著者

Ken OKABAYASHI Takanori NARITA Saki TAKASHIRO Sawako NADAOKA Shuichiro KANAI Daisuke ITO Masato KITAGAWA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.18-0491, (Released:2019-01-22)

被引用文献数

5

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This study was undertaken to establish a method for measuring mRNA expression by using real-time RT-PCR in the diagnosis of canine meningiomas. When performing real-time RT-PCR, it is essential to include appropriate control tissues and to select appropriate housekeeping genes as an internal standard. Based on the results of our study, RPS18 constitutes a suitable internal standard for the comparison of mRNA expression between normal meninges and meningiomas. The results showed increased mRNA expression of VEGFA and EGFR; however, mRNA expression of KDR was reduced. Measuring mRNA expression by using real-time RT-PCR with appropriate control tissues and internal standards can provide useful information to understanding the pathogenesis of canine meningiomas, which corresponds with immunohistochemical findings.

著者

Seongjae CHOI Ye-In OH Keun-Ho PARK Jeong-Seok LEE Jin-Hyung SHIM Byung-Jae KANG

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.18-0158, (Released:2019-01-18)

被引用文献数

15

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Limb-sparing surgery is one of the surgical options for dogs with distal radial osteosarcoma (OSA). This case report highlights the novel application of a three-dimensional (3D)-printed patient-specific polycaprolactone/β-tricalcium phosphate (PCL/β-TCP) scaffold in limb-sparing surgery in a dog with distal radial OSA. The outcomes evaluated included postoperative gait analysis, complications, local recurrence of tumor, metastasis, and survival time. Post-operative gait evaluation showed significant improvement in limb function, including increased weight distribution and decreased asymmetry. The implant remained well in place and increased bone opacity was observed between the host bone and the scaffold. There was no complication due to scaffold or surgery. Significant improvement in limb function and quality of life was noted postoperatively. Local recurrence and pulmonary metastasis were identified at 8 weeks postoperatively. The survival time from diagnosis of OSA to death was 190 days. The PCL/β-TCP scaffold may be an effective alternative to cortical allograft in limb-sparing surgery for bone tumors.

著者

Adam STERN

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.18-0586, (Released:2018-12-14)

被引用文献数

2

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Cases of hyperthermia caused by exposure to high environmental temperature are not uncommonly encountered in dogs. The circumstances surrounding the exposure to high environmental temperature may be accidental or intentional; thus highlighting the importance to perform a forensic autopsy. This report documents three cases of canine environmentally induced hyperthermia and all dogs in this report died less than 6 hrs after exposure to the high environmental temperatures. The most commonly observed macroscopic findings included cutaneous petechial and ecchymotic hemorrhage, pulmonary edema and congestion, and epicardial and endocardial hemorrhage. Microscopically, there was systemic vascular congestion and hemorrhage, fibrin thrombi formation, and occasional enterocyte and/or renal tubular necrosis. The findings from all cases were consistent with hyperthermia induced disseminated intravascular coagulation.

著者

Shintaro KIMURA Midori YAMAZAKI Manabu TOMOHISA Takashi MORI Tokuma YANAI Sadatoshi MAEDA Hiroaki KAMISHINA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.18-0257, (Released:2018-11-08)

被引用文献数

8

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A 4-year-old, male Bernese mountain dog was evaluated for a 1-year history of right hemiparesis. Computed tomography revealed a large hypoattenuating mass severely deforming the C5 vertebral arch, invading the C6 spinal canal, and causing spinal cord compression. The signal characteristics of magnetic resonance imaging indicated a lesion composed of adipose tissue. The mass was removed via right hemilaminectomy, and histopathological examination confirmed it was an infiltrative lipoma. The compressive lesion remained unresolved, so the dog underwent a second operation, after which he regained some ambulatory function. Although postoperative adjunctive radiation therapy was performed, the dog died 201 days after the first operation.

