- 著者
- Maki Fukuda Tsuyoshi Ohta Hiroshi Okabayashi Noritaka Masahira Toshiki Matsuoka Kenji Okada Takaya Tsuno Shota Nishimoto Yusuke Ueba
- 出版者
- The Japanese Society for Neuroendovascular Therapy
- 雑誌
- Journal of Neuroendovascular Therapy (ISSN:18824072)
- 巻号頁・発行日
- vol.14, no.4, pp.151-156, 2020 (Released:2020-04-20)
- 参考文献数
- 8
- 被引用文献数
- 1 1
Objective: The objective of this study was to evaluate the reproducibility of three-dimensional (3D) images of the aortic arch reconstructed using a novel image processing algorithm for non-enhanced computed tomography (CT) images of the cervicothorax and abdomen obtained before emergency endovascular surgery.Case Presentations: In all, 46 patients who underwent acute mechanical thrombectomy between January and December 2018 were examined. The anatomical variations of the aortic arch were reproduced in all cases; however, the reproduction of the carotid arteries was difficult.Conclusion: Our novel 3D analysis system enables obtaining information on the aortic arch easily from plain CT data that may be useful in acute endovascular treatment.
- 著者
- Hiroo OHMORI Jack Hiroki IGUCHI Tsuyoshi OHTA Atsuko TERAZONO Kengo HIKITA
- 出版者
- The Association of Japanese Geographers
- 雑誌
- 地理学評論 (ISSN:13479555)
- 巻号頁・発行日
- vol.77, no.5, pp.301-320, 2004-04-01 (Released:2008-12-25)
- 参考文献数
- 32
- 被引用文献数
- 1 1
In order to investigate the vegetation response to global warming, experimental research was carried out on a high mountain of Japan for three years from 1997 to 1999. The experimental site was in the alpine zone at 2, 780m above sea level, near the peak of Mt. Norikura (3, 026m) in central Japan. Vegetation growing period is about 4 months without snow cover from early June to early October. Five open top chambers with a diameter of 80cm and a height of 30cm were used for temperature enhancement, and another five places were selected as controls outside the chambers. The main objectives were to clarify the differences in vegetation growth, phenology, biomass and coverage of plant between temperature-enhanced chambers and controls. To prove temperature enhancement, air temperature at vegetation height of 5cm high above ground and ground temperature at root layer of 3cm depth were recorded every hour in each chamber and at each control. Vegetation growth and phenology of several alpine species were measured at about four-week intervals, and biomass and coverage were measured on the last experimental day every year. The mean air temperature at vegetation height and mean ground temperature at root layer in chambers were about 0.65°C and 0.25°C higher than in the controls, respectively. Vegetation growth was significantly accelerated, and phenology was surely affected by the extension of growth period due to temperature enhancement for most of the plants observed. Vegetation growth and phenology, however, varied with species, indicating that species vary in response to warming. Differences in biomass between chambers and controls were not significant for all years, suggesting that the total growth of plants in the unit area is controlled by nutrient conditions of the soil. Through three years of experiment, coverage of Loiseleuria procumbens (Ericaceae) recognizably increased, overcoming other species in chambers, while there were no conspicuous changes in controls. It suggests that L. procumbens whose canopy expands horizontally over the other forbs might be more physiologically active than others under warming conditions, although vegetation growth showed positive response to temperature enhancement for most species.
- 著者
- Kei Kawada Tomoaki Ishida Kohei Jobu Tsuyoshi Ohta Hitoshi Fukuda Shumpei Morisawa Tetsushi Kawazoe Naohisa Tamura Mitsuhiko Miyamura
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Biological and Pharmaceutical Bulletin (ISSN:09186158)
- 巻号頁・発行日
- vol.45, no.6, pp.720-723, 2022-06-01 (Released:2022-06-01)
- 参考文献数
- 24
- 被引用文献数
- 3
Aggression is the most common adverse effect of antiepileptic drugs (AEDs). This study aimed to investigate the association of aggression with AED use. The reporting odds ratio (ROR) from adverse event reports, submitted to the Japanese Adverse Drug Event Report database between 2004 and 2020, was used to calculate and investigate the association between AEDs and aggression. We also analyzed the association of aggression with the combined use of AEDs and the relationship between AED-associated aggression and patient characteristics. A total of 433 patients developed aggression. Significant aggression signals were detected for perampanel (crude ROR: 325.04, 95% confidence interval (CI): 118.48–752.58, p < 0.01), levetiracetam (crude ROR: 17.14, 95% CI: 10.33–26.90, p < 0.01), lacosamide (crude ROR: 16.90, 95% CI: 2.02–62.51, p < 0.01), lamotrigine (crude ROR: 15.98, 95% CI: 9.99–24.39, p < 0.01), valproate (crude ROR: 6.68, 95% CI: 4.27–10.02, p < 0.01), and carbamazepine (crude ROR: 2.47, 95% CI: 1.17–4.59, p < 0.01). The combined therapy with perampanel and levetiracetam had a significant aggression signal (adjusted ROR: 25.90, 95% CI: 1.14–59.10, p < 0.01). In addition, we found that aggression frequently occurred in patients <60 year (adjusted ROR: 2.88, 95% CI: 1.49–5.56, p < 0.01) treated with levetiracetam. These results may be useful for minimizing the risk of aggression during the treatment of AEDs.
