文献一覧: 今井明 (著者)

3 0 0 0 OA 鉄剤と各種制酸剤の相互作用の検討

著者: 水上恵美小田晃司番場孝野中潤今井明古川征治
出版者: 一般社団法人日本医療薬学会
雑誌: 医療薬学 (ISSN:1346342X)
巻号頁・発行日: vol.28, no.6, pp.559-563, 2002-12-10 (Released:2011-03-04)
参考文献数: 22
被引用文献数: 1

The concomitant use of oral iron preparations and antacids causes iron to form macromolecular polymer thereby reducing its absorption as a result of a pH elevation in the stomach. We measured the Iron recovery after ultrafiltration to assess macromolecular polymer using sodium ferrous citrate (SFC) and ferrous sulfate (FS) preparations plus eight types of antacids Aluminum hydroxide (Al), Magnesium oxide (Mg), Calcium carbonate (Ca), and Sodium bicarbonate (NaHCO3) preparations and four combinations.The samples were mixed under two conditions : (1) a mixture of the maximum single oral dose of each iron preparation and an antacid dissolved in a hydrochloric acid solution adjusted to various pH levels (4, 5, 6, 7, 8, and 9) (2) pH not adjusted. Iron recovery rate was measured using the O-phenanthroline method after ultrafiltration (fractions with a molecular weight of 10, 000).As a result, we obtained the following results : (1) the iron recovery rate decreased according to elevation of pH. In addition, macromolecular polymer formation was pH dependent. The iron recovery rate of FS when mixed with all antacids except Mg was less than 60 % at a pH of 7. The iron recovery rate of SFC was not less than 60% at a pH of 7 with any antacid. (2) the iron recovery rate of FS when mixed with Ca, NaHCO3, the Al + Mg combination and Mg was less than 60%. The iron recovery rate of SFC was less than 60 % with only Mg.FS formed macromolecular polymer in the presence of Ca, NaHCO3, the Al+Mg combination and Mg. As a result, the iron absorption was suggested to decrease when FS was administered with these antacids. SFC showed little formation of macromolecular polymer in the presence of antacids, and it was therefore suggested that the absorption would only be slightly influenced by the concomitant use of SFC with antacids. Therefore, the formation of macromolecular polymers differed between the two oral iron preparations, FS and SFC, when mixed with antacids. These findings suggest that iron absorption may differ between FS and SFC in concomitant use with antacids.

2022-10-17 03:30:34
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1 0 0 0 OA 脳卒中患者の生命予後と死因の5年間にわたる観察研究: 栃木県の調査結果とアメリカの報告との比較

著者: 今井明鈴木ひろみ渡辺晃紀梅山典子塚田三夫中村勤松崎圭一加藤開一郎冨保和宏
出版者: 一般社団法人日本脳卒中学会
雑誌: 脳卒中 (ISSN:09120726)
巻号頁・発行日: vol.32, no.6, pp.572-578, 2010-11-26 (Released:2010-12-03)
参考文献数: 10
被引用文献数: 2 2

脳卒中の自然経過を検討する目的で,生命予後と死因について調査し,AHAによる報告と比較した.対象は1998年4月から1999年3月に脳卒中を発症し,栃木県内で登録された5,081人である.発症から5年9カ月までの死亡の有無と,死因簡単分類で死因を調査した.生存率はKaplan-Meier法で算出した.脳卒中全体の5年生存率は62.3%であり,病型別の5年生存率は,くも膜下出血54.9%,脳出血57.9%,脳梗塞62.8%であった.死因の観察では,すべての病型で1位を脳卒中,2位を循環器系の疾患が占め,3位はくも膜下出血と脳出血では悪性新生物,脳梗塞では呼吸器系の疾患が占めた.くも膜下出血と脳出血では原疾患による急性期死亡が多く,75歳以上の脳梗塞では肺炎による死亡が多かった.AHAの報告によると,脳卒中の5年以内の致死率は男性47%,女性51%であり,栃木県の致死率は男性38.5%,女性36.7%とアメリカの報告より低かった.脳卒中の生命予後の改善には,急性期治療の充実と慢性期脳梗塞の肺炎に対する対策が重要と考える.