著者

安永 峻五 下村 脩

出版者

日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.74, no.7, pp.778-780, 1954

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In electrochromatography, five kinds of different filter paper holders were used and the velocity of migration, area of colored band, and migration distance of each position on the filter paper were measured under identical conditions so as to examine the separatory ability and equality of rate of each apparatus. It was thereby found that the best separation is effected by placing the paper in a convex form, with the middle higher, while for uniform mobility, the filter paper should be cooled directly by closely adhering the lower surface on a cooling vat.

著者

安永 峻五 下村 脩

出版者

日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.74, no.1, pp.62-66, 1954

被引用文献数

2

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A filter paper wetted with an electrolyte was placed between two glass plates coated with a silicone resin. Electric current was passed through this paper in order to find the relationship between the time, voltage, electric current, and temperature with degree of mobility of numerous inorganic ions. It was found that a linear relation always existed, in any of the electrolyte used, between the distance of mobility and time and voltage. The effect of electric current was examined with sodium nitrate as an electrolyte and it was found that electric current did not influence the mobility of the ions as much as voltage. A metallic thermostatic vat, coated with insulating paint, was devised and the mobility of ions at various temperatures was examined and it was found that the mobility generally increased with the increase of temperature and this influence was found to be greater the larger the mobility of the ion. Influence of evaporation by the warming of the filter paper was quantitatively examined, using the Durrum apparatus, with either direct or alternative current as the electric source, from the relationship between the position of the sample placed and the distance of ionic mobility. It was thereby unexpectedly found that a great deal of effect was caused by evaporation.

著者

安永 峻五 下村 脩

出版者

日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.73, no.12, pp.1350-1353, 1953

被引用文献数

3

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By the use of the same method of capillary filled with alumina as given in the previous paper, order of adsorption, limit of detection, separation of several kinds of anions, and the method of microdetection of I^-, NO₂^-, and CN^- ions were examined. It was found that the separations of Cl^- and PO₄^---, Cl^- and AsO₄^---, PO₄^--- and AsO₄^----, AsO₃^--- and AsO₄^---, I^-, CrO₄^--, and PO₄^---, NO₂^- and CrO₄^--, were possible. The coloration reagents used were, besides the known AgNO₃ method, CuCl₂, Hg(NO₃)₂, FeCl₃, and benzidine. Chromatographic separation of metal complexes were also carried out by the same method and the separation of Cr and Pb, which was previously reported as being comparatively difficult was found to be possible by preparing a tartaric acid complex, while that of cobalt, nickel, and cadmium waa found to be possible by the ammonium complex method.

著者

下村 脩

出版者

日本化学会

雑誌

日本化學雜誌 (ISSN:03695387)

巻号頁・発行日

vol.76, no.5, pp.562-566, 1955

著者

下村 脩

出版者

長崎大学薬学部 長薬同窓会

雑誌

長薬同窓会報

巻号頁・発行日

no.35, pp.42-44, 1995

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本文中の「安永峻吾先生」は「安永峻五先生」の間違い(42ページ2行目)

著者

安永 峻五 下村 脩

出版者

日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.74, no.1, pp.66-68, 1954

被引用文献数

2

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Relationship between the pH of the electrolyte solution and the degree of mobility was examined with inorganic ions. Electrolyte used were sodium nitrate, potassium thiocyanate, and tartaric acid series, and the ions detected were Ba⁺⁺, Pb⁺⁺, Cu⁺⁺, Zn⁺⁺, Ni⁺⁺, Fe⁺⁺⁺, Br^-, CNS^-, AsO₄^---, CrO₄^--, Fe(CN)₆^---, NO₂^-, and BO₃^---. Except in the case of extremely acid or alkaline range, the effect of pH was found to be rather small in inorganic ions in general, both in cations and anions. However, in the case of amphoteric metals, such as zinc, they behave similar to amino acids. Use of complex salt-forming electrolyte in the case of metallic ions, the effect of pH was found to be extremely great. In the case of tartaric acid electrolyte, metals were found to move as a cation in the acid range of lower pH while they behaved as anions in a higher pH range, and there is a certain pH (isoelectric point) at which each metal does not move at all. From these facts, it was found that the complex salt-forming electrolyte was suitable for the separation of metals.

著者

安永 峻五 下村 脩

出版者

日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.73, no.12, pp.1346-1350, 1953

被引用文献数

6

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A glass capillary of approximately 0.8mm. inside diameter and approximately 10cm. long, filled with alumina and having a pinhole at one end was used as a means of detecting several kinds of mixed ions by suction of sample solution and coloration reagents into the capillary through the pinhole. Limit of detection of metallic ions by various coloration reagents was examined and the present method was found to be far sharper than the paper spot test and the best suited for the detection of a minute amout of ions. The feature of this method may be said to lie in the fact that only a minute amount of sample and alumina are needed and that the procedure is simple and time short.

