著者
小森 浩二 山崎 裕己 古前 竜平 玉登 まき 福田 洋 板橋 司 菊田 真穂 高田 雅弘 宮﨑 珠美 中野 祥子 三田村 しのぶ 首藤 誠 山本 淑子 塙 由美子
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.40, no.3, pp.186-192, 2014-03-10 (Released:2015-03-10)
参考文献数
12
被引用文献数
1

Loxoprofen (Loxonin®) is a widely administered non-steroidal anti-inflammatory drug (NSAID) in Japan, with annual sales exceeding 50 billion Japanese yen. Although it is a very versatile drug and is often administered to breastfeeding women, the information available regarding its mammary gland transfer is inadequate.Therefore, in this study, we analyzed loxoprofen levels in the blood and milk of four breastfeeding women who received the drug for pain relief. These women visited the Obstetrics and Gynecology Department of Hanwa Sumiyoshi General Hospital for consultation or a cesarean section.One tablet of Loxonin® (loxoprofen 60 mg) was orally administered to each of the four women, and blood and milk samples were collected 0, 30, 90, 150 and 330 min after drug administration. Twenty microliters of ethanol was added to the blood and milk samples (10 μL), and the mixture was centrifuged at 12000 g for 15 min. The supernatant was analyzed by high-performance liquid chromatography (HPLC).Loxoprofen levels in blood peaked 90 min after its oral administration in all four patients, with the highest level being 4.5 μg/mL in patient II, whereas loxoprofen level in milk was below the detection limit (0.1 μg/mL) at all time points. Taken together, the data suggest low mammary gland transfer of loxoprofen, and thereby a low lactation risk.
著者
中野 祥子 田中 共子
出版者
多文化関係学会
雑誌
多文化関係学 (ISSN:13495178)
巻号頁・発行日
vol.14, pp.59-77, 2017 (Released:2020-09-10)
参考文献数
23

本研究では、日本人とムスリム留学生との関係形成を、日本人側の視点から実証的に探索した。具体的には、ムスリム留学生と親しい関わりを持つ、日本人6名に半構造化面接を行い、交流時の葛藤や戸惑い、関係形成・維持のための工夫を尋ねた。その結果、交流時の葛藤及び戸惑いは、4つにまとめられた「: 宗教的な実践への戸惑い」、「宗教的価値観を用いた応答への戸惑い」、「宗教的な議論への戸惑い」、「宗教的な禁忌への不安」。また、関係形成・維持のための工夫は、5つにまとめられた「: 宗教的実践への配慮」、「宗教的実践への不干渉」、「共通点への注目」、「率直な自己表現」、「積極的な働きかけ」。本研究の日本人ホストは、文化差への戸惑いを抱きつつも、「適度な距離感」を保ちながら場の共有が可能になるよう努めて、交流を楽しんでいた。良好な関係形成・維持を可能にする鍵となる、双方にとっての「適度な距離感」は、最低限でさりげない配慮、過度に干渉しない姿勢、宗教的価値観を受け入れたうえで率直な意見を述べようとする態度のバランスによって創出されるものと考えられた。
著者
小森 浩二 塙 由美子 山本 淑子 古前 竜平 山崎 裕己 中野 祥子 三田村 しのぶ 宮﨑 珠美 菊田 真穂 高田 雅弘 首藤 誠
出版者
公益社団法人 日本薬学会
雑誌
藥學雜誌 (ISSN:00316903)
巻号頁・発行日
vol.133, no.8, pp.905-911, 2013
被引用文献数
2

&nbsp;&nbsp;Loxoprofen (Loxonin<sup>&reg;</sup>), an antipyretic painkiller, was approved as an over-the-counter (OTC) drug (Loxonin<sup>&reg;</sup>-S) in January 2011. With regard to self-medication using OTC drugs, the information that pharmacists provide to consumers is very important. Although loxoprofen is a very versatile drug and can be used during breastfeeding, information regarding its mammary gland transfer is inadequate. In this study, we established a simple method to evaluate mammary transfer of drugs, and compared loxoprofen's mammary gland transfer with that of aspirin. Loxoprofen 12 mg/kg and aspirin 132 mg/kg was orally administered to mother mice (ddY), and blood and milk samples were collected. Twenty microliters of ethanol was added to the blood and milk samples (10 &mu;L), and the mixture was centrifuged for 15 min (12000 <i>g</i>); the supernatant was analyzed by high-performance liquid chromatography. Since aspirin was immediately metabolized, we analyzed salicylic acid concentrations. Maximum concentration of loxoprofen was observed at around 15 min after its oral administration, with the concentrations in the blood and milk being 2.9 and 0.5 &mu;g/mL, respectively. The drug was metabolized promptly thereafter. In contrast, maximum concentration of salicylic acid was observed at 30 min after aspirin administration, with the concentrations in the blood and milk being 187.2 and 64.4 &mu;g/mL, respectively. These concentrations remained constant from 60 to 120 min. Salicylic acid could be detected 240 min after aspirin administration. Thus, mammary gland transfer of loxoprofen is lower than that of aspirin, suggesting that loxoprofen does not accumulate in milk.<br>
著者
高田 雅弘 中野 祥子 三田村 しのぶ 宮﨑 珠美 菊田 真穂 小森 浩二 首藤 誠 七山(田中) 知佳 森谷 利香 吉村 公一 石橋 文枝 塙 由美子 山本 淑子
出版者
日本社会薬学会
雑誌
社会薬学 (ISSN:09110585)
巻号頁・発行日
vol.34, no.2, pp.116-127, 2015-12-10 (Released:2015-12-25)
参考文献数
10

With regard to proper drug use in home care, the failure of approximately half of all elderly patients to comply with their doctor’s medication instructions and many other issues have been reported. However, pharmacists’ involvement in home care support remains inadequate, as highlighted by a Ministry of Health, Labor and Welfare report which noted the lack of full utilization of pharmacists in community medicine as well as the fact that home nurses often have to manage their patients’ medications. The Setsunan University Faculty of Nursing was established in 2012, and the university’s Faculties of Pharmaceutical Sciences and Nursing collaborate in their educational activities. To increase pharmacists’ involvement in home care support, we launched a project to create a home care support model in which pharmacists and nurses work in collaboration, utilizing their respective faculty resources. In this study, we conducted a questionnaire survey of pharmacies and visiting nurse stations in Osaka Prefecture regarding the present status of and problems related to pharmacists’ participation in the home care system and visiting nurses’ current involvement in medication management, as well as what is expected of pharmacists. Based on these results, we are constructing a model in which Faculties of Pharmaceutical Sciences and Nursing collaboratively support the home care system with the aim of establishing the role that universities should play in a comprehensive regional care program.