文献一覧: Takeshi Nakamura (著者)

3 0 0 0 OA Erythropoietin Prevention Trial of Coronary Restenosis and Cardiac Remodeling After ST-Elevated Acute Myocardial Infarction (EPOC-AMI)

著者: Norimasa Taniguchi Takeshi Nakamura Takahisa Sawada Kinya Matsubara Keizo Furukawa Mitsuyoshi Hadase Yoshifumi Nakahara Takashi Nakamura Hiroaki Matsubara
出版者: The Japanese Circulation Society
雑誌: Circulation Journal (ISSN:13469843)
巻号頁・発行日: vol.74, no.11, pp.2365-2371, 2010 (Released:2010-10-25)
参考文献数: 37
被引用文献数: 52 63

Background: Erythropoietin (EPO) enhances re-endothelialization and anti-apoptotic action. Larger clinical studies to examine the effects of high-dose EPO are in progress in patients with acute myocardial infarction (AMI). Methods and Results: The aim of this multi-center pilot study was to investigate the effect of `low-dose EPO' (6,000 IU during percutaneous coronary intervention (PCI), 24 h and 48 h) in 35 patients with a first ST-elevated AMI undergoing PCI who was randomly assigned to EPO or placebo (saline) treatment. Neointimal volume, cardiac function and infarct size were examined in the acute phase and 6 months later (ClinicalTrials.gov identifier: NCT00423020). No significant regression in in-stent neointimal volume was observed, whereas left ventricular (LV) ejection fraction was significantly improved (49.2% to 55.7%, P=0.003) and LV end-systolic volume was decreased in the EPO group (47.7 ml to 39.0 ml, P=0.036). LV end-diastolic volume tended to be reduced from 90.2% to 84.5% (P=0.159), whereas in the control group it was inversely increased (91.7% to 93.7%, P=0.385). Infarction sizes were significantly reduced by 38.5% (P=0.003) but not in the control group (23.7%, P=0.051). Hemoglobin, peak creatine kinase values, and CD34+/CD133+/CD45dim endothelial progenitors showed no significant changes. No adverse events were observed during study periods. Conclusions: This is a first study demonstrating that short-term `low-dose' EPO to PCI-treated AMI patients did not prevent neointimal hyperplasia but rather improved cardiac function and infarct size without any clinical adverse effects. (Circ J 2010; 74: 2365-2371)

2019-10-19 05:41:33
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2 0 0 0 OA Short-Term Change in Gait Speed and Clinical Outcomes in Older Patients With Acute Heart Failure

著者: Shinya Tanaka Kentaro Kamiya Nobuaki Hamazaki Ryota Matsuzawa Kohei Nozaki Takeshi Nakamura Masashi Yamashita Emi Maekawa Chiharu Noda Minako Yamaoka-Tojo Atsuhiko Matsunaga Takashi Masuda Junya Ako
出版者: The Japanese Circulation Society
雑誌: Circulation Journal (ISSN:13469843)
巻号頁・発行日: vol.83, no.9, pp.1860-1867, 2019-08-23 (Released:2019-08-23)
参考文献数: 33
被引用文献数: 20 24

Background:Evidence for the prognostic value of gait speed is largely based on a single measure at baseline, so we investigated the prognostic significance of change in gait speed in hospitalized older acute heart failure (AHF) patients.Methods and Results:This retrospective study was performed in a cohort of 388 AHF patients ≥60 years old (mean age: 74.8±7.8 years, 228 men). Routine geriatric assessment included gait speed measurement at baseline and at discharge. The primary outcome of this study was all-cause death. Gait speed increased from 0.74±0.25 m/s to 0.98±0.27 m/s after 13.5±11.0 days. Older age, shorter height and lower hemoglobin level at admission, prior HF admission, and higher baseline gait speed were independently associated with lesser improvement in gait speed. A total of 80 patients died and 137 patients were readmitted for HF over a mean follow-up period of 2.1±1.9 years. In multivariate analyses, change in gait speed showed inverse associations with all-cause death (hazard ratio [HR] per 0.1 m/s increase: 0.83; 95% confidence interval [CI]: 0.73 to 0.95; P=0.006) and with risk of readmission for HF (HR: 0.91; 95% CI: 0.83 to 0.99; P=0.036).Conclusions:Short-term improvement in gait speed during hospitalization was associated with reduced risks of death and readmission for HF in older patients with AHF.

