著者

Ataru NAKANISHI Tadahisa MASHITA Kyoko AKIYAMA Wakana NAKANISHI Takashi MORI Masaki YANO Tetsuo ASAI Rui KANO Syunsuke SHIMAMURA Jun YASUDA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0319, (Released:2015-01-16)

被引用文献数

4

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A 9-year-old spayed female cat was examined for cheek skin drainage. The skin lesion did not respond to medical therapy; thereafter, facial deformity developed. A computed tomography revealed an intranasal mass and maxillary osteolysis. The mass was histopathologically diagnosed as suppurative granulomatous inflammation caused by filamentous bacteria. The lesion responded well to radiation therapy. Although actinomycosis was suspected histopathologically, no actinomycetes were detected in the nasal lesion by a bacterial culture conducted at a commercial laboratory. The submandibular lymph node and subcutaneous tissue exhibited swelling. Microbiological examination and genetic analysis based on 16S rDNA gene sequence revealed that Nocardia spp. were isolated from both lesions.

著者

Hiroshi SUNAHARA Yoko FUJII Keisuke SUGIMOTO Takuma AOKI Gou SUGAHARA Kinji SHIROTA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0242, (Released:2014-09-23)

被引用文献数

3

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A two-month-old female Chihuahua was diagnosed as severe pulmonary valvular stenosis (PS). Although balloon valvuloplasty (BV) was successfully performed, restenosis was observed 19 months after the procedure. Euthanasia was chosen due to low output syndrome during the surgical repair attempted when the dog was 5 years old. Postmortem examination revealed markedly thickened pulmonary valve due to the increase of extracellular matrix which might be produced by increased α smooth muscle actin-positive myofibroblasts. The thickening of the valve was associated with restriction of the valve’s motion, resulting in restenosis in the present case. This is the first case report documented histopathological and immunohistochemical findings of the restenotic pulmonary valve in dogs with PS after BV.

著者

佐藤 雪太 萩原 未央 山口 剛士 湯川 眞嘉 村田 浩一

出版者

社団法人日本獣医学会

雑誌

The journal of veterinary medical science (ISSN:09167250)

巻号頁・発行日

vol.69, no.1, pp.55-59, 2007-01-25

被引用文献数

3 15

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日本の野鳥に感染が見られたロイコチトゾーン(Leucocytozoon spp.)の分子系統関係の解析を試みた.血液塗沫観察によりロイコテトゾーン感染を確認した北アルプス立山および爺ヶ岳に生息するライチョウ9個体および兵庫県内で保護された野鳥7種13個体(ハシブトガラス4羽,ハシボソガラス2羽,コノハズク2羽,ヤマドリ1羽,イカル1羽,ホンドフクロウ1羽,ヒヨドリ2羽),計22個体の血液からDNAを抽出した.次いでロイコチトゾーンのミトコンドリアチトクロームb(cytb)の部分塩基配列に基づきプライマーを設計し,nested PCRで特異的増幅を試み,増幅産物のシーケンスを決定して配列比較を行った.その結果,ライチョウ9個体すべて(100%),その他の野鳥(ハシブトガラス,ハシボソガラス,イカル,ヒヨドリおよびコノハズク)13個体中11個体(84.6%)でPCR増幅が見られた.増幅されたcytb部分塩基配列約465bpを用いて系統樹を構築したところ,ライチョウと他鳥種寄生のロイコテトゾーンとの間で大きく分岐した.本研究は,日本における野鳥寄生ロイコチトゾーンを分子系統学的に解析した初めての報告である.

著者

Hirofumi SATO Yasuhito FUJINO Junko CHINO Masashi TAKAHASHI Kenjiro FUKUSHIMA Yuko GOTO-KOSHINO Kazuyuki UCHIDA Koichi OHNO Hajime TSUJIMOTO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0260, (Released:2014-02-10)

被引用文献数

4 41

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The present study was carried out to analyze the prognosis of 163 cats with lymphoma classified anatomically and cytomorphologically. Anatomically, alimentary lymphoma was the most common form, and showed significantly shorter survival than mediastinal and nasal lymphomas in cats. Cytomorphologically, there was no predominant subtype in feline lymphomas. Immunoblastic type (18%), centroblastic type (16%), globule leukocyte type (15%), lymphocytic type (12%), lymphoblastic type (12%), pleomorphic medium and large cell type (10%) and anaplastic large cell type (7%) were relatively common subtypes. Most of cats with globule leukocyte lymphoma were alimentary formed. Comparing median survival time among the classification, cats with globule leukocyte lymphoma showed significantly shorter survival than those with high-grade and other low-grade lymphomas. Futhermore, cats with high-grade lymphoma showed significantly shorter survival than cats with other low-grade lymphoma. The present study indicated the clinical significance of anatomical and cytomorphological evaluation in feline lymphomas.

