著者

Yaping Liang Xiaojia Xu Mingjuan Yin Yan Zhang Lingfeng Huang Ruoling Chen Jindong Ni

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.66, no.1, pp.51-63, 2019 (Released:2019-01-28)

参考文献数

52

被引用文献数

76

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We conducted a systematic review and meta-analysis to evaluate the effect of Berberine on glucose in patients with type 2 diabetes mellitus and identify potential factors may modifying the hypoglycemic effect. We searched PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, and Wanfang Database to identify randomized controlled trials that investigated the effect of Berberine. We calculated weighted mean differences (WMD) and 95% confidence interval (CI) for fasting plasma glucose (FPG), postprandial plasma glucose (PPG) and glycated haemoglobin (HbA1c) levels. Twenty-eight studies were identified for analysis, with a total of 2,313 type 2 diabetes mellitus (T2DM) patients. The pool data showed that Berberine treatment was associated with a better reduction on FPG (WMD = –0.54 mmol/L, 95% CI: –0.77 to –0.30), PPG (WMD = –0.94 mmol/L, 95% CI: –1.27 to –0.61), and HbA1c (WMD = –0.54 mmol/L, 95% CI: –0.93 to –0.15) than control groups. Subgroup-analyses indicated that effects of Berberine on blood glucose became unremarkable as the treatment lasted more than 90 days, the daily dosage more than 2 g/d and patients aged more than 60 years. The efficiency of Berberine combined with hypoglycaemics is better than either Berberine or hypoglycaemic alone. The dosage and treatment duration of Berberine and patients’ age may modify the effect.

著者

Junxiu CAI Rebiya NULI Yan ZHANG Yangyi ZHANG Manfutong ABUDUSEMAITI Aizhatiguli KADEER Xiaoli TIAN Hui XIAO

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.65, no.4, pp.362-374, 2019-08-31 (Released:2019-08-31)

参考文献数

44

被引用文献数

10

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Observational and interventional studies have showed associations between dietary patterns and the risk of type 2 diabetes (T2DM). The aim of the present study was to identify dietary patterns and examine their association with incident of T2DM and physiopathologic mechanism in the Uygur population of Xinjiang, China. A community-based case control study in Urumqi, Xinjiang Uygur Autonomous Region, China. We enrolled 836 Uygur adults (345 newly diagnosed T2DM and 491 healthy controls) receiving physical examination in community health service centers. Dietary patterns were evaluated using a validated 121 items semi-quantitative food frequency questionnaire (SQFFQ). Dietary patterns were identified by exploratory factor analysis. Data on demographic, anthropometric, socioeconomic characteristics were collected. Homeostasis model assessment index for insulin resistance (HOMA-IR) and for β cell function (HOMA-β) were calculated. Multivariate logistic regression were used to estimate the associations between dietary patterns and the risk of T2DM and multiple linear regression were used to evaluate the association between dietary patterns and fasting plasm glucose (FPG), fasting insulin (FINS), HOMA-IR and HOMA-β, adjusting for confounding factors. Five major dietary patterns were identified: (1) the “vegetable and tubes” pattern; (2) the “fruit and nut” pattern; (3) the “refined grains and meat” pattern; (4) the “dairy, legume and egg” pattern; and (5) the “oil and salt” pattern. Logistic regression results demonstrated that the “vegetable and tubes” dietary pattern and the “fruit and nut” dietary pattern were related to T2DM, OR values were 0.223 (95% CI: 0.135-0.371), 0.160 (95% CI: 0.093-0.275), respectively. The “refined grains and meat” dietary pattern and the “oil and salt” dietary pattern were related to T2DM, OR values were 6.146 (95% CI: 3.217-11.739), 9.554 (95% CI: 5.668-16.104), respectively. Multiple linear regression analysis showed that the above five dietary patterns were related to log (FPG), β values were −0.040, −0.039, 0.028, −0.010 and 0.036, respectively, all p<0.05. The “vegetable and tubes” pattern, the “fruit and nut” pattern, the “refined grains and meat” pattern and the “oil and salt” pattern were related to log (HOMA-IR), β values were −0.061, −0.060, 0.045, and 0.042, and were related to log (HOMA-β), β values were 0.071, 0.063, −0.035 and −0.070, respectively, all p<0.05. The “refined grains and meat” dietary pattern and the “oil and salt” dietary pattern may be the important reason for the rapid increase of T2DM incidence among Chinese Uygur residents. Our findings suggest that modifying dietary patterns could reduce T2DM incidence in the adult Uygur population.

