著者

Shunsuke Ochiai Atsuya Watanabe Hideshi Oda Hiroshi Ikeda

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.26, no.2, pp.281-284, 2014 (Released:2014-02-28)

参考文献数

30

被引用文献数

4 17 1

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[Purpose] Superficial heat treatment is one of the most widely used physical therapies for osteoarthritis (OA). We clinically evaluated the effects of local heat treatment and exercise therapy for knee OA, and evaluated the articular cartilage using magnetic resonance imaging (MRI) T2 mapping. [Subjects and Methods] Eighteen females aged 50–69 (59.5 ± 8.5 years, mean ± SD) years diagnosed with early-stage knee OA were randomly assigned using computer-generated random numbers to either a local heat treatment group (LH group, 9 subjects) or an exercise therapy group (EX group, 9 subjects). These groups were subjected to a 12-week intervention experiment. MRI T2 mapping was performed for cartilage imaging and quantitative evaluation. For clinical evaluation, the Japanese Knee Osteoarthritis Measure (JKOM) and the Timed Up and Go (TUG) test were performed. Both clinical and MRI evaluations were performed at the beginning and end of the intervention (0 week (Time 0) and 12 weeks). [Results] The total JKOM score had a significantly decreased in the LH group at 12 weeks. However, in the EX group the total JKOM scores at Time 0 and 12 weeks were not significantly different. The TUG time in the EX group was significant shorter at 12 weeks, whereas it showed no significant change in the LH group at 12 weeks, though the TUG times of 7 of the 9 patients decreased, exhibiting some improvement. The T2 value of the LH group was significantly shorter at 12 weeks. However, the T2 value in the EX group showed no significant change at 12 weeks. [Conclusion] After local heat treatment using heat- and steam moisture-generating sheets for 12 weeks, we observed improvements in clinical symptoms and walking abilities. Moreover, positive effects on cartilage metabolism were suggested.

著者

Hiroki Nagashima Shuhei Kawaoka Yasunori Matsui Takashi Tachikawa Hiroshi Ikeda Yasuhiro Kobori

出版者

The Society of Photopolymer Science and Technology(SPST)

雑誌

Journal of Photopolymer Science and Technology (ISSN:09149244)

巻号頁・発行日

vol.31, no.2, pp.163-167, 2018-06-25 (Released:2018-09-05)

参考文献数

26

被引用文献数

1

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The singlet fission (SF) is expected to be powerful tool for exceeding the theoretical limit of the power conversion efficiency on the organic solar cells. However, little is known on the intermolecular SF mechanism in the solid state. In the present study, we have investigated intermolecular SF in 2-phenyl-6,11-bis(triisopropylsilylethynyl)tetracene (TIPS-Ph-Tc) in frozen solutions using a time-resolved electron paramagnetic resonance measurement at a low temperature. SF-born quintet states (Q) and subsequent dissociations into two triplet states (T + T) were detected for a diluted solute concentration of 10-4 M in dichloromethane. The microsecond triplet dissociation was found to occur due to the amorphous morphology in the frozen aggregate, suggesting that Q is generated as a trapped state. Furthermore, it was also suggested that the T + T dissociation follows the Q generation due to a T-T repulsion, whose energy were determined by the negative exchange couplings in the triplet pairs, (TT).

著者

Ryota TATEZAWA Taku SUGIYAMA Shuho GOTOH Takafumi SHINDO Hiroshi IKEDA Masaaki HOKARI Katsumi TAKIZAWA Naoki NAKAYAMA Miki FUJIMURA

出版者

The Japan Neurosurgical Society

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

pp.2023-0116, (Released:2023-08-30)

参考文献数

34

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Delayed foreign body reactions to either or both clipping and coating materials have been reported in several small series; however, studies in the titanium clip era are scarce. This study aims to survey the contemporary status of such reactions to titanium clips and coating materials. Among patients who received a total of 2327 unruptured cerebral aneurysmal surgeries, 12 developed delayed intraparenchymal reactions during outpatient magnetic resonance imaging (MRI) follow-up. A retrospective investigation was conducted. The patients' average age was 58.6 (45-73) years, and 11 were women. The aneurysms were located in the middle cerebral artery (n = 7), internal carotid artery (n = 4), or anterior communicating artery (AComA, n = 1). In 10 patients, additional coating with tiny cotton fragments was applied to the residual neck after clipping with titanium clips; however, only the clipping with titanium clips was performed in the remaining two. The median time from surgery to diagnosis was 4.5 (0.3-60) months. Seven (58.3%) patients were asymptomatic, and three developed neurological deficits. MRI findings were characterized by a solid- or rim-enhancing lobulated mass adjacent to the clip with surrounding parenchymal edema. In 11 patients, the lesions reduced in size or disappeared; however, in one patient, an AComA aneurysm was exacerbated, necessitating its removal along with optic nerve decompression. In conclusion, cotton material is a strongly suspected cause of delayed foreign body reactions, and although extremely rare, titanium clips alone may also induce such a reaction. The prognosis is relatively good with steroid therapy; however, caution is required when the aneurysm is close to the optic nerve, as in AComA aneurysms.

