著者

中島 尚登 矢野 耕也

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.74, pp.18028, 2019 (Released:2019-04-13)

参考文献数

70

被引用文献数

1 1

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Objectives: To clarify the performance of health systems (performance), the state of prefectures was investigated.Methods: Using the method developed by the Organisation for Economic Co-operation and Development, we conducted the study using 27 indicators. To evaluate the performance, we examined the signal-to-noise ratio of transcription (η) by integrating indicators using the Mahalanobis-Taguchi method. The η was separated by a median. The ratio of prefectures in East or West Japan and the presence or absence of ordinance-designated cities were studied using the chi-square test. Furthermore, the correlation among the total component η (T-η), each component η, and expenditures, and the correlation between T-η and life expectancy, were studied.Results: The T-η positively correlated with the risk factors (RF)-η and the resources (R)-η, and negatively correlated with the health status (HS)-η. The number pf prefectures without ordinance-designated cities where the T-η and RF-η exceeded the median was large. The number of prefectures with ordinance-designated cities where the HS-η exceeded the median was also large. In addition, there were many prefectures where the T-η was in the top 25% in West Japan. There were positive correlations between the total expenditures and the T-η, the expenditures and the RF-η, and the expenditures and the R-η. There was a negative correlation between the expenditures and the HS-η, and the T-η and the life expectancy.Conclusions: For life expectancy, prefectures with too good performance were recognized. In these prefectures, correction of resources is necessary.

著者

中島 尚登 星 順隆 浅井 治 山本 純子 竹内 直子 神谷 昌弓 加藤 敦子 長谷川 智子 山崎 恵美 中山 一

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.37, no.6, pp.795-802, 1991-12-25 (Released:2010-03-12)

参考文献数

18

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A new red cell preservation solution is described in which the red cells may be stored for 42 and 49 days. An in vivo and vitro study of 42 and 49 days stored red cells with saline, adenine, glucose, mannitol (SAGM) preservation solution (OPTISOL, Terumo Corporation) was conducted using 20 healthy volunteers to document in vivo efficacy and analyze the validity of the 51Cr technique. Standard in vitro parameters of OPTISOL red cell concentrates were well preserved with low levels of hemolysis and high levels of red cell ATP which is compatible with their survival after 42 and 49 days storage. Osmotic pressure at hemolysis ending point of 42 and 49 days stored red cells did not change, while osmotic pressure at hemolysis starting point increased on 49 days. The red cell viscosity increased and scanning electron-microscopic studies showed that the majority of them became echinocyte and spherocyte on 49 days. In vivo autologous post-transfusion recovery was measured by using a 51Cr-labeled red cells. After 42 days of storage, post-transfusion 24-hour recovery averaged 82.3±8.4% and 48-hour recovery was 79.1±9.1%, and after 49 days, 24-hour recovery was 75.9±3.6%, but 48-hour recovery, which averaged 69.9±5.2%, was significantly lower.The present study reports in vivo and in vitro evaluation of a new red cell storage medium which allows high levels of post-transfusion recovery and permits without significant hemolysis. The results suggested that 42 days if a more suitable shelf life than 49 days.

著者

山内 眞義 平川 淳一 木村 和夫 中島 尚登 中原 正雄 中山 一 北原 敏久 大畑 充 片山 辰郎 高原 仁 藤沢 洌 亀田 治男

出版者

一般社団法人 日本肝臓学会

雑誌

肝臓 (ISSN:04514203)

巻号頁・発行日

vol.30, no.6, pp.643-648, 1989-06-25 (Released:2009-07-09)

参考文献数

15

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雌と雄ラットに慢性アルコール投与を行い,アルコール性肝障害の発症と伸展に及ぼす性差の影響を検討した.雌アルコール群で最も肝ハイドロオキシプロリンの増加を認め,雌のほうが雄に比べてアルコール性肝障害になりやすいことを実験的に明らかにした.雌アルコール群では,雌コントロール群に対して,アルコール脱水素酵素(ADH),アルデヒド脱水素酵素(ALDH)活性及びエタノール除去率はいずれも低下するのに対して,雄アルコール群では雄コントロール群に対してADH,ALDHは高活性を示し,エタノール除去率も速やかとなった.以上より女性のアルコール性肝障害に対する高感受性の原因として,男女間の常習飲酒に対するアルコール代謝の変動の差異が一因と考えられた.

著者

中島 尚登 高田 圭 矢野 宏 矢野 耕也 高木 一郎 大畑 充 小宮 佐和子 戸田 剛太郎

出版者

一般社団法人 品質工学会

雑誌

品質工学 (ISSN:2189633X)

巻号頁・発行日

vol.12, no.2, pp.63-72, 2004-04-01 (Released:2016-09-30)

参考文献数

7

被引用文献数

1

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Using health forecasts made with the Mahalanobis distance from the results of health checkups over a two-year period, medical examination items were selected, an economic evaluation was carried out by a loss function, and the potential for reducing costs was verified. The functional limit △0, costA, lossA0, and distance tolerance △ were determined. As a result, from the value of Δ obtained by economic calculation of the loss function, it became evident that 1.5 was an appropriate threshold value for distinguishing healthy from unhealthy individ uals. This was also confirmed from the results of calculation of the standard S/N ratio. When threshold values were studied and examination items were selected on the basis of these results, one small enterprise was able to reduce its costs by 10 million yen, and the results suggested that healthy/unhealthy diagnoses could be made from health checkup data for two or three years without a medical examination by a doctor.