文献一覧: Tetsuya Yamamoto (著者)

8 0 0 0 OA Predictors of Outcomes Six Months after Endovascular Coil Embolization of Poor-Grade Aneurysmal Subarachnoid Hemorrhage

著者: Taisuke Akimoto Makoto Ohtake Takafumi Kawasaki Shuto Fushimi Wataru Shimohigoshi Hiroshi Manaka Takashi Kawasaki Katsumi Sakata Ichiro Takeuchi Tetsuya Yamamoto
出版者: The Japanese Society for Neuroendovascular Therapy
雑誌: Journal of Neuroendovascular Therapy (ISSN:18824072)
巻号頁・発行日: pp.oa.2022-0043, (Released:2023-01-07)
参考文献数: 24

Objective: To identify factors associated with the outcome and prognosis of coil embolization for poor-grade aneurysmal subarachnoid hemorrhage (aSAH).Methods: We retrospectively reviewed 118 patients with World Federation of Neurosurgical Societies (WFNS) grade IV or V subarachnoid hemorrhage at our institute between January 2010 and December 2020. Outcomes were assessed using modified Rankin Scale (mRS) scores at discharge and at six months after aSAH onset. In addition, patient background, aneurysm characteristics, and treatment outcome were compared between patients showing favorable (mRS scores: 0–2) and unfavorable (mRS scores: 3–6) outcomes at six months. Factors for change of mRS during follow-up were explored, and cut off values were calculated for age using the receiver operating characteristic analysis.Results: Endovascular treatment was performed in 51 of the 118 enrolled patients. Data were analyzed for 43 of these patients who underwent coil embolization of ruptured aneurysms and had complete datasets. The mean age was 61.7 years and 24 (55.8%) patients had WFNS grade V aSAH. Coil embolization-related complications were observed in three patients. There were no treatment-related deaths; however, eight patients (18.6%) died at three months. Multivariate analysis showed that the maximum diameter of the aneurysm (p=0.041) and the postoperative dual antiplatelet therapy (DAPT) (p=0.040) were associated with unfavorable and favorable outcomes, respectively. Older age (p=0.033) was independently associated with mRS score deterioration following discharge. Age 72 years and older was the cut off value for mRS deterioration.Conclusion: Aneurysm size and postoperative DAPT might be associated with outcomes at 6 months. Moreover, we identified older age as an independent factor that influences mRS deterioration following discharge; thus, especially in cases of elderly patients over 72 years of age, it is highly likely that long-term care to prevent disuse and regular follow-up on imaging will be necessary.

2023-01-16 19:54:32
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6 0 0 0 OA Epilepsy in Five Long-term Survivors of Pineal Region Tumors

著者: Yutaro TAKAYAMA Kazutaka JIN Shin-ichiro OSAWA Masaki IWASAKI Kazushi UKISHIRO Yosuke KAKISAKA Teiji TOMINAGA Tetsuya YAMAMOTO Nobukazu NAKASATO
出版者: The Japan Neurosurgical Society
雑誌: NMC Case Report Journal (ISSN:21884226)
巻号頁・発行日: vol.8, no.1, pp.773-780, 2021 (Released:2021-11-02)
参考文献数: 32

Cognitive decline is a well-known chronic side effect of multidisciplinary treatment of pineal region tumors, whereas epilepsy is an under-reported chronic consequence caused by multiple potential factors including radiotherapy, surgery, or chemotherapy. Some long-term survivors have suffered drug-resistant epilepsy after treatment, which impaired the quality of life. We report five consecutive patients with drug-resistant epilepsy after combined treatment of pineal region tumor (5 men, aged 21–42 years) among 1201 epilepsy patients who underwent comprehensive evaluation in our tertiary epilepsy center from 2011 to 2018. The comprehensive epilepsy evaluation included medical interview, long-term video electroencephalography (EEG) monitoring (VEM), and magnetic resonance (MR) imaging. The patients started to have seizures at 2–22 years after initial treatment for the tumor. Four of the five patients had focal impaired awareness seizures, whereas one patient had only visual aura. All patients had EEG seizures during VEM, which confirmed the diagnosis of focal epilepsy, but three patients had no interictal epileptiform discharges (IEDs). Two patients had diagnoses of focal epilepsy arising from the left occipital region based on ictal EEG findings. Both patients had MR imaging lesion in the left occipital lobe, radiation-induced cavernoma, or surgical injury. The remaining three patients showed poor localization of epileptogenic foci based on VEM and MR imaging. Drug-resistant epilepsy after multidisciplinary treatment of pineal region tumor is characterized by focal impaired awareness seizures with poorly localized EEG onset or rare interictal spikes.