著者

Yusuke KIMURA Takashi HARADA Takafumi SASAKI Tomoko IMAI Noboru MACHIDA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.18-0272, (Released:2018-09-21)

被引用文献数

3

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A 10-week-old miniature dachshund presented with acute onset of weakness. Electrocardiography showed sustained ventricular tachycardia, and thoracic and abdominal radiography revealed pleural and peritoneal effusion. Echocardiography revealed severely hypokinetic left and right ventricles. Thoracocentesis and abdominocentesis and subsequent transfer to an oxygen chamber yielded no clinical improvement, and the dog died about 1 hr after admission. Gross examination of a longitudinal section through the entire heart revealed poorly demarcated focal or patchy areas of grayish-white tissue infiltrating extensively into the myocardium. Histologically, these lesions were consistent with infiltrative proliferation of neoplastic lymphoid cells. Immunohistochemical staining confirmed the diagnosis of primary cardiac lymphoma (PCL) of T-cell origin. There have been no previous reports of such young dogs with PCL.

著者

Mohamed ABDO Khaled SHOGHY Yoshinao Z. HOSAKA Tomohiro IMAGAWA Safwat ALI Atef ERASHA Masato UEHARA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0225, (Released:2014-07-30)

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This article has been retracted by the Editorial Board of Journal of Veterinary Medical Science due to a violation of the journal's “Information for Authors”.

著者

Shin-ichi HAYAMA Sachie NAKIRI Fumiharu KONNO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.73, no.6, pp.809-812, 2011 (Released:2011-07-05)

参考文献数

14

被引用文献数

4 10

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This study is the first to determine the conception dates of specific individuals and estimate the pregnancy rate of a wild population in Japanese monkeys. The conception dates estimated from the embryonic ages of 37 fetuses were distributed over 128 days between September 17 and January 23, with a mean conception date of November 19 (SD=29.2 days). A comparison of the mean conception dates among age groups showed a significantly delayed conception in the subadult animals (aged 4 to 5 years; December 5, n=8) than in the adult animals (aged 6 or more years; November 15, n=29; P<0.03). The mean pregnancy rate among animals aged 4 years or more in this local population was estimated to be 48.5% (32/66).

著者

山田 英一 住吉 浩 山我 義則 岡本 芳晴

出版者

社団法人日本獣医学会

雑誌

The journal of veterinary medical science (ISSN:09167250)

巻号頁・発行日

vol.68, no.7, pp.669-674, 2006-07-25

参考文献数

16

被引用文献数

1 5

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犬猫におけるレーザー腸管溶接法を開発した.腸管は本実験用に開発した有窓式鉗子(LW鉗子)ではさみ,2種類の接触型プローブ(先端鈍:レーザー・バイポーラ・デセクター(LBD),先端鋭:スーパー・スカルペル・デセクター(SSD))を用いてLW鉗子の有窓部よりレーザーを照射し,腸管を溶接・切離した.半導体レーザー出力と溶接力の結果より,LBDを用いた場合の至適条件は犬猫ともに回腸では6〜10W,結腸では8〜10Wであった.また,SSDにおいては大の回腸では6〜8W,結腸では8〜10Wであった.一方,猫の回腸では10W,結腸では6〜8Wであった.さらにLBD,SSDともに回腸と結腸の間に溶接力の大きな差は見られなかった.有意差は認められなかったが,同一出力ではLBDの方が溶接力が強い傾向にあった.組織学的に,溶接部は完全に接合されていることが確認された.以上のことより,犬および猫の回腸または結腸のレーザー溶接は,LW鉗子を用い,LBDまたはSSDプローブで半導体レーザーを約8W,50-80秒(400-640J/cm)の条件で行えることがあきらかとなり,生体にも十分臨床応用できるものと思われた.

