文献一覧: Tetsuya Kobayashi (著者)

5 0 0 0 OA Cytomorphological and Immunological Classification of Feline Lymphomas: Clinicopathological Features of 76 Cases

著者: Junko CHINO Yasuhito FUJINO Tetsuya KOBAYASHI Kazuhiro KARIYA Yuko GOTO-KOSHINO Koichi OHNO Hiroyuki NAKAYAMA Hajime TSUJIMOTO
出版者: 公益社団法人日本獣医学会
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: pp.12-0246, (Released:2013-01-21)
被引用文献数: 5 23 2

Of the various classification systems for non-Hodgkin’s lymphoma, the updated Kiel classification is valuable for veterinary practice, because of its utility to classify the subtypes not only by histopathology but also by cytomorphology. However, there are only a few reports of small number of feline lymphomas to apply the updated Kiel classification. In this study, immunogical subtypes and morphology of 76 feline lymphomas were evaluated and classified into subtypes of the updated Kiel classification. Of the cases, 49% were T-cell lymphoma, 25% were B-cell lymphoma and 26% were undetermined immunological subtype. Based on the updated Kiel classification, most subtypes were identified also in feline lymphomas as in dogs and humans. Globule leukocyte lymphoma was specific for cats and relatively common in feline alimentary lymphomas. Of the present cases, 64% were high-grade subtypes, whereas 36% were low-grade subtypes. The present study indicated that feline lymphomas could be morphologically classified by the modified updated Kiel classification.

2013-01-27 17:39:27
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4 0 0 0 OA Localized pulmonary histiocytic sarcomas in Pembroke Welsh Corgi

著者: Yumiko KAGAWA Yuko NAKANO Tetsuya KOBAYASHI Kazushi ASANO Satoshi TAKAGI
出版者: 公益社団法人日本獣医学会
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: pp.15-0284, (Released:2015-07-04)
被引用文献数: 9

Nineteen cases of histiocytic sarcomas in Pembroke Welsh Corgi were examined histopathologically. Focal or multiple masses were detected in the lung or in regional lymph nodes, or in both lung and nodes. All neoplastic lesions had common histological features characterized by the proliferation of pleomorphic histiocytic cells combined with various inflammatory cells. Most of the pleomorphic neoplastic cells were immunopositive for human leukocyte antigen (HLA)-DR and Iba-1. The median survival time for all dogs was 133 days. In the present study, several prognostic factors, such as gender, age, single or multiple lesions, lymph node involvement at the time of diagnosis, surgical resection status and additional chemotherapy, were examined, although none of these factors approached statistical significance. Histiocytic sarcoma must be considered in the differential diagnosis of dogs with pulmonary masses, especially in the canine breed.

2015-07-08 07:12:38
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3 0 0 0 OA Familial clustering of mice consistent to known pedigrees enabled by the genome profiling (GP) method

著者: Harshita Sharma Fumihito Ohtani Parmila Kumari Deepti Diwan Naoko Ohara Tetsuya Kobayashi Miho Suzuki Naoto Nemoto Yoshibumi Matsushima Koichi Nishigaki
出版者: 日本生物物理学会
雑誌: BIOPHYSICS (ISSN:13492942)
巻号頁・発行日: vol.10, pp.55-62, 2014 (Released:2014-09-06)
参考文献数: 32
被引用文献数: 1

Familial clustering without any prerequisite knowledge becomes often necessary in Behavioral Science, and forensic studies in case of great disasters like Tsunami and earthquake requiring body-identification without any usable information. However, there has been no well-established method for this purpose although conventional ones such as short tandem repeats (STR) and single nucleotide polymorphism (SNP), which might be applied with toil and moil to some extent. In this situation, we could find that the universal genome distance-measuring method genome profiling (GP), which is made up of three elemental techniques; random PCR, micro-temperature gradient gel electrophoresis (μTGGE), and computer processing for normalization, can do this purpose with ease when applied to mouse families. We also confirmed that the sequencing approach based on the ccgf (commonly conserved genetic fragment appearing in the genome profile) was not completely discriminative in this case. This is the first demonstration that the familial clustering can be attained without a priori sequence information to the level of discriminating strains and sibling relationships. This method can complement the conventional approaches in preliminary familial clustering.

