著者

Jiayu He Yuanyuan Liu Ai Zhang Qianfeng Liu Xueli Yang Naixiu Sun Baoqun Yao Fengchao Liang Xiaochang Yan Yang Liu Hongjun Mao Xi Chen Nai-jun Tang Hua Yan

出版者

The Japanese Society for Hygiene

雑誌

Environmental Health and Preventive Medicine (ISSN:1342078X)

巻号頁・発行日

vol.28, pp.3, 2023 (Released:2023-01-11)

参考文献数

41

被引用文献数

3

---

Background: Weather conditions are a possible contributing factor to age-related macular degeneration (AMD), a leading cause of irreversible loss of vision. The present study evaluated the joint effects of meteorological factors and fine particulate matter (PM2.5) on AMD.Methods: Data was extracted from a national cross-sectional survey conducted across 10 provinces in rural China. A total of 36,081 participants aged 40 and older were recruited. AMD was diagnosed clinically by slit-lamp ophthalmoscopy, fundus photography, and spectral domain optical coherence tomography (OCT). Meteorological data were calculated by European Centre for Medium-Range Weather Forecasts (ECMWF) reanalysis and were matched to participants’ home addresses by latitude and longitude. Participants’ individual PM2.5 exposure concentrations were calculated by a satellite-based model at a 1-km resolution level. Multivariable-adjusted logistic regression models paired with interaction analysis were performed to investigate the joint effects of meteorological factors and PM2.5 on AMD.Results: The prevalence of AMD in the study population was 2.6% (95% CI 2.42–2.76%). The average annual PM2.5 level during the study period was 63.1 ± 15.3 µg/m3. A significant positive association was detected between AMD and PM2.5 level, temperature (T), and relative humidity (RH), in both the independent and the combined effect models. For PM2.5, compared with the lowest quartile, the odds ratios (ORs) with 95% confidence intervals (CIs) across increasing quartiles were 0.828 (0.674,1.018), 1.105 (0.799,1.528), and 2.602 (1.516,4.468). Positive associations were observed between AMD and temperature, with ORs (95% CI) of 1.625 (1.059,2.494), 1.619 (1.026,2.553), and 3.276 (1.841,5.830), across increasing quartiles. In the interaction analysis, the estimated relative excess risk due to interaction (RERI) and the attributable proportion (AP) for combined atmospheric pressure and PM2.5 was 0.864 (0.586,1.141) and 1.180 (0.768,1.592), respectively, indicating a synergistic effect between PM2.5 and atmospheric pressure.Conclusions: This study is among the first to characterize the coordinated effects of meteorological factors and PM2.5 on AMD. The findings warrant further investigation to elucidate the relationship between ambient environment and AMD.

著者

Falko JUDT Daniel KLOCKE Rosimar RIOS-BERRIOS Benoit VANNIERE Florian ZIEMEN Ludovic AUGER Joachim BIERCAMP Christopher BRETHERTON Xi CHEN Peter DÜBEN Cathy HOHENEGGER Marat KHAIROUTDINOV 小玉 知央 Luis KORNBLUEH Shian-Jiann LIN 中野 満寿男 Philipp NEUMANN William PUTMAN Niklas RÖBER Malcolm ROBERTS 佐藤 正樹 澁谷 亮輔 Bjorn STEVENS Pier Luigi VIDALE Nils WEDI Linjiong ZHOU

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

vol.99, no.3, pp.579-602, 2021 (Released:2021-06-10)

参考文献数

68

被引用文献数

26

---

近年のコンピューターとモデル開発の進歩により、全球ストーム解像モデルの時代が始まり、それに伴って気象や気候予測が一変する可能性を秘めている。本研究では、この新しいクラスのモデルを検証するという一般的なテーマの中で、9つの全球ストーム解像モデルについて、熱帯低気圧(TC)をシミュレートする能力を評価した。その結果、大まかにいえば、これらのモデルは現実的な熱帯低気圧を再現し、熱帯低気圧の強度の正確なシミュレーションを可能とするなど、全球モデルの長年の課題が解消されていることが示された。一方、TCはモデルの設計に強く影響され、全てのモデルはTCの数、強度、大きさ、構造に関して独自のバイアスを持っている。いくつかのモデルは他のモデルよりも優れたTCをシミュレートするが、全ての点で優れたモデルが存在するわけではなかった。全体的な結果は、全球ストーム解像モデルがTC予測の新時代を切り拓くことが可能であることを示しているが、その可能性を最大限に引き出すためには改良が必要である。

著者

Yan Qing JIA Xiang Wei WANG Xi CHEN Xin Xin QIU Xing Long WANG Zeng Qi YANG

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.84, no.3, pp.473-483, 2022 (Released:2022-03-30)

参考文献数

30

被引用文献数

5

---

Interferon-induced protein-35 kDa (IFI35) was an antiviral protein induced by interferon (IFN)-γ, which plays an important role in the IFN-mediated antiviral signaling pathway. Here, we cloned and identified IFI35 in the chicken for the first time. Chicken IFI35 (chIFI35) contains an open reading frame (ORF) of 1,152 bp encoding a protein of 384 amino acids containing two conserved Nmi/IFI35 domain (NID) motifs. Tissue distribution analysis of chIFI35 in healthy and Newcastle disease (ND) virus-infected chickens indicated a positive correlation between chIFI35 mRNA transcription and ND viral loads in various tissues. The role of chIFI35 in regulation NDV replication were further assessed by up- or down-regulated chIFI35 expression in DF-1 cells transfected with plasmid harboring chIFI35, pCMV-3HA-chIFI35 or shRNA targeting chIFI35, pshRNA-chIFI35 plasmids. NDV replications in DF-1 cells were significantly reduced or slightly increased by over- or under-expression of the chIFI35 protein, respectively, indicating the role of chIFI35 in anti-NDV infection. Moreover, chIFI35 also involved in regulation of viral gene transcription and IFNs expression. The collected data were meaningful for research of chicken antiviral immunity and shed light on the pleiotropic antiviral effect of chIFI35 during NDV infection.

著者

小笠原 永久 千葉 矩正 山田 浩之 Xi CHEN

出版者

The Japanese Society for Experimental Mechanics

雑誌

実験力学 (ISSN:13464930)

巻号頁・発行日

vol.12, no.1, pp.26-32, 2012-03-28 (Released:2012-09-28)

参考文献数

13

被引用文献数

1

---

An identification method with a sharp indentation for elastoplastic properties of film/substrate system is proposed. The method is based on extensive finite element computation on "soft film on hard substrate" cases indented with a sharp indenter. The method utilizes the substrate effect on load versus displacement relation in the indentation; this effect has often been regarded as undesirable. The computational results are expressed as response surfaces in a material parameter space. Based on the surfaces, and employing experimentally obtained load versus displacement relation, the elastoplastic properties of the film are identified. To determine the elastoplastic properties more accurately, it is important to use not only the loading curve but also the unloading curve. Numerical examples determined by this method for film/substrate system are given.