2023-12-06 19:37:04
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2 0 0 0 OA The Cytokine Expression in Patients with Cardiac Complication after Immune Checkpoint Inhibitor Therapy

著者: Toshihiro Tsuruda Naoki Yoshikawa Motoaki Kai Masashi Yamaguchi Reiko Toida Tsuyoshi Kodama Kei Kajihara Takayuki Kawabata Takeshi Nakamura Koji Sakata Kinta Hatakeyama Toshihiro Gi Yujiro Asada Tetsuya Tono Kazuo Kitamura Ryuji Ikeda
出版者: The Japanese Society of Internal Medicine
雑誌: Internal Medicine (ISSN:09182918)
巻号頁・発行日: pp.5317-20, (Released:2020-09-19)
参考文献数: 33
被引用文献数: 15

We herein report the cytokine expression at different stages for three patients who developed cardiac complications after immune checkpoint inhibitor (ICI) therapy. Patient 1 with biopsy-proven myocarditis showed increased levels of interleukin (IL)-8, monocyte chemotactic and activating factor, and granulocyte macrophage colony-stimulating factor (GM-CSF) when he developed Takotsubo cardiomyopathy. Patient 2 with subclinical myocarditis showed predominant activation of IL-8 during the progressive clinical course. Patient 3 with cytokine-releasing syndrome showed substantial activations of IL-6, IL-8, GM-CSF, and interferon-γ. Our data suggest the development of unique cytokine activation in individual patients with cardiac complications after ICI therapy.

2021-01-28 21:23:06
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2 0 0 0 OA Predictors of Increased Left Ventricular Filling Pressure After Transcatheter Atrial Septal Defect Closure

著者: Michiyo Yamano Tetsuhiro Yamano Takeshi Nakamura Kan Zen Hirokazu Shiraishi Takeshi Shirayama Satoaki Matoba
出版者: The Japanese Circulation Society
雑誌: Circulation Reports (ISSN:24340790)
巻号頁・発行日: vol.2, no.2, pp.113-120, 2020-02-10 (Released:2020-02-10)
参考文献数: 23
被引用文献数: 2

Background:The aim of this study was to identify factors of left ventricular filling pressure (LVFP) elevation following transcatheter atrial septal defect (ASD) closure.Methods and Results:The study involved 97 adult patients with sinus rhythm who underwent both transcatheter ASD closure and transthoracic echocardiography. Elevated LVFP was diagnosed during the first month of follow-up according to the American Society of Echocardiography guidelines: that is, ratio of transmitral early filling to the lateral annular diastolic velocity (lateral E/e’) >13 was used to exclude the effect of the device on the atrial septum. Fifteen patients (15.5%) were diagnosed with increased LVFP during the 1-month follow-up period (median lateral E/e’: from 9.2, IQR, 6.6–10.8; to 15.5, IQR, 13.8–17.8; P<0.001). Independent predictors of LVFP elevation were left ventricular (LV) relative wall thickness, lateral E/e›, and peak tricuspid regurgitation pressure gradient (TRPG) at baseline (OR, 1.67; 95% CI: 1.04–2.69; OR, 1.52; 95% CI: 1.07–2.15; and OR, 1.14; 95% CI: 1.04–1.25; cut-offs: 0.42, 7.5, and 27.0 mmHg, respectively). Median lateral E/e› returned to baseline in most patients with LVFP elevation during 6 months of subsequent follow-up (1-month–6-month follow-up: 15.5, IQR, 13.8–17.8; 11.1, IQR, 8.8–14.8, respectively; P=0.001).Conclusions:The increase in Doppler-estimated LVFP following transcatheter ASD closure may be related to LV hypertrophy, diastolic dysfunction, and peak TRPG in elderly patients.