著者

Satoshi TAKAGI Yumiko KAGAWA Kiwamu HANAZONO Shoko MURAKAMI Tatsuya DEGUCHI Yusuke IZUMI Kenji HOSOYA Sangho KIM Masahiro OKUMURA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.18-0148, (Released:2018-07-13)

被引用文献数

1

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A 10-year-old cat presented for evaluation with a 1-month history of salivation and oral bleeding. A right mandibular mass was palpated and computed tomography examination revealed entire bone proliferation. Mandibular bone biopsy was performed, and histopathological diagnosis was vascular hamartoma. The cat suddenly died on day 140.

著者

Sangwan PARK Kiwoong KIM Youngbeum KIM Kangmoon SEO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0532, (Released:2017-12-15)

被引用文献数

6

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A seven-month-old female domestic shorthaired cat was presented for buphthalmos in the right eye and corneal cloudiness in the left eye. Full ophthalmic examinations were performed for both eyes and enucleation was done for the right nonvisual eye. Congenital glaucoma caused by anterior segment dysgenesis was confirmed for the right eye. In the left eye, slit-lamp examination revealed focal corneal edema with several iris strands from iris collarette to the affected posterior corneal surfaces. Circular posterior corneal defect was suggested to be the cause of edema. Goniodysgenesis, additionally, was identified. Taken together, the diagnosis of Peters’ anomaly which is a subtype of anterior segment dysgenesis was suggested in the left eye.

著者

Akihisa SUWA Tetsuya SHIMODA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0619, (Released:2018-06-25)

被引用文献数

15

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Hemophagocytic syndrome (HPS) is a clinicopathological entity characterized by histiocytic proliferation, with marked hemophagocytosis in the reticuloendothelial organs. HPS caused by lymphoma is termed lymphoma-associated hemophagocytic syndrome (LAHS), and there are few reports on canine and feline LAHS. The objective of this study was to examine the clinical, diagnostic, and clinicopathologic features of LAHS in six dogs. The diagnostic criteria of LAHS consisted of lymphoma, bicytopenia or pancytopenia in the blood, and increased hemophagocytosis in the reticuloendothelial organs. In one dog, an ocular form of lymphoma was recognized. A splenic form was recognized in two dogs, and a hepatosplenic form was recognized in three dogs. Immunophenotyping revealed T-cell origin in five dogs and B-cell origin in one dog by polymerase chain reaction for antigen receptor rearrangement analysis. Nonspecific esterase stain was performed to differentiate between neoplastic lymphocytes and hemophagocytes. All five dogs with T-cell lymphoma were diagnosed with large granular lymphocyte (LGL) lymphoma. In three cases, palliative therapy with glucocorticoids was conducted, while the other three cases received chemotherapy as well. The survival times for the three dogs with glucocorticoids only were 6, 6, and 10 days and were 30, 54, and 68 days for the three treated with anticancer therapy. The median survival time for the dogs was 20 days. This report indicates that canine LAHS is likely to be caused by LGL lymphoma, and it has an aggressive behavior and poor general prognosis, as seen in humans.

著者

Yasutomo HORI Kensuke NAKAMURA Nobuyuki KANNO Makoto HITOMI Yohei YAMASHITA Satoshi HOSAKA Noriko ISAYAMA Takahiro MIMURA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0557, (Released:2018-06-22)

被引用文献数

1

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Alacepril is a relatively novel angiotensin-converting enzyme inhibitor; however, the safety, tolerance, and efficacy of alacepril in terms of cough suppression in dogs with mitral valve disease (MVD) remain unknown. The aim of this study was to investigate the safety, tolerance, and cough suppression efficacy of alacepril in dogs with MVD. This was a multi-center, prospective study. Forty-two dogs with echocardiographic or radiographic evidence of cardiac enlargement in addition to cough were enrolled. Dogs were treated with alacepril (1.0–3.0 mg/kg/day) for at least 4 weeks. One dog (2.4%) developed complications, including appetite loss, lethargy, and vomiting. Thirty-six dogs were re-evaluated after 4 weeks of treatment. Cough resolved or improved in 20 dogs (55.6%) after treatment. Based on the efficacy of alacepril, the dogs were divided into an effective group (n=20) and an ineffective group (n=16). After treatment, the left ventricular end-diastolic internal diameter corrected for body weight was significantly increased from baseline in the ineffective group but was significantly decreased in the effective group. Univariate binomial logistic regression analyses showed that high atrial natriuretic peptide level, N-terminal pro-B-type natriuretic peptide level, and E wave velocity at baseline were significantly correlated with alacepril inefficacy. Alacepril as treatment for MVD is well tolerated in most dogs, and different conditions of cardiac loading may influence the effect of the drug. Alacepril is expected to improve the quality of life of dogs with early stage MVD.

