著者

安田 広康 野口 まゆみ 遠山 ゆり子 大戸 斉 阿部 力哉

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.38, no.5, pp.596-600, 1992-11-15 (Released:2010-03-12)

参考文献数

21

---

Transfusion-associated graft-versus-host disease (TA-GVHD) was described as occurring after nonirradiated blood tranfusion not only in immunosuppressed but also in immunocompetent recipients who share one HLA haplotype with HLA-homozygous blood donors.From the distribution of 1% or more frequencies of HLA-A, -B, -C, -DR, -DQ haplotypes obtained at the 11th International Histocompatibility Workshop (1991), using the fomulae of Kanter, we tried to calculate the potential risk of TA-GVHD as a result of directed donations from relatives in the Japanese and other ethnic groups.The Japanese have the greatest risk of TA-GVHD than any other populations because are more homogeneous in HLA and have a common haplotype: A24-CBL-Bw52-DRw15-DQw1 (7.5%).Of noteworthing, the risk of transfusion of HLA-homozygotes to heterozygotes among 1st-degree relatives in the Japanese was 4.7-folds compared with that of transfusion in the U. S. A. population. And, the risk of TA-GVHD among the Japanese unrelated was near to that of transufusion among the French first degree relatives.Therefore, we recommend that donations of blood components from recipient's relatives should be irradiated essentially, and as possible even from unrelated donors in the Japanese population.

著者

林 正則

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.41, no.3, pp.300-303, 1995 (Released:2010-03-12)

参考文献数

15

被引用文献数

1

著者

内田 立身 西村 拓史 瀧本 宏美 佐藤 美津子 西尾 由美子 福家 洋子 野崎 正範

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.44, no.1, pp.33-34, 1998-02-01 (Released:2010-03-12)

参考文献数

6

---

We evaluated the effect of repeated apheresis on storage iron status in 82 males and 138 females. Storage iron was calculated according to the formula proposed by the National Health and Nutrition Examination Survey (NHANES) as previously described. Calculated storage iron after repeated apheresis was 362±282mg in male donors and 128±176mg in females. These values were significantly lower than those in normal subjects and 400-ml repeated whole blood donors. A total of 12.2% of males and 45.7% of females were in negative iron balance before donation. The high prevalence of storage iron deficiencfy may be due to residual blood in the circuit or other factors.

著者

中島 尚登 星 順隆 浅井 治 山本 純子 竹内 直子 神谷 昌弓 加藤 敦子 長谷川 智子 山崎 恵美 中山 一

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.37, no.6, pp.795-802, 1991-12-25 (Released:2010-03-12)

参考文献数

18

---

A new red cell preservation solution is described in which the red cells may be stored for 42 and 49 days. An in vivo and vitro study of 42 and 49 days stored red cells with saline, adenine, glucose, mannitol (SAGM) preservation solution (OPTISOL, Terumo Corporation) was conducted using 20 healthy volunteers to document in vivo efficacy and analyze the validity of the 51Cr technique. Standard in vitro parameters of OPTISOL red cell concentrates were well preserved with low levels of hemolysis and high levels of red cell ATP which is compatible with their survival after 42 and 49 days storage. Osmotic pressure at hemolysis ending point of 42 and 49 days stored red cells did not change, while osmotic pressure at hemolysis starting point increased on 49 days. The red cell viscosity increased and scanning electron-microscopic studies showed that the majority of them became echinocyte and spherocyte on 49 days. In vivo autologous post-transfusion recovery was measured by using a 51Cr-labeled red cells. After 42 days of storage, post-transfusion 24-hour recovery averaged 82.3±8.4% and 48-hour recovery was 79.1±9.1%, and after 49 days, 24-hour recovery was 75.9±3.6%, but 48-hour recovery, which averaged 69.9±5.2%, was significantly lower.The present study reports in vivo and in vitro evaluation of a new red cell storage medium which allows high levels of post-transfusion recovery and permits without significant hemolysis. The results suggested that 42 days if a more suitable shelf life than 49 days.