2023-12-15 16:22:03
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5 0 0 0 OA Diagnostic Accuracy of Pre-Transcatheter Aortic Valve Replacement Nitroglycerin-Free Fractional Flow Reserve-Computed Tomography-Based Physiological Assessment in Patients With Severe Aortic Stenosis for Predicting Post-Transcatheter Aortic Valve Replacement Ischemia

著者: Satoru Sasaki Hiroyuki Kawamori Takayoshi Toba Ryo Takeshige Yusuke Fukuyama Takashi Hiromasa Hiroyuki Fujii Tomoyo Hamana Yuto Osumi Seigo Iwane Tetsuya Yamamoto Shota Naniwa Yuki Sakamoto Koshi Matsuhama Yuta Fukuishi Toshiro Shinke Ken-ichi Hirata Hiromasa Otake
出版者: The Japanese Circulation Society
雑誌: Circulation Journal (ISSN:13469843)
巻号頁・発行日: pp.CJ-23-0312, (Released:2023-10-07)
参考文献数: 20
被引用文献数: 2

Background: Fractional flow reserve-computed tomography (FFRCT) has not been validated in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) for coronary artery disease due to theoretical difficulties in using nitroglycerin for such patients.Methods and Results: In this single-center study, we prospectively enrolled 21 patients (34 vessels) and performed pre-TAVR FFRCTwithout nitroglycerin, pre-TAVR invasive instantaneous wave-free ratio (iFR) measurements, and post-TAVR FFR measurements using a pressure wire. The diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of pre-TAVR FFRCT≤0.80 to predict post-TAVR invasive FFR ≤0.80 were 82%, 83%, 82%, 71%, and 90%, respectively. A receiver operating characteristic analysis demonstrated an optimal cutoff of 0.78 for pre-TAVR FFRCTto indicate post-TAVR FFR ≤0.80, with an area under the curve (AUC) of 0.84, and the counterpart cutoff of pre-TAVR iFR was 0.89 with an AUC of 0.86.Conclusions: FFRCTwithout nitroglycerin could be a useful non-invasive imaging modality for assessing the severity of coronary artery lesions in patients with severe AS.

2023-10-08 15:30:12
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2 0 0 0 OA Neoadjuvant Therapy with Everolimus for Subependymal Giant Cell Astrocytoma: A Case Report

著者: Hiroki KARITA Kyoji TSUDA Maya KONO Tetsuya YAMAMOTO Satoshi IHARA
出版者: The Japan Neurosurgical Society
雑誌: NMC Case Report Journal (ISSN:21884226)
巻号頁・発行日: vol.10, pp.291-297, 2023-12-31 (Released:2023-10-14)
参考文献数: 20

Direct surgical resection remains to be the standard treatment for tuberous sclerosis complex (TSC) with subependymal giant cell astrocytoma (SEGA). Medical therapy with everolimus (mammalian target of rapamycin inhibitor or mTOR) serves as a second-line treatment for patients with SEGA who are determined to be ineligible for surgical resection. Some recent studies have reported that neoadjuvant therapy for SEGA may be a useful, novel treatment.In this study, we herein present a case of SEGA and demonstrate the efficacy of preoperative everolimus therapy. We have also examined the utility and safety of neoadjuvant therapy for SEGA and investigated four previously reported cases of preoperative administration of mTOR inhibitors. In these cases, everolimus was administered preoperatively to shrink the tumor although the duration of treatment varied. Afterward, gross total tumor removal was conducted in all the cases. No postoperative complications were reported during the follow-up period. These findings indicate that neoadjuvant therapy with an mTOR inhibitor can be a potential treatment for SEGA. The findings of this present study also suggested that a short administration period of about 2 months may be sufficient to achieve preoperative tumor reduction.