著者

Yaping Liang Xiaojia Xu Mingjuan Yin Yan Zhang Lingfeng Huang Ruoling Chen Jindong Ni

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ18-0109, (Released:2018-11-03)

被引用文献数

76

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We conducted a systematic review and meta-analysis to evaluate the effect of Berberine on glucose in patients with type 2 diabetes mellitus and identify potential factors may modifying the hypoglycemic effect. We searched PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, and Wanfang Database to identify randomized controlled trials that investigated the effect of Berberine. We calculated weighted mean differences (WMD) and 95% confidence interval (CI) for fasting plasma glucose (FPG), postprandial plasma glucose (PPG) and glycated haemoglobin (HbA1c) levels. Twenty-eight studies were identified for analysis, with a total of 2,313 type 2 diabetes mellitus (T2DM) patients. The pool data showed that Berberine treatment was associated with a better reduction on FPG (WMD = –0.54 mmol/L, 95% CI: –0.77 to –0.30), PPG (WMD = –0.94 mmol/L, 95% CI: –1.27 to –0.61), and HbA1c (WMD = –0.54 mmol/L, 95% CI: –0.93 to –‍0.15) than control groups. Subgroup-analyses indicated that effects of Berberine on blood glucose became unremarkable as the treatment lasted more than 90 days, the daily dosage more than 2 g/d and patients aged more than 60 years. The efficiency of Berberine combined with hypoglycaemics is better than either Berberine or hypoglycaemic alone. The dosage and treatment duration of Berberine and patients’ age may modify the effect.

著者

張 艶 Yan Zhang

雑誌

二松学舎大学國際政経論集

巻号頁・発行日

vol.14, pp.137-158, 2008-03

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中国の株式市場は1990年から本格的にスタートし、中国経済の急成長とともに急速に伸びてきた。現在、新興国の株式市場として大きく注目されており、その存在感はますます高まっている。中国株式市場が成長する一方、株価の変動も激しく、低迷の時期も経験した。政府は株式市場の安定成長を目指して、非流通株の放出、法制度の整備など、次々と政策を打ち出し、試行錯誤を繰り返しながら、中国の株式市場はその形を整えつつある。本論文では、中国の株式市場を考察し、株式市場の発展、問題点および株式市場に影響する要因を明らかにし、株式市場に対する政策のインプリケーションを導き出す。本論文では、中国の株式市場を分析対象として、まず、株式市場の発展過程と問題点などについて考察した。そして、中国の株式市場をより的確に理解するために、データ生成過程(DGP)の慎重な検討を踏まえて、I(0)変数という点で、上海総合指数、固定資産投資、工業総生産、社会商品小売総額の4変数について、Granger因果性テスト、インパルス反応、分散分解などの分析を試みた。Granger因果性テストでは、上海総合指数に対して、固定資産投資、社会商品小売総額からGrangerの意味での因果関係はあった。工業総生産は上海総合指数に対し、Grangerの意味での因果関係はない。さらに、DGPの視点から、4変数VARモデルが中国の株価を分析する上で有益であることを明らかにした。インパルス反応では、固定資産投資、工業総生産、社会商品小売総額3変数のうち、株価にもっとも影響するのは固定資産投資であった。次は、家計消費の代理変数と考えられる社会商品小売総額であった。分散分解では、上海総合指数の変動は3変数のうち、固定資産投資がもっとも大きく説明できた。固定資産投資は中国経済の高度成長を牽引しているだけでなく、中国の株式市場にも影響していることが分かった。高成長の中国では、過剰な固定資産投資はいつも問題視されているが、その急激な縮小は不測の混乱をもたらす恐れがあるため、緩やかな調整が望まれる。The stock market in China started in 1990, and has expanded rapidly. Stock fluctuation has been very sharp as the stock market has matured in China. The government has implemented policies one after another aiming at the stable growth of the stock market. The purpose of this paper was as follows. I clarified development and problems of the stock market in China, analyzed the factors that influence the stock market, and derived implications of the policy for the stock market. In this paper, first of all, development and problems of the stock market were considered. Then after the data generation process was carefully examined, from the viewpoint of 1(0) variables, analyses were tried using the Granger test, impulse response, and variance decomposition of four variables (Shanghai stock exchange composite index, investment in fixed assets, total industrial production, and total retail amount of commodities). With the Granger test for the Shanghai stock exchange composite index, there were Granger causal relations from investment in fixed assets and the total retail amount of commodities, but there was not a Granger causal relation from total industrial production. Furthermore, it was clarified that a four-variable VAR model was useful for analyzing the stock market in China from the viewpoint of DGP. In impulse response, it was investment in fixed assets that influenced the Shanghai stock exchange composite index most among the three variables. Next in order of influence was total retail amount of commodities. In variance decomposition, investment in fixed assets was most useful in explaining the fluctuation of the Shanghai stock exchange composite index among the three variables. It has been understood that investment in fixed assets not only stimulates the high growth of the economy, but also influences the stock market in China. Although excessive investment in fixed assets is always brought into question now, gradual adjustment is expected because sudden reduction might bring unexpected confusion.

