著者

上ノ土 武 飯尾 靖枝 只熊 幸代 原塚 柳子 神奈川 芳行 今村 知明 古江 増隆

出版者

福岡医学会

雑誌

福岡醫學雜誌 (ISSN:0016254X)

巻号頁・発行日

vol.96, no.5, pp.183-184, 2005-05-25

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ダイオキシンやダイオキシン関連化合物の,次世代に対する影響について社会的関心が高まっている.吉村らは1968年から1977年の間に,油症患者から出生した85人の性比を,一般人の期待される男女比0.514と比較し,明確な差はない,と報告した.しかしながら,曝露者が父親か母親かと,親の曝露時の年齢との関連についての検討は,油症ではまだ行われていない.油症と同様に,PCBやダイオキシン関連化合物が食用油に混入した例としては,台湾で発生したYuchengがある.Yu-chengの原因物質は,油症の原因物質と極めて類似しており,Polychlorinatedbiphenyls(PCBs)やPolychlorinateddibenzofurans(PCDFs)が主なものである.ダイオキシンやダイオキシン関連化合物質に曝露された例は,イタリアのSevesoをはじめ複数の国から報告がある.Yu-chengや,Seveso,ロシアやオーストリアの塩素ざ瘡コホートでは,20歳前や20代の前半に,ダイオキシンやダイオキシン類関連化合物に曝露した男性が父親である児の男女比は有意に低下している,との報告されている.一方で,曝露した女性が母親である児の男女比については影響が認められない,との報告がYu-chengやSevesoからなされている.

著者

新小田 春美 末次 美子 加藤 則子 浅見 恵梨子 神山 潤 内村 直尚 樗木 晶子 西岡 和男 大久保 一郎 松本 一弥 南部 由美子 加来 恒壽

出版者

福岡医学会

雑誌

福岡醫學雜誌 (ISSN:0016254X)

巻号頁・発行日

vol.103, no.1, pp.12-23, 2012-01-25 (Released:2013-06-19)

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Purpose : To find the relationship between parents' sleeping and living behaviors and their children's sleeping habits, and to investigate factors specifically related to children staying up late in recent Japan. Methods : During regular health check-ups of children at three local health centers in the city A, we recruited the parents of one-and-half-year-old and three-year-old children to participate in the Child Sleep Cohort Project (ChiSCoP). Parents of 184 children who consented to participation were mailed three questionnaires by placement method. These are "sleeping diary for 10 days," "sleeping and lifetime rhythm survey," and "emotional behavior assessment scale (CBCL : Child Behavior Checklist 2rd/3rd edition)," of which valid data on 178 children were collected over two years and analyzed. Analysis : Participants' demographic data, perceived and actual sleeping and living habits, and bedtime patterns were compared among the groups classified by bedtime of children. Bedtimes were classified as early (before 21 : 00), normal (21 : 00 to 21 : 59), and late (after 22 : 00). Using one-way analysis of variance with two (early vs. late) and three bedtime categories, significant differences were found among the three bedtime categories about childcare environmental factors (meal, daytime activity, TV, nap, and bath). So we performed logistic regression analysis with "late bedtime" as the dependent variable and scores of environmental factors (upper or lower than median values) as independent variables in a stepwise manner to eliminate collinear variables and to obtain adjusted odds ratios. Results : 1) Among the 178 children, 96 and 82 were recruited during the physical check-up for one-and-half-year-old and three-years-old, respectively. There were 49, 72, and 57 children in the early, normal, and late bedtime groups, respectively, and no significant difference in attribute factors was found. 2) In children of the early bedtime group, proportions of those with "efforts to establish good life rhythm" (P < 0. 0001), "efforts to cultivate sleeping habits" (P < 0. 0001), and "keeping a regular bedtime" (P < 0.05) were significantly higher, as well as for children who had more than 105 minutes of "daytime nap" compared to children who had less (P < 0.05). 3) Children's bedtimes were significantly correlated with "mother's wake-up time on weekdays" (r = 0. 33) and "mother's bedtime on weekdays" (r = 0. 33). Children's wake-up times were also correlated with "mother's wake-up time on weekdays and weekends" (r = 0. 49) and "mother's bedtime on weekdays" (r = 0.34), which indicates that children's wake-up times had relationship with mother's sleeping and life habits. 4) Later "wake-up time on weekends" (odds ratio = 4.9) and "regular bedtime hour" (odds ratio = 3.53) were found to be the determinant of late bedtimes of children. Conclusions : To encourage earlier bedtimes in children, it is important to take he mother's sleeping and living habits into account and to maintain a regular wake-up and bedtime schedule across weekdays and weekends.

