著者

安部 益文

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.93, no.9-10, pp.941-949, 1981-10-30 (Released:2009-03-30)

参考文献数

14

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マイクロ波は周波数300MHz~30GHzの電波であるが,このマイクロ波の電界に誘電物質をおくと,電波エネルギーは物質に吸収され熱エネルギーに変る.この高周波誘電加熱に立脚して開発された電子レンジが日常の簡易滅菌に如何なる有効性を示すかを検討した.供試微生物はS. aureus, E. coli, Ps. aeruginosa, B. subtilisの芽胞, C. albicans, Echo virus及びHerpes simplexである.これらをガラス及びプラスティク哺乳瓶に定量的に附着させ電子レンジ(2450MHz 500W)で照射した.微生物の大低のものは5~6分,芽胞でも7分で完全死滅した.付着後乾燥状態にした場合はやや長時間を要したが,芽胞やウイルスでも12分では完全死滅した.以上のことから,マイクロ波による滅菌はその局部内部加熱作用が微生物の滅菌に有効に働き,包装状態のままで短時間で行える上に,プラスティク,ゴムなどの容器は損傷されず極めて有用性の高いことが判明した.

著者

前橋 明

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.102, no.11-12, pp.1229-1239, 1990 (Released:2009-03-30)

参考文献数

15

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In order to determine the effects of physical loading on the health status of children who attend swimming classes, subjective and objective changes caused by exercise were studied. In addition, this study also attempts to understand the place of outdoor exercise in daily life and to grasp fundamental problems of health care for children.In my investigation, 43 children exercised in a swimming pool for 75 minutes, and subjective symptoms of fatigue, flicker fusion values, and excretion of uninary protein before and after swimming were analyzed.The results revealed that so-called Group I and III subjective symptoms of fatigue were increased after swimming as compared with before suggesting that physical and nervous symptoms were induced by swimming. However, Group II symptoms, i.e. psychological complaints, were decreased, compared with before swimming.Second, flicker fusion values for the whole sample before and after physical loading were not changed by exercise, though swimming tended to decrease flicker fusion values in boys (p<0.05). On the other hand, the flicker fusion value tended to increase in girls (p<0.05).Third, the excretion of urine per hour was increased (p<0.05) after swimming in an exercise-dependent manner, though the specific gravity of urine significantly decreased (p<0.01).Finally, urinary pH tended to decrease in boys but did not change in girls after swimming, and the concentration of urinary protein was significantly lower after swimming (p<0.01).

著者

大月 三郎 秋山 一文 森本 清

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.103, no.3, pp.187-196, 1991-06-18 (Released:2009-08-24)

参考文献数

46

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Abuse of psychostimulants such as methamphetamine by humans leads to psychotic symptoms which are virtually indistinguishable from those of paranoid schizophrenia. A similar progressive augmentation was observed in locomotion and stereotyped behavior of animals receiving chronic administration of methamphetamine. Thus, such behavioral sensitization or reverse tolerance phenomenon has been well established as an animal model of susceptibility to exacerbation of methamphetamine-induced paranoid psychosis and schizophrenia. On the other hand, kindling refers to a phenomenon whereby a progressively increasing epileptiform discharge emerges after repeated electrical stimulation in a limbic area and finally culminates in a generalized seizure. Kindling has been best characterized as a model of human temporal lobe epilepsy. This review summarizes the studies on reverse tolerance and kindling phenomenon so far conducted in our department. Acute exacerbation following a re-challenge of methamphetamine in the methamphetamine-treated animals is associated with enhancement of dopamine release in the striatum. The pharmacological and electrophysioloical studies of kindling revealed cumulative evidence that excitatory amino acids play an important role in the induction mechanism of kindling, but that the seizure triggering mechanism may be related to collapse of inhibitory gamma-aminobutyric acid function. Further studies are necessary to understand these two important phenomena for psychiatry.

