- 著者
- 成田 正直 眞岡 孝至 蛯谷 幸司 西野 輔翼
- 出版者
- 公益社団法人 日本水産学会
- 雑誌
- 日本水産学会誌 (ISSN:00215392)
- 巻号頁・発行日
- vol.79, no.1, pp.48-54, 2013 (Released:2013-01-24)
- 参考文献数
- 24
- 被引用文献数
- 4 5
ホタテガイの赤燈色貝柱における成分分析および色素の同定を行い,その抗酸化作用を調べた。赤燈色貝柱の一般成分,遊離アミノ酸は通常貝柱と有意差がみられなかった。MS および NMR スペクトルの結果から,赤燈色貝柱の主な色素はペクテノロンと同定した。ペクテノロンは,アスタキサンチンよりはやや弱いが,β-カロチンより強い抗酸化作用を示し,有用なカロテノイドと考えられた。
1 0 0 0 OA 食品中の発がん抑制因子
- 著者
- 西野 輔翼
- 出版者
- Japanese Society for Food Hygiene and Safety
- 雑誌
- 食品衛生学雑誌 (ISSN:00156426)
- 巻号頁・発行日
- vol.39, no.6, pp.345-349, 1998-12-05 (Released:2009-12-11)
- 参考文献数
- 17
- 著者
- 三巻 祥浩 神本 敏弘 黒田 明平 指田 豊 西野 敦子 里見 佳子 西野 輔翼
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.43, no.7, pp.1190-1196, 1995-07-15 (Released:2008-03-31)
- 参考文献数
- 25
- 被引用文献数
- 17 31
Phytochemical study on the underground parts of Hosta longipes gave six new steroidal saponins together with a known one. The structures of the new compounds were determined by detailed analysis of their 1H-and 13C-NMR spectra including two-dimensional NMR spectroscopy, acid-catalyzed hydrolysis followed by chemical correlation, and by comparison with spectral data of known compounds. The isolated saponins and their aglycones were examined for inhibitory activity on 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated 32P-incorporation into phospholipids of HeLa cells to identify new antitumor-promoter compounds.
- 著者
- 津島 己幸 真岡 孝至 勝山 政明 小塚 睦夫 松野 隆男 徳田 春邦 西野 輔翼 岩島 昭夫
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- Biological and Pharmaceutical Bulletin (ISSN:09186158)
- 巻号頁・発行日
- vol.18, no.2, pp.227-233, 1995-02-15 (Released:2008-04-10)
- 参考文献数
- 26
- 被引用文献数
- 43 77
As a screening study for anti-tumor promoters, 51 carotenoids with diverse structures were examined for their inhibitory effects on the Epstein-Barr virus activation activity of 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. The results showed that most of the carotenoids exhibited inhibitory activity, and in general, no cytotoxicity on Raji cells was observed in the assay. Among the carotenoids, β-cryptoxanthin, lutein, and lactucaxanthin showed the strongest inhibitory activity, superior to the well known anti-tumor promoter, β-carotene. Heteroxanthin, peridinin, and halocynthiaxanthin showed cytotoxicity at the high concentration (1000 molar ratio per TPA), but indicated a strong inhibitory effect at the lower concentrations, which were only weakly toxic (500 and 100 molar ratios). Based on these results, the essential moiety for the activity of carotenoids was considered to be the 3-hydroxy-ε-end group.