著者

下村 脩

出版者

日本化学会

雑誌

日本化學雜誌 (ISSN:03695387)

巻号頁・発行日

vol.76, no.9, pp.973-977, 1955

著者

下村 脩 羽根田 弥太

出版者

横須賀市自然博物館

雑誌

横須賀市博物館研究報告. 自然科学 : Science report of the Yokosuka City Museum (ISSN:05132622)

巻号頁・発行日

no.34, pp.p1-5, 1986-12

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シンガポールの発光カタツムリ Quantula striata は人工的な刺激によって発光せず, また一皮凍結したあとは発光させることができない。 しかし冷凍試料の抽出液は, Fe2+, H2O2 とメルカプトエタノールを加えると発光する。抽出液中に存在する発光物質を精製して純晶を得たが, この物質はカタラーゼの一種であることが判明した。ただし, このカタラーゼがカタツムリ発光の発光物質であるという確証はまだ得られていない。

著者

下村 脩

出版者

日本化学会

雑誌

日本化学雑誌 (ISSN:03695387)

巻号頁・発行日

vol.81, no.1, pp.179-184, 1960-01

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(第2報) 海ホタルルシフェリンの性質および分子式について約5kgの良質な乾燥海ホタルから海ホタルルシフェリンの結晶約70mgをうることができたので, これを用いて吸収スペクトル, 酸化および還元による変化, 呈色反応などについて調べ, 加水分解によって構成成分を知り, また分子量測定および元素分析により分子式を求めた。その結果, 海ホタルルシフェリンの構造中にはイソロイシン, γ-グアニジノ酪酸およびトリプタミンの骨格を含み, 分子式C21H28O2N6・2HClを有することを知った。(第3報) 海ホタルルシフェリンおよびヒドロルシフェリンの推定構造海ホタルルシフェリンおよびその誘導体について前報までに得られた知見をもとにし, あらたにいくつかの実験を行ない, これらに考察を加えて, ヒドロルシフェリンの構造をⅡ, 海ホタルルシフェリンの構造をⅨと推定した。名古屋大学に学位論文として提出

著者

岸 義人 後藤 俊夫 平田 義正 下村 脩

出版者

天然有機化合物討論会

雑誌

天然有機化合物討論会講演要旨集

巻号頁・発行日

no.9, pp.60-66, 1965-10

著者

中村 英士 Musicki B. 岸 義人 Morse D. Hastings J. 下村 脩

出版者

天然有機化合物討論会

雑誌

天然有機化合物討論会講演要旨集

巻号頁・発行日

no.30, pp.276-283, 1988-09

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The bioluminescence of dinoflagellates involves air-oxidation of luciferin (enzyme substrate) by luciferase (enzyme). On the other hand, Euphausia krills utilize highly fluorescent substance F not only as the catalyst for air-oxidation of a protein but also as the light-emitter. Fluorescent substance F exhibits chemical properties similar to those of dinoflagellate luciferin. Using alumina and ion exchange chromatography at low temperature under inert atmosphere (Sheme 1), the substance F (1) was successfully isolated from Euphausia pacifica. The structure of F was elucidated on the basis of degradation reaction summarized in Fig. 1 as well as the spectroscopic data of F (1) and oxy-F (2). The ring D part of the proposed structure, including relative stereochemistry, was unambiguously established by chemical means; ozonolysis of F, followed by CH_2N_2 treatment, yielded the expected product 7, the structure of which was determined by chemical synthesis. Dinoflagellate luciferin could be isolated from the dinoflagellate Pyrocystis lunula (Scheme 2). The structures of luciferin 8, oxidized luciferin 9 and blue compound 10 were elucidated by comparing their spectroscopic data with those of fluorescent substance F and oxy-F. Dinoflagellate luciferin and krill fluorescent substance F are apparently a member of the bile pigments. To the best of our knowledge, however, these are the first naturally occurring bile pigments, which structurally relate to chlorophylls rather than to haems. Studies on the mechanism of dinoflagellate bioluminescence is in progress.