2020-02-10 23:32:56
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1 0 0 0 OA Usefulness of the Simplified Frailty Scale in Predicting Risk of Readmission or Mortality in Elderly Patients Hospitalized with Cardiovascular Disease

著者: Keita Aida Kentaro Kamiya Nobuaki Hamazaki Ryota Matsuzawa Kohei Nozaki Takafumi Ichikawa Takeshi Nakamura Masashi Yamashita Emi Maekawa Minako Yamaoka-Tojo Atsuhiko Matsunaga Junya Ako
出版者: International Heart Journal Association
雑誌: International Heart Journal (ISSN:13492365)
巻号頁・発行日: vol.61, no.3, pp.571-578, 2020-05-30 (Released:2020-05-30)
参考文献数: 40
被引用文献数: 7 9

The simplified frailty scale is a simple frailty assessment tool modified from Fried's phenotypic frailty criteria, which is easy to administer in hospitalized patients. The applicability of the simplified frailty scale to indicate prognosis in elderly hospitalized patients with cardiovascular disease (CVD) was examined.This cohort study was performed in 895 admitted patients ≥ 65 years (interquartile range, 71.0-81.0, 541 men) with CVD. Patients were classified as robust, prefrail, or frail based on the five components of the simplified frailty scale: weakness, slowness, exhaustion, low activity, and weight loss. The primary endpoint was the composite outcome of all-cause mortality and unplanned readmission for CVD.Patients positive for greater numbers of frailty components showed higher risk of all-cause mortality or unplanned CVD-related readmission (P for trend < 0.001). Classification as both frail (adjusted HR: 3.27, 95% confidence interval [CI]: 1.49-7.21, P = 0.003) and prefrail (adjusted HR: 2.19, 95% CI: 1.00-4.79, P = 0.049) independently predicted the composite endpoint compared with robust after adjusting for potential confounding factors. The inclusion of prefrail, frail, and number of components of frailty increased both continuous net reclassification improvement (0.113, P = 0.049; 0.426, P < 0.001; and 0.321, P < 0.001) and integrated discrimination improvement (0.007, P = 0.037; 0.009, P = 0.038; and 0.018, P = 0.002) for the composite endpoint.Higher scores on the simplified frailty scale were associated with increased risk of mortality or readmission in elderly patients hospitalized for CVD.

2023-09-13 22:52:45
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1 0 0 0 OA Posterior Reversible Encephalopathy Syndrome with Extensive Deep White Matter Lesions Including the Temporal Pole

著者: Junichiro Ohira Nobuyuki Mori Shunsuke Kajikawa Takeshi Nakamura Tetsuya Arisato Makio Takahashi
出版者: The Japanese Society of Internal Medicine
雑誌: Internal Medicine (ISSN:09182918)
巻号頁・発行日: vol.55, no.23, pp.3529-3533, 2016-12-01 (Released:2016-12-01)
参考文献数: 20
被引用文献数: 9 7

Posterior reversible encephalopathy syndrome (PRES) typically affects the posterior subcortical white matter. We report the case of a 55-year-old man with atypical PRES, who had malignant hypertension and renal dysfunction. Magnetic resonance imaging of the brain revealed extensive vasogenic edema in the deep white matter including the temporal pole, as well as in the brainstem and cerebellum. Antihypertensive therapy and hemodialysis contributed to both clinical and radiological improvement. Involvement of the deep white matter including the temporal pole, which is rarely affected in an ischemic stroke, should be recognized as a potential sign of PRES.