2023-11-15 10:50:59
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2 0 0 0 OA Combined Endovascular Antegrade and Direct Retrograde Carotid Artery Stenting for Chronic and Long Segment Common Carotid Artery Occlusion: Technical Note and Review of Literature

著者: Shigeta MIYAKE Yasunobu NAKAI Taisuke AKIMOTO Shun ISHIKAWA Wakiko SARUTA Hiroki KURODA Satoru SHIMIZU Tetsuya YAMAMOTO
出版者: The Japan Neurosurgical Society
雑誌: Neurologia medico-chirurgica (ISSN:04708105)
巻号頁・発行日: pp.2022-0397, (Released:2023-04-06)
参考文献数: 8

Common carotid artery (CCA) occlusion (CCAO) is a rare cause of ischemic stroke and bypass surgery is the common treatment approach. However, safer alternatives should be developed to treat CCAO. A 68-year-old male was diagnosed with left-sided CCAO with decreased left visual acuity due to neck radiation therapy for laryngeal cancer. Recanalization therapy using a pull-through technique was initiated because cerebral blood flow progressively decreased during the follow-up period. First, after a short sheath was inserted into the CCA, the occluded CCA was retrogradely penetrated through the sheath. Second, a micro-guidewire was guided to the aorta from the femoral sheath where it was caught using a snare wire guided from the cervical sheath. Subsequently, the micro-guidewire was gently pulled out from the cervical sheath, penetrated the occluded lesion, and was secured to the femoral and cervical sheaths. Finally, the occluded lesion was dilated using a balloon, and the stent was placed. Five days postprocedure, the patient was discharged uneventfully and exhibited improved left visual acuity. In terms of reliable penetration of obstructive lesions and reduction of embolic and hemorrhagic complications, combined endovascular antegrade and direct retrograde carotid artery stenting is a versatile and minimally invasive treatment option for CCAO.

2023-04-09 03:42:56
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2 0 0 0 OA High Uric Acid Promotes Atherosclerotic Plaque Instability by Apoptosis Targeted Autophagy

著者: Weidong Liu Wei Yu De Xie Qiang Wang Hairong Zhao Jiaming Lv Furong He Chenxi Xu Binyang Chen Tetsuya Yamamoto Hidenori Koyama Jidong Cheng
出版者: Japan Atherosclerosis Society
雑誌: Journal of Atherosclerosis and Thrombosis (ISSN:13403478)
巻号頁・発行日: pp.63645, (Released:2022-11-26)
参考文献数: 32

Aims: Acute rupture or erosion of unstable atherosclerotic plaques is a major cause of adverse consequences of atherosclerotic cardiovascular disease, often leading to myocardial infarction or stroke. High uric acid (HUA) is associated with the increasing risk of cardiovascular events and death. However, the mechanism by which HUA promotes atherosclerosis and whether HUA affects plaque stability are still unclear. Methods: We constructed an atherosclerotic Apoe−/− mouse model with HUA. The progression of atherosclerosis and plaques was determined by Oil Red O staining, hematoxylin and eosin (H&E) staining, and Masson staining. TdT-mediated dUTP nick-end labeling assay and immunohistochemistry were used to observe the changes of apoptosis and autophagy in plaques, respectively. Then, we validated the in vivo results with RAW 264.7 cell line. Results: HUA promoted atherosclerosis and exacerbated plaque vulnerability, including significantly increased macrophage infiltration, lipid accumulation, enlarged necrotic cores, and decreased collagen fibers. HUA increased cell apoptosis and inhibited autophagy in plaques. In vitro results showed that HUA decreased cell viability and increased cell apoptosis in foam cells macrophages treated with oxidized low-density lipoprotein. An activator of autophagy, rapamycin, can partially reverse the increasing apoptosis. Conclusion: HUA promoted atherosclerosis and exacerbated plaque vulnerability, and HUA facilitates foam cell apoptosis by inhibiting autophagy.