2014-10-17 17:01:33
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3 0 0 0 OA Imatinib Responsiveness in Canine Mast Cell Tumors Carrying Novel Mutations of c-KIT Exon 11

著者: Yuko NAKANO Tetsuya KOBAYASHI Fukiko OSHIMA Eri FUKAZAWA Tetsushi YAMAGAMI Yozo SHIRAISHI Masamine TAKANOSU
出版者: 公益社団法人日本獣医学会
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: pp.13-0156, (Released:2013-11-29)
被引用文献数: 4 12

In 2 individual cases of canine mast cell tumors, we identified 2 novel c-KIT mutations in exon 11: a 9-base pair (bp) deletion (c.1663-1671del) and a point mutation (c.1676T>A). The 9-bp deletion mutation caused a loss of 3 amino acids, corresponding to p.Gln555_Lys557del, and the point mutation resulted in the substitution of valine by aspartic acid (p.Val559Asp) in the juxtamembrane domain of the protein. Imatinib mesylate, a therapeutic agent for canine mast cell tumors, was used to treat both tumors. Complete remission was achieved at 33 and 14 days after administration, respectively. However, in both cases, the therapeutic response subsequently tapered with the duration of remission lasting 66 and 255 days, respectively. Although these 2 novel c-KIT mutations in exon11 were not confirmed to be gain-of-function mutations, a further study may help clarify relevance between mutations identified in this report and responsiveness.

2013-12-06 20:36:11
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2 0 0 0 OA Clinical features and prognosis of retroperitoneal hemangiosarcoma in dogs with surgical resection with or without adjuvant doxorubicin

著者: Masanao ICHIMATA Atsushi TOSHIMA Fukiko MATSUYAMA Eri FUKAZAWA Kei HARADA Ryuzo KATAYAMA Yumiko KAGAWA Tetsushi YAMAGAMI Tetsuya KOBAYASHI
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: pp.22-0533, (Released:2023-10-17)

Retroperitoneal hemangiosarcoma (RPHSA) is a rare tumor in dogs with a poorly understood prognosis after surgery. The objectives of this study were to investigate the clinical features and prognosis of canine RPHSA that had undergone surgical resection. In this single-center, retrospective cohort study, we reviewed the medical records of dogs that had undergone surgical resection for retroperitoneal tumors and received a histopathologic diagnosis of HSA between 2005 and 2021. The median progression-free survival (PFS) and overall survival (OS) were 77.5 days and 168 days, respectively. In the present study, canine RPHSA had an aggressive biological behavior similar to visceral HSA. Further studies in larger canine populations are needed to evaluate the efficacy of adjuvant chemotherapy.

2023-10-18 09:40:01
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2 0 0 0 OA Safety and pharmacokinetics of thalidomide in tumor-bearing dogs

著者: Fukiko MATSUYAMA Yukiyoshi FUJITA Eri FUKAZAWA Tetsuya KOBAYASHI
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: pp.23-0200, (Released:2023-10-10)

Thalidomide, an angiogenesis inhibitor, has recently been used to treat malignant canine tumors. This study retrospectively investigated the adverse events (AEs) of thalidomide administered to tumor-bearing dogs. We investigated the pharmacokinetics of thalidomide after administration and the rate of body weight change before and after administration. The initial thalidomide dose was 5 mg/kg per os once daily, which was increased to 10 mg/kg once daily in dogs with no significant AEs. Pharmacokinetics were measured in four dogs after the 5 mg/kg or 10 mg/kg dose. We evaluated AEs related to clinical signs in 51 patients; 9/51 had lethargy, 6/51 had tremor, 4/51 had dizziness, 31/51 had decreased appetite, 8/51 had vomiting, and 16/49 had soft stool/diarrhea. We evaluated hematologic toxicity in 44 patients with grade 3 or higher adverse events; 1/44 had thrombocytopenia, 1/44 had increased blood urea nitrogen concentrations, and 5/44 had increased alanine aminotransferase activities. The mean thalidomide blood levels were Cmax=1.4 ± 0.7 μg/mL (Area under the curve [AUC] 0-24=8.5 ± 4.7 μg・hr /mL) and Cmax=3.2 ± 2.1 μg/mL (AUC0-24=22.0± 14.7 μg・hr/mL) in the 5 mg/kg and 10 mg/kg groups, respectively. The Cmax and AUC in the 10 mg/kg group were comparable to the effective blood concentrations seen in humans administered thalidomide. The weight fluctuation rates were assessed in 24 dogs approximately 1 month after the start of thalidomide administration; more than half showed weight maintenance or gain. Most AEs were clinically acceptable; however, peripheral nerve signs were seen in some dogs.

