文献一覧: 山本淑子 (著者)

8 0 0 0 OA ロキソプロフェンの母乳への移行性

著者: 小森浩二山崎裕己古前竜平玉登まき福田洋板橋司菊田真穂高田雅弘宮﨑珠美中野祥子三田村しのぶ首藤誠山本淑子塙由美子
出版者: 一般社団法人日本医療薬学会
雑誌: 医療薬学 (ISSN:1346342X)
巻号頁・発行日: vol.40, no.3, pp.186-192, 2014-03-10 (Released:2015-03-10)
参考文献数: 12
被引用文献数: 1

Loxoprofen (Loxonin®) is a widely administered non-steroidal anti-inflammatory drug (NSAID) in Japan, with annual sales exceeding 50 billion Japanese yen. Although it is a very versatile drug and is often administered to breastfeeding women, the information available regarding its mammary gland transfer is inadequate.Therefore, in this study, we analyzed loxoprofen levels in the blood and milk of four breastfeeding women who received the drug for pain relief. These women visited the Obstetrics and Gynecology Department of Hanwa Sumiyoshi General Hospital for consultation or a cesarean section.One tablet of Loxonin® (loxoprofen 60 mg) was orally administered to each of the four women, and blood and milk samples were collected 0, 30, 90, 150 and 330 min after drug administration. Twenty microliters of ethanol was added to the blood and milk samples (10 μL), and the mixture was centrifuged at 12000 g for 15 min. The supernatant was analyzed by high-performance liquid chromatography (HPLC).Loxoprofen levels in blood peaked 90 min after its oral administration in all four patients, with the highest level being 4.5 μg/mL in patient II, whereas loxoprofen level in milk was below the detection limit (0.1 μg/mL) at all time points. Taken together, the data suggest low mammary gland transfer of loxoprofen, and thereby a low lactation risk.

2021-05-04 15:44:26
1 知恵袋
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2 0 0 0 インタビュー及川光博--天の邪鬼は有言実行僕の使命は、あなたをうっとりさせること

著者: 及川光博山本淑子
出版者: 中央公論新社
雑誌: 婦人公論
巻号頁・発行日: vol.86, no.17, pp.22-27, 2001-09-07

2015-02-02 23:25:56
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https://ci.nii.ac.jp/naid/40003330840

1 0 0 0 薬物の乳汁移行性を検討するためのHPLCを用いた一手法 —泌乳マウスを用いた一般用医薬品(ロキソニン®-S錠,バファリン®A錠)の検討

著者: 小森浩二塙由美子山本淑子古前竜平山崎裕己中野祥子三田村しのぶ宮﨑珠美菊田真穂高田雅弘首藤誠
出版者: 公益社団法人日本薬学会
雑誌: 藥學雜誌 (ISSN:00316903)
巻号頁・発行日: vol.133, no.8, pp.905-911, 2013
被引用文献数: 2

Loxoprofen (Loxonin®), an antipyretic painkiller, was approved as an over-the-counter (OTC) drug (Loxonin®-S) in January 2011. With regard to self-medication using OTC drugs, the information that pharmacists provide to consumers is very important. Although loxoprofen is a very versatile drug and can be used during breastfeeding, information regarding its mammary gland transfer is inadequate. In this study, we established a simple method to evaluate mammary transfer of drugs, and compared loxoprofen's mammary gland transfer with that of aspirin. Loxoprofen 12 mg/kg and aspirin 132 mg/kg was orally administered to mother mice (ddY), and blood and milk samples were collected. Twenty microliters of ethanol was added to the blood and milk samples (10 μL), and the mixture was centrifuged for 15 min (12000 g); the supernatant was analyzed by high-performance liquid chromatography. Since aspirin was immediately metabolized, we analyzed salicylic acid concentrations. Maximum concentration of loxoprofen was observed at around 15 min after its oral administration, with the concentrations in the blood and milk being 2.9 and 0.5 μg/mL, respectively. The drug was metabolized promptly thereafter. In contrast, maximum concentration of salicylic acid was observed at 30 min after aspirin administration, with the concentrations in the blood and milk being 187.2 and 64.4 μg/mL, respectively. These concentrations remained constant from 60 to 120 min. Salicylic acid could be detected 240 min after aspirin administration. Thus, mammary gland transfer of loxoprofen is lower than that of aspirin, suggesting that loxoprofen does not accumulate in milk.

