著者

中村 健一 高田 勗 鈴木 永子 杉浦 由美子 小林 てるみ

出版者

The Japanese Society for Hygiene

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.35, no.6, pp.851-857, 1981-02-28 (Released:2009-02-17)

参考文献数

19

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An experiment using rats was carried out to evaluate the effects of calcium deficiency on the interaction of cadmium (Cd) and zinc (Zn) in vivo.Eighty-four female rats were divided into two groups. One group was fed a calcium-sufficient diet (normal Ca group), and a second group was fed a calcium-deficient diet (low Ca group). These two groups were divided into 4 subgroups. The diet of subgroup I was supplemented with 50μg/g of Cd, that of subgroup II with 50μg/g of Zn, and that of subgroup III with 50μg/g of Cd and Zn, Subgroup IV served as the control group.After 5 months on this regimen, the rats were killed and metal levels in the liver, the right kidney, the blood and the femur were analyzed. The left kidneys were examined histopathologically.The results were as follows:1) Growth retardation was observed in the low Ca group especially in subgroups I and III.2) Whereas renal Cd concentrations in subgroup I were higher than those in subgroup III for the normal Ca group, the reverse was found in the low Ca group. Similar findings were also observed in the cases of renal Zn and Cu.3) Zn in the liver increased with the administration of Cd in the low Ca group. Zn levels in the blood of the low Ca group were higher than those in the normal Ca group.4) Ca in the femur decreased with the administration of Cd in the normal Ca group. For the low Ca group, Ca concentrations in each subgroup were lower than those of each corresponding subgroup of the normal Ca group. Ca/P ratios of the low Ca group and of the metal administered subgroups in the normal Ca group were lower than those of subgroup IV in the normal Ca group.5) No significant histopathologic changes in the kidney were found in the normal Ca group but slight changes were observed in some animals of the low Ca group regardless of which metal was administered.From these results, the interaction of Cd and Zn on renal accumulations of Cd has been shown to be disturbed by a Ca deficient condition.

著者

増山 伸夫 高田 勗 一杉 正治 相澤 好治 高橋 英尚 前田 厚志 橋本 起一郎 中村 賢

出版者

北里大学

雑誌

北里医学 (ISSN:03855449)

巻号頁・発行日

vol.13, no.6, pp.406-416, 1983-12-31

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交替制勤務の身体影響に関する報告は,現在までに多数なされてきたが,長期にわたって経過を追ったものはほとんどない。そこで,本研究では,長期間の交替制勤務の影響を観察するために,6年間隔で,交替制と常日勤の同一作業者に実施された健康診断の結果を検討した。喫煙率は,6年の経過中,常日勤務作業者群,交替制勤務作業者群の両群とも低下傾向を示したが,初年度,6年目とも,交替制勤務作業者群の喫煙率が高かった。飲酒状況では,両群間に有意の差はなかったが,6年の経過中,両群とも飲酒率の増加傾向を示した。自覚症状に関しては,動悸,息切れなどの循環器症状,食欲不振,嘔気,胸やけ,胃のもたれなどの胃腸症状,頭痛,頭重感,めまい,耳鳴り,視力低下,肩こりなどの神経系症状,倦怠感,易疲労感などの全身症状を訴える者が,初年度は交替制勤務作業者群に多い傾向があったが,6年の経過中に,交替制勤務作業者群に有訴率の低下があり,両群間に明らかな差はなくなった。血圧,尿検査,末梢血液検査,肝機能検査の臨床検査では,両群間に明らかな差はなく,経年変化も明らかではなかった。

著者

工藤 光弘 宇都宮 忠生 相沢 好治 栗原 稔 高田 勗

出版者

公益社団法人日本産業衛生学会

雑誌

産業医学 (ISSN:00471879)

巻号頁・発行日

vol.28, no.7, 1986-12-20