著者

森 範行 長谷川 香奈

出版者

北海道教育大学大学院教育学研究科学校臨床心理専攻

雑誌

学校臨床心理学研究 : 北海道教育大学大学院研究紀要 (ISSN:13497251)

巻号頁・発行日

no.13, pp.71-81, 2015

著者

山本 哲也 長谷川 香子 小野田 誠 田中 啓一

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.136, no.6, pp.905-911, 2016 (Released:2016-06-01)

参考文献数

13

被引用文献数

1 7

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Iguratimod (IGU), a disease-modifying antirheumatic drug launched in September 2012, has been reported to carry a risk of severe hemorrhages through a suspected interaction with warfarin (WF) in the all-case surveillance and early postmarketing-phase vigilance. To elucidate possible mechanisms of adverse interaction between IGU and WF, we analyzed the effects of IGU on the pharmacodynamics and pharmacokinetics of WF in rats. IGU was orally administered to male Wistar rats once daily for 5 d at 10 or 30 mg/kg in combination with WF at an oral dose of 0.25 mg/kg. Coadministration of IGU 30 mg/kg enhanced the anticoagulant activity of WF; prolonged blood coagulation time (prothrombin time and activated partial thromboplastin time) and decreased levels of vitamin K (VK)-dependent blood coagulation factors (II, VII, IX, and X) were observed. On the other hand, the pharmacokinetic parameters of WF including maximum plasma concentration (Cmax) and area under the plasma concentration-time curve from 0 to 24 h (AUC0-24 h) were not affected by the combination with IGU. IGU alone did not change blood coagulation time at doses up to 100 mg/kg, while VK-dependent blood coagulation factors decreased slightly at 30 and 100 mg/kg. These results suggest that the pharmacodynamic effect of IGU on VK-dependent blood coagulation factors is involved in the mechanism of drug-drug interaction of IGU with WF.

著者

長谷川 香

出版者

日本建築学会

雑誌

日本建築学会計画系論文集 (ISSN:13404210)

巻号頁・発行日

vol.82, no.738, pp.2081-2087, 2017 (Released:2017-08-30)

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The purpose of this study is to clarify the characteristics of the ceremonial space associated with the nation and the Imperial Court in modern Tokyo. Focusing on the temporary use of parade grounds and imperial estates in the western part of Tokyo, I derived the possible factors for the site selection and the characteristics of the ceremonial spaces of modern imperial funerals in Tokyo. The subjects of investigation are the imperial funerals of Empress Eisho in 1897, Emperor Meiji in 1911, Empress Shoken in 1914 and Emperor Taisho in 1927. In the second chapter, I digested the history of the western part of Tokyo, as a condition of the thesis. Extending from the center part to the periphery, parade grounds and imperial estates were located in modern Tokyo to be concentrated on the north side of the Oyama Road (Current Aoyama St.). On the other hand, during the expansion of the urban area of Tokyo, the Nihon Railway Shinagawa line and the Kobu Railway were built to connect the western part of Tokyo to the center of Tokyo and also to the western Japan, then the western part of Tokyo became the hub for travel and transportation, especially for the military purpose. In the third chapter, I examined the process of site selection, the plan, the scale and the route of each imperial funeral by researching the government documents, then I clarified the fact that the site had sifted from Aoyama Parade Ground to Yoyogi Parade ground and to Shinjuku Gyoen, influenced by the environmental changes of the western part of Tokyo. Then I also revealed that the site of the modern era was larger than that of the early modern era and all sites had the same layout plan of temporary buildings in funerals. As for the route, I pointed that all of them were 4-7 km, containing the Oyama Road and that the whole route served as the urban scale ceremonial space. From the above analysis, I derived the four possible conditions of the site for imperial funerals; 1 possession, 2 history, 3 size and figure, and 4 location. Ueno Park and the Imperial Palace Plaza also met the condition 1, 2 and 3, but as for the condition 4, the parade grounds and imperial estates in the western part of Tokyo were favorable because they were close to the Oyama Road, the Nihon Railway Shinagawa line and the Kobu Railway. It can be argued that the site selection was much influenced by the limited use of the parade grounds and imperial estates and also the existence of the military installations and the development of the traffic networks. The candidate sites were almost limited to the parade grounds and the imperial estates in the western part of Tokyo by the conditions, and the site for each funeral was selected according to the situation at the time. Then, in adapting to the different site, the ceremonial space in modern Tokyo had become universal, not defined by any specific site or institution. The site in the early modern era, Sennyu-ji temple has been strongly connected to the Imperial Court from the medieval era, while those in the modern era had been connected to the Imperial Court since the Meiji era and become commemorative places by being used as the site for imperial funeral, and then it led to the development of the surrounding area after that.