著者

福森 泰雄 田中 成憲 杉本 昭子 大軒 子郎 山口 英夫

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.36, no.5, pp.580-586, 1990-10-30 (Released:2010-03-12)

参考文献数

13

---

Irradiation with X-ray to blood products is a standard practice recommended for prevention of post-transfusion graft versus host disease in patients. In order to seek the optimal condition of irradiation to minimize the lesion of red blood cell (RBC) with complete inactivation of lymphocytes, we studied the effects of irradiation with X-ray on the quality of RBC in whole blood (WB) and concentrated red blood cells (CRC) in the range of 5 to 50 Gy.X-ray irradiation did not alter ATP and 2, 3-DPG content, hemolysis ending point and morphology of RBC, while it caused a slight increase of osmotic pressure at hemolysis starting point of RBC and potassium concentration in plasma. Considerable increase of hemolysis was observed with higher dose of irradiation in both WB and CRC. However, it was so small as below 2-3×10-2 percent that is acceptable level in blood products.Therefore, we concluded that the X-ray irradiation of WB and CRC with up to 50 Gy has no significant effects on in vitro characteristics of RBC.

著者

天野 尹

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.29, no.6, pp.597-606, 1984 (Released:2010-03-12)

参考文献数

8

---

The term of 37 years, from 1925 to 1961, could be divided into five periods. The first corresponds to one with a stable and high birth rate, the second to that of Japan-China War, the third to that of World War II, the fourth to that of postwar with its rapid drop in birth rate and the fifth to that with a low birth rate since then. This classification of period shows the change of historical conditions of Japan.The materials for the test of homogeneity were prepared from random sample from the cards of the registered donors in Shimane, Yamaguchi, Akita and Iwate Prefectures and Bernstein's method was applied to estimate the gene frequencies (p: gene of A, q: gene of B, r: gene of O).The results of the test of homogeneity between each period could be expressed as follows: in Shimane Prefecture; q in the third period decreased, in Akita Prefecture; q in the third peroid decreased, in Yamaguchi Prefecture; p in the fourth period increased and in Iwate Prefecture, q in the latter half of the fifth period decreased.The effect of hybridisation, areal biased donation, immigration and inbreeding must be considered as possible factors in the change of gene frequency.There is very little hybridisation in Japan and is not relevant here.Areal biased donation which means an increase or a decrease of coming donors from particular districts was demonstrated in the survey of Shimane blood center, and in the population size of the blood center level this biased donation shows no significant change of gene frequency.An assumption of 4% immigration, from Akita to Shimane Prefecture, revealed no change of gene frequency, but when immigration amounted to 10% in two or more years the test verified that there is a significant change in the distribution of gene frequency. But such an excessive immigration is not the real condition in prefectures of country-side.If there is an effect of inbreeding, there must be a significant difference of p2, q2 and r2 between the first period and the fifth period, since the fifth period corresponds to the second generation of the first period. But the results of these computations were not significant in any of the four prefectures. The change of previously mentioned social and historical conditions have led to decrease of the number of birth, the fractionising of population, the temporary isolation of inhabitans and then subsequent relaease of fractionising and isolation. The consequence of these changes is the so called “bottle-neck effect”.In countries of the world where a high frequency of hybridisation takes place the results such as mentioned here would be difficult to obtain.

著者

菊地 金男 正宗 良知

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.33, no.6, pp.710-715, 1987 (Released:2010-03-12)

参考文献数

9

---

Relation between perioperative blood transfusion and prognosis after surgery for gastric cancer was studied retrospectively on 2086 patients who had undergone histologically curative operation in the 2nd study of Cooperative Study Group of Surgical Adjuvant Chemotherapy for Gastric Cancer. These patients were divided into the 3 groups according to the administraiton of anticancer drugs (A: MMC, B: MMC+FT, C: FT). The survival and recurrence rate of transfused patients were compared with those of non-transfused patients in each histological stage of A, B and C groups.Macroscopic factors of recurrence such as lymph nodal metastases, tumor size and serosal invasion in transfused patients were overestimated, and total gastrectomy with splenectomy and wide extirpation of lymph nodes were performed along with blood transfusion. But microscopic factors of recurrence in transfused patients were better than in non-transfused patients.Five-year actuarial survival rate in transfused patients was generally lower than in non-transfused patients. Especialy the 5-year survival rates of transfused patients in stage II of A, C groups and stage III of A, B groups were respectively lower than those of non-transfused patients. Five-year actuarial recurrence rate in transfused patients was higher than in non-transfused patients. The 5-year recurrence rates of transfused patients in stage I of A, B groups, stage II of A group and stage III of B group were severally higher than those of non-transfused patients. Those rates were statistically significant.