著者

Chikako TANAKA Takayuki MIYAZAWA Masahisa WATARAI Naotaka ISHIGURO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.67, no.9, pp.951-953, 2005 (Released:2005-10-07)

参考文献数

17

被引用文献数

20 55

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Some public areas in Japan such as parks and gardens can be highly contaminated with pigeon feces. We examined levels of four bacterial contaminations in fecal samples from feral pigeons in 7 prefectures. We isolated Salmonella Typhimurium and S. Cerro from 17 (3.9%) of 436 samples, as well as Mycobacterium spp. including M. avium-intracellulare complex from 29 (19.0%) of 153 samples. The polymerase chain reaction detected Chlamydia psittaci and C. pecorum in 106 (22.9%) of 463 samples, but E. coli O-157 was not isolated from any of the samples. Our results indicate that pigeon feces are a source of several zoonotic agents for birds, animals and humans.

著者

木村 祐哉 原 茂雄

出版者

社団法人日本獣医学会

雑誌

The journal of veterinary medical science (ISSN:09167250)

巻号頁・発行日

vol.70, no.4, pp.349-352, 2008-04-25

被引用文献数

10

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鍼治療のもつ長期的効果の検討のため,犬の自律神経の概日リズムに対して電気鍼刺激がもつ影響について,コサイナー法を用いて評価した.自律神経機能の指標としては心拍変動の周波数解析を用いた.温度,日照時間をコントロールした環境制御室において馴化させたビーグル犬を用い,保定のみの場合,あるいは保定した上で電気鍼刺激を加えた場合の24時間心電図データを求めた.保定のみの場合では15分間保定台にくくりつけるのみとし,電気鍼刺激はその間,脊椎上に存在する2箇所の経穴(GV-5, GV-20)に刺入した鍼を電極として5V, 250μsecの電流を2Hzの頻度で加えた.心電図データからは心拍数および心拍変動の変動係数(CVRR),高周波数成分(HF),低周波数成分/高周波数成分比(LF/HF)を求めた.得られた5頭分のデータによると,心拍数は刺激後に最大となり,その後減少する傾向が見られた.その他の心拍変動の指標では明期に減少し,暗期には次第に増加する傾向が見られた.コサイナー法によると刺激の有無に関わらずいずれの指標も有意な24時間周期を示し,それぞれの周期性を比較すると,交感神経活動の指標とされるLF/HFで水準の上昇(P=0.006)と頂点位相の前進(P=0.012)がみられた.結論として,電気鍼刺激は犬における交感神経の概日リズムを前進させ,またその水準を上げる効果をもつことがわかった.

著者

Seishiro CHIKAZAWA Yasutomo HORI Fumio HOSHI Kazutaka KANAI Naoyuki ITO Seiichi HIGUCHI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0147, (Released:2013-06-25)

被引用文献数

1 4

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Serum ferritin concentration increases in dogs in association with various diseases. In this study, we measured serum ferritin levels in dogs with splenic masses, using a sandwich ELISA assay. Eleven dogs with hemangiosarcoma (HSA), six with hematoma, one with hemangioma and three with lymphoma, were enrolled. All dogs with HSA had serum ferritin concentrations above the normal limit (1,357 ng/ml, mean + 2× standard deviation of normal). Increased serum ferritin concentrations have also been observed in few cases of hematoma, hemangioma and lymphoma. Therefore, hyperferritinemia is not specific for splenic HSA, but may have clinical usefulness as a sensitive test for the disease. Further evaluation of serum ferritin concentrations in dogs with splenic HSA is needed.

