著者
安宅 弘司 伊藤 雅文 柴田 高
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
vol.125, no.12, pp.937-950, 2005-12-01 (Released:2005-12-01)
参考文献数
50
被引用文献数
3 5

Wood creosote, the principal ingredient in Seirogan, has a long history as a known gastrointestinal microbicidal agent. When administered orally, the intraluminal concentration of wood creosote is not sufficiently high to achieve this microbicidal effect. Through further animal tests, we have shown that antimotility and antisecretory actions are the principal antidiarrheal effects of wood creosote. Wood creosote inhibits intestinal secretion induced by enterotoxins by blocking the Cl- channel on the intestinal epithelium. Wood creosote also decreases intestinal motility accelerated by mechanical, chemical, or electrical stimulus by the inhibition of the Ca2+ influx into the smooth muscle cells. In this overview, the antimotility and antisecretory effects of wood creosote are compared with those of loperamide. Wood creosote was observed to inhibit stimulated colonic motility, but not normal jejunal motility. Loperamide inhibits normal jejunal motility, but not stimulated colonic motility. Both wood creosote and loperamide inhibit intestinal secretion accelerated by acetylcholine. Wood creosote was found to have greater antisecretory effects in the colon than loperamide. Based upon these findings, we conclude that the antidiarrheal effects of wood creosote are due to both antisecretory activity in the intestine and antimotility in the colon, but not due to the microbicidal activity as previously thought. Wood creosote was found to have no effects on normal intestinal activity. These conclusions are supported by the results of a recent clinical study comparing wood creosote and loperamide, which concluded that wood creosote was more efficacious in relieving abdominal pain and comparable to loperamide in relieving diarrhea.
著者
川合 亮佑 藤野 雅彦 宮田 完志 湯浅 典博 竹内 英司 後藤 康友 三宅 秀夫 永井 英雅 小林 陽一郎 伊藤 雅文
出版者
一般社団法人 日本消化器外科学会
雑誌
日本消化器外科学会雑誌 (ISSN:03869768)
巻号頁・発行日
vol.44, no.5, pp.549-555, 2011

症例は73歳の男性で,66歳時に十二指腸乳頭部腺腫に対して内視鏡的乳頭切除術が施行されている.68歳時に悪性リンパ腫に対して化学療法を施行され完全寛解を得ている.平成20年9月,心窩部痛を主訴に当院を受診した.内視鏡的逆行性胆管膵管造影で総胆管結石と中部胆管の狭窄を認め,切石と狭窄部の生検,内視鏡的経鼻胆管ドレナージを行った.生検で腺癌と診断されたため,肝外胆管癌と診断し膵頭十二指腸切除術を施行した.胆管癌は肉眼的に乳頭浸潤型で表層拡大進展を呈した.病理組織学的に浸潤部はほとんど扁平上皮癌であったが,表層拡大進展部の粘膜内および線維筋層浸潤部に腺癌・扁平上皮癌の二方向性分化を認めた.また,固有筋層に浸潤する胆嚢癌も伴っていた.肝外胆管原発腺扁平上皮癌の本邦報告43例の中で,粘膜内で腺癌・扁平上皮癌の二方向性分化を認めた症例はなく,自験例は腺扁平上皮癌の組織発生を考察するうえで貴重な症例である.
著者
岡田 基 松井 明男 米沢 千佳子 伊藤 雅文 柴田 偉雄
出版者
公益社団法人 日本臨床細胞学会
雑誌
日本臨床細胞学会雑誌 (ISSN:03871193)
巻号頁・発行日
vol.33, no.3, pp.479-484, 1994 (Released:2011-11-08)
参考文献数
12

婦人科標本中に認められたいわゆるヘマトイジン結晶様物質 (以下ヘマトイジン様結晶と略す) について, 4年6ヵ月の問に当院を受診した41,274人, 標本件数116,360件を対象に検討した.35人 (45件) にヘマトイジン様結晶を認めた.35例の年齢分布は24歳から52歳 (平均38.7歳) であった.疾患内訳は, 腟部ビラン17名, 妊娠7名, 切迫流産4名, 異形成2名, 上皮内癌1名であった.ヘマトイジン様結晶の出現頻度は, 子宮腟部擦過で0.05%, 子宮頸管擦過で0.04%であった.結晶の出現様相は, パパニコロー染色で黄金色ないし黄褐色調に染色され, ロゼット状配列, 樹枝状配列を呈する集塊が主体で, 一部は散在性に楕円形結晶として出現した.大きさは1~341.5μ であった.大多数の結晶は, 組織球や好中球からなる炎症細胞集塊中に認められた.特殊染色ではPAS染色が陽性を呈したが, ほかの粘液染色, 鉄染色, ビリルビン染色は陰性であり, 免疫染色ではフェリチン, S-100蛋白, EMA陰性であった.以上の所見から婦人科標本中に認められたヘマトイジン様結晶は, ヘマトイジンとは異なる物質で, ヘモグロビン系の色素ではないと考えられた.
著者
安宅 弘司 伊藤 雅文 柴田 高
出版者
公益社団法人日本薬学会
雑誌
藥學雜誌 (ISSN:00316903)
巻号頁・発行日
vol.125, no.12, pp.937-950, 2005-12-01
被引用文献数
2 5

Wood creosote, the principal ingredient in Seirogan, has a long history as a known gastrointestinal microbicidal agent. When administered orally, the intraluminal concentration of wood creosote is not sufficiently high to achieve this microbicidal effect. Through further animal tests, we have shown that antimotility and antisecretory actions are the principal antidiarrheal effects of wood creosote. Wood creosote inhibits intestinal secretion induced by enterotoxins by blocking the Cl^- channel on the intestinal epithelium. Wood creosote also decreases intestinal motility accelerated by mechanical, chemical, or electrical stimulus by the inhibition of the Ca^<2+> influx into the smooth muscle cells. In this overview, the antimotility and antisecretory effects of wood creosote are compared with those of loperamide. Wood creosote was observed to inhibit stimulated colonic motility, but not normal jejunal motility. Loperamide inhibits normal jejunal motility, but not stimulated colonic motility. Both wood creosote and loperamide inhibit intestinal secretion accelerated by acetylcholine. Wood creosote was found to have greater antisecretory effects in the colon than loperamide. Based upon these findings, we conclude that the antidiarrheal effects of wood creosote are due to both antisecretory activity in the intestine and antimotility in the colon, but not due to the microbicidal activity as previously thought. Wood creosote was found to have no effects on normal intestinal activity. These conclusions are supported by the results of a recent clinical study comparing wood creosote and loperamide, which concluded that wood creosote was more efficacious in relieving abdominal pain and comparable to loperamide in relieving diarrhea.