著者

鈴江 懐 畑 精 浜島 義博

出版者

日本癌学会

雑誌

癌 (ISSN:0016450X)

巻号頁・発行日

vol.48, no.4, pp.491, 1957

著者

星 昭夫 池川 哲郎 池田 善明 白川 貞雄 飯郷 正明 榑谷 和男 福岡 文子

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.67, no.2, pp.321-326, 1976-04-30 (Released:2008-10-23)

参考文献数

13

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The antitumor activity of berberine, berberrubine, and their derivatives against sarcoma-180 ascites was determined by the total packed cell volume method. Berberine and tetrahydroberberine derivatives had no antitumor activity, but berberrubine (9-demethylberberine) and the ester derivatives of berberrubine had a strong antitumor activity. ED90 of berberrubine, its acetate and benzoate, were 15, 23, and 44mg/kg, respectively. The therapeutic indices (LD10/ED90 by the present method) of these compounds were as follows: Berberrubine hydrochloride, 6.7∼9.4; 9-acetyl-9-demethylberberine (9-acetylberberrubine) chloride, 7.6∼8.7; 9-benzoyl-9-demethylberberine (9-benzoylberberrubine) chloride, 3.4∼4.9.

著者

藤井 節郎 中村 芳正 武田 節夫 森田 健一 佐藤 俊幸 丸中 照義 川口 安郎 采見 憲男

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.71, no.1, pp.30-44, 1980-02-29 (Released:2008-10-23)

参考文献数

14

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The metabolism, antitumor activity, and acute toxicity of 5-fluoro-1, 3-bis-(tetrahydro-2-furanyl)-2, 4-pyrimidinedione (FD-1) were investigated in animals, compared with 5-fluoro-1-(tetrahydro-2-furanyl)-2, 4-pyrimidinedione (FT). It was found that after oral administration of FD-1, the level of 5-fluorouracil (5-FU) was maintained higher and longer than after administration of FT, and that a large amount of 5-FU was released from FD-1 by liver microsomal drugmetabolizing enzymes or spontaneous hydrolysis via 5-fluoro-3-(tetrahydro-2-furanyl)-2, 4-pyrimidinedione (3-FT) and FT. FD-1 had a significant activity against the solid form of Ehrlich carcinoma, sarcoma-180, hepatoma AH130, Yoshida sarcoma, Walker carcinosarcoma-256, and leukemia L1210 and P388, but not the ascitic forms, and it produced greater inhibition of tumor growth than FT. The acute toxicity of FD-1 was less than that of FT.

著者

中島 松一 小野 史郎 林 宏仁

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.65, no.5, pp.411-416, 1974-10-31 (Released:2008-10-23)

参考文献数

25

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Both humoral and cell-mediated immunity were suppressed by four intravenous injections of 100μg each of 4-hydroxyaminoquinoline 1-oxide, employing bacterial α-amylase and picryl chloride as antigens. Preimmunization of mice with diazotized 4-aminoquinoline 1-oxide-conjugated rabbit serum protein by the use of complete Freund's adjuvant prevented immunosuppression by 4-hydroxyaminoquinoline 1-oxide. Anti-hapten titers of these mice were 25 to 28 estimated by passive hemagglutination during the course of the experiments. Passive immunization by transfer of the specific anti-hapten antibody induced prevention from immunosuppression by the reagent. Therefore, it was suggested that the humoral anti-hapten antibody might play an important role in preventing mice from immunosuppression by the reagent by preimmunization with the hapten-carrier conjugate.

著者

Shozo TAKAYAMA Yoko NAKATSURU Mitsunobu MASUDA Hiroko OHGAKI Shigeaki SATO Takashi SUGIMURA

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.75, no.6, pp.467-470, 1984 (Released:2008-03-17)

参考文献数

22

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The mutagenic compound 2-amino-3-methylimidazo[4, 5-f]quinoline, originally isolated from broiled sardines and also present in cooked beef and beef extract, is being tested for carcinogenicity in F344 rats of both sexes. High incidences of tumors of the Zymbal gland, colon, small intestine and liver in males have been observed in the first 300 days of the experiment.

著者

河原 修三

出版者

The Japanese Cancer Association

雑誌

癌 (ISSN:0016450X)

巻号頁・発行日

vol.46, no.2-3, pp.304-305, 1955-09-01 (Released:2008-11-14)

著者

永田 親義 福井 謙一 米沢 貞次郎 北野 尚男 稲本 善昭 金井 克至 田頭 勇作

出版者

The Japanese Cancer Association

雑誌

癌 (ISSN:0016450X)

巻号頁・発行日

vol.46, no.2-3, pp.346-348, 1955-09-01 (Released:2008-11-14)

被引用文献数

2

著者

内田 正男 高木 弘

出版者

The Japanese Cancer Association

雑誌

癌 (ISSN:0016450X)

巻号頁・発行日

vol.48, no.2, pp.205-217, 1957-08-01 (Released:2008-11-14)

参考文献数

21

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砂川等が新しく合成した p-Phenylenediphosphoric acid tetraethyleneimid (O, O'-p-Phenylene N, N', N", N'''-tetraethylene-tetramidodiphosphate) は Ehrlich 腹水癌腹水型, 皮下腫瘍型, C3H系及びA系ハツカネズミ乳癌 (第一代雑種への移植癌) に対し制癌作用を示した。1) LD50 (マウス)腹腔内注射177~217mg/kg, 皮下注射202~224mg/kg, 静脈注射190~215mg/kg.2) 薬剤を試験管内で Ehrlich 腹水癌腹水に作用させたところ, 該腹水を接種したマウスは全く腹水癌の発生をみなかった。3) 毎日1回6日間連続腹腔内注射で Ehrlich 腹水癌の発生を抑制した。30mg~60mg/kgが有効量とみとめられる。4) Ehrlich 腹水癌細胞の有糸分裂を抑制した。5) Ehrlich 腹水癌皮下腫瘍周囲に皮下注射したが, いちじるしい効果はみとめなかった。6) C3H系マウスに自然発生した乳癌をSM×C3H/F1に移植し, またA系マウスに自然発生した乳癌をddN×A/F1に移植して, 腫瘍周囲に皮下注射したところ, 結節癌の増大抑制をみとみた。

著者

塚本 憲甫 酒井 一夫 網野 三郎

出版者

The Japanese Cancer Association

雑誌

癌 (ISSN:0016450X)

巻号頁・発行日

vol.47, no.3, pp.661-662, 1956

著者

岩鶴 竜三 河田 肇 増田 泰造 池田 哲夫 川村 祐二

出版者

The Japanese Cancer Association

雑誌

癌 (ISSN:0016450X)

巻号頁・発行日

vol.48, no.4, pp.613-615, 1957