著者

Toyotaka SATO Shin-ichi YOKOTA Torahiko OKUBO Kanako ISHIHARA Hiroshi UENO Yasukazu MURAMATSU Nobuhiro FUJII Yutaka TAMURA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0186, (Released:2012-11-14)

被引用文献数

8 30

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Fluoroquinolone resistance is mainly caused by mutations in quinolone resistance-determining regions of DNA gyrase and topoisomerase IV in Escherichia coli. The AcrAB-TolC efflux pump contributes to resistance against fluoroquinolone and other antimicrobials. In this study, we investigated a high-level mechanism of fluoroquinolone resistance in E. coli that was isolated from human clinical samples and canine fecal samples. E. coli strains with high levels of fluoroquinolone resistance have been found to be frequently resistant to cephalosporins. Strains with high-level fluoroquinolone resistance exhibited lower intracellular enrofloxacin (ENR) concentrations, higher expression of AcrA, and a greater reduction in the fluoroquinolone minimum inhibitory concentration for treatment with an efflux pump inhibitor. The frequency of strains with enhanced ENR resistance selection and the survival rate of E. coli in the presence of ENR in vitro were correlated well with AcrA protein expression levels in the parental strains. These results suggest that AcrAB-TolC efflux pump over-expression is related to high-level fluoroquinolone resistance and the selection of strains with enhanced fluoroquinolone resistance.

著者

田中 智久 田上 銀平 山崎 真大 高島 郁夫 迫田 義博 落合 謙爾 梅村 孝司

出版者

社団法人日本獣医学会

雑誌

The journal of veterinary medical science (ISSN:09167250)

巻号頁・発行日

vol.70, no.6, pp.607-610, 2008-06-25

被引用文献数

1 2

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2005年度冬季に北海道で大量死した野鳥のうちの13羽について,病理検査とインフルエンザ,ウエストナイル両ウイルスの検出を行った.病理検査では全身性の急性循環障害が共通して認められ,ウイルス検出は陰性であった.これら検査結果,冬季限定の発生状況および文献検索から,融雪剤中毒の可能性が高いと考えられた.また,融雪剤を投与した鶏雛は急性経過で死亡し,野鳥と類似の病変を示した.鶏雛で血漿Na濃度の上昇があったことから,野鳥の死因の確定には罹患症例の電解質検査が必要と考えられた.

著者

杉山 広 森嶋 康之 亀岡 洋祐 荒川 京子 川中 正憲

出版者

社団法人日本獣医学会

雑誌

The journal of veterinary medical science (ISSN:09167250)

巻号頁・発行日

vol.66, no.8, pp.927-931, 2004-08-25

被引用文献数

7

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関東地方における大平肺吸虫陽性カニの検出は,千葉県内を流れて太平洋に注ぐ河川に限られていた.そこで埼玉県・東京都を流れて東京湾に注ぐ荒川を選び,下流にある東京都の7つの区に12の調査地区を定めて,カニの採集と肺吸虫の検出を試みた.その結果,検査したクロベンケイガニ922匹のうち177匹(19%)から肺吸虫メタセルカリアが検出された.寄生率は葛飾区四ツ木地区が最多(89%)で,陽性カニ1匹当たりのメタセルカリアの平均寄生数(32.9個),および最大寄生数(190個)も最多を示した.メタセルカリアは楕円形を呈するものが大部分で,大きさ(内嚢の外径)は302μm×232μm(50個の平均値),口吸盤背縁に穿棘を,体肉内に赤色顆粒を認めた.試験感染ラットから得た成虫は,卵巣が複雑に分岐し,皮棘は群生していた.このようなメタセルカリアと成虫の形態学的特徴から,虫体を大平肺吸虫と同定した.メタセルカリアを検索材材料として得たリボソームDNA・ITS2領域の塩基配列からも,この結論が支持された.カニからの大平肺吸虫メタセルカリアの検出は,東京都ではこれが初めての報告となる.

著者

二宮 博義 猪股 智夫 白水 博

出版者

社団法人日本獣医学会

雑誌

The journal of veterinary medical science (ISSN:09167250)

巻号頁・発行日

vol.66, no.12, pp.1491-1495, 2004-12-25

参考文献数

10

被引用文献数

1 3

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ツチクジラ(5頭,成獣)の肺の血管系を組織学的および血管樹脂鋳型標本を作製して走査型電子顕微鏡で観察した.肺胞は厚く,結合組織を挟むようにして両面の肺胞毛細血管網で構成されていた.この二重の肺胞毛細血管網は肺胞管および肺胞中隔に常時認められた.末端の肺胞では,しばしば毛細血管網が一層であった.肺胞毛細血管は肺胞の末端に近づくにつれ,互いに融合して,二重の毛細血管網が次第に失われ,末端の肺胞では一層になる傾向が見られた.細静脈では膠原繊維がリング状に血管内皮下を走っており,樹脂鋳型では30〜100μm間隔のリング状の溝として観察された.最初の静脈弁は肺胞毛細血管が集合する集合細静脈に見られた.この静脈弁はフラップ様,漏斗状,煙突状の構造で,きわめて特徴的であった.

