著者

Tetsuya Izawa Jun-etsu Ogasawara Takuya Sakurai Sachiko Nomura Takako Kizaki Hideki Ohno

出版者

一般社団法人日本体力医学会

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.1, no.3, pp.381-387, 2012-09-25 (Released:2012-10-23)

参考文献数

64

被引用文献数

2

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White adipose tissue (WAT) is located beneath the skin as subcutaneous adipose tissue (SAT), around internal organs as visceral adipose tissue (VAT), pericardial and epicardial adipose tissue, and inside muscles in human beings. Recent studies indicate that developmental and patterning genes are differentially expressed in SAT and VAT, and some of these genes exhibit changes in expression that closely correlate with the extent of obesity and pattern of fat distribution. Furthermore, the development of adipocytes from mesenchymal stem/progenitor cells is thought to be mediated by developmental signaling molecules including nodal, Wnt/wingless (Wg), bone morphogenetic proteins (BMPs), fibroblast growth factors (FGF), and others. Of these, BMPs and the FGF family have been suggested to play a role in maintaining energy homeostasis. However, it remains unclear whether these developmental and patterning genes are associated with morphological changes in WAT in response to exercise training (TR). On the other hand, when TR reduces the number of adipocytes in WAT, it increases preadipocyte factor 1 mRNA expression but down-regulates peroxisome proliferator-activated receptor-γ mRNA expression in stromal-vascular fraction cells, including adipose tissue-derived stromal cells, via the up-regulation of hypoxia-inducible factor-1α, which may also up-regulate the mRNA expression of vascular endothelial growth factor-A and its receptor. The purpose of this review is to summarize the research to date on the morphology of WAT and adipose tissue cellularity in exercise adaptation.

著者

大野 義一朗 大日方 一夫 下枝 宣史 大谷 眞二 宮田 敬博 藤原 久子 三上 春夫 大野 秀樹 福地 光男 渡邉 研太郎 森本 武利 Giichiro Ohno Ichio Obinata Nobuhito Shimoeda Shinji Otani Takahiro Miyata Hisako Fujiwara Haruo Mikami Hideki Ohno Mitsuo Fukuchi Kentaro Watanabe Taketoshi Morimoto

雑誌

南極資料 = Antarctic Record (ISSN:00857289)

巻号頁・発行日

vol.51, no.2, pp.241-249, 2007-07

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南極医学医療研究集会は,わが国の南極医学研究と医療問題についての研究成果を報告・討論し,次期の観測隊における医学研究に寄与することを目的として毎年行われている.2006年の本研究集会は8月26日,国立極地研究所講堂で行われた.27施設から42名が参加し18の演題報告がなされ,近年では最大規模の研究集会となった. 参加者は越冬経験医師をはじめ,共同研究を行っている大学や研究機関の研究者,関連領域の研究を行っている宇宙開発機構やスポーツ科学研究所などの研究者,南極に興味のある一般病院の臨床医など多彩であった. 2004年より昭和基地に導入されたテレビ会議システムを活用して,昭和基地の医師もリアルタイム映像で討論に参加した.また韓国,中国の越冬医師が初めて参加した.これは3カ国の極地研究所による事前の準備と連携により実現した.集会では各国の南極基地の医療状況や医学研究活動が報告され,活発な意見交換がなされた.南極医学医療研究分野におけるアジア連携の端緒となることが期待される.A workshop on Antarctic Medical Research and Medicine 2006 was held at the National Institute of Polar Research (NIPR) on 26 August, 2006. Forty two participants from 27 institutes attended. The members consist of medical doctors with Antarctic experience, human biologists, research scientists in other fields, logistic staff members of the expedition and also medical doctors interested in Antarctica. The current resident doctor at Syowa Station joined the discussion through a telecommunication system. Doctors with Antarctic experience from China and Korea also participated in the workshop. They gave presentations on their Antarctic activities, followed by an active discussion session. Eighteen presentations were given on various topics, including the International Polar Year (IPY) 2007-2008 in medical research, space medicine, telemedicine, an international comparative study of medical operations, psychological surveys, Antarctic high-altitude medicine, Legionella surveillance and nutritional studies.

著者

Hideki OHNO Shunsuke GOTO Masao OWAKI Joji OHTA Naoshi NAKAJIMA Kaori NAKATA Ken-ichiro MUTOH Toshifumi OYAMADA Kazuki YOSHIOKA

出版者

オカジマ・フォリア・アナトミカ・ヤポニカ編集部

雑誌

Okajimas Folia Anatomica Japonica (ISSN:0030154X)

巻号頁・発行日

vol.90, no.2, pp.31-39, 2013 (Released:2013-10-10)

参考文献数

18

被引用文献数

1

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Androgen is closely involved as the cause of rupture of anterior cruciate ligament (ACL) in human. In dogs, however, factors contributing to rupture of ACL remain unknown. In this study, expression of androgen receptor (AR) and histological distribution of blood vessels in ACL, and serum testosterone concentration were investigated in relation with age and sex to confirm whether canine ACL is an androgen-responsive tissue. Materials of ACL were obtained from 26 dogs: 12 young female Beagles, 2 old female mixed breeds, 9 young male Beagles, and 3 old male mixed breeds. In all canine ACL, positive AR expression was recognized in the nuclei of the fibrocytes, fibroblasts, synovial cells, and vascular endothelial cells of ACL. Expressions of AR were lesser in old males compared to the young males; however, females had no age difference in expression. Distributions of blood vessels in the synovial membrane of the ligament were fewer in old dogs both of males and females than youngs. Although distributions of vessels in the interstitium were apparently fewer in young females. Serum testosterone concentration was significantly higher in young males. Females had no age difference in the levels. From these results, it is suggested that canine ACL is an androgen-responsive tissue, and this consideration seems to closely relate to the epidemiological background that the incidence of rupture of ACL of dogs is higher in females than in males.

著者

Hideki OHNO Yoko KOWATARI Masao OWAKI Joji OHTA Naoshi NAKAJIMA Kazuki YOSHIOKA Ken-ichiro MUTOH Toshifumi OYAMADA

出版者

オカジマ・フォリア・アナトミカ・ヤポニカ編集部

雑誌

Okajimas Folia Anatomica Japonica (ISSN:0030154X)

巻号頁・発行日

vol.89, no.2, pp.35-38, 2012 (Released:2012-10-27)

参考文献数

10

被引用文献数

3 7

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Anterior cruciate ligament (ACL) fibroblasts obtained from beagle dogs were cultured in basal medium containing different concentrations of 1 to 10-3 µM 5α-dihydrotestosterone (DHT) and in basal medium itself as a control. It was demonstrated that DHT promoted cell proliferation activity, expression of androgen receptor, and collagen synthesis in ACL fibroblasts as compared with control. These results suggest that sex hormones are involved in the sex difference seen in ACL rupture of dogs.