著者

長谷川 香織

出版者

立命館大学人文学会

雑誌

立命館文學 (ISSN:02877015)

巻号頁・発行日

no.565, pp.52-78, 2000-06

著者

一重 喬一郎 長谷川 隆大 長谷川 香織 寺澤 健治 山中 一憲 服部 順昭

出版者

一般社団法人 日本木材学会

雑誌

木材学会誌 (ISSN:00214795)

巻号頁・発行日

vol.59, no.5, pp.269-277, 2013-09-25 (Released:2013-09-30)

参考文献数

13

被引用文献数

7 6

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木材は環境にやさしい材料とみなされてきたが,そのことを定量的に検証するための基礎的なデータが不足していることから,国産丸太のライフサイクルアセスメントを実施した。その結果,国産丸太1m3を生産するまでに11.1kgのCO2が排出され,70.6円の環境影響が生じると算出された。さらに,国産丸太の環境影響の低減のためには,間伐や主伐といった収穫作業の改善が重要であることが分かった。特に高性能林業機械を使用する作業の効率を向上させ,軽油の消費を抑制することが効果的であると考える。

著者

田崎 和江 長谷川 香織 松本 和也

出版者

地学団体研究会

雑誌

地球科學 (ISSN:03666611)

巻号頁・発行日

vol.56, no.2, pp.87-104, 2002-03-25

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かつての鉱山活動は重金属を外界に排出し,今日でも水質や土壌汚染の原因となっている.岐阜県神岡町にある大規模なZn-Pb鉱山の一つである神岡鉱山は,神通川の重金属汚染源となってきた.Cd,Pb,ZnそしてFeなどの重金属が高原川-神通川水系に未処理のまま廃棄され,下流域の住民の健康に影響を与えた.重金属の中でも特にCdは,イタイイタイ病の病原物質と見なされた.Cd汚染問題は未だに解決されていない.消石灰を投入し,中和凝集処理された廃滓の沈殿池が神岡鉱山にいくつか存在する.廃滓や廃棄場から排出された汚染水は,神通川の上流の高原川に流れ込んでいる.本研究では,重金属を含む堆積物の特性を明らかにするため,高原川-神通川水系にある五つのダムの堆積物を採取した.ダム堆積物の鉱物的・化学的組成を明らかにするため,それぞれの試料についてXRD,ED-XRFによる分析を行った.その結果,神岡鉱山の上流域に位置する浅井田ダムの堆積物はCd,粘土鉱物そして有機物が少なく,神岡鉱山の下流域に位置する新猪谷ダム,神通川第一,第二,第三ダムにおいては,汚泥,スメクタイトそしてZn,Cdのような重金属が多く含まれていることが明らかになった.また,本研究では,水中の重金属の浄化能力を見積もるための実験を行った.その結果,バクテリアを使ったバイオレメディエーションは重金属の固定に効果的であることを示した.室内実験系においてバイオフロック中の糸状菌は,一週間で細胞壁の表面にPb,Zn,Cdを選択的に濃集した.バイオレメディエーションの能力を持つバクテリアは,鉱山地域における下流のダム堆積物中でも重金属を固定する重要な役割を演じている.