著者

Ying Zou Hongying Guo Yuyi Zhang Zhengguo Zhang Yu Liu Jiefei Wang Hongzhou Lu Zhiping Qian

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

BioScience Trends (ISSN:18817815)

巻号頁・発行日

pp.2020.03086, (Released:2020-04-30)

参考文献数

15

被引用文献数

73

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To investigate the characteristic of coagulation function in 303 patients with Coronavirus disease 2019 (COVID-19), we evaluated the correlation between coagulation function and disease status. We retrospectively analyzed 303 patients diagnosed with COVID-19 and evaluated the clinical data of 240 patients who were discharged. The coagulation function of the two groups (mild and severe) was compared. Compared with the mild group, majority of patients in the severe group were male (76.9% vs. 49.8%) and elderly (median age 65 vs. 50), and the proportion with chronic underlying diseases was higher (73.1% vs. 36.1%). There were 209 abnormalities (69.0%) of coagulation parameters in 303 patients admitted to hospital. Comparison of various indexes of coagulation function between the two groups in admission, the proportion of abnormal coagulation indicators in the severe group was higher than that in the mild group (100% vs. 66.1%). The median coagulation parameters in the severe group were higher than those in the mild group: international normalized ratio (1.04 vs. 1.01), prothrombin time (13.8 vs. 13.4) seconds, activated partial thromboplastin time (43.2 vs. 39.2) seconds, fibrinogen (4.74 vs. 4.33) g/L, fibrinogen degradation products (2.61 vs. 0.99) µg/mL, and D-dimer (1.04 vs. 0.43) µg/mL, the differences were statistically significant (p < 0.05). Coagulation dysfunction is common in patients with COVID-19, especially fibrinogen and D-dimer elevation, and the degree of elevation is related to the severity of the disease. As the disease recovers, fibrinogen and activated partial thromboplastin time also return to normal.

著者

Zhiqiang Wang Xin Liu Zhiqiang Li Xiaosong Wang Minghua Wang Quan Li Yan Li Yu Liu

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE Electronics Express (ISSN:13492543)

巻号頁・発行日

vol.19, no.23, pp.20210286, 2022-12-10 (Released:2022-12-10)

参考文献数

35

被引用文献数

1

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This paper presents a four-way current-combining Ka-band power amplifier (PA) in 65-nm CMOS technology. A symmetrical, transmission line based four-way current combiner, together with output transformers, is used to transfer the high load impedance (4*ZL) to the desired Zopt for each power unit cell. Besides, both interstage/input flexible matching transformers and the power splitter are optimized to improve the performance. Based on the methodology mentioned above, the power amplifier demonstrates a small-signal gain of about 24.12 dB, a saturated output power of 21.56 dBm, and a peak power-added efficiency of 27.3% at 35GHz.

著者

Zhe-Yu Liu Jiao-Jiao Ji Feng Jiang Xing-Rui Tian Jian-Kuan Li Jian-Ping Gao

出版者

Japanese Society for Plant Biotechnology

雑誌

Plant Biotechnology (ISSN:13424580)

巻号頁・発行日

vol.39, no.3, pp.251-257, 2022-09-25 (Released:2022-09-25)

参考文献数

33

被引用文献数

4

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Codonopsis pilosula, a traditional Chinese medicinal and edible plant, contains several bioactive components. However, the biosynthetic mechanism is unclear because of the difficulties associated with functional gene analysis. Therefore, it is important to establish an efficient genetic transformation system for gene function analysis. In this study, we established a highly efficient Agrobacterium-mediated callus genetic transformation system for C. pilosula using stems as explants. After being pre-cultured for 3 days, the explants were infected with Agrobacterium tumefaciens strain GV3101 harboring pCAMBIA1381-35S::GUS at an OD600 value of 0.3 for 15 min, followed by co-cultivation on MS induction medium for 1 day and delayed cultivation on medium supplemented with 250 mg l−1 cefotaxime sodium for 12 days. The transformed calli were selected on screening medium supplemented with 250 mg l−1 cefotaxime sodium and 2.0 mg l−1 hygromycin and further confirmed by PCR amplification of the GUS gene and histochemical GUS assay. Based on the optimal protocol, the induction and transformation efficiency of calli reached a maximum of 91.07%. The establishment of a genetic transformation system for C. pilosula calli lays the foundation for the functional analysis of genes related to bioactive components through genetic engineering technology.