2023-03-12 19:25:22
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2 0 0 0 OA Predictors of Outcomes Six Months after Endovascular Coil Embolization of Poor-Grade Aneurysmal Subarachnoid Hemorrhage

著者: Taisuke Akimoto Makoto Ohtake Takafumi Kawasaki Shuto Fushimi Wataru Shimohigoshi Hiroshi Manaka Takashi Kawasaki Katsumi Sakata Ichiro Takeuchi Tetsuya Yamamoto
出版者: The Japanese Society for Neuroendovascular Therapy
雑誌: Journal of Neuroendovascular Therapy (ISSN:18824072)
巻号頁・発行日: vol.17, no.2, pp.47-55, 2023 (Released:2023-02-20)
参考文献数: 24

2023-02-27 16:26:58
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1 0 0 0 OA Academic Activities of Female Neurosurgeons in All Branch Meetings of the Japan Neurosurgical Society

著者: Nobuo SUGO Sayaka TERAZONO Chie MATSUURA Yutaka FUCHINOUE Yuki SAKAEYAMA Mitsuyoshi ABE Masataka MIKAI Syuhei KUBOTA Kosuke KONDO Shoko SHIMOKAWA Taketoshi MAEHARA Hiroyoshi AKUTSU Fusao IKAWA Yukiko ENOMOTO Kazuko KAMIYA Satoshi KURODA Hideo TAKESHIMA Noriko TAMURA Tomohito HISHIKAWA Masazumi FUJII Takamitsu FUJIMAKI Tetsuyoshi HORIUCHI Junkoh YAMAMOTO Tetsuya YAMAMOTO Yoko KATO
出版者: The Japan Neurosurgical Society
雑誌: Neurologia medico-chirurgica (ISSN:04708105)
巻号頁・発行日: pp.2023-0051, (Released:2023-07-25)
参考文献数: 26

This study aims to evaluate the academic activities of female neurosurgeons at all branch meetings of the Japan Neurosurgical Society and identify related issues they encountered. The programs of all seven branch meetings of the Japan Neurosurgical Society (Hokkaido, Tohoku, Kanto, Chubu, Kinki, Chugoku/Shikoku, and Kyushu) were used to determine the number of presentations and chairpersons by sex. The covered period was from January 2008 to December 2020, which was available for viewing during the survey. Of note, only the Kinki branch used data from January 2008 to December 2019. The Neurologia Medico-chirurgica (NMC), the journal of the Japan Neurosurgical Society, was also reviewed to identify publication achievements during the same period. In all seven branches, the percentage of presentations given by female physicians increased from 7.9% in 2008 to 9.6% in 2020 (p < 0.05).Conversely, the percentage of female chairpersons in all branch meetings did not change over time and it was significantly lower (1.1%) than that of female presenters (7.9%) for all branch meetings combined in over 13 years (p < 0.01). In the NMC, the number of articles with female physicians as first authors did not increase or decrease over the years. We conclude that efforts to smoothly promote female neurosurgeons as chairpersons and increase the number of female first authors are necessary to facilitate their academic activities.

2023-07-28 16:32:29
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1 0 0 0 Enhancement of the Classification Performance of Electrical Field-Flow Fractionation Using Horizontal Electrophoresis

著者: Tetsuya Yamamoto Takahisa Tatekawa Kunihiro Fukui Hideto Yoshida
出版者: The Society of Chemical Engineers, Japan
雑誌: JOURNAL OF CHEMICAL ENGINEERING OF JAPAN (ISSN:00219592)
巻号頁・発行日: vol.44, no.6, pp.398-404, 2011-06-20 (Released:2011-06-20)
参考文献数: 12
被引用文献数: 5 5