著者

大場 太郎 濱津 隆之 黒田 陽介 平田 貴文 真崎 一郎 井上 博道 木戸 晶孔 舟橋 玲 島 一郎 磯 恭典 馬場 秀夫 前原 喜彦

出版者

福岡医学会

雑誌

福岡醫學雜誌 (ISSN:0016254X)

巻号頁・発行日

vol.94, no.12, pp.347-350, 2003-12-25

被引用文献数

5

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A 69-year old man was found a mass becoming larger in abdominal computed tomography. The mass consisted of intermingling solid and cystic component was located below the liver. Abdominal angiography showed tumor staining supplied from right gastroepiploic artery. We considered the mass cystadenoma, lymphangioma, cystic mesothelioma, or gastrointestinal stromal tumor (GIST) preoperatively, and then surgical resection was performed. The tumor was found localized in the greater omentum. Pathological examination showed the tumor composed of proliferation of atypical sort spindle cells and tumor cellswere immunohistochemically positive for C-KIT and CD34, identifying the tumor as a primary GIST of the greater omentum.

著者

Nagayama Junya Takasuga Takumi Tsuji Hiroshi Umehara Motomi Sada Takehiko Iwasaki Teruaki

出版者

Fukuoka Medical Association

雑誌

福岡醫學雜誌 (ISSN:0016254X)

巻号頁・発行日

vol.94, no.5, pp.118-125, 2003-05-25

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Thirty-five years have been passing since the outbreak of Kanemi rice oil poisoning, namely, Yusho in the western Japan. However, even now the patients with Yusho have been still suffering from several objective and subjective symptoms. In order to improve or, if possible, to cure the such symptoms, the most important therapeutic treatment is considered to actively excrete the most toxic causative PCDFs/DDs congeners, that is, 2,3,4,7,8-pentachlorodibenzofuran (PenCDF) and 1,2,3,6,7,8-hexachlorodibenzo- p-dioxin (HxCDD) from the bodies of the patients and to reduce their body burdens. In rats, dietary fiber and chlorophyll have been shown to promote the fecal excretion of dioxins and to reduce their levels in rat liver. In this study, we examined whether such kinds of effect were also observed by FBRA, which was the health food and relatively rich with dietary fiber and chlorophyll in nine married Japanese couples. As a result, concentrations of PenCDF and HxCDD on the lip id weight basis in the blood of the FBRA-intake group in which they took 7.0 to 10.5g of FBRA after each meal and three times a day for one year were more lowered than those in the blood of the nonintake group ; Blood levels of PenCDF and HxCDD in the FBRA-intake group were decreased by 30.5 and 33.9%, respectively, and those decreases were 22.0 and 24.5% in the non-intake group. Their total body burdens just before and one year after the study were calculated on the assumptions that the body fat was also contaminated with these congeners at their blood levels on the lipid weight basis and the content of body fat was 20% of the body weight. Then, we computed the average amounts in excretion of PenCDF and HxCDD from the body in both the FBRA-intake and non-intake groups. Consequently, the amounts of excretion of PenCDF and HxCDD in the FBRA-intake group were 2.1 and 1.9 times, respectively, greater than those in the non-intake group. Therefore, FBRA seemed to promote the fecal excretion of PenCDF and HxCDD, the main causative PCDFs/DDs congeners of Yusho, from the human body. We also expect FBRA to reduce th eir body burdens of patients with Yusho and to improve some objective and subjective symptoms of Yusho patients.カネミ油症中毒事件が発生してから35年が経過しようとしているが, 今でも油症患者は種々様々な自覚および他覚症状で苦しんでいる. このような症状を改善し治療するには, その主要な原因物質である2,3,4,7,8一五塩化ダイベンゾフラン(PenCDF)と1,2,3,6,7,8一六塩化ダイオキシン(HxCDD)を積極的に体外へ排泄し, 汚染レベルを低下させることが第一である. この研究では動物実験によりダイオキシン類の体外排泄促進作用の認められている食物繊維と葉緑素を比較的多量に含む栄養補助食品FBRAによるカネミ油症原因物質の体外排泄促進を9組の夫婦の協力により調べた. その結果, 毎食後7~10.5gのFBRAを1日3回1年間摂取することにより, 血液脂質重量当りのPenCDFとHxCDDの濃度が非摂取群よりもそれぞれ8.5%と9.4%低下した. この血液脂質濃度で体脂肪も汚染されており, 体脂肪率を体重の20%と仮定し, 1人当り1年間の体外排泄量を両化学物質について計算した. そうすると, FBRAを摂取することによりPenCDFとHxCDDの排泄量がそれぞれ2.1倍と1.9倍高まることが示された. 以上のような結果より, FBRAは油症原因物質のPenCDFとHxCDDの体外への排泄を促進するので, 油症患者の治療にも有効と考えられた.