著者

蟻田 功

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.43, no.2, pp.175a, 1997 (Released:2010-03-12)

著者

太田 和恵

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.41, no.3, pp.290-296, 1995 (Released:2010-03-12)

参考文献数

5

著者

三原 正和 片山 善章 伊藤 敬一 中島 伸之

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.30, no.5, pp.334-339, 1984 (Released:2010-03-12)

参考文献数

16

被引用文献数

5 5

---

Total of 102 patients who received blood transfusion for their cardiovascular surgery were the materials of this investigation.The incidence of post-transfusion hepatitis in correlation to guanase (guanine deaminase) activity was studied.Diagnosis of post-transfusion hepatitis was made when a patient showed elevation of s-GPT over 100 units in three weeks after surgery. The follow up periods were ranging from three to six months.13 patients were developed post-transfusion hepatitis which accounted 12.7% of incidence. Patients were divided into two groups according to the level of guanase activity. Significantry high incidence was observed in the groups of patients who received transfusion with guanase activity over 2.6IU/L (12.7% VS 64.3%, χ20=18.06>χ20 (1, 0.001)=10.83)The guanase activity in transfusion blood may be feasible as a parameter for the prevention of posttransfusion non-A, non-B type hepatitis.

著者

内田 立身 西村 拓史 瀧本 宏美 佐藤 美津子 西尾 由美子 福家 洋子 野崎 正範

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.42, no.5, pp.215-217, 1996-10-01 (Released:2010-03-12)

参考文献数

8

被引用文献数

1

---

We evaluated the effect of repeated 400ml whole blood donation on storage iron status in 26 males and 196 females. Iron status was estimated from hemoglobin concentration, transferrin saturation and serum ferritin. Storage iron was calculated according to the formula proposed by the National Health and Nutrition Examination Survey (NHANES). Calculated storage iron after repeated donation of 400ml was 806±174mg in male donors and 292±248mg in females. Levels after 400ml donation decreased to 606mg in males and to 92mg in females. Among females, 20.5% were in negative iron balance before donation, increasing to 37.7% after donation. However, no significant decrease in storage iron by repeated blood donation was recognized, when standards for blood collection were strictly complied with.

著者

榊原 欣作

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.21, no.4-6, pp.89-98, 1975 (Released:2010-03-12)

参考文献数

6

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.39, no.1, pp.150-185, 1993-03-01 (Released:2010-03-12)

著者

小松 文夫 矢野 節子 岡村 経一 佐藤 ヒロミ

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.29, no.2, pp.170-174, 1983 (Released:2010-03-12)

参考文献数

20

被引用文献数

1 1

---

The frequency of anti-E antibody formation has a very important problem especially in Japanese, and it has been studies in our laboratory since 1981. The anti-E positive specimens were found in 10 of 250 (4.0%) Rh(ee) recipients who received more than 10 units of blood. On the other hand, the frequency of anti-E formation was only about 2% in all Rh(ee) recipients in cluding cases received less than 10 units of blood. In the latter series, almost a half recipients were transfused with less than 10 units. And in general, the incidence of Rh(ee) recipients who receive E-positive blood in random transfusion is presumed to be about 25% in Japanese.Consequently it is likely that the frequency of anti-E antibody formation is approximately 0.4-0.5% in all transfused recipients in Japan.