著者

Seita T. Watanabe Kazuhiko Hayashi Katsuro Arakawa Shizuka Fuse Hidetoshi Nagamasu Hiroshi Ikeda Atsushi Kuyama Piyakaset Suksathan Manop Poopath Rachun Pooma Yong-Ping Yang Minoru N. Tamura

出版者

The Japanese Society for Plant Systematics

雑誌

Acta Phytotaxonomica et Geobotanica (ISSN:13467565)

巻号頁・発行日

vol.72, no.3, pp.179-204, 2021-10-31 (Released:2021-11-27)

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Based on molecular phylogenetic evidence, phylogenetic analyses of both cpDNA and nrDNA sequences based on 76 (cp) and 77 (nr) samples representing 64 species, two subspecies, and three (cp) and two (nr) varieties of Lilium and six (cp) and five (nr) samples from Cardiocrinum, Fritillaria, and Notholirion as outgroups were used to better understand relationships within Lilium and to revise its infrageneric classification. The same individuals were used for both cpDNA and nrDNA analyses to avoid confusion caused by genetic polymorphism within a species. Nine thousand eight hundred thirty seven bp from 10 cpDNA regions and 1069 bp from the nuclear (ITS + ETS) regions were analyzed. The same twelve clades were formed in Lilium in both the chloroplast and nuclear trees (one clade of the former tree and one clade of the latter tree were not strictly formed because of low resolution). In light of the cpDNA and nrDNA trees obtained, 13 morphological characters, including a pair of marginal ridges along a central groove on the adaxial surface of the tepals were examined with attention given for the first time to the use of this character as having diagnostic value. The morphological evidence supported the twelve clades. Based on molecular and morphological evidence, a revised infrageneric classification of Lilium recognizing twelve clades as twelve sections is proposed.

著者

Makoto MIZUSHIMA Yukitomo ISHI Hiroshi IKEDA Ikuma ECHIZENYA Takuya OTSUKA Tomoko MITSUHASHI Shigeru YAMAGUCHI Miki FUJIMURA

出版者

The Japan Neurosurgical Society

雑誌

NMC Case Report Journal (ISSN:21884226)

巻号頁・発行日

vol.9, pp.237-242, 2022-12-31 (Released:2022-07-27)

参考文献数

25

被引用文献数

5

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Methotrexate-associated lymphoproliferative disorder (MTX-LPD) occurs in patients with rheumatoid arthritis (RA) treated with methotrexate (MTX). MTX-LPD is typically associated with Epstein-Barr virus (EBV) infection and regresses with MTX discontinuation. On the other hand, EBV-negative MTX-LPDs are less common and are more likely to show partial or no regression after MTX discontinuation. There were no standard chemotherapeutic options for refractory MTX-LPD. We present a case of EBV-negative MTX-LPD in the central nervous system (CNS) that was successfully treated with rituximab, methotrexate, procarbazine, and vincristine (R-MPV), followed by reduced-dose whole-brain radiotherapy (rdWBRT), following the same treatment protocol as primary CNS lymphoma. A 59-year-old woman with RA treated with MTX presented with gradually developing staggered gait, memory deficit, and disorientation. Multiple lesions with heterogeneous contrast enhancement were discovered using brain magnetic resonance imaging. The patient was suspected of having MTX-LPD, but discontinuing MTX did not result in regression of the brain lesions. She underwent a biopsy from the left parietal lesion. The tissue was pathologically diagnosed as diffuse large B-cell lymphoma. Furthermore, pathological examination through EBV-encoded ribonucleic acid in situ hybridization demonstrated a lack of EBV infection. She was ultimately diagnosed with EBV-negative CNS MTX-LPD. We applied chemotherapy with R-MPV and rdWBRT. The patient achieved a complete response. In the case of CNS MTX-LPD without EBV infection, chemotherapy with R-MPV followed by rdWBRT may be considered.

著者

Yuki NAGAMATSU Hiroshi NAGAMATSU Hiroshi IKEDA Hiroshi SHIMIZU

出版者

The Japanese Society for Dental Materials and Devices

雑誌

Dental Materials Journal (ISSN:02874547)

巻号頁・発行日

vol.40, no.6, pp.1309-1319, 2021-11-25 (Released:2021-12-01)

参考文献数

47

被引用文献数

2

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Electrolyzed waters, containing mainly hypochlorous acid, are used in dental practice because of their high microbicidal effect. For wider use, three neutral electrolyzed water-based gels, namely, HOCl-containing aqueous gels were prepared with a thickening/gelling agent in this study. We evaluated their microbicidal effects against four strains and storage stabilities indicated by available chlorine concentration. Immediately after preparation, all gels (70 ppm) could completely remove microbes by a 3-min treatment. The gel prepared with xanthan gum remarkably reduced its available chlorine concentration even under shaded and refrigerated storage conditions, failing to maintain its microbicidal effect following 1-day storage, whereas other gels, prepared with carboxyvinyl polymer or agar, maintained effective concentration (>20 ppm), with high microbicidal effects following 9-day and 21-day storage, respectively. Neutral electrolyzed water-based gels might be useful to remove oral microbes. Based on our results, agar is the most suitable thickening/gelling agent from the viewpoint of storage stability.