著者

Yu Liu Kento Emoto Kiminori Matsuzaki Zhenjiang Hu

出版者

Information and Media Technologies 編集運営会議

雑誌

Information and Media Technologies (ISSN:18810896)

巻号頁・発行日

vol.9, no.1, pp.73-82, 2014 (Released:2014-03-15)

参考文献数

28

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MapReduce programming model attracts a lot of enthusiasm among both industry and academia, largely because it simplifies the implementations of many data parallel applications. In spite of the simplicity of the programming model, there are many applications that are hard to be implemented by MapReduce, due to their innate characters of computational dependency. In this paper we propose a new approach of using the programming pattern accumulate over MapReduce, to handle a large class of problems that cannot be simply divided into independent sub-computations. Using this accumulate pattern, many problems that have computational dependency can be easily expressed, and then the programs will be transformed to MapReduce programs executed on large clusters. Users without much knowledge of MapReduce can also easily write programs in a sequential manner but finally obtain efficient and scalable MapReduce programs. We describe the programming interface of our accumulate framework and explain how to transform a user-specified accumulate computation to an efficient MapReduce program. Our experiments and evaluations illustrate the usefulness and efficiency of the framework.

著者

Chih-Hsiu Cheng Hao-Tsung Su Ling-Wei Yen Wen-Yu Liu Hsin-Yi Kathy Cheng

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.27, no.4, pp.1271-1276, 2015 (Released:2015-04-30)

参考文献数

15

被引用文献数

4 30

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[Purpose] Nonspecific neck pain is a common musculoskeletal disease. Therapeutic exercise has been shown to improve pain and disability in short-term and midterm follow-ups. This study performed a literature review of the long-term effects of therapeutic exercise on subjects with nonspecific chronic neck pain. [Subjects and Methods] The databases of the CINAHL, MEDLINE, PEDro and PubMed were used. Randomized controlled trials (RCT) published from January 2000 to January 2014 and explicitly including a one-year follow-up were identified. [Results] Only six articles were included in this review. They had scores of 5 to 8 points on the PEDro scale, and the level of evidence was grade I. The study results show that the main exercises used were cervical strengthening and endurance training exercise. Short-term exercises (10 to 12 weeks) helped to improve the body function, structure, activity and participation immediately after the intervention, but not at the long-term follow-up. On the other hand, long-term interventions (1 year) resulted in improvements in body function and structure at the 3 year follow-up. [Conclusion] The results of the six high-quality studies suggest that long-term exercise have long-term benefits for patients with nonspecific neck pain in terms of body function and structure.

著者

Po-Yu Liu Chin-Fu Lin Kwong-Chung Tung Ching-Lin Shyu Ming-Ju Wu Jai-Wen Liu Chi-Sen Chang Kun-Wei Chan Jin-An Huang Zhi-Yuan Shi

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.52, no.4, pp.431-438, 2013 (Released:2013-02-15)

参考文献数

50

被引用文献数

6 43

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Objective Shewanella bacteremia is an uncommon but potentially fatal disease. Although hepatobiliary diseases have been proposed to be risk factors for various Shewanella infections, little is known about the features of Shewanella bacteremia in patients with hepatobiliary diseases. This study aims to characterize the presentation and risk factors of Shewanella bacteremia in patients with hepatobiliary diseases. Methods We retrospectively investigated the clinical features, microbiology and outcomes of patients with Shewanella bacteremia who were admitted to a tertiary medical center between January 2001 and December 2010. All isolates were confirmed to the species level using 16S rRNA sequencing analyses. The English language medical literature was searched for previously published reports. Results Fifty-nine cases of Shewanella bacteremia, including nine at the hospital, were identified, 28 (47.4%) of which involved underlying hepatobiliary diseases, representing an important risk factor. In 12 of the 28 cases, the infections involved the hepatobiliary system; with a tendency towards an Asian origin. In our case series of nine patients, Shewanella haliotis was isolated in five patients. The majority of our patients lived in coastal areas, consumed seafood regularly and developed bacteremia during the summer season. Conclusion It is recommended that the possibility for Shewanella infection be considered in patients with bacteremia and also underlying hepatobiliary diseases, particularly if patients present with hepatobiliary infections, a history of seafood, or development of the disease during the summer.