1 0 0 0 OA 犬との接触により生じたBartonella henselae感染症の2例
- 著者
- 村野 一郎 常岡 英弘 飯野 英親 亀井 敏昭 中村 功 塚原 正人
- 出版者
- 一般社団法人 日本感染症学会
- 雑誌
- 感染症学雑誌 (ISSN:03875911)
- 巻号頁・発行日
- vol.75, no.9, pp.808-811, 2001-09-20 (Released:2011-02-07)
- 参考文献数
- 8
- 被引用文献数
- 7 7
Two patients were reported as having been infectd with Bartonella henselae after having contact with a dog. Both of the patients owned a dog, but had no contact with cats.One patient was a 10-year-old boy who had experienced a fever of 38-39°C for 11 days, as well as having bilateral cervical lymphadenopathy. The boy's serum IgM antibodies to B. henselae were negative on the 6th and 16th day of his illness, whereas his IgG value, using indirect fluorescence antibody (IFA) method, was found to be elevated from 1: 256 to 1: 1, 024. B. henselae DNA was detected, by PCR method, in swabs from the gingiva and buccal membrane of the dog with which the boy had been in contact. The boy was first treated with cefdinir (300mg daily) for 6 days without beneficial effect. He responded, however, to minocycline (100mg daily) with symptom resolution in four days.The other patient was a 64-year-old man who had experienced a fever of 38-39°C for 27 days, as well as having right inguinal lymphadenopathy. The man's serum IgM antibody to B. henselae was negative, although his IgG value, determined by IFA, was 1: 1, 024. In addition, B. henselae DNA was detected, by PCR method, in parafin-embedded tissue obtained from the biopsied inguinal lymph nodes. The man was treated with cefazolin (2g daily). His fever resolved, but his lymph nodes remained swollen. After a regimen of erythromycin (1, 200mg daily), the swelling in his inguinal lymphnodes gradually disappeared.Careful review of suspected CSD victims' history of contact with animals is important in making a prompt diagnosis of B. henselae infection.
1 0 0 0 猫・犬寄生ノミのBartonella henselae感染
1 0 0 0 OA 猫ひっかき病の新たな血清学的診断法の確立
猫ひっかき病(Cat Scratch Disease : CSD)の新たな血清学的方法としてBartonella henselae IgG抗体価測定用Enzyme-Linked Immuno Sorbent Assay (ELISA)を確立した。本法の特徴は液体培地で培養したBartonella henselaeATCC49882株をN-ラウリルーサルコシン液で処理し、その上清液を抗原とするものである。本法の感度は0.952、特異度は0.987であり、その臨床的有用性が期待される。