著者

TAJIMA Yuko MAEDA Kaori K. YAMADA Tadasu

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.77, no.1, pp.45-51, 2015

被引用文献数

9

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One hundred and twenty stranding events of Stejneger's beaked whales were reported in Japan between 1999 and 2011. The purpose of this study is to introduce pathological data and to discuss probable causes of death for 44 Stejneger's beaked whales among them. The significant pathological findings were the pulmonary edema, parasitic granulomatous nephritis, emaciation, amyloidosis, suppurative bronchopneumonia and so on. The probable causes of death were categorized as noninfectious in 43 of the cases, which included drowning, starvation and secondary amyloidosis. One individual was diagnosed with septicemia, which was the only example of an infectious disease. Because we could not always perform advanced analyses, such as microbiology tests, biotoxin examinations or contaminant analyses, the finality of our findings may be impaired. However, the present study has broad implications on the causes of death of Stejneger's beaked whales of the seas around Japan, which are valuable for the future studies and for the detection of emerging diseases.

著者

Minami GOTO Kayoko YONEMARU Akihiro HIRATA Hidenari FURUHASHI Tokuma YANAI Hiroki SAKAI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0602, (Released:2018-01-25)

被引用文献数

4

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A mass was found at the base of the dorsum linguae of a male 11-year-old Labrador retriever. The tumor comprised of ganglion cells and Schwannian cells with Verocay bodies. The ganglion cells were positive for neuron-specific enolase, S-100, nerve growth factor receptor, and beta III tubulin. The Schwannian cells were positive for neuron-specific enolase, S-100, nerve growth factor receptor, and glial fibrillary acidic protein. The lingual mass was diagnosed as a ganglioneuroma. To our knowledge, there has been no previous report of a lingual ganglioneuroma in a dog.

著者

Daji NOH Wooson CHOI Woochan SON Manhee LEE Seungchun PARK Kija LEE

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0357, (Released:2017-11-14)

被引用文献数

2

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Liposarcoma of the spermatic cord is extremely rare in dogs and humans. This report describes the clinical signs, typical diagnostic imaging including ultrasound and computed tomography, and treatment of a liposarcoma of the spermatic cord of a Toy Poodle confirmed by histological examination after a surgical procedure. This case highlights the importance of preoperative diagnostic imaging and histopathological examination in dogs with an inguinal or scrotal mass.

著者

Luciana Gonçalves TEIXEIRA Michelli Westphal De ATAIDE Vanessa MILECH Felipe Baldissarella GAVIOLI Bernardo Nascimento ANTUNES Stephanie Lanzarini ABATI Mauricio Veloso BRUN Saulo Tadeu Lemos PINTO FILHO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0280, (Released:2017-10-31)

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Urethral prolapse is a rare condition in dogs and cats. A 7-month-old male cat presented with intermittent penile bleeding and a red mass protruding from the tip of the penis. Urethral prolapse was diagnosed by using a surgical microcamera to examine the genital area. Urethroplasty and preputial advancement surgery were performed using a surgical microscope, to successfully correct the urethral prolapse.