2018-11-14 06:45:20
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1 0 0 0 OA 薬局及び訪問看護ステーションにおける他職種連携に関する調査研究

著者: 高田雅弘中野祥子三田村しのぶ宮﨑珠美菊田真穂小森浩二首藤誠七山(田中) 知佳森谷利香吉村公一石橋文枝塙由美子山本淑子
出版者: 日本社会薬学会
雑誌: 社会薬学 (ISSN:09110585)
巻号頁・発行日: vol.34, no.2, pp.116-127, 2015-12-10 (Released:2015-12-25)
参考文献数: 10

With regard to proper drug use in home care, the failure of approximately half of all elderly patients to comply with their doctor’s medication instructions and many other issues have been reported. However, pharmacists’ involvement in home care support remains inadequate, as highlighted by a Ministry of Health, Labor and Welfare report which noted the lack of full utilization of pharmacists in community medicine as well as the fact that home nurses often have to manage their patients’ medications. The Setsunan University Faculty of Nursing was established in 2012, and the university’s Faculties of Pharmaceutical Sciences and Nursing collaborate in their educational activities. To increase pharmacists’ involvement in home care support, we launched a project to create a home care support model in which pharmacists and nurses work in collaboration, utilizing their respective faculty resources. In this study, we conducted a questionnaire survey of pharmacies and visiting nurse stations in Osaka Prefecture regarding the present status of and problems related to pharmacists’ participation in the home care system and visiting nurses’ current involvement in medication management, as well as what is expected of pharmacists. Based on these results, we are constructing a model in which Faculties of Pharmaceutical Sciences and Nursing collaboratively support the home care system with the aim of establishing the role that universities should play in a comprehensive regional care program.

2015-12-26 00:40:26
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1 0 0 0 OA コカイン及びメタンフェタミンによる不安惹起作用と内因性カンナビノイド受容体作用薬などの抗不安薬

著者: 早瀬環山本淑子山本啓一
出版者: 日本毒性学会
雑誌: 日本トキシコロジー学会学術年会第32回日本トキシコロジー学会学術年会
巻号頁・発行日: pp.121, 2005 (Released:2005-06-08)

我々はこれまで、濫用薬物であるコカイン(COC)やメタンフェタミン(MA)の不安惹起作用について、マウスにおける高架式十字迷路法などの方法によって調べてきた。COCやMAによる不安症状は、他の原因による不安症状同様、ベンゾジアゼピン受容体やセロトニン受容体などの受容体と関係があるといわれ、様々な抗不安薬による抑制効果が検討されてきたが、最近カンナビノイド(CB)受容体との関係が示唆されている。特にanandamide(AEA)など内因性CB受容体作用薬(内因性CB)は抗不安作用など様々な治療効果を示すことが証明されている。本研究ではCOC及びMAによる不安症状に対する内因性CBの影響を調べ、他の抗不安薬との比較を試みた。【方法】雄ICRマウスでCOC及びMAの不安惹起作用に対するベンゾジアゼピン受容体(diazepamなど)、セロトニン受容体(ketanserin、ondansetronなど)などに関係のある抗不安薬、及び内因性CBであるAEA、2-arachidonylglycerol、N-arachidonyldopamine(NADA)、noladin ether、virodhamine(VD)の影響を高架式十字迷路法(壁のあるenclosed armへの嗜好性の変化)によって調べた。【結果と考察】高架式十字迷路法では、COC 30mg/kg又はMA 4mg/kgの急性投与群(腹腔内投与)、及びCOC 15 mg/kg又はMA 2mg/kgの慢性投与群(7日間の投与)の両方で、3日間以上の不安症状(壁のないopen armへの移動回数の減少、壁のあるclosed armへの移動回数の増加、open armでの滞在時間の減少、open armに最初に移動するまでの時間の延長、すくみ緊張姿勢の増加など)の継続が認められたが、(最終)投与40分後では、急性投与群のみで著明な不安症状が認められた。抗不安薬については、投与40分後では、diazepam(5mg/kg)、chlormethiazole(10mg/kg)、ketanserin(5mg/kg)、ondansetron(0.01mg/kg)、及びCB受容体に対して部分antagonistとしても作用するVD以外の内因性CBの抗不安作用(上記の評価値の回復)が急性投与群で認められたが、投与3日後では、内因性CBのみに急性投与群と慢性投与群の両群での抗不安作用が認められ、作用の継続性とCOCやMAの退薬症状に対する効果の可能性が示唆された。また内因性CBなどの効果がCOC群とMA群の両群で認められることが示された。