著者

三巻 祥浩 指田 豊 安達 得夫 吉成 清

出版者

日本生薬学会

雑誌

生薬学雑誌 (ISSN:13403443)

巻号頁・発行日

vol.48, no.1, pp.p86-91, 1994-03

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Barks of Prunns lannesiana var. speciosa, P. maximowiczii, P. apetala, P. pendula forma ascendens and P. yedoensis of the subgenus Cerasus, and P. laurocerasus and P. spinulosa of the subgenus Laurocerasus were assayed for their constituents. The barks of the Cerasus plants were formed to be rich in flavonoids and their glucosides, and to contain 5, 4'-dihydroxy-7-methoxyflavanone 5-O-β-D- glucopyranoside (sakuranin) as a common flavonoid. On the other hand, no flavonoid was detected in the barks of the Padus and Laurocerasus plants, but they both contained cyanogenic glucosides as a common component. The difference of the constituents observed between the barks of the Cerasus plants and those of the Padus and Laurocerasus was well correlated to the taxonomic theory proposed by T. T. Yu (1984).

著者

下村 裕子 指田 豊 大島 行雄 我妻 禎 斎藤 昌彦

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.100, no.11, pp.1164-1166, 1980-11-25 (Released:2008-05-30)

参考文献数

8

被引用文献数

5 5

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Scopoletin, protocatechualdehyde, ethyl and methyl caffeate and phytosterols were isolated from stems and leaves of Artemisia apiacea HANCE (Compositae).

著者

指田 豊

出版者

日本薬史学会

雑誌

薬史学雑誌 (ISSN:02852314)

巻号頁・発行日

vol.55, no.2, pp.203-209, 2020 (Released:2021-01-28)

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目的:香の 1 種である詹糖香は「神農本草経集注」(502?536),「新修本草」(659)に初めて登場する.前書は樹の傷口から滲出する含油樹脂,後書はミカン類に似た植物の枝葉の煎じ液である.しかし,清代に至るまで基原植物の考察は行われていない.そこで,詹糖香の基原植物を明らかにする目的で研究を行った. 方法: 主として中国の本草書の調査を行った.詹糖香の基原植物と推定される植物については「新修本草」に基づいて濃縮水エキスを作った.エキスの香りは香司が評価した. 結果:唐の高僧,鑑真和上は海南島で詹糖香の樹を見ている.「唐大和上東夷伝」(779)に書かれた樹の特徴はゲッキツ Murraya paniculata(ミカン科)を思わせる.またその特徴は「新修本草」,「本草綱目」の記載と一致する.このように唐代(日本の平安時代)の詹糖香の基原植物はゲッキツである.清代の「植物名実図考」(1848)は詹糖香の基原植物をカナクギノキ Lindera erythrocarpa(クスノキ科)とした.現代の中国はこの説に従っている.しかしカナクギノキはミカン類とは似ていない.そこでゲッキツ,カナクギノのエキスが香として使えるかどうか実験を行った.「新修本草」に準じてエキスを作った.両エキスとも甘い香りがあり,香りの五味もよく似ていた.これらは香として十分使えるものであった. 結論:唐代の詹糖香の基原植物はゲッキツ,清代のそれはカナクギノキである.両植物から得たエキスの香りはよく似ており,香として使えるものであった.カナクギノキはゲッキツを産しない地域でその代用として使われたものと思われる.

著者

三巻 祥浩 神本 敏弘 黒田 明平 指田 豊 西野 敦子 里見 佳子 西野 輔翼

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.43, no.7, pp.1190-1196, 1995-07-15 (Released:2008-03-31)

参考文献数

25

被引用文献数

17 31

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Phytochemical study on the underground parts of Hosta longipes gave six new steroidal saponins together with a known one. The structures of the new compounds were determined by detailed analysis of their 1H-and 13C-NMR spectra including two-dimensional NMR spectroscopy, acid-catalyzed hydrolysis followed by chemical correlation, and by comparison with spectral data of known compounds. The isolated saponins and their aglycones were examined for inhibitory activity on 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated 32P-incorporation into phospholipids of HeLa cells to identify new antitumor-promoter compounds.

著者

油井 聡 三上 正彰 三巻 祥浩 指田 豊 山崎 正利

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.121, no.2, pp.167-171, 2001-02-01

被引用文献数

22

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We previously demonstrated that Amaryllidaceae alkaloids, lycorine and lycoricidinol, inhibit induction of apoptosis by calprotectin derived from neutrophils, and that the latter alkaloid showed suppression in rat adjuvant-induced arthritis model. These findings suggest that the alkaloids have a modulating activity against inflammatory reaction. To explore further the mechanism of the suppression for inflammation, we studied the effect of the alkaloids on macrophage tumor necrosis factor(TNF-α) production in vitro, since TNF-α is recognized as a pivotal cytokine to regulate inflammation. As a result of this study, lycorine and lycoricidinol inhibited TNF-α production of murine macrophages stimulated with lipopolysaccharide(ID_<50> were 0.2μg/ml and 0.002μg/ml, respectively). The inhibition was also observed in macrophages treated by Gram-positive bacteria, Enterococcus faecalis. Both lycorine and lycoricidinol reportedly have inhibitory activity for protein biosynthesis. Although the inhibition of TNF-α production by lycoricidinol was mainly due to the inhibition of protein biosynthesis, lycorine showed inhibition against TNF-α prodictuon at lower concentrations than the case that they inhibited ^<35>S-Cysteine/^<35>S-Methionine incorporation into macrophages. These facts sugges that the inhibition of TNF-α production is not due to the inhibitory activity against protein translation at least at lower concentrations. From these results, it was concluded that these alkaloids exert inhibitory effects not only on neutrophil apoptosis-inducing protein, calprotectin, but also on macrophage TNF-α production.