著者

森下 敬一 早川 貞夫 増田 進致 篠島 敏子 久田 美智子

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.15, no.3, pp.105-112, 1968 (Released:2010-03-12)

参考文献数

15

---

Blood pressures, specific gravities of whole blood and the hematocrit values of more than 4000 volunteer donors (male 2900, female 1300) who visited The Tokyo Red Cross Blood Center from January, 1965 till December, 1966, ranging from 16 to 60 years old, were tested. The correlation between the specific gravities of whole blood by copper sulfate method and the hematocrit values was investigated. The results obtained were summarized as follows.1. Blood pressure: The systolic blood pressure was higher in young people, both men and women, than the standard value of the Japanese reported by Watanabe in 1947, whereas the diastolic blood pressure was the same as the standard. It is noteworthy that the systolic blood pressure of young people became higher than at 20 years ago.2. Specific gravities of whole blood: Specific gravities of whole blood lay around 1.) 57 in male and around 1.) 53 in female.3. Hematocrit values: Hematocrit values obtained by using capillaries made of Panlite corresponded to the standard values, being 45% for male and 40% for female.4. Some correlation existed between the specific gravities of whole blood and the hematocrit values. There was a tendency, however, that the latter showed a relatively wide range against one definite value of the former. For example, the hematocrit values of blood samples which have the same specific gravity of 1.052 had a range from 32% to 48%.5. Judging from the specific gravities persons whose values are 1.051 or lower cannot donate blood. Judging from the hematocrit values, however, 89.3% and 62.5% of persons whose specific gravities are 1.051 and 1.050 respectively, can donate their blood for transfusion.6. According to our opinion exclusion of prospective donors on the basis of specific gravities of whole blood does not seem superior than on the basis of hematocrit values.

著者

堀江 真理子 堀木 ちさと 飯田 俊二 大谷 智司 岡田 基文 平井 健策 大久保 康人

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.37, no.5, pp.651-655, 1991-11-15 (Released:2010-03-12)

参考文献数

4

---

In the United States, the FDA licenses Red Blood Cells Frozen (RBCF) up to 10 years and the AABB (AMERICAN ASSOCIATION OF BLOOD BANKS)'s Standards allow frozen storage of blood for routine transfusion up to 10 years.But in Japan, the storage period of RBCF for routine transfusion allowed is 5 years and that of the thawed, deglycerolized red blood cells (DRBC) is only 12 hours at 4-6°.The quality of RBCF stored for 5 years or 10 years was investigated to extend the storage period of RBCF and DRBC.ATP levels and morphology scores of DRBC stored for 10 years were high as those of DRBC stored for 5 years but 2, 3-DPG levels were slightly low.The hemolysis of DRBC immediately after deglycerolization was low, but increased rapidly with the storage. The result obtained indicated that the quality of the DRBC was maintained in good conditions. We would like to propose to extend the storage period of the RBCF up to 10 years.

著者

長田 広司 松本 光弘

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.45, no.6, pp.661-668, 1999-12-01 (Released:2010-03-12)

参考文献数

7

著者

二之宮 景光

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.31, no.1, pp.11-14, 1985 (Released:2010-03-12)

参考文献数

3

被引用文献数

1 1

著者

吉永 直胤 磧本 力 園田 健乙 田中 二秀 橋口 泰豊 斎藤 重明 大石 功

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.5, no.4, pp.156-160, 1958 (Released:2010-03-12)

参考文献数

18

---

The authors made statistical observations on the incidence of post-transfusion jaundice during the period from January 1, 1954 to October 30, 1957 in 365 patients answering their questionnaires.1). The frequency of post-transfusion jaundice was 4.1per cent, the incubation period being 30-120 days (mean value: 65 days) and the duration of the disease 5-60 days (mean value: 39 days).2). No relationship was found between the morbidity and blood type or sex. The highest incidence was in individuals below 20 years of age, followed by those between 30 and 50 years.3). Both fresh and preserved bloods produced the disease and the difference between the two was difficult to estimate, since the use of fresh blood was made only in a few cases.4). The incidence seemed to be higher in transfusions of more than 4, 000cc of blood than in those of lesser amounts.5). The disease occurred more frequently in patients with tuberculosis who received large quantities of blood both before and after the operation, and less in those with gastric cancer.6). The prognosis was generally good and there were no fatalities.

著者

松本 尚浩 重松 昭生

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.45, no.4, pp.425-429, 1999-08-01 (Released:2010-03-12)

参考文献数

14

被引用文献数

2 2