著者

松田 孝 景井 美帆 亀井 俊之 桑村 海光 人見 久城 磯部 征尊 大森 康正 山崎 貞登 Takashi MATSUDA Miho KAGEI Toshiyuki KAMEI Kaiko KUWAMURA Hisaki HITOMI Masataka ISOBE Yasumasa OOMORI Sadato YAMAZAKI

出版者

上越教育大学

雑誌

上越教育大学研究紀要 = Bulletin of Joetsu University of Education (ISSN:24359629)

巻号頁・発行日

vol.40, no.2, pp.631-640, 2021-03-31

著者

Yuichi Ueya Masakazu Umezawa Yuka Kobayashi Kotoe Ichihashi Hisanori Kobayashi Takashi Matsuda Eiji Takamoto Masao Kamimura Kohei Soga

出版者

The Japan Society for Analytical Chemistry

雑誌

Analytical Sciences (ISSN:09106340)

巻号頁・発行日

pp.21P283, (Released:2021-10-15)

被引用文献数

5

著者

Masaharu NODA Takashi MATSUDA

出版者

The Japan Academy

雑誌

Proceedings of the Japan Academy, Series B (ISSN:03862208)

巻号頁・発行日

vol.98, no.7, pp.283-324, 2022-07-29 (Released:2022-07-29)

参考文献数

314

被引用文献数

9

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Extracellular fluids, including blood, lymphatic fluid, and cerebrospinal fluid, are collectively called body fluids. The Na+ concentration ([Na+]) in body fluids is maintained at 135–145 mM and is broadly conserved among terrestrial animals. Homeostatic osmoregulation by Na+ is vital for life because severe hyper- or hypotonicity elicits irreversible organ damage and lethal neurological trauma. To achieve “body fluid homeostasis” or “Na homeostasis”, the brain continuously monitors [Na+] in body fluids and controls water/salt intake and water/salt excretion by the kidneys. These physiological functions are primarily regulated based on information on [Na+] and relevant circulating hormones, such as angiotensin II, aldosterone, and vasopressin. In this review, we discuss sensing mechanisms for [Na+] and hormones in the brain that control water/salt intake behaviors, together with the responsible sensors (receptors) and relevant neural pathways. We also describe mechanisms in the brain by which [Na+] increases in body fluids activate the sympathetic neural activity leading to hypertension.