2023-10-14 02:49:46
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2 0 0 0 OA Long-term survival in a dog with primary hepatic neuroendocrine tumor treated with toceranib phosphate

著者: Masanao ICHIMATA Shinichiro NISHIYAMA Fukiko MATSUYAMA Eri FUKAZAWA Kei HARADA Ryuzo KATAYAMA Atsushi TOSHIMA Yumiko KAGAWA Tetsushi YAMAGAMI Tetsuya KOBAYASHI
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: pp.21-0254, (Released:2021-08-17)
被引用文献数: 2

Primary hepatic neuroendocrine tumors (PHNETs) are rare in dogs, and limited information exists about the treatment of these tumors. A 12-year-old castrated male French bulldog was presented to our clinic with gastrointestinal signs. Diagnostic tests revealed increased hepatic enzyme levels, a mass in the hepatic quadrate lobe, multiple intrahepatic nodules, and enlarged hepatic hilar lymph nodes. The liver mass was diagnosed cytologically as a malignant epithelial tumor suspected to be of neuroendocrine origin. The dog was treated with single-agent toceranib phosphate (TOC) and survived 25.1 months after the initial presentation. On necropsy, a liver mass was found and was subsequently diagnosed as a PHNET on histopathology. To the best of our knowledge, this is the first report of long-term survival in a dog with PHNET treated with TOC.

2021-08-19 02:33:57
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1 0 0 0 OA Gene expression profiles associated with early relapse during first remission induction in canine multicentric high-grade B-cell lymphoma

著者: Hiroto TOYODA Akiyoshi TANI Yuko GOTO-KOSHINO Tomoki MOTEGI Mika SAKAMOTO Takako MOCHIZUKI Kei HARADA Tetsuya KOBAYASHI Asuka SETOGUCHI Yohei SHIZUTA Takuya MIZUNO Mitsuhiro IRIE Jun NAKAMICHI Hajime TSUJIMOTO Aki OHMI Ray FUKUOKA Yasukazu NAKAMURA Hirotaka TOMIYASU
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: vol.86, no.1, pp.18-27, 2024 (Released:2024-01-10)
参考文献数: 49
被引用文献数: 1

Although chemotherapy using CHOP-based protocol induces remission in most cases of canine multicentric high-grade B-cell lymphoma (mhBCL), some cases develop early relapse during the first induction protocol. In this study, we examined the gene expression profiles of canine mhBCL before chemotherapy and investigated their associations with early relapse during the first whole CHOP-based protocol. Twenty-five cases of mhBCL treated with CHOP-based protocol as first induction chemotherapy were included in this study. Sixteen cases completed the first whole CHOP-based protocol without relapse (S-group), and nine developed relapse during the chemotherapy (R-group). RNA-seq was performed on samples from neoplastic lymph nodes. Differentially expressed genes (DEGs) were extracted by the comparison of gene expression profiles between S- and R-groups, and the differences in the expression levels of these genes were validated by RT-qPCR. Extracted 179 DEGs included the genes related to chemokine CC motif ligand, T-cell receptor signaling pathway, and PD-L1 expression and PD-1 checkpoint pathway. We focused on chemokine CC motif ligand, and CCL4 was confirmed to be significantly downregulated in the R-group (P=0.039). We also focused on the genes related to T-cell signaling pathway, and CD3E (P=0.039), ITK (P=0.023), and LAT (P=0.023) genes were confirmed to be significantly upregulated in the R-group. The current results suggest that both changes in tumor cells and the interactions between tumor cells and immune cells are associated with the efficacy of the chemotherapy for first remission induction.

2024-01-11 03:56:17
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1 0 0 0 OA Clinical features and prognosis of retroperitoneal hemangiosarcoma in dogs with surgical resection with or without adjuvant doxorubicin

著者: Masanao ICHIMATA Atsushi TOSHIMA Fukiko MATSUYAMA Eri FUKAZAWA Kei HARADA Ryuzo KATAYAMA Yumiko KAGAWA Tetsushi YAMAGAMI Tetsuya KOBAYASHI
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: vol.85, no.11, pp.1231-1236, 2023 (Released:2023-11-18)
参考文献数: 18

2023-11-22 19:12:00
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1 0 0 0 OA Gene expression profiles associated with early relapse during first remission induction in canine multicentric high-grade B-cell lymphoma

著者: Hiroto TOYODA Akiyoshi TANI Yuko GOTO-KOSHINO Tomoki MOTEGI Mika SAKAMOTO Takako MOCHIZUKI Kei HARADA Tetsuya KOBAYASHI Asuka SETOGUCHI Yohei SHIZUTA Takuya MIZUNO Mitsuhiro IRIE Jun NAKAMICHI Hajime TSUJIMOTO Aki OHMI Ray FUKUOKA Yasukazu NAKAMURA Hirotaka TOMIYASU
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: pp.23-0269, (Released:2023-11-13)
被引用文献数: 1

2023-11-13 20:05:19
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1 0 0 0 OA Localized pulmonary histiocytic sarcomas in Pembroke Welsh Corgi

著者: Yumiko KAGAWA Yuko NAKANO Tetsuya KOBAYASHI Kazushi ASANO Satoshi TAKAGI
出版者: 公益社団法人日本獣医学会
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: vol.77, no.12, pp.1659-1661, 2015 (Released:2016-01-01)
参考文献数: 10
被引用文献数: 9

2016-01-16 03:15:26
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