著者

吉井 清水

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.70, no.3, pp.879-903, 1958-03-31 (Released:2009-03-30)

参考文献数

17

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1. The author has made researches, in summer, autumn and winter, of the quantitative variation, following the time after death, of the non-protein nitrogen in bones and cartilages, and the anorganic phosphoric, sulphuric and nitric acid in brains, lungs, livers, kidneys and spleens of rabbits.2. Each quantities of the non-protein nitrogen in bones and cartilages increase following the time for a certain period after death. The quantities of the anorganic acids in these five organs increase similarly following the time after death, and then decrease after a certain period.3. The author has proved that the disintegration of dead bodies is more speedy 8-11 times in summer and 3-4 times in autumn than in winter.

著者

長島 洋

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.98, no.7-8, pp.669-685, 1986-08-30 (Released:2009-03-30)

参考文献数

28

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The purpose of the present study was to investigate experimentally the formation of ethanol in corpses and stored biological samples important in medicolegal examination, and to study the mechanism of ethanol formation.In the tissues and bodily fluids of corpses, ethanol, n-propanol, iso-propanol, acetaldehyde, acetone and others may be formed to various degrees according to the post-mortem conditions. The criteria of post-mortem ethanol formation are 20°C and 24 hours of post-mortem time, and a significant amount of ethanol can be formed at higher temperatures and longer times. The presence of n-propanol in samples may be useful for ascertaining post-mortem ethanol formation. The amount of ethanol formed post-mortemly may be presumed to be under 20 times of the amount of n-propanol simultaneously detected.Post-mortem ethanol formation is not increased by ante-mortem ethanol intake. Ethanol may be produced in biological samples including cadaveric blood. Fresh aseptic blood is not conducive to ethanol formation within five days.The formation of n-propanol due to yeast in the stomach of corpses is lower than that due to bacteria in other organs and bodily fluids. The addition of antibiotics, which suppress the bacterial growth in the samples, and the addition of chemical inhibitors of ADH and ALDH contained in bacteria comletely blocked ethanol formation.It may be considered that ADH and ALDH in the bacteria in corpses produce ethanol from carbohydrates such as glucose and pyruvic acid through the reverse pathway of ethanol metabolism in living subjects.

著者

水野 一郎

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.71, no.8-2, pp.5221-5229, 1959-08-15 (Released:2009-03-30)

参考文献数

16

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Several experiments on the adhesion of tenden were performed with adult rabbits, and following results were obtained.1). Adhesion of tendon seen after removal of the paratenon was most intensive in two to three weeks.2). The adhesion was less in the tendon preserved paratenon, which was thought to be a factor affecting the adhesion of tendon.3). Although the adhesion was slight in the crushed tendon, for the paratenon was preserved, the fixation of two to three weeks' duration was necessary for restoration of the tendon.4). On the prevention of adhesion the effect of wrapping tendon in living fascia or polyethylene membrane was studied comparatively. The result was better in polyethylene membrane, which prevented the adhesion perfectly.5). It was undesirable to wrap tendon in polyethylene membrane immediately after suture or transplantation, because of its complete interception of cell permeation disadvantageous to repair of the tendon.6). Repair of the tendon were thought to be incompatible with prevention of adhesion. It was, therefor, reasonable to intend prevention of readhesion after separation of adhesion, and best result was obtained with polyethylene membrane.

著者

松海 信彦

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.101, no.11-12, pp.1049-1061, 1989 (Released:2009-03-30)

参考文献数

44

被引用文献数

1

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The thermal damage threshold of brain tissue was estimated from the immediate and delayed histological changes caused by 2450 MHz microwave antenna and an antenna cooling system of a device used for interstitial hyperthermia treatment. An antenna within a cooling system was inserted through the small cranietomy under general anesthesia. The temperature at a reference point, 4 mm radially away from the surface of the cooling system, was maintained at 42 °C, 43 °C, 44 °C, 45 °C or 46 °C for 60 minutes. In a non-survival experiment, 18 animals were used and sacrificed immediately after the treatment. In a survival experiment, 9 animals were used and sacrificed seven days after the treatment. The histological changes were evaluated by microscopic examination with hematoxylin and eosin, Klüver-Barrera, or Bodian stainings. In the non-survival experiment, areas heated below 44 °C showed no obvious irreversible change. In the survival experiment, areas heated at 44 °C or above showed coagulative necrosis. Those histological findings indicate that the thermal damage occurs in normal brain tissue after heating at 44 °C or above for 60 minutes, and suggest that the safety limit for brain hyperthermia is 43 °C for 60 minutes.

