- 著者
- 田原 寛之 ルドルフ ジェイソン クアリア 林 智広
- 出版者
- 公益社団法人 日本表面真空学会
- 雑誌
- 表面と真空 (ISSN:24335835)
- 巻号頁・発行日
- vol.62, no.3, pp.141-146, 2019-03-10 (Released:2019-03-10)
- 参考文献数
- 33
- 被引用文献数
- 1
In this review, we present the current situation of designs of biomaterials using techniques of informatics. In particular, we discuss the prediction the responses of proteins and cells toward materials and data-driven design of new biomaterials. We introduce our recent work, in which we analyzed the correlation among chemical structures of molecules constituting self-assembled monolayers (SAMs), amounts of adsorbed protein, a density of adhered platelets by machine learning using an artificial neural network model. The main conclusion is that the quality of the database is a critical factor in determining the accuracy of the prediction and material design. We also discuss technical issues to develop databases efficiently and systematically to expand the possibility of data-driven strategies to design biomaterials.
- 著者
- 徳田 英幸 林 智広
- 出版者
- 公益社団法人 応用物理学会
- 雑誌
- 応用物理 (ISSN:03698009)
- 巻号頁・発行日
- vol.92, no.10, pp.584-587, 2023-10-01 (Released:2023-10-01)
1 0 0 0 原子間力顕微鏡を用いた生体不活性表面近傍の水分子の解析
- 著者
- 小出 裕基 久保 光亮 関根 泰斗 水下 佳紀 GANBAATAR Narangerel 林 智広
- 出版者
- The Surface Science Society of Japan
- 雑誌
- 表面科学 : hyomen kagaku = Journal of the Surface Science Society of Japan (ISSN:03885321)
- 巻号頁・発行日
- vol.34, no.9, pp.494-499, 2013-09-10
- 被引用文献数
- 1
The mechanism underlying the bioinertness of nonfouling self-assembled monolayers was investigated with protein adsorption experiments, platelet adhesion tests, and surface force measurements with an atomic force microscope. Our force measurements revealed strong repulsion operating between nonfouling SAMs in the range of 4 to 6 nm in PBS buffer solution. In addition, we found that the protein-adsorbing and cell-adhering SAMs did not exhibit such repulsion. We concluded that the repulsion originated from structured interfacial water molecules. Considering the correlation among the above results, we propose that the structured interfacial water with a thickness of 2 to 3 nm (half of the range of the repulsion observed in the surface force measurements) plays an important role in deterring proteins and cells from adsorption or adhesion.