著者

Hiroshi Yatsuya Yuanying Li Yoshihisa Hirakawa Atsuhiko Ota Masaaki Matsunaga Hilawe Esayas Haregot Chifa Chiang Yan Zhang Koji Tamakoshi Hideaki Toyoshima Atsuko Aoyama

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20170048, (Released:2018-03-17)

参考文献数

36

被引用文献数

12

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Background: Relatively little evidence exists for type 2 diabetes mellitus (T2DM) prediction models from long-term follow-up studies in East Asians. This study aims to develop a point-based prediction model for 10-year risk of developing T2DM in middle-aged Japanese men.Methods: We followed 3,540 male participants of Aichi Workers’ Cohort Study, who were aged 35–64 years and were free of diabetes in 2002, until March 31, 2015. Baseline age, body mass index (BMI), smoking status, alcohol consumption, regular exercise, medication for dyslipidemia, diabetes family history, and blood levels of triglycerides (TG), high density lipoprotein cholesterol (HDLC) and fasting blood glucose (FBG) were examined using Cox proportional hazard model. Variables significantly associated with T2DM in univariable models were simultaneously entered in a multivariable model for determination of the final model using backward variable selection. Performance of an existing T2DM model when applied to the current dataset was compared to that obtained in the present study’s model.Results: During the median follow-up of 12.2 years, 342 incident T2DM cases were documented. The prediction system using points assigned to age, BMI, smoking status, diabetes family history, and TG and FBG showed reasonable discrimination (c-index: 0.77) and goodness-of-fit (Hosmer-Lemeshow test, P = 0.22). The present model outperformed the previous one in the present subjects.Conclusion: The point system, once validated in the other populations, could be applied to middle-aged Japanese male workers to identify those at high risk of developing T2DM. In addition, further investigation is also required to examine whether the use of this system will reduce incidence.

著者

Yan ZHANG Xiaoyan HUANG Wenfang LIU Zeneng CHENG Chuanpin CHEN Lihui YIN

出版者

(社)日本分析化学会

雑誌

Analytical Sciences (ISSN:09106340)

巻号頁・発行日

vol.29, no.10, pp.985-990, 2013-10-10 (Released:2013-10-10)

参考文献数

34

被引用文献数

3 24

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Illegal chemicals, which could cause unpredictable side effects, may be added into traditional Chinese medicine (TCM) for a rapid healing effect. In this report, a surface-enhanced Raman scattering (SERS) analysis method for five kinds of illegally added drugs (rosiglitazone maleate, phenformin hydrochloride, metformin hydrochloride, pioglitazone hydrochloride and sibutramine hydrochloride) in Chinese traditional patent medicine (CTPM) has been demonstrated, including simultaneous detections of drug mixtures with CTPM. Silver colloidal, prepared by a sodium citrate reaction, was used as a SERS substrate. The optimum pH condition for each drug has also been explored because of its combined effect on protonation, surface charge, repulsion of an analyte and nanoparticles. Furthermore, the simultaneous detection of two or three kinds of these chemicals has been carried out. Characteristic peaks are employed for qualitative analysis. This is the first research using SERS for the analysis of drug mixtures in CTPM without any separation process.

著者

Dongliang Wang Maoxuan Liu Jichao Cao Yanna Cheng Chen Zhuo Hongyan Xu Shousheng Tian Yan Zhang Jian Zhang Fengshan Wang

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.35, no.12, pp.2128-2132, 2012-12-01 (Released:2012-12-01)

参考文献数

28

被引用文献数

9 48

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Colla corii asini (E’jiao), donkey-hide gelatin prepared by stewing and concentrating from Equus asinus L. donkey hide, is a traditional Chinese medicine preparation widely used in clinical hematic antanemic therapy in China. The aim of the present study was to investigate potential anti-aging effect of Colla corii asini and explore related mechanisms in D-galactose (gal) induced aging model mice. The mice were artificially induced aging by subcutaneously injection with D-gal at the dose of 100 mg/kg·d for 8 weeks. Colla corii asini was simultaneously treated to them once daily by intragastric gavage. Appetite, mental condition, body weight, and organ index were observed. Activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), as well as levels of malondialdehyde (MDA) in serum, brain, and liver were determined by according assay kits. Western blotting analysis was used to detect p16 and p21 expression. Results indicated that Colla corii asini could improve appetite, mental condition, body weight, and organ condition of model mice, improve SOD, CAT, and GSH-Px activities, reduce MDA levels, and modulate age-related genes expression in D-gal induced mice. Therefore, Colla corii asini may have effect to suppress the aging process through enhancing antioxidant activity, scavenging free radicals, and modulating aging-related gene expression.