著者

石津 日出雄 宮石 智 山本 雄二 高田 真吾

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.105, no.9-10, pp.839-845, 1993 (Released:2009-03-30)

参考文献数

5

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A 63-year-old male died in the hospital from erroneous drip infusion of thrombin, a local hemostatic, after polypectomy for intestinal polyposis. At autopsy, thromboses were observed in the cutaneous veins of the right arm, the right axillary vein and the right subclavian vein, and soft fibrin clots in the superior vena cava, the right atrium, the right ventricle and the pulmonary arteries. Thrombi were also found in the rami of the arteries in both lungs under the microscope. Leucocyte infiltration was recognized in the thrombus, but no organization. This finding shows that the thrombi were fresh. The remainder (150ml) of the drip solution was analyzed for thrombin activity and 8 to 16 units of thrombin activity per ml were demonstrated. From these results, the cause of death was considered pulmonary thrombosis due to intravenous administration of thrombin.

著者

国府島 泉 山本 洋 山本 マリリア明美 中村 知明 長町 栄子 寺坂 昌子 金政 泰弘

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.96, no.3-4, pp.385-389, 1984-04-30 (Released:2009-03-30)

参考文献数

11

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電子レンジによるおしぼり付着菌の殺菌効果について検討した.菌付着おしぼりを1本ずつ照射する実験ではE. coli, S. aureus, P. aeruginosaの細菌類は2分間程度のマイクロ波照射で殺菌された.真菌類のC. albicansも3分で殺菌された.しかしB. subtilisの芽胞は5分間のマイクロ波照射でも10%の生残が認められた.実際面を考慮しておしぼり10本程度を同時に行なう場合は,効率的にやや長時間を要するが,芽胞以外のものを対照にする限り5分照射で充分である.電子レンジによるおしぼりの殺菌は手軽に短時間にしかも効果的になされることが判明し,自家処理おしぼりの殺菌にはもちろんのこと業者処理おしぼりの追加殺菌にも有用であると考えられる.

著者

牧山 宏志

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.71, no.6-1, pp.3077-3084, 1959-05-01 (Released:2009-03-30)

参考文献数

18

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On the basis of the findings on the relationship between tubal muscles and the Eustachian tube as described in the previous report, the actions of various tubal muscles on the Eustachian tube are discussed, and the observations carried out by the methods described below on the movements in vivo of the naso-haryngeal orifice at the time of phonation and of swallowing reveaied the following results.1. Observations were carried out with the use of a nasopharyngoscope.2. Observations were done on the patients who underwent the radical operation for the cancer of maxillar sinus. As the inferior nasal concha was already removed at the time of the operation, it was possible to insert a small nasal mirror into the posterior nasal cavity of the operated side to catch the whole view around the tubal orifice of healty side.3. For the children over 5-6 years old with cleft palate, observations were carried out directly on the pharyngeal orifice through the mouth cavity (motion pictures were taken in this instance).At a result it has been found that the nasopharyngeal orifice of the tube is widened because the posterior lip and the mucous membrane of the base of the Eustachian tube move slightly outward at the time of swallowing. In anatomically summarizing these observations the author arrived at the following conclusions.At the time of swallowing the tensor muscle of the palate dilates the Eustachian tube at the points near the middle part and the anterior part of the tube. The levator palatini muscle assists the opening action of the tensor muscle by fixing or by drawing the base of the tube slightly toward the inferior-interior side. The salpingopharyngeus muscle or the salpingopharyngeal fold, being drawn inward by the cephalopharyngeal muscle and pahryngopalatine muscle and widening the nasopharygeal orified, assists the dilatating action of the tensor muscles.When the muscles are relaxed, the Eustachian tube is closed probably by the elasticity of the lateral cartilaginous lamina and by the pressure of the tissues surrounding the tube.

