著者
中島 尚登 星 順隆 浅井 治 山本 純子 竹内 直子 神谷 昌弓 加藤 敦子 長谷川 智子 山崎 恵美 中山 一
出版者
一般社団法人 日本輸血・細胞治療学会
雑誌
日本輸血学会雑誌 (ISSN:05461448)
巻号頁・発行日
vol.37, no.6, pp.795-802, 1991-12-25 (Released:2010-03-12)
参考文献数
18

A new red cell preservation solution is described in which the red cells may be stored for 42 and 49 days. An in vivo and vitro study of 42 and 49 days stored red cells with saline, adenine, glucose, mannitol (SAGM) preservation solution (OPTISOL, Terumo Corporation) was conducted using 20 healthy volunteers to document in vivo efficacy and analyze the validity of the 51Cr technique. Standard in vitro parameters of OPTISOL red cell concentrates were well preserved with low levels of hemolysis and high levels of red cell ATP which is compatible with their survival after 42 and 49 days storage. Osmotic pressure at hemolysis ending point of 42 and 49 days stored red cells did not change, while osmotic pressure at hemolysis starting point increased on 49 days. The red cell viscosity increased and scanning electron-microscopic studies showed that the majority of them became echinocyte and spherocyte on 49 days. In vivo autologous post-transfusion recovery was measured by using a 51Cr-labeled red cells. After 42 days of storage, post-transfusion 24-hour recovery averaged 82.3±8.4% and 48-hour recovery was 79.1±9.1%, and after 49 days, 24-hour recovery was 75.9±3.6%, but 48-hour recovery, which averaged 69.9±5.2%, was significantly lower.The present study reports in vivo and in vitro evaluation of a new red cell storage medium which allows high levels of post-transfusion recovery and permits without significant hemolysis. The results suggested that 42 days if a more suitable shelf life than 49 days.
著者
李 在麟 太田 啓路 河合 隆史 吉田 菜穂子 井澤 修平 野村 忍 イームズ ダグラス 山崎 恵 貝谷 久宣
出版者
特定非営利活動法人 日本バーチャルリアリティ学会
雑誌
日本バーチャルリアリティ学会論文誌 (ISSN:1344011X)
巻号頁・発行日
vol.12, no.1, pp.57-65, 2007-03-31 (Released:2017-02-01)

Recently, attention is being brought to exposure treatment methods using Virtual Reality for those suffering from panic disorder accompanied by agoraphobia. Overseas, contents for exposure treatment introducing Virtual Reality began development in the 1990s and positive evaluations are being made regarding its treatment methods and treatment effects. On one hand, there are still no cases developed professionally in Korea and even evaluations cases introduced into treatment are being made using contents developed overseas. For such reasons, this study has attempted to develop Virtual Reality Exposure contents which fully reflect Japan's culture and environment. Developed contents were focused on subway environments where avoidance was shown the most among patients receiving treatment in community hospitals. Contents were produced through Virtual Reality by modeling existing places and objects in their actual size to express a high sense of reality. Also, mutual interaction functions were strengthened to allow exposure suitable to the diverse symptoms of each patient. Although evaluations through this study are still in progress, changes in avoidance behavior regarding anxiety and fear are being confirmed and treatment effects are being verified through additional experiments.
著者
植木 雄志 高橋 剛史 太田 久幸 正道 隆介 山崎 恵介 梅津 哉 堀井 新
出版者
日本内分泌外科学会・日本甲状腺外科学会
雑誌
日本内分泌・甲状腺外科学会雑誌 (ISSN:21869545)
巻号頁・発行日
vol.37, no.1, pp.55-59, 2020 (Released:2020-06-16)
参考文献数
14

【症例】71歳女性。骨粗鬆症で加療を受けていたが高カルシウム血症を指摘され,当院に紹介となった。FDG-PETで副甲状腺腫瘍と骨への多数の集積を認め,99mTc-MIBIシンチグラフィでは左下副甲状腺への強い集積と,骨病変への弱い集積を認めた。シナカルセトを投与するも高カルシウム血症が改善しないため腫瘍摘出術を施行したところ,病理診断は副甲状腺癌であった。術後血清カルシウム,PTH-intactは正常化した。術後1年経過した時点でFDG-PET再検したところ,骨病変の集積は消退し,硬化性変化が進行していたため,Brown tumorの合併であったと判断した。【まとめ】副甲状腺癌とBrown tumorの合併はきわめて稀であるが,副甲状腺腫瘍に骨病変を伴う場合はBrown tumorを念頭に置き原発巣切除後の画像検査で骨病変の評価を行うことで,侵襲的な検査・治療を回避できる可能性が考えられた。