著者
和田 芳直
出版者
一般社団法人 日本質量分析学会
雑誌
Journal of the Mass Spectrometry Society of Japan (ISSN:13408097)
巻号頁・発行日
vol.51, no.2, pp.368-373, 2003 (Released:2007-10-16)
参考文献数
26
被引用文献数
2 1

Mass spectrometry (MS) is proud of its high-throughput and sensitivity in the proteomic studies. However, the measurement of DNA by MS has not been in practice mainly due to its inherently large molecular size, though various applications of genetic analysis have been proposed so far. Now in the post-genome era, one of the highest demands on the genome analysis is the single nucleotide polymorphism genotyping, which is, in principle, the determination of single nucleotide substitutions at specific sites. A number of different methods using MS have been developed for this purpose, and some of those enabling multiplex analysis have advantages over other gel- or hybridization-based methods.
著者
近藤 文雄 鈴木 匡弘
出版者
一般社団法人 日本質量分析学会
雑誌
Journal of the Mass Spectrometry Society of Japan (ISSN:13408097)
巻号頁・発行日
vol.51, no.1, pp.114-118, 2003 (Released:2007-10-16)
参考文献数
19
被引用文献数
5 3

During the past 20 years, outbreaks of enterohemorrhagic Escherichia coli (EHEC) have been increasing worldwide and have been recognized as a potential health concern. Vero toxins produced by EHEC seem to be the most common cause of hemolytic uremic syndrome. Rapid diagnosis of EHEC infection is important to prevent the expansion of infection. Diagnosis is carried out by both isolation of EHEC and detection of Vero toxins in fecal extracts or fecal cultures. This review describes briefly about the current knowledge of the EHEC and Vero toxins, and about the determination methods for Vero toxins. The attempt to identify Vero toxins by electrospray ionization-liquid chromatography/mass spectrometry is also discussed.

1 0 0 0 OA イオン光学

著者
松田 久
出版者
The Mass Spectrometry Society of Japan
雑誌
Journal of the Mass Spectrometry Society of Japan (ISSN:13408097)
巻号頁・発行日
vol.12, no.25, pp.47-58, 1964-05-30 (Released:2010-06-28)
参考文献数
11
被引用文献数
2 2

最近は2次の収束性をもつ質量分析器や,従来用いられてきた一様磁場,円筒電場以外の非一様磁場やトロイダル電場を用いた質量分析器の議論が盛になってきている。このような質量分析器を設計したり理解したりするにはイオン光学の知識がなければならないが,わが国にはこれに関する入門書がほとんどないので,非才を省みずイオン光学の概要をまとめてみた。問題をできるだけ平易に解析的にとりあげるようにしたので,すこし長たらしくなったきらいはあるが,初歩の微積分と力学の知識があれば御理解いただけるものと考えている。第1篇で1次近似の結果を,第2篇で2次の収差について,第3篇で端縁場の影響について述べる予定である。
著者
中山 充 江口 鎮子 松尾 昭彦 林 修一 菱田 真三郎 加藤 義昭
出版者
一般社団法人 日本質量分析学会
雑誌
質量分析 (ISSN:13408097)
巻号頁・発行日
vol.20, no.3, pp.239-247, 1972
被引用文献数
1

Mass spectra of pterocarpan derivatives (I∼VII) are recorded in Figs. 1∼5 and Tables 1∼6. The major fragmentation pathways of these compounds are shown in Scheme1. The results illustrate that the observed fragmentation patterns are of considerable utility in the application of mass spectro metry to structure elucidation in this series.
著者
吉野 健一
出版者
一般社団法人 日本質量分析学会
雑誌
Journal of the Mass Spectrometry Society of Japan (ISSN:13408097)
巻号頁・発行日
vol.55, no.4, pp.298-309, 2007 (Released:2007-08-15)
参考文献数
7
被引用文献数
5 5

The term “mass spectrometry” is usually abbreviated as “MS.” It is confusing that “MS” is also used as an abbreviation for “mass spectrometer,” “mass spectroscopy,” “mass spectrograph,” “mass spectrum (spectra),” and “mass separation.” “Masu” in Japanese is an ambiguous word and originates from “mass” in English or “Mass” in German. In addition to the meaning of mass, however, “masu” is used as an abbreviation for “mass spectrometry,” “mass spectrometer,” “unified atomic mass unit,” and “a quantity of m/z= 1” by Japanese mass spectrometrists. Because of the ambiguity in the usage of “MS” and “masu,” some inappropriate terms, such as “peptide MS fingerprinting” for “peptide mass fingerprinting” and “TOF-mass” for “time-of-flight mass spectrometer,” were used by Japanese mass spectrometrists.
著者
藤巻 奨 古屋 寛子 神原 静香 平岡 賢三
出版者
一般社団法人 日本質量分析学会
雑誌
Journal of the Mass Spectrometry Society of Japan (ISSN:13408097)
巻号頁・発行日
vol.52, no.3, pp.149-153, 2004 (Released:2005-10-28)
参考文献数
13
被引用文献数
2 3

A direct gas introduction type atmospheric pressure Penning ionization source for on-site analysis of environmental organic pollutants was developed. The long-lived metastable argon atoms Ar* (3P2 and 3P0) were utilized for Penning ionization. As the excitation energies of Ar* are 11.5 eV (3P2) and 11.8 eV (3P0), the major components of air such as N2, O2, CO2, CO, and H2O are not ionized with Ar* but most of the organic compounds can be ionized. Atmospheric pressure Penning ionization mass spectra of all samples studied in our experiment showed abundant molecular-related ions (M+, [M+H]+, and [M-H]+) as base peaks. In the mass spectra of sample gases (M) mixed with methanol, intense ion [M+CH3]+ was observed in addition to [M+H]+ and [2M+H]+. The appearance of [M+CH3]+ is due to the occurrence of the methyl cation transfer reaction, CH3OH2++M→CH3+M+H2O.
著者
兼廣 春之
出版者
一般社団法人 日本質量分析学会
雑誌
Journal of the Mass Spectrometry Society of Japan (ISSN:13408097)
巻号頁・発行日
vol.47, no.6, pp.319-321, 1999 (Released:2007-10-16)
被引用文献数
1 1

The distribution and abundance of plastic litter, especially resin pellets, were investigated. Resin pellets are widespread in the coastal waters and beaches of Japan. Such pellets that are the raw materials of plastic products are important marine pollutants for many species of marine life such as ingestion by seabirds and fishes. In this report, organic pollutants in resin pellets collected from beaches and coastal waters were analyzed. NP (nonylphenol), PCB (polychlorinated biphenyls), and DDE (dichlorodiphenyldichloroethylene) were identified by GC/MS measurement. Their concentrations in 1 g of pellet sample (polypropylene and polyethylene) were as follows: NP (130-25,000 ng), PCB (5-120 ng), and DDE (0.2-3.1 ng). GC/MS analysis of resin pellets suggests that these pollutants were derived from the ambient seawater.