著者

山元 敦也

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.105, no.5-6, pp.629-639, 1993 (Released:2009-03-30)

参考文献数

13

被引用文献数

1 1

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It was previously reported that the elevation of inorganic fluorine level in plasma after inkalation of methoxyflurane causes acute renal failure. This study investigated whether the peak concentration or the duration of the inorganic fluorine is responsible for the renal failure. Continuous infusion (5 millimols/liter and 10 millimols/liter) or a single intravenous bolus injection (720 millimols/liter) of sodium fluoride solution was administered to rabbits. The plasma concentration and the duration of the plasma fluorine was measured.There werer no signs of pathological or biochemical changes that suggested renal failure when the peak plasma concentration was less than 50 millimols/liter for over 4 hours (5 millimols/liter, 24 hours), or whether peak concentration of plasma inorganic fliorine was over 50 millimols/liter for less than 4 hours (720 millimols/liter, intravenous bolus). However when 10 millimols/liter of sodium fluoride solution was administered at a speed of 10 milliliters/hour for 24 hours, the rabbits showed a peak plasma inorganic fluorine concentration over 50 micromols/liter for more than 4 hours and signs of renal failure developed ata plasma concentration of 65.8 micromols/liter 24 hours after the beginning of infusion. renal failure was mainly inthe form of edema of the tubular cells in both the cortex and medulla and abnormal biochemical changes (blood urea nitrogen 55.8±12.5 milligrams/deciliter, plasma creatinine 1.2±0.1 milligrams/deciliter).Inorganic fluorine can cause renal changes when its paek plasma concentration reaches more than 50 micromols/liter and lasts for more than 4 hours.

著者

片山 昭

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.91, no.7-8, pp.847-860, 1979-08-30 (Released:2009-03-30)

参考文献数

12

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In order to study the fundamental touch in piano playing, the physiological mechanics of the player and the kinetic mechanics of the swing-stroke system in the piano need to be studied.Equipment for analyzing and measuring the intensity of the swing-strokes has been developed to study the fundamental touch in piano playing. This equipment measures the velocity of the hammer and indicates the relationship of the intensity and the velocity of the swing-strokes.The tone-volume depends on the amount of kinetic energy which the player spends in striking the key. The kinetic energy is in direct proportion to the mass set in motion and is the square of the velocity.The mass set is always constant and the energy depends only upon the velocity of the hammer. Thus it is possible to analyze the tone-volume by measuring the velocity of the hammer.Two methods of swing-strokes were set up to analyze the movement of the swing-stroke. Two experiments were performed: (a) static swing-stroke in which the height of the swingstroke was fixed and the weight was changed and (b) dynamic swing-stroke in which the weight of the swing-stroke was fixed and the height was changed.Experiments with the swing-stroke were made by a skilled pianist. The control system of the intensity of the swing-strokes is discussed.

著者

平木 潔 太田 善介 入野 昭三 三好 勇夫 瀬崎 達雄 原田 英雄 鈴木 信也 大里 尚司 永森 俤一郎 守屋 純一郎 六車 昌士 高杉 潔 駄場崎 浩 池田 一彦

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.77, no.5-6, pp.795-835, 1965-06-30 (Released:2009-03-30)

参考文献数

229

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Morphologic characteristics of most of known oncogenic viruses, some of which were investigated by us, were described in relation to their oncogenicity and their localizations in tumor tissues.Oncogenic viruses were classified into six groups: type A, B, C, D, E and F. Viruses pertaining to type A were presumably not mature virus particles. Some of them could, however, be immature form or incomplete form of oncogenic virus particles. Viruses belonging to type B, C, D, E, and F were represented by mammary tumor virus of mice, leukemia viruses of mice and chickens, polyoma virus, Shope fibroma virus and Lucké renal adenocarcinoma virus, respectively. They were different in size and shape, and in the mode of development.It was presumed that type B and C viruses were members of the Myxovisus group and type D viruses belonged to Adenovirus and the Papova virus group. It was also believed that type E and F viruses had in general the feature of the Pox virus group and Herpes virus group, respectively.