著者

Yuki NAGAMATSU Hiroshi NAGAMATSU Hiroshi IKEDA Hiroshi SHIMIZU

出版者

The Japanese Society for Dental Materials and Devices

雑誌

Dental Materials Journal (ISSN:02874547)

巻号頁・発行日

pp.2020-454, (Released:2021-06-30)

参考文献数

47

被引用文献数

2

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Electrolyzed waters, containing mainly hypochlorous acid, are used in dental practice because of their high microbicidal effect. For wider use, three neutral electrolyzed water-based gels, namely, HOCl-containing aqueous gels were prepared with a thickening/gelling agent in this study. We evaluated their microbicidal effects against four strains and storage stabilities indicated by available chlorine concentration. Immediately after preparation, all gels (70 ppm) could completely remove microbes by a 3-min treatment. The gel prepared with xanthan gum remarkably reduced its available chlorine concentration even under shaded and refrigerated storage conditions, failing to maintain its microbicidal effect following 1-day storage, whereas other gels, prepared with carboxyvinyl polymer or agar, maintained effective concentration (>20 ppm), with high microbicidal effects following 9-day and 21-day storage, respectively. Neutral electrolyzed water-based gels might be useful to remove oral microbes. Based on our results, agar is the most suitable thickening/gelling agent from the viewpoint of storage stability.

著者

Taketo Kojima Ikumi Kawajiri Jun-ichi Nishida Chitoshi Kitamura Hiroyuki Kurata Mirai Tanaka Hiroshi Ikeda Takeshi Kawase

出版者

(社)日本化学会

雑誌

Bulletin of the Chemical Society of Japan (ISSN:00092673)

巻号頁・発行日

pp.20160093, (Released:2016-05-24)

被引用文献数

8

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A series of 2,3-diphenylphenanthro[9,10-b]furans were prepared by the reactions of phenanthrene-9,10-dione with two equivalents of benzylidenetriphenylphosphoranes as a key step. The bis(4-bromophenyl) derivative can be readily lithiated by the action of n-butyllithium in diethyl ether. The corresponding 4-trimethylsilyl and 4-methylthio derivatives were obtained by quenching the dilithio derivative with trimethylsilyl chloride and dimethyl disulfide, respectively. The Buchwald–Hartwig amination of the bromide with diphenylamine afforded the diphenylamino derivative in a good yield. Crystallographic analysis of the parent diphenyl derivative reveals that the phenanthrofuran moiety has a slightly twisted helicene-like structure, and the compound forms a columnar stacking in the crystal. The phenanthrofurans display intense blue fluorescence both in CH2Cl2 and in the solid state. Their electrochemical properties obviously indicate high HOMO energy levels of the furans, as predicted by the density functional theory calculations.

著者

目代 邦康 池田 宏 飯島 英夫 Kuniyasu MOKUDAI Hiroshi IKEDA Hideo IIJIMA 筑波大 筑波大 筑波大

雑誌

地形 = Transactions, Japanese Geomorphological Union (ISSN:03891755)

巻号頁・発行日

vol.25, no.3, 2004-07-25

著者

Hiroshi Ikeda Kazuki Matsuo Yasunori Matsui Masaya Matsuoka Kazuhiko Mizuno

出版者

The Chemical Society of Japan

雑誌

Bulletin of the Chemical Society of Japan (ISSN:00092673)

巻号頁・発行日

pp.1104260289, (Released:2011-05-07)

参考文献数

67

被引用文献数

3

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The mechanism of the Cope rearrangement of 1,5-hexadienes remains controversial. Two pathways for the rearrangement of 2,5-diphenyl-1,5-hexadiene have been debated over the past several decades. The first is a concerted route that takes place via a pericyclic transition state and the other is a stepwise process via a biradical intermediate or biradicaloid transition structure. In this study, we explored a new intramolecular trapping approach to examine the possible existence of the putative biradical that might intervene in the stepwise Cope rearrangement. For this purpose, a study was carried out in which a 1,5-hexadiene, bearing two lophyl radicals at C2 and C5 positions, moieties capable of trapping a putative biradical intermediate intramolecularly, was designed, generated, and characterized both experimentally and with density functional theory.