著者
田中 輝和 田中 恭子 高原 二郎 藤岡 譲 田村 敬博 山ノ井 康弘 北条 聰子 高橋 敏也 三木 茂裕 中村 之信
出版者
公益財団法人 日本感染症医薬品協会
雑誌
The Japanese Journal of Antibiotics (ISSN:03682781)
巻号頁・発行日
vol.47, no.6, pp.790-797, 1994-06-25 (Released:2013-05-17)
参考文献数
13

MRSAとその複数菌感染症に対し, Arbekacin (ABK), Fosfomycin (FOM) 投与30分後に Ceftazidime (CAZ) を投与する時間差併用療法を設定し, 基礎的, 臨床的検討を行い以下の成績を得た。臨床分離のMRSA 1727及びPseudomonas aeruginosa KIに対し, 1/4~1/8MICのABK, FOM, CAZの同時及び時間差処理を行い, 殺菌効果を比較したところ, 時間差処理群により優れた相乗的殺菌効果が認められた。両菌による複数菌感染にマクロファージを用いた系では, 三薬剤の時間差併用により, マクロファージによる著しい殺菌効果の増強が認められた。MRSA感染症を呈した15症例に対する臨床的検討では, 有効率は80.0%であった。MRSAに対する除菌率は60.0%であった。ABK, FOM, CAZを用いた時間差併用療法は, MRSAを含む複数菌感染症に対し, 非常に有効な治療法であると考えられる。
著者
谷崎 勝朗 高橋 清 上田 暢男 斉藤 勝剛 細川 正雄 小野 波津子 石橋 健 合田 吉徳 中村 之信 佐々木 良英 守谷 欣明 木村 郁郎
出版者
Okayama Medical Association
雑誌
岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日
vol.89, no.9-10, pp.1261-1265, 1977-10-30 (Released:2009-08-24)
参考文献数
8
被引用文献数
1 1

A skin test using buckwheat extract was performed on 182 cases of bronchial asthma. Thirty-three of them showed a positive skin test to buckwheat extract.Buckwheat allergy (bronchial asthma, urticaria, allergic rhinitis, allergic gastroenteropathy and allergic conjunctivities) was found in 19 (57.6%) of the 33 cases showing a positive skin test to buckwheat extract.Basophils from 8 cases of buckwheat asthma showed a strong response to buckwheat extract, although basophils from 10 cases with a postive skin test only, without buckwheat allergy, did not response to buckwheat extract.Bronchial asthma induced by buckwheat (16 of the 19 cases) had some special features. Their asthma attack was induced by the introduction into the body through either mouth or airway and started in childhood. Buckwheat pillows were used in 13 of the 19 cases. Ten of the 13 cases obtained alleviation of asthma upon discontinuation of buckwheat pillows. Most of the buckwheat asthma patients showed a high serum IgE level and had a hereditary factor. The results showed that cases of buckwheat asthma might be sensitized in their childhood.
著者
谷崎 勝朗 中田 安成 高橋 清 細川 正雄 小野 波津子 石橋 健 合田 吉徳 中村 之信 佐々木 良英 木村 郁郎
出版者
The Japanese Respiratory Society
雑誌
日本胸部疾患学会雑誌 (ISSN:03011542)
巻号頁・発行日
vol.16, no.2, pp.98-102, 1978-02-25 (Released:2010-02-23)
参考文献数
14

Allergo-immunologic investigations and examinations of the autonomic nerve system were performed in a case of bronchial asthma with myasthenia gravis. The results were as follows:1) Asthma attacks and blephaloptosis were observed to tend to appear alternately.2) The same trend was shown by administration of mecholyl or other anti-cholinergic drugs and when such drugs were given asthma attacks increased, although blephaloptosis improved.3) Asthma attacks in this patient resembling those of many patients with bronchial asthma were observed mainly in the early morning.4) Allergy examinations showed normal serum IgE level, negative skin reaction tests and no peripheral eosinophilia.These results show that asthma attacks and symptoms of myasthenia gravis seemed to appear alternately in interaction of acetylcholine, showing a see-saw phenomenon and suggest that the autonomic nervous system participates in an induction mechanism or process in asthma.