著者

高橋 義雄 難波 祐三郎 岸本 晃司 光嶋 勲

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.113, no.3, pp.279-284, 2001-12-31 (Released:2009-03-30)

参考文献数

9

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GENDER IDENTITY DISORDER (GID) is a unique human condition that is classified behaviorally and treated medically with hormones and surgery in the severe form. This condition has been and still somewhat remains controversial by religious beliefs, social institutions and health care delivery systems. We described the surgical management of transsexuals, so called SEX REASSGINMENT SURGERY (SRS) and showed the team for gender treatment, GENDER CLINIC. A gender treatment team composing staff members from the Psychiatric, Plastic Surgery, Urology, Obstetric/Gynecological Surgery, and the Social Service, was established at the Hospital of Okayama University Medical schools in 1999. Female-to-Male procedures include mastectomy, phalloplasty, Phalloplasty are completion and an appurtenance, something pleasing to others. Male-to-Female program includes the genital surgery. The genital change surgery consists of the penile inversion, orchiectomy, vaginoplasty. Other procedures include reduction thyroid chondroplasty, hair transplant, voice change, laryngeal surgery, epilation with the laser.SRS is the only effective treatment available today in the management of GID. The aesthetic and functional results achievable from various procedures are generally satisfactory and are acceptable to the patients. On the other hand, we should remember that the numerous steps of information for SRS will be required.

著者

松原 一志

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.99, no.3-4, pp.287-301, 1987-04-30 (Released:2009-03-30)

参考文献数

23

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The infuluence of 2 stout build on the body surface electrocardiogram was studied by comparing the body surface isopotential maps of 93 normal men and 107 obese men without cardiovascular abnormalities. There were no clear differences in the mean map patterns between these groups, although the position of the peak maximum positive potential shifted slightly leftward in the obese group. The maximum positive potentials of the QRS wave (Rmax V) and T wave (Tmax V) at 87 lead points on the left anterior chest and back surface were significantly greater in the obese group. However, on the lower anterior chest surface, the values of Rmax V were smaller in the obese group. The correlations between the Rmax V of the lead points where significant differences between the groups were found and the relative body weight, skinfold thickness, chest configuration, mean frontal QRS axis of ECG, age and respiratory function (% VC, FEV 1.0%) were studied statistically. There were good correlations between Rmax V and the QRS axis and relative body weight. However, there were no apparent correlations between Rmax V and the chest configuration and skinfold thickness. These results suggest that obesity might lead to an increase in abdominal grith and elevation of the diaphragma that produces a mechanical effect on the heart, causing a left-axis shift.

著者

古元 順子

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.77, no.5-6, pp.773-794, 1965-06-30 (Released:2009-03-30)

