crania are typically fractured, fragmented, and deformed due to compaction and diagenesis. Furthermore, recovery of all component fragments of fossil crania is rare. Restoration of the brain morphology of fossil crania therefore necessitates correct assembly of the available fragments, eliminating distortions, and compensating for missing parts as a first step. This paper reviews the current status of computerized reconstruction methods, then provides an overview and future directions toward digital reconstruction of fossil crania and the associated brain morphology.