The purpose of the present study was to enhance the classification performance of electrical field-flow fractionation (EFFF). In recent research by this group, the surface potential of silica particles treated with a bead mill displayed size dependency—smaller particles had a more negative zeta potential. This phenomenon and the EFFF system were used to classify the particles, with the bottom and top plates of the EFFF channel serving as negative and positive electrodes, respectively.In the present study, improvements to the EFFF channel were carried out to enhance classification accuracy. Walls of deionized water were utilized to prevent particles from contacting the electrodes. Because vertical electrophoresis led to the disturbance of particle trajectories in the channel by gravitational sedimentation, horizontal electrophoresis was applied. Furthermore, hydrodynamic force was induced in the channel creating differing linear velocities of the slurry and the water at the inlet. As a result, 200-nm particles could be classified at an applied voltage of 5 V with high accuracy when compared with the previous method that used vertical electrophoresis.

2020-07-31 13:48:03
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1 0 0 0 OA Profile Analysis of Chemotherapy-induced Nausea and Vomiting in Patients Treated with Concomitant Temozolomide and Radiotherapy: Results of a Prospective Study

著者: Masahide MATSUDA Tetsuya YAMAMOTO Eiichi ISHIKAWA Kei NAKAI Hiroyoshi AKUTSU Kuniyuki ONUMA Akira MATSUMURA
出版者: 社団法人日本脳神経外科学会
雑誌: Neurologia medico-chirurgica (ISSN:04708105)
巻号頁・発行日: vol.55, no.9, pp.749-755, 2015 (Released:2015-09-15)
参考文献数: 21
被引用文献数: 2 5

Temozolomide (TMZ) as a concomitant and adjuvant chemotherapy to radiotherapy following maximal surgical resection is the established standard therapy for patients with newly diagnosed high-grade glioma. However, detailed analysis of chemotherapy-induced nausea and vomiting (CINV) associated with concomitant TMZ has not been sufficiently described. We prospectively analyzed the profile of CINV associated with concomitant TMZ. Eighteen consecutive patients with newly diagnosed high-grade glioma treated with concomitant chemoradiotherapy including TMZ were enrolled. CINV was recorded using a daily diary including nausea assessment, emetic episodes, degree of appetite suppression, and antiemetic medication use. The observed incidence rates of all grade nausea, moderate/severe (CTC grade 2, 3) nausea, emetic episodes, and appetite suppression for the overall period were 89%, 39%, 39%, and 83%, respectively. Moderate/severe nausea and severe (CTC grade 3) appetite suppression were frequently observed during the delayed phase of the treatment. Emetic episodes and moderate/severe nausea were significantly correlated with female gender. Moderate/severe nausea and severe appetite suppression were significantly correlated with low lymphocyte counts before chemoradiotherapy. For CINV associated with concomitant TMZ, enhanced antiemetic therapy focused on the delayed phase of the treatment will likely be beneficial, especially in female patients with a low lymphocyte count before chemoradiotherapy.

2016-05-18 23:36:36
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1 0 0 0 OA Mild Encephalitis/Encephalopathy With a Reversible Splenial Lesion: Evaluation by Diffusion Tensor Imaging

著者: Satoru OSUKA Hironori IMAI Eiichi ISHIKAWA Akira MATSUSHITA Tetsuya YAMAMOTO Hiroki NOZUE Tatsuyuki OHTO Kousaku SAOTOME Yoji KOMATSU Akira MATSUMURA
出版者: 社団法人日本脳神経外科学会
雑誌: Neurologia medico-chirurgica (ISSN:04708105)
巻号頁・発行日: vol.50, no.12, pp.1118-1122, 2010 (Released:2010-12-25)
参考文献数: 13
被引用文献数: 9 23

Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a clinico-radiological syndrome with a very particular clinical course. Three patients with MERS were evaluated by various sequences of magnetic resonance imaging with diffusion tensor imaging. Initial diffusion-weighted imaging showed reduction in the apparent diffusion coefficient values in the lesions, which completely resolved with the elimination of symptoms. However, diffusion anisotropy of the lesions showed no remarkable abnormalities in the early or delayed phases. These results may indicate that white matter architecture is preserved in both early and delayed phases in MERS.