著者

Sunghyun S HONG Sungryong KIM Myung-Kyo SEO Mi-Na HAN Jeongho KIM Sang-Myeong LEE Ki-Jeong NA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.23-0312, (Released:2024-01-01)

被引用文献数

1

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Parrot bornavirus (PaBV) has been reported to cause indigestion and other wasting symptoms such as weight loss and lethargy. The pathogenesis of PaBV has yet to be fully elucidated. This study reports PaBV infections in South Korea and suggests a trend in the genetic information gathered from clinical cases. A total of 487 birds with or without clinical symptoms were tested for bornavirus. Twelve of 361 asymptomatic birds tested positive for bornavirus, while 15 of 126 birds with various symptoms tested positive. A segment of approximately 1,540 bps including the N, X, P and M proteins were obtained from 23 of the positive strains and analyzed with other strains found on GenBank that had clinical information. PaBV was type 2 and 4 in South Korea, and certain amino acid sequences showed a difference between symptom presenting animals and asymptomatic animals in the X protein and P protein. When considering that some asymptomatic cases may have been latent infections at the time of examination, it is plausible these trends may grow stronger with time. Majority of PaBV was type 4 in South Korea. If these trends are confirmed, diagnosis of potentially pathogenic PaBVs in a clinical manner will be possible during the early stages of infection.

著者

Ayumi SUMI James K CHAMBERS Soma ITO Kazuhiro KOJIMA Tetsuo OMACHI Masaki DOI Kazuyuki UCHIDA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.23-0293, (Released:2023-11-28)

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Merkel cell carcinoma (MCC) is a cutaneous neuroendocrine tumor, and more than 90% of feline MCC cases test positive for Felis catus papillomavirus type 2 (FcaPV2). In the present study, basal cell markers p40, p63, and p73 and the stem cell marker SOX2 and cytokeratin 14 (CK14) were immunohistochemically examined in normal fetal, infant, and adult feline skin tissues. The expression of these proteins was examined in tumors positive for FcaPV2, including MCC, basal cell carcinoma (BCC), Bowenoid in situ carcinoma (BISC), and squamous cell carcinoma (SCC). Infant and adult feline skin tissues had mature Merkel cells, which were CK14-, CK18+, CK20+, SOX2+, synaptophysin+ and CD56+, while fetal skin tissue had no mature Merkel cells. MCC was immunopositive for p73, CK18, and SOX2 in 32/32 cases, and immunonegative for CK14 in 31/32 cases and for p40 and p63 in 32/32 cases. These results indicate that MCC exhibits different immunophenotypes from Merkel cells (p73-) and basal cells (p40+, p63+, and SOX2-). In contrast, all 3 BCCs, 1 BISC, and 2 SCCs were immunopositive for the basal cell markers p40, p63, and p73. The life cycle of papillomavirus is closely associated with the differentiation of infected basal cells, which requires the transcription factor p63. Changes in p63 expression in FcaPV2-positive MCC may be associated with unique cytokeratin expression patterns (CK14-, CK18+, and CK20+). Furthermore, SOX2 appears to be involved in Merkel cell differentiation in cats, similar to humans and mice.