参考文献数

54

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16才女子高校生にみられた約2ヵ月間にわたる全生活史健忘例の発端および経過として,1. 長期間に準備された不安・葛藤状態があり2. 健忘発端の一日前に偶発的な一酸化炭素中毒に罹患し3. ついで驚愕体験にひき続く意識障碍より覚醒した時に全生活史健忘が始まり,4. 自発性催眠様状態で過去の生活を継時的に追体験し遂に一酸化炭素に罹る直前の状態で覚醒し健忘の回復をみたが,5. 健忘回復後もなお情緒の動揺に関連し,癲癇自動症を疑わせる発作および頭痛が頻発し,これらは精神療法により情緒の安定が得られるまで持続した.検査所見としては1. 一酸化炭素中毒以前より存在したと思われる脳室拡大,頭蓋骨指圧痕,髄液圧亢進が認められ,2. 発端となつた意識障碍とも或程度の関係が推定され,その後の自動症と発作の相関は確実と思われる脳波異常として,後頭側頭部優位の同期性,間歇性のirregular slow wave burstおよび散発性のsharp waveないしはspiky waveが全径過を通じ安静時記録で認められたが睡眠誘発で賦活されず,情緒動揺の著明な時期に一致して上記所見が増強し,とくに右側々頭部で6 c/s positive spikeが繰り返し出現するのが確められ,3. ロールシャッハテストでも不安・神経症徴候および重篤な現実との接触喪失徴候とならんで,癲癇徴候がことに健忘回復後に増強するのが認められた.以上の経過,所見により,本例において健忘の発端となつた意識障碍に対する一酸化炭素および癲癇(とくに情動により誘発される癲癇)の関与如何につき,文献的に比較検討,綜合的に考察し,一酸化炭素の関与は完全には否定し難いが比較的に少く,ごく軽度の意識水準低下として発生準備状態の一要素を形成はていたと推定されるにとどまり,一方癲癇の関与は,発端の意識障宮が情動により誘発された癲癇それ自身であつたか,原始反応としての意識障害を惹起する準備状態の器質的主要因であつたかは別として,相当大きな比重をもつものと推定されることを述べ,併せて全生活史健忘というヒステリー反応が器質的意識障害の機構を利用しても起り得ることを推論した.

著者

谷崎 勝朗 高橋 清 上田 暢男 斉藤 勝剛 細川 正雄 小野 波津子 石橋 健 合田 吉徳 中村 之信 佐々木 良英 守谷 欣明 木村 郁郎

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.89, no.9-10, pp.1261-1265, 1977-10-30 (Released:2009-08-24)

参考文献数

8

被引用文献数

1 1

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A skin test using buckwheat extract was performed on 182 cases of bronchial asthma. Thirty-three of them showed a positive skin test to buckwheat extract.Buckwheat allergy (bronchial asthma, urticaria, allergic rhinitis, allergic gastroenteropathy and allergic conjunctivities) was found in 19 (57.6%) of the 33 cases showing a positive skin test to buckwheat extract.Basophils from 8 cases of buckwheat asthma showed a strong response to buckwheat extract, although basophils from 10 cases with a postive skin test only, without buckwheat allergy, did not response to buckwheat extract.Bronchial asthma induced by buckwheat (16 of the 19 cases) had some special features. Their asthma attack was induced by the introduction into the body through either mouth or airway and started in childhood. Buckwheat pillows were used in 13 of the 19 cases. Ten of the 13 cases obtained alleviation of asthma upon discontinuation of buckwheat pillows. Most of the buckwheat asthma patients showed a high serum IgE level and had a hereditary factor. The results showed that cases of buckwheat asthma might be sensitized in their childhood.

著者

出井 清雄

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.70, no.8, pp.2829-2884, 1958-08-31 (Released:2009-03-30)