2015-10-25 19:43:04
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1 0 0 0 OA Preoperative Endovascular Embolization for Hemangioblastoma in the Posterior Fossa

著者: Noriaki SAKAMOTO Eiichi ISHIKAWA Yasunobu NAKAI Hiroyoshi AKUTSU Tetsuya YAMAMOTO Kei NAKAI Masanari SHIIGAI Hideo TSURUSHIMA Tomonori ISOBE Shingo TAKANO Koji TSUBOI Akira MATSUMURA
出版者: 社団法人日本脳神経外科学会
雑誌: Neurologia medico-chirurgica (ISSN:04708105)
巻号頁・発行日: vol.52, no.12, pp.878-884, 2012 (Released:2012-12-25)
参考文献数: 27
被引用文献数: 9 30 5

Intracranial hemangioblastomas (HBs) are hypervascular neoplasms mainly located in the posterior fossa of the central nervous system. Preoperative embolization of the feeding arteries is one proposal for reduction of intraoperative hemorrhage, although indications for the procedures should be evaluated carefully due to the potential complications. This retrospective study investigated clinical outcomes and complications of 15 patients with HBs in the posterior fossa to evaluate the safety and effectiveness of endovascular procedures as well as angiographical procedures. Surgical excision without presurgical embolization was performed in 8 cases, and excision with presurgical embolization was performed in 7 cases, using Guglielmi detachable coils with or without polyvinyl alcohol (GDC ± PVA) in 4 cases and only n-butyl 2-cyanoacrylate (NBCA) in 3 cases. The embolization was applied for selected cases in which feeding arteries were located in a deep site and hard to coagulate surgically. Partial embolization was achieved in 5 cases, and all feeders were successfully embolized in 2 cases. Total removal was achieved in 12 cases, and subtotal/partial removal was achieved in 3 cases. Subarachnoid hemorrhage with intratumoral hemorrhage occurred in 1 case during the angiographic procedure and in 1 case during the embolization procedures. The mean volume of intraoperative blood loss was clearly less in the NBCA group than in the GDC ± PVA group. HBs are mainly located in the posterior cranial fossa, so the risk of severe clinical complication may be high if vascular problems occur. In our series, presurgical embolization using NBCA made tumor removal safe and reduced bleeding volume in posterior fossa HBs.

2014-09-27 18:23:56
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1 0 0 0 OA Valproic Acid Inhibits Angiogenesis In Vitro and Glioma Angiogenesis In Vivo in the Brain

著者: Satoru OSUKA Shingo TAKANO Shinya WATANABE Eiichi ISHIKAWA Tetsuya YAMAMOTO Akira MATSUMURA
出版者: 社団法人日本脳神経外科学会
雑誌: Neurologia medico-chirurgica (ISSN:04708105)
巻号頁・発行日: vol.52, no.4, pp.186-193, 2012 (Released:2012-04-23)
参考文献数: 31
被引用文献数: 14 52

Antiangiogenic strategy is promising for malignant glioma. Histone deacetylase inhibitors (HDACIs) are unique anticancer agents that exhibit antiangiogenic effects. The in vitro and in vivo antiangiogenic effects of HDACIs, valproic acid (VPA), were investigated in malignant glioma in the brain. In vitro, VPA preferentially inhibited endothelial cell proliferation compared to glioma cell proliferation at the optimum concentration in a dose-dependent manner. VPA reduced vascular endothelial growth factor (VEGF) secretion of glioma cells in a dose-dependent manner under both normoxic and hypoxic conditions. VPA was also found to inhibit tube formation in the angiogenesis assay. In vivo, treatment with VPA combined with irinotecan reduced the number of vessels expressing factor VIII in the brain tumor model. VPA inhibits glioma angiogenesis by direct (inhibition of endothelial cell proliferation and tube formation) and indirect (decreased secretion of VEGF by glioma cells) mechanisms. These data suggest a potential role for VPA as an adjuvant therapy for patients with malignant glioma.

2012-06-18 17:39:22
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