著者

Mako KIMURA Asuka SHODA Midori MURATA Yukako HARA Sakura YONOICHI Yuya ISHIDA Youhei MANTANI Toshifumi YOKOYAMA Tetsushi HIRANO Yoshinori IKENAKA Nobuhiko HOSHI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.85, no.4, pp.497-506, 2023 (Released:2023-04-22)

参考文献数

63

被引用文献数

4

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Diamide insecticides activate ryanodine receptors expressed in lepidopteran skeletal muscle and promote Ca2+ release in the sarcoplasmic reticulum, causing abnormal contractions and paralysis, leading to death of the pest. Although they had been thought not to act on nontarget organisms, including mammals, adverse effects on vertebrates were recently reported, raising concerns about their safety in humans. We investigated the neurotoxicity of the acute no-observed-adverse-effect level of chlorantraniliprole (CAP), a diamide insecticide, in mice using clothianidin (CLO), a neonicotinoid insecticide, as a positive control. The CLO-administered group showed decreased locomotor activities, increased anxiety-like behaviors, and abnormal human-audible vocalizations, while the CAP-administered group showed anxiety-like behaviors but no change in locomotor activities. The CAP-administered group had greater numbers of c-fos–immunoreactive cells in the hippocampal dentate gyrus, and similar to the results in a CLO-administered group in our previous study. Blood corticosterone levels increased in the CLO-administered group but did not change in the CAP-administered group. Additionally, CAP was found to decreased 3-Methoxytyramine and histamine in mice at the time to maximum concentration. These results suggest that CAP-administered mice are less vulnerable to stress than CLO-administered mice, and the first evidence that CAP exposure increases neuronal activity and induces anxiety-like behavior as well as neurotransmitter disturbances in mammals.

著者

Satoshi TAHARAGUCHI Takehisa SOMA Motonobu HARA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.10, pp.1355-1358, 2012 (Released:2012-11-02)

参考文献数

15

被引用文献数

2 17

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From 2001 to 2010, 17,392 Japanese cats were examined for feline coronavirus (FCoV) antibodies. The seroprevalence of purebreds (66.7%) was higher than that of random breds (31.2%). Seroprevalence increased greatly in purebreds by three months of age, while it did not fluctuate greatly in random breds with aging, indicating that cattery environments can contribute to FCoV epidemics. Purebreds from northern regions of Japan were likely to be seropositive (76.6% in Hokkaido, 80.0% in Tohoku), indicating cattery cats in cold climates might be more closely confined. Among purebreds, the American shorthair, Himalayan, Oriental, Persian, and Siamese showed low seroprevalence, while the American curl, Maine coon, Norwegian forest cat, ragdoll and Scottish fold showed high seroprevalence. There would also be breed-related differences in Japan similar to the previous studies in Australia.

著者

Shingo MAEDA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.23-0204, (Released:2023-06-28)

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The development of molecular biology and bioinformatics using next-generation sequencing has dramatically advanced the identification of molecules involved in various diseases and the elucidation of their pathogenesis. Consequently, many molecular-targeted therapies have been developed in the medical field. In veterinary medicine, the world's first molecular-targeted drug for animals, masitinib, was approved in 2008, followed by the multikinase inhibitor toceranib in 2009. Toceranib was originally approved for mast cell tumors in dogs but has also been shown to be effective in other tumors because of its ability to inhibit molecules involved in angiogenesis. Thus, toceranib has achieved great success as a molecular-targeted cancer therapy for dogs. Although there has been no progress in the development and commercialization of new molecular-targeted drugs for the treatment of cancer since the success of toceranib, several clinical trials have recently reported the administration of novel agents in the research stage to dogs with tumors. This review provides an overview of molecular-targeted drugs for canine tumors, particularly transitional cell carcinomas, and presents some of our recent data.

著者

Aprilia MAHARANI Keisuke AOSHIMA Shinichi ONISHI Kevin Christian Montecillo GULAY Atsushi KOBAYASHI Takashi KIMURA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.80, no.2, pp.213-218, 2018 (Released:2018-02-09)

参考文献数

21

被引用文献数

8 15

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Canine hemangiosarcoma (HSA) is one of the most common mesenchymal tumors in dogs. Its high metastatic and growth rates are usually associated with poor prognosis. Neoplastic cells of HSA can show various levels of cellular atypia in the same mass and may consist of various populations at different differentiated stages. Up to present, however, there is no report analyzing their differentiation states by comparing cellular atypia with differentiation-related protein expressions. To evaluate whether cellular atypia can be used as a differentiation marker in HSA, we analyzed correlation between cellular atypia and intensities of CD31 and von Willebrand Factor (vWF) staining in HSA cases. We also compared cellular atypia and expression levels of CD31 and vWF in each growth patterns. Our results show that cellular atypia was negatively correlated to CD31 and vWF expression levels but no significant correlation was found between growth patterns and cellular atypia or CD31 and vWF expression levels. Our study suggests that cellular atypia is useful for identifying differentiation levels in HSA cases. This study also provides useful information to determine differentiation levels of cell populations within HSA based only on morphological analysis, which will aid further HSA research such as identifying undifferentiation markers of endothelial cells or finding undifferentiated cell population in tissue sections.