参考文献数

167

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By the use of trypan blue, i.e. lipoid insoluble acid stain, in order to make observation of absorption activity of the oral mucosa, animals' mucosa with rapid absorption activity, its location, absorbing process, and absorbing conditions were investigated. Then clinical and biological observation on absorption of hormone of the salivary gland was tried.I. Mixture containing equal parts of 1 per cent solution of trypan blue and saturated sodium bicarbonate solution was dropped and painted over the normal oral mucosa of various kinds of animals, such as dog, cat, hamster, albino rat, chicken, elaphis virgatus, lizard, rana esculenta, eft, and crusian and absorption of the solution was observed.The results obtained were as follows:1) Absorption varied according to the kinds of animals.2) In general absorption of the lower verbetrata was more remarkable than that of mammals and birds.3) In mammals that of dogs was more marked than that of cat, hamster and albino rat.4) In dogs marked absorption was seen in buccal and sublingual mucosa, particularly at the sublingual and parotid salivary papillae and their surrounding areas.5) In albino rats absorption was made at the hard palate corresponding to the tip of the tongue.II. In premature dogs it was equal to that of mature dogs.III. No absorption was seen in the oral mucosa of the dog's and rabbit's fetus, while slight one was seen around the erupted teeth of the guinea-pig's fetus.IV. T. B. was not introduced into the ep. cells of rabbit's oral mucosa in case of vital staining.V. The effects of various factors on T. B. absorption of the oral mucosa in dogs' experiments were as follows:Absorption-stimulating factors are, local thermal stimulation, Grace helio lamp irradiation. roentgen irradiation of amount of 60 r to 100 r, radium irradiation of amount of 33 mg. h, to 66 mg. h., intracranial amputation of maxillary and mandibular divisions of trigeminal nerve just after the procedure. and local injection of Teabrom (T. E. A. B.), in the early stage of injection, while absorption-inhibiting factor was local cold stimulation and no absorption was stimulated in case of anemia of the head following ligation of the common carotid artery.VI. Parotin and Saliva-parotin, i.e. hormone of the salivary gland was painted over the oral mucosa of man, dog and rabbit. The results obtained were as follows:1) Leucocytosis was noticed in cases of dog (1.2-5.0 mg./kg. of Parotin administered) and man (0.2-0.4 mg./kg. of Parotin or 0.1-0.2 mg./kg. of Saliva-parotin administered), 2) decrease of serum Ca. and leucocytosis in case of rabbit (1.0-5.0 mg./kg. of Parotin and Saliva-parotin administered), and 3) stimulated calcification of dentine in case of rabbit (5 mg./kg. of Parotin administered).These results will suggest us the following factors as those effecting on absorbing mechanism of the oral mucosa, especially of the epithelium: 1) resistance, 2) intensity of surface tension, 3) intercellular density, 4) characteristics of chemical substances and solvent, and 5) special vital function of the cells.

著者

玉井 守

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.104, no.11-12, pp.1007-1014, 1992 (Released:2009-03-30)

参考文献数

29

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C3H mice were subcutaneously (s. c.) injected with a tumorigenic dose (1mg/mouse) of 3-methylcholanthrene (MC) and tumor development was observed for 18 weeks. OK-432 or Ge-132 was intraperitoneally administered either after MC injection (post-treatment) or both before and after MC injection (pre- and post-treatment).Pre- and post-treatment with OK-432 significantly inhibited the development of tumors from 10 to 12 weeks after MC injection as compared with a control group. In all of the groups, the incidence of tumors was 100 percent 18 weeks after MC injection. With respect to Ge-132, both post-treatment and pre- and post-treatment administration reduced tumor growth in a similar manner to pre- and post-treatment of OK-432.After pre-treatment with OK-432 or Ge-132 for two weeks, the percentage of large granular lymphocytes in peripheral blood and the natural killer activity of splenic cells in mice were increased.These results suggest that the immune status plays an important role in the defense mechanisms against chemically-induced tumors.

著者

康 逸雄

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.78, no.1, pp.159-170, 1966-01-30 (Released:2009-02-13)

参考文献数

24

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In this experiment, the author investigated the changes of blood and urine of the rescue team workers engaging in heavy tasks in high thermal conditions, in addition to the reaffirmation of the previous results. Further, he encountered several cases of heat stroke occasionally. The followings were the results obtained: 1. Change of pulse pressure which the results were obtained previously was affirmed statistically by increasing the number of the cases. 2. The cases of heat stroke suggested that the threshold limit of the increase of pulse pressure seemed to exist around the rate of 150%. 3. The threshold limit of body temperature (under tongue) was around 39°C. 4. By remarkable sweating after the task, blood was concentrated, resulting the increase of specific gravity of the total blood, proteine in plasma, hematocrit value and hemoglobin content. 5. The group of heat stroke showed higher pulse pressure, higher pulse rate, higher temperature under the tongue and has a tendency of a higher rate of blood concentration. 6. Life-saving mask type 4 produced heat when soda lime absorbed CO2 expired in the circulaing air. But the influence of the high temperature and high humidity of the environment was greater than the heated air-input of the mask. 7. The limitation of the continuity of the task in such a high thermal condition seemed to be around 30 minutes. The resting time was needed at least 90 minutes for adequate recovery.