著者

下村 脩 江口 昇次

出版者

日本化学会

雑誌

日本化学雑誌 (ISSN:03695387)

巻号頁・発行日

vol.81, no.9, pp.1434-1439, 1960-09

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(第1報) 1,2,4-トリ置換-5-イミダゾロンの合成ならびにその紫外線吸収スペクトル2-メチル-4-ベンジリデン-5-オキサゾロン(Ⅰ)に種々のアミン類を作用させてアミドとし, このアミドを脱水閉環して1-置換-2-メチル-4-ベンジリデン-5-イミダゾロンをえたが, トフェニル置換体の場合にはアミドを経由するよりも, オキサゾロン(Ⅰ)とアニリンの直接反応による方が, はるかに容易に合成できることを知った。また, 2位へのメチル基以外のアルキル基の導入, 4位のイソプロピリデン基の導入, ならびに合成した14種のトリ置換-5-イミダゾロンの紫外線吸収スペクトルについても検討した。(第2報) 5-イミダゾロン類の接触還元ならびに生成物のPKa'4-ベンジリデン-5-イミダゾロン類および4-イソプロピリデン-5-イミダゾロン類をメタノール中でAdamsの酸化白金あるいはパラジウム黒を触媒として接触還元した。酸化白金を用いた場合には 1mol の水素による還元生成物(以下1モル還元物と呼ぶ)を結晶状に得ることはできなかったが, 2モル還元物(5-イミダゾリドン)は15種の化合物を塩酸塩結晶として得ることができた。パラジウム黒を用いた場合には 1mol の水素を吸収したのち還元が停止し, 1-フェニル-2-メチル-4-ベンジリデン-5-イミダゾロンからは mp82度~84度Cの結晶を得た。また, 得られた15種のイミダゾリドンのPKa'を測定して, その結果から5-イミダゾリドン環のpKa'におよはす種々の置換基の影響についての考察を試みた。

著者

安永 峻五 下村 脩

出版者

日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.73, no.12, pp.1353-1356, 1953

被引用文献数

3

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By the determination of the stepwise change of pH in the absorption tube during cation adsorption and the amount of cerresponding anion adsorbed, precipitation of basic salt of metals was assumed, and following tests were carried out. Hydrogen ion concentration at the time of precipitation was determined with glass electrode pH meter and the relationship between pH at the time of absorption and the amount absorbed were examined by static adsorption, and it was found that the precipitation pH range and the order of adsorption were in good agreement and that the adsorption of cation became maximum in the precipitation pH range. From these facts, it was assumed that the adsorption of metallic ions by alumina was chiefly due to the precipitation of their basic salts. It was also found that the influence of anions was rather great in the adsorption of mercury salt, as the adsorption of mercury became extremely small in the presence of a chloride and this was assumed to be due to the formation of mercuric chloride of small degree of dissociation.

著者

下村 脩

出版者

アトー株式会社

雑誌

バイオサイエンス最前線

巻号頁・発行日

no.22, pp.2-12, 1998-04

被引用文献数

1

著者

下村 脩 SHIMOMURA Osamu

巻号頁・発行日

1960-04-15

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約5kgの良質な乾燥海ホタルから海ホタルルシフェリンの結晶約70mgをうることができたので, これを用いて吸収スペクトル,酸化および還元による変化, 呈色反応などについて調べ, 加水分解によって構成成分を知り, また分子量測定および元素分析により分子式を求めた。 その結果, 海ホタルルシフェリンの構造中にはイソロイシン, γ-グアジニノ酪酸およびトリプタミンの骨格を含み, 分子式C2lH2802N6・2HC1を有することを知った。

著者

下村 脩

出版者

名古屋大学

巻号頁・発行日

1960

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「日本化学雑誌」Vol.81 No.1 (1960) pp.179-184.「海ホタルルシフェリンの構造(第2~3報)」を博士論文として提出したもの。

著者

平田 義正 江口 昇次 下村 脩

出版者

天然有機化合物討論会

雑誌

天然有機化合物討論会講演要旨集

巻号頁・発行日

no.3, pp.83-93, 1959-10-17

著者

安永 峻五 下村 脩

出版者

日本薬学会

雑誌

薬学雑誌 (ISSN:00316903)

巻号頁・発行日

vol.74, no.7, pp.778-780, 1954-07

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In electrochromatography, five kinds of different filter paper holders were used and the velocity of migration, area of colored band, and migration distance of each position on the filter paper were measured under identical conditions so as to examine the separatory ability and equality of rate of each apparatus. It was thereby found that the best separation is effected by placing the paper in a convex form, with the middle higher, while for uniform mobility, the filter paper should be cooled directly by closely adhering the lower surface on a cooling vat.

著者

下村 脩

出版者

日本解剖学会

雑誌

解剖學雜誌 (ISSN:00227722)

巻号頁・発行日

vol.85, no.3, pp.99-106, 2010-09-01