著者

Takuro NAGAHARA Koichi OHNO Taisuke NAKAGAWA Yuko GOTO-KOSHINO James K CHAMBERS Kazuyuki UCHIDA Naomi MIZUSAWA Chiaki KAGA Maho NAGAZAWA Hirotaka TOMIYASU Hajime TSUJIMOTO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.22-0172, (Released:2023-01-02)

被引用文献数

3

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Intestinal lymphangiectasia (IL) is a common complication in dogs. This study analyzed intestinal microbiota using 16S rRNA amplicon analysis as candidate factors that strongly influence the small intestinal lymphatic vessels in dogs with and without IL. Twelve dogs were included, of which six were diagnosed with lymphoplasmacytic enteritis, four with small-cell lymphoma, and two with large-cell lymphoma. Seven of these dogs had IL, whereas five did not. First, the microbial diversity analyzed by Faith pd index was significantly decreased in dogs with IL compared to dogs without IL. Then, the relative amounts of each bacterial taxa were compared between dogs with and without IL using Linear discriminant analysis effect size analysis. At the genus level, the Ruminococcus gnavus groupsignificantly increased in dogs with IL compared to dogs without IL. A total of four genera, including Ruminococcus torques group and Faecalibacterium, which produce butyrate, significantly decreased in dogs with IL. This study showed decreased intestinal bacterial diversity and several alterations of intestinal microbiota, including a decrease in butyrate-producing bacteria in dogs with IL, compared to dogs without IL.

著者

Shingo HATOYA Ryoji KANEGI Tomoyo NABETANI Shoko OJI Takeshi IZAWA Satoshi HIRAI Kikuya SUGIURA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.22-0322, (Released:2022-11-14)

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An 8-year-old intact male pointer presented with lethargy and hypoalbuminemia. On abdominal ultrasonography, both adrenal glands were reduced in thickness. Based on the ACTH stimulation test results and the absence of electrolyte abnormalities, the dog was diagnosed with atypical hypoadrenocorticism. After treatment with low-dose prednisolone, his general condition improved, and blood tests normalized. The dog died 818 days later, and a complete autopsy was performed. Histologically, the architecture of the zonae fasciculata and reticularis was disrupted in both adrenal glands; however, the zona glomerulosa remained relatively normal. In summary, in this study, we detailed the pathological presentation of atypical hypoadrenocorticism without electrolyte abnormalities.

著者

Hakimullah HAKIM Md. Shahin ALAM Natthanan SANGSRIRATANAKUL Katsuhiro NAKAJIMA Minori KITAZAWA Mari OTA Chiharu TOYOFUKU Masashi YAMADA Chanathip THAMMAKARN Dany SHOHAM Kazuaki TAKEHARA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.78, no.7, pp.1123-1128, 2016 (Released:2016-08-01)

参考文献数

50

被引用文献数

15 23

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The capacity of slightly acidic hypochlorous acid water (SAHW), in both liquid and spray form, to inactivate bacteria was evaluated as a potential candidate for biosecurity enhancement in poultry production. SAHW (containing 50 or 100 ppm chlorine, pH 6) was able to inactivate Escherichia coli and Salmonella Infantis in liquid to below detectable levels (≤2.6 log10 CFU/ml) within 5 sec of exposure. In addition, SAHW antibacterial capacity was evaluated by spraying it using a nebulizer into a box containing these bacteria, which were present on the surfaces of glass plates and rayon sheets. SAHW was able to inactivate both bacterial species on the glass plates (dry condition) and rayon sheets within 5 min spraying and 5 min contact times, with the exception of 50 ppm SAHW on the rayon sheets. Furthermore, a corrosivity test determined that SAHW does not corrode metallic objects, even at the longest exposure times (83 days). Our findings demonstrate that SAHW is a good candidate for biosecurity enhancement in the poultry industry. Spraying it on the surfaces of objects, eggshells, egg incubators and transport cages could reduce the chances of contamination and disease transmission. These results augment previous findings demonstrating the competence of SAHW as an anti-viral disinfectant.