著者
谷川原 祐介 西 弘二 西牟田 章戸
出版者
慶應義塾大学
雑誌
基盤研究(B)
巻号頁・発行日
2011-04-01

抗がん剤の効果にみられる個人差はがん治療における大きな課題のひとつである。本研究は、タンパク質を介する応答を分析するプロテオーム解析と細胞内代謝を介する応答を分析するメタボローム解析という最新手法を用いて、癌に対する化学療法薬の作用機序と耐性メカニズムの解明を目的とした。薬理作用と耐性に関与する細胞内応答解析によって、抗がん剤反応性の個人差(有効または無効)を予測しうるバイオマーカー分子を複数見出し、個別化投薬へ展開するための基礎的知見を得た。
著者
今村 知世 加藤 有紀子 下方 智也 安藤 雄一 谷川原 祐介
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.41, no.11, pp.759-767, 2015-11-10 (Released:2016-11-10)
参考文献数
21
被引用文献数
1

The renal clearance of carboplatin, which is a second-generation platinum compound, is correlated with the glomerular filtration rate (GFR). As the area under the concentration-time curve (AUC) of free carboplatin is related with efficacy and toxicity following carboplatin administration, carboplatin dosing is defined as a target AUC and generally calculated by the Calvert formula according to the patient's GFR. We conducted a survey on the usage of the Calvert formula to clarify the current situation in Japan. As a result, the value of creatinine clearance (CLcr), which is higher than GFR due to the tubular secretion of creatinine, has been used as a substitute for GFR for the Calvert formula without appropriate correction in 71 of 109 institutions, where CLcr estimated by a Cockcroft-Gault equation and/or obtained by 24-h urinary collection are used. On the other hand, body surface area-indexed values of renal function have been directly used without conversion to individual values in 42 of 71 institutions, where GFR estimated by a Japanese equation and/or CLcr estimated by a Jelliffe equation are used. It was found that the desired dosing of carboplatin has not been administered to patients in a number of institutions. Back to the original concept of the Calvert formula, it is reasonable to use a GFR estimated by the Japanese equation and converted to an individual value. In addition, we need to assess tolerability following carboplatin administration and discuss the appropriateness of the starting dose for each patient without being overly reliant on the dose obtained by the Calvert formula.
著者
谷川原 祐介
出版者
じほう
雑誌
月刊薬事 (ISSN:00165980)
巻号頁・発行日
vol.47, no.11, pp.1791-1793, 2005-10