2023-07-29 14:37:18
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1 0 0 0 OA Utility of biphasic calcium phosphate cement as a seal for root-end filling

著者: Takeshi NAKAMURA Makoto HAYASHI Muneaki TAMURA Masahiro KAKETANI Tomoka ITO Toshiki TAKAMIZAWA Yusuke SUZUKI Takuya YASUKAWA Akiyoshi SUGAWARA Osamu TAKEICHI
出版者: The Japanese Society for Dental Materials and Devices
雑誌: Dental Materials Journal (ISSN:02874547)
巻号頁・発行日: pp.2022-250, (Released:2023-03-18)
参考文献数: 32

The recently developed biphasic calcium phosphate cement (BCPC) consists of α-tricalcium phosphate-tetracalcium phosphate as the solid phase and calcium phosphate solution as the liquid phase. BCPC powder is composed of a single solid solution with a monomodal size distribution. Here, we used a bacterial leakage model to examine the utility of BCPC as a seal for root-end filling. We prepared large (median particle size=9.96 µm; BCPC-L) and small (median particle size=4.84 µm; BCPC-S) BCPC powders. In total, 45 single-rooted teeth were instrumented, resected at the root-end, and retrofilled with experimental materials. Mineral trioxide aggregate (MTA) was used as the control. After visual confirmation of BCPC powder size and retrofilling quality by microscopy, bacterial leakage tests were conducted using Enterococcus faecalis. The bacterial leakage tests did not reveal any significant differences between BCPC-S and MTA. Our findings suggest that BCPC-S is useful for root-end filling.

2023-03-20 16:50:27
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1 0 0 0 OA Efficacy of prototype endodontic obturators for novel root canal obturation techniques using a resin-based sealer in various powder-liquid ratios

著者: Akiko Takatsuki-Hira Masahiro Kaketani Kohei Shimizu Takahito Tamura Takeshi Nakamura Yurika Toyama Takayuki Yoneyama Osamu Takeichi
出版者: Nihon University School of Dentistry
雑誌: Journal of Oral Science (ISSN:13434934)
巻号頁・発行日: pp.20-0543, (Released:2021-02-17)
参考文献数: 40

Purpose: This study aimed to examine novel techniques using prototype endodontic obturators to obturate a resin-based sealer.Methods: Powder-liquid ratios of MetaSEAL Soft were changed to obtain suitable root canal sealing, and the physical properties for various powder-liquid ratios were analyzed according to ISO-6876. Tensile bond strength was also examined. Prototype endodontic obturators with a combination of thread numbers and pitch angles were analyzed for sealing ability after MetaSEAL Soft was obturated in simulated root canals.Results: Powder-liquid ratios of 1.0:1, 1.1:1, 1.2:1, and 1.3:1 showed suitable physical properties; however, flow for 1.4:1 was below a standard value. Tensile bond strength increased gradually when the powder-liquid ratio changed from 1.0:1 to 1.3:1, and 1.3:1 and 1.4:1 showed the highest and lowest bond strengths, respectively. Sealing ability increased when pitch angles of the obturators were 5°, 8°, and 11°; 11° showed the best results. Similarly, sealing ability increased when the thread number was 12, 17, and 22 pitches; 22 showed the best results.Conclusion: These findings suggest that the prototype endodontic obturator can be useful for obturating MetaSEAL Soft, and a powder-liquid ratio of 1.3:1 MetaSEAL Soft may be the most suitable for achieving excellent sealing.

2021-02-27 09:09:59
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1 0 0 0 OA Usefulness of the Simplified Frailty Scale in Predicting Risk of Readmission or Mortality in Elderly Patients Hospitalized with Cardiovascular Disease

著者: Keita Aida Kentaro Kamiya Nobuaki Hamazaki Ryota Matsuzawa Kohei Nozaki Takafumi Ichikawa Takeshi Nakamura Masashi Yamashita Emi Maekawa Minako Yamaoka-Tojo Atsuhiko Matsunaga Junya Ako
出版者: International Heart Journal Association
雑誌: International Heart Journal (ISSN:13492365)
巻号頁・発行日: pp.19-557, (Released:2020-05-15)
参考文献数: 40
被引用文献数: 9

2020-12-18 07:59:14
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1 0 0 0 OA Predictors of In-hospital Outcomes after Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction in Patients with a High Killip Class

