著者

頼高 朝子 深江 治郎 渡辺 宏久 三輪 英人 志村 秀樹 河尻 澄宏 下 泰司 前田 哲也 大塚 千久美 山田 大介 富山 誠彦 阿部 隆志 平沢 基之 木原 武士 斎木 英資 鈴木 千賀子 風間 明日香 大野 欽司 伊藤 美佳子

出版者

順天堂大学

雑誌

基盤研究(C)

巻号頁・発行日

2015-04-01

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水素分子はパーキンソン病(PD)疾患モデル動物のドパミン神経細胞の減少を抑制した。この事実を基にレボドパ内服中のPD患者に対して水素水を48週間飲水させた無作為化二重盲検試験でその症状を改善させた。初期及び進行例を含めたPD患者に対象拡大し72週に延長し、無作為化二重盲検並行群間試験を14施設で実施した。レボドパ未内服の患者を含めた178例を登録し、水素水群91例とプラセボ群86例に試験水を1日1l飲水した。水素水による有害事象は認めなかった。主要評価であるPD評価スケールの開始時から72週目までの変化量は水素水群とプラセボ群で統計学的な有意差は認めず、有効性は認めなかった。

著者

西岡 智哉 池脇 義弘 秋山 諭 山本 圭吾 田中 咲絵 宮原 一隆 原田 和弘 山下 泰司 濱﨑 正明 長谷川 尋士 本田 恵二

出版者

日本プランクトン学会

雑誌

日本プランクトン学会報 (ISSN:03878961)

巻号頁・発行日

vol.65, no.2, pp.36-43, 2018-08-25 (Released:2018-10-26)

参考文献数

19

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A widespread bloom of the harmful raphidophyte Chattonella ovata Y. Hara & Chihara occurred for the first time in the east Seto Inland Sea in the summer of 2016. From July 11 to 17, cell densities in Hiuchi-Nada and Bisan-Seto reached 10 cells mL-1. From July 19 to 24, the highly dense distribution area expanded to Harima-Nada, and cell densities reached their peak (max. 222 cells mL-1) in all areas affected from July 25 to 31. In Harima-Nada, the species decreased rapidly, whereas the level at Hiuchi-Nada and Bisan-Seto was maintained until August. From July 11 to 18, a westerly wind had prevailed in the Takamatsu area facing Bisan-Seto while the wind was weak during other periods. That caused eastward wind-induced passage flow, and expansion of the cell distribution from Bisan-Seto to Harima-Nada. In addition, the sunlight hours were long (average 8.6 h) and the water temperature was high (approximately 25 to 29˚C).Furthermore, salinity remained at around optimum for C. ovata (approximately 28 to 31) in the east Seto Inland Sea while the species bloomed. This indicates that these environmental conditions were suitable for growth of this species, which is adapted to strong irradiance, high water temperature and high salinity. In Bisan-Seto and Hiuchi-Nada, Chattonella marina and Chattonella antiqua appeared at high cell densities in mid-July when the distribution of C. ovata expanded. However, in Harima-Nada, C. marina and C. antiqua maintained low cell densities consistently. In Harima-Nada, DIN (dissolved inorganic nitrogen) and DIP (dissolved inorganic phosphorus) remained at 0.51–1.17 µM and 0.08–0.25 µM, respectively, from July 4 to August 15. The minimum cell quotas of nitrogen for C. ovata are lower than for C. antiqua. We presumed this gave a competitive advantage to C. ovata for growth. In Harima-Nada, cell density of diatoms decreased temporarily in late-July, but the density remained above 100 cells mL-1 after August. However, in Hiuchi-Nada and Bisan-Seto, cell densities of diatoms were kept below 100 cells mL-1 through the observation period. We inferred that a low concentration of nutrients, less westerly wind, and a high density of diatoms were factors that led to the regulation of the low level of C. ovata after August in Harima-Nada. We considered that the low diatom density was one of the causes of the C. ovata bloom being prolonged in Hiuchi-Nada and Bisan-Seto.

著者

大下 泰司 満園 良一 伊集院 俊博

出版者

久留米大学

雑誌

久留米大学健康・スポーツ科学センター研究紀要 (ISSN:13463055)

巻号頁・発行日

vol.12, pp.37-40, 2004-12

被引用文献数

2