- 著者
- Tsuyoshi OHTA Shirabe MATSUMOTO Ryu FUKUMITSU Hirotoshi IMAMURA Hidemitsu ADACHI Yoshie HARA Kohkichi HOSODA Hidehito KIMURA Kazuyuki KUWAYAMA Takashi MIZOWAKI Yasuhiko MOTOOKA Shiro MIYATA Narihide SHINODA Yasushi UENO Ikuya YAMAURA Yasuhisa YOSHIDA Chiaki SAKAI Nobuyuki SAKAI
- 出版者
- The Japan Neurosurgical Society
- 雑誌
- Neurologia medico-chirurgica (ISSN:04708105)
- 巻号頁・発行日
- pp.2023-0090, (Released:2023-08-30)
- 参考文献数
- 22
The current study aims to evaluate the incidence and results of aneurysmal subarachnoid hemorrhage (aSAH) throughout Kobe City. Based on a multicenter retrospective registry-based descriptive trial involving all 13 primary stroke centers in Kobe City, patients with aSAH treated between October 2017 and September 2019 were studied. A total of 334 patients were included, with an estimated age-adjusted incidence of 11.12 per 100,000 person-years. Curative treatment was given to 94% of patients, with endovascular treatment (51%) preferred over surgical treatment (43%). Of the patients, 12% were treated by shunt surgery for sequential hydrocephalus with a worse outcome at 30 days or discharge (14% vs. 46%, odds ratio (OR): 0.19, 95% confidence interval (CI): 0.088-0.39, p-value <0.001). As for vasospasm and delayed cerebral ischemia, most patients were given intravenous fasudil infusion (73%), with endovascular treatment for vasospasm in 24 cases (7.2%). The fasudil group had more good outcomes (42% vs. 30%, OR: 1.64, 95% CI: 0.95-2.87, p-value = 0.075) and significantly less death (3.3% vs. 35%, OR: 0.064, 95% CI: 0.024-0.15, p-value <0.001) at 30 days or discharge. Mortality rose from 12% at 30 days or discharge to 17% at 1 year, but neurological function distribution improved over time (modified Rankin Scale 0-2 was 39% at 30 days or discharge, 53% at 60 days, and 63% at 1 year). Our retrospective registered trial presented various statistics on aSAH, summarizing the current treatment status and prognosis.
- 著者
- Tsuyoshi Ohta Tetsu Satow Manabu Inoue Kanta Tanaka Junpei Koge Takeshi Yoshimoto Eika Hamano Taichi Ikedo Masatake Sumi Koji Shimonaga Yuji Kushi Hisae Mori Koji Iihara Masafumi Ihara Masatoshi Koga Kazunori Toyoda Hiroharu Kataoka
- 出版者
- The Japanese Society for Neuroendovascular Therapy
- 雑誌
- Journal of Neuroendovascular Therapy (ISSN:18824072)
- 巻号頁・発行日
- pp.oa.2022-0018, (Released:2022-07-20)
- 参考文献数
- 17
Objective: To evaluate whether changes in the practice of mechanical thrombectomy could affect the clinical outcomes during the coronavirus disease (COVID-19) pandemic.Methods: Patients who underwent mechanical thrombectomy from April 2019 to March 2021 for anterior circulation proximal large artery occlusion in our institute were divided into two groups of pre- and post-COVID-19, with April 2020 assumed to be the start of the COVID-19 era with the first declaration of a state of emergency. We compared patient characteristics, proportions of patient selection depending on rapid processing of perfusion and diffusion (RAPID) CT perfusion, outcomes including treatment variables such as time and reperfusion status, and patient independence at 3 months.Results: Data for 112 patients (median age, 79 years; 44 females) were included in the analysis. A total of 50 patients were assigned to the pre-COVID-19 group (45%). More patients were selected with RAPID CT perfusion in the post-COVID-19 compared with the pre-COVID-19 (69% vs. 16%; P <0.001). Treatment details and clinical outcomes did not differ between the groups, including the door-to-puncture time (median [interquartile range], 66 [54–90] min vs. 74 [61–89] min; P = 0.15), proportions of significant reperfusion (82% vs. 87%; P = 0.60), and modified Rankin scale score of ≤2 at 3 months (46% vs. 45%; P >0.99). Multivariate logistic regression analysis for the clinical outcome of modified Rankin scale score of ≤2 at 3 months was performed and included the following factors: age, sex, the onset-to-door time, significant reperfusion, and pre- and post-COVID-19. The treatment period did not influence the outcomes (post-COVID-19 group, odds ratio, 0.79; 95% confidence interval, 0.34–1.85, P = 0.59).Conclusion: In the setting of a limited access to emergency MRI during the COVID-19 pandemic, RAPID CT perfusion was performed significantly more often. Changes in the practice of mechanical thrombectomy with the protected code stroke did not bring the different level of treatment and clinical outcomes as before.
- 著者
- Hiroki TAKAMURA Hiroshi KADOMURA Hidehiro SOHMA Norio TASE Hiromi HAMADA Yuichi SUZUKI Akihiko INAMURA Hiroshi SHIMAZU Payzulla ZAYDUN Tsuyoshi OHTA Masaya YASUHARA Tashpolat TIYIP Tadashi KONO Hamid YIMIT Heigang XIONG Wei ZHONG Heigang XIONG Nurbay ABDUSALIH Peipou HUANG Hiroyuki SAWADA Hiroshi UMEMURA Kentaro SUZUKI Gulmira OMAR Kunihiko ENDO Motoko KANEMAKI Xiaoyu MA Jianli DING Jianqian ZHAN
- 出版者
- The Association of Japanese Geographers
- 雑誌
- 地理学評論 (ISSN:13479555)
- 巻号頁・発行日
- vol.75, no.12, pp.750-761, 2002-10-01 (Released:2008-12-25)