著者: Jun Shiraishi Yoshio Kohno Takeshi Nakamura Takashi Yanagiuchi Sho Hashimoto Daisuke Ito Masayoshi Kimura Akihiro Matsui Hirokazu Yokoi Masayasu Arihara Masayuki Hyogo Takatomo Shima Takahisa Sawada Satoaki Matoba Hiroyuki Yamada Akiyoshi Matsumuro Takeshi Shirayama Makoto Kitamura Keizo Furukawa on Behalf of the AMI-Kyoto Multi-Center Risk Study Group
出版者: 一般社団法人日本内科学会
雑誌: Internal Medicine (ISSN:09182918)
巻号頁・発行日: vol.53, no.9, pp.933-939, 2014 (Released:2014-05-01)
参考文献数: 27
被引用文献数: 2 16

Objective The predictors of in-hospital outcomes after primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) complicated with heart failure or cardiogenic shock at presentation remain unclear. Methods Using the AMI-Kyoto Multi-Center Risk Study database, the clinical background characteristics, angiographic findings, primary PCI results, and in-hospital prognoses were retrospectively compared between primary PCI-treated AMI patients with a Killip class status of ≥2 (Killip 2-4 patients, n=390) and those with a Killip class 1 status (Killip 1 patients, n=1,057). Results The Killip 2-4 patients were more likely to have a higher age and proportion of women and exhibited a higher prevalence of previous myocardial infarction, diabetes mellitus and chronic kidney disease or anemia on admission, lower systolic blood pressure (SBP) values on admission, a higher rate of multivessels or left main trunk as the culprit artery, a larger number of diseased vessels, a lower Thrombolysis In Myocardial Infarction (TIMI) grade in the infarct-related artery (IRA) before/after primary PCI and a significantly higher in-hospital mortality rate than the Killip 1 patients. According to a multivariate analysis, age was found to be an independent positive predictor of in-hospital mortality, while admission SBP was an independent positive predictor of in-hospital survival in both groups. In contrast, anemia on admission was found to be an independent predictor of in-hospital death, while the TIMI 3 flow in the IRA after PCI was found to be an independent factor for survival in the Killip 2-4 patients, but not the Killip 1 patients. Conclusion Anemia on admission and the final TIMI 3 flow in the IRA are critical determinants of in-hospital death in AMI patients with a Killip class status of ≥2 undergoing primary PCI.

2017-09-13 23:15:03
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1 0 0 0 OA MODELING THE SHALLOW SUBSURFACE STRUCTURE IN THE URBAN AREA OF KOCHI CITY

著者: Michihiro OHORI Seckin CITAK Takeshi NAKAMURA Minoru SAKAUE Shunsuke TAKEMURA Takashi FURUMURA Teito TAKEMOTO Kazuhisa IWAI Atsuki KUBO Kazuo KAWATANI Sawa TAJIMA Narumi TAKAHASHI Yoshiyuki KANEDA
出版者: 公益社団法人日本地震工学会
雑誌: 日本地震工学会論文集 (ISSN:18846246)
巻号頁・発行日: vol.15, no.3, pp.3_95-3_113, 2015 (Released:2015-06-22)
参考文献数: 34

We have constructed a shallow underground structural model of Kochi City for an area 10.5 km east-west by 5.5 km south-north with a resolution of 125 m, which could control seismic amplification in the short period up to 1 s. By compiling the geological information given by the Committee of Kochi Geo-Hazard Evaluation (2011), we constructed a multilayered model overlying the engineering bedrock with an S-wave velocity of 700 m/s. Based on our newly developed model, the dispersion characteristics of theoretical surface waves at two sites were calculated and verified by comparison with observed data derived from our microtremor array experiments. The predominant periods along two north-south lines calculated from our model were coincident with previous observations derived from microtremor H/V spectral ratios by Mori et al. (2001). We also conducted a seismic response analysis using the synthesized ground motion data from the Central Disaster Management Council of Japan (2003) as the input motion applied to the basement of the developed subsurface structural model. We confirmed that the area where relatively high seismic intensity was predicted corresponded well with the area that was severely damaged during the 1946 Nankai Earthquake.

2015-07-01 22:46:05
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