著者

Won Dong-Sun Park Chul In Young-Joo PARK Hee-Myung

出版者

社団法人日本獣医学会

雑誌

The journal of veterinary medical science (ISSN:09167250)

巻号頁・発行日

vol.66, no.5, pp.551-553, 2004-05-25

参考文献数

9

被引用文献数

7

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3ヵ月齢のメスのシベリアトラが,後肢運動失調を主訴として建国大学獣医学教育病院に来院した.患畜は離乳後牛肉のみを給餌されており,カルシウム剤やビタミン剤は与えられていなかった.その症状は運動失調と,触診による後躯の疼痛であった.さらに,歩行異常,体動嫌悪,また神経学的検査により反射運動低下がみられた.レントゲンのラテラル像およびV-D像で腰仙骨の骨軟化性変化が観察された.PTHレベルは,猫のそれと比較して,上昇が認められた.以上の所見から本症例は栄養性二次性上皮小体機能亢進症と診断された.患畜の症状はビタミンDおよびカルシウム投与後,改善された.すなわち本症例は,カルシウムとリンの音量が不均衡な肉食で飼育された野生動物に発生した栄養性上皮小体機能亢進症である.

著者

Miyuu TANAKA Shinobu YAMAGUCHI Hideo AKIYOSHI Masaya TSUBOI Kazuyuki UCHIDA Takeshi IZAWA Jyoji YAMATE Mitsuru KUWAMURA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0487, (Released:2017-10-10)

被引用文献数

1

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Neuroaxonal dystrophy (NAD) is a neurodegenerative disease characterized by severe axonal swelling (spheroids) throughout the nervous system. In dogs, NAD has been reported in several breeds and a missense mutation in PLA2G6 gene has recently been identified in the Papillon dog NAD. Here we performed ultrastructural analysis to clarify the detailed ultrastructural features of the Papillon dog NAD. Dystrophic axons consisted of accumulation of filamentous materials, tubulovesicular structures, and swollen edematous mitochondria with degenerated inner membranes were often observed in the CNS. At axonal terminals, degeneration of presynaptic membrane was also detected. As reported in Pla2g6 knockout mice, mitochondrial and presynaptic degeneration may be related with the pathogenesis of NAD in Papillon dogs.

著者

Akihisa SUWA Tetsuya SHIMODA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.79, no.4, pp.736-739, 2017 (Released:2017-04-08)

参考文献数

19

被引用文献数

10

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A 9-year-old, spayed female Golden Retriever dog was referred to us for lymphocytosis and lymphadenopathy, secondary to suspected chronic lymphocytic leukemia (CLL). The dog had a clinical history of anorexia, vomiting and melena lasting two days. The popliteal lymph node contained small-to-intermediate lymphocytes, which led us to suspect low-grade lymphoma. Thickened lesions in the stomach and small intestine were detected by ultrasonography. Histopathology of the popliteal lymph node and small intestine revealed a simultaneous presence of T-zone lymphoma (TZL) and high-grade gastrointestinal (GI) cytotoxic T-cell lymphoma. Large granular lymphocytes (LGLs) were seen on cytological examination. Polymerase chain reaction (PCR) revealed that both lymphomas originated in the T-cells. The dog died 15 days after diagnosis, despite chemotherapy.

著者

Jung-Hyun KIM Ji-Hee JEON Kang-Hyo PARK Hun-Young YOON Joon-Young KIM

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0075, (Released:2017-08-25)

被引用文献数

3

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A 10-month-old male Welsh Corgi with a history of acute blindness underwent neuro-ophthalmological testing and magnetic resonance imaging (MRI). Vision testing revealed complete visual deficits but the electroretinograph and pupillary light reflex were normal in both eyes. The motor and sensory functions of the eyelids and eyes were also normal. The MRI revealed compression of the optic chiasm caused by severe ventriculomegaly in the lateral and third ventricles. Such lesions are associated with inflammatory stenotic lesions in the mesencephalic aqueduct. Moderate neutrophilic pleocytosis was observed during cerebrospinal fluid analysis and Acinetobacter lwoffii was isolated, leading to a diagnosis of Acinetobacter-positive obstructive hydrocephalus. This is the first reported case of culture-proven Acinetobacter-associated postencephalitic hydrocephalus with acute blindness in a dog.