出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.95, no.S.Update, pp.100-107, 2019-06-20 (Released:2019-07-17)

著者

小川 さつき

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.56, no.9, pp.1182-1199, 1980-09-20 (Released:2012-09-24)

参考文献数

21

被引用文献数

4 5

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In order to elucidate the diurnal and circadian rhythms of oxytocin secretion, and the relation of estrogen, progesterone, testosterone and LH-RH to oxytocin secretion, plasma oxytocin levels were determined before and after the administration of these hormones in normal and hypogonadal subjects. The results were as follows.(1) In females with normal menstrual cycle, plasma oxytocin levels in the morning after overnight fasting were significantly higher (4.5 ± 2.6 pg/ml (mean ± SE)) in the follicular phase than they were (2.1 ± 1.3 pg/ml) in the luteal phase (p<0.01). Plasma oxytocin levels were higher in the follicular and ovulatory phases than they were in the luteal phase. In the luteal phase, the mean oxytocin concentration was higher during sleeping than during waking; however, in the follicular phase a variation of plasma oxytocin level was higher during waking than during sleeping.(2) In healthy males, plasma oxytocin level in the morning after overnight fasting was 3.5 ± 1.7 pg/ml, which was higher during sleeping than during waking. But the variation of plasma oxytocin levels during waking was larger than that during sleeping. Plasma oxytocin levels did not show cyclic changes in a year, but they were higher in summer than in winter.(3) Plasma oxytocin levels rose significantly after estradiol administration in normal females and males and did not change significantly after progesterone, and estradiol and progesterone administrations. A significant positive correlation was observed between plasma oxytocin level and the ratio of estradiol to progesterone concentrations in plasma in females and males.Plasma oxytocin levels rose significantly after testosterone administration in normal males. A significant positive correlation was observed between oxytocin and testosterone levels in plasma after the administration of testosterone.In the male subjects with hypogonadism, plasma oxytocin levels were elevated markedly 15 minutes after LH-RH administration.From these findings, it is suspected that in females with normal menstrual cycle, estrogen or LH-RH stimulates oxytocin secretion which is inhibited by progesterone, and that testosterone or LH-RH stimulates oxytocin secretion in normal males. On the other hand, a transient elevation of oxytocin secretion during waking in both females and males may be attributed to stimuli other than the sex hormones.The results also suggest that oxytocin secretion is affected by mechanism related to the hypothalamus-pituitary-gonadal system, and by mechanisms other than the system.

著者

石突 吉持 広岡 良文 谷川 俊一

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.70, no.10, pp.1093-1100, 1994-12-20 (Released:2012-09-24)

参考文献数

20

被引用文献数

1 4

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In order to evaluate whether or not iodine intake in Japanese is variable among different aged subjects and also whether this variation is concordant with the age distribution in patients with chronic thyroiditis, we tried to examine the urinary iodine excretion of euthyroid people in various decades of age.One hundred and twenty outpatients without thyroid disorders, aged 22 to 77 y. o., were selected at random and were divided into 6 groups according to age. Mean total urinary iodine excretion (UIT) and concentration (UIC) were 336.1μg/day and 31.4μg/dl/cr, respectively, and they were in good correlation (r=+0.82, p<0.001). A straight line on log normal probability was recognized between the ratio of cumulative frequency and values of UIT. UIT and UIC were significantly correlated with serum nonhormonal iodine, respectively (r=+0.21, p<0.01; r=+0.28, p<0.01). These indicators in the 3rd decade were lower than those in the 6th decade (p<0.01, p<0.05). UIT increased with age up to the 6th decade and then decreased gradually to the 8th decade. Therefore, UIT in all the subjects formed a bell-shaped distribution with a significant peak in the 6th decade (H=12.1, p<0.05). Rates of renal iodine clearance (UIC/SNI) in the 6th decade increased significantly more than those in the 4th decade (p<0.01), and the distribution of those rates in the 6 groups were similar to that of UIT. The mean frequency of UIT in less than 200 μg/day of the necessary amounts of iodine intake was 32.5%, but it was 63.6% in the 3rd decade, whereas it was 19% in the 6th decade. The difference between the 3rd and 6th decades was significant (p<0.01).It was indicated that differences in the amounts of iodine intake in Japanese euthyroid people were present and that the distribution was virtually matched to the age distribution of the patients with chronic thyroiditis. The data suggest that the increment of iodine intake in the middle-aged group could affect the pathophysiology of autoimmune thyroid disorders.

著者

高島 裕美 恒川 卓 津留 香里 山口 麻里子 溝口 暁 尾方 秀忠 片平 正人

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.98, no.S.Update, pp.24-27, 2022-07-20 (Released:2022-07-12)

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.97, no.5, pp.1375-1547, 2021 (Released:2022-03-19)

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.94, no.S.Update, pp.64-74, 2018-06-20 (Released:2018-07-18)

著者

榑松 由佳子 河邉 良枝 出口 泰地 松本 直也 池 茉美香 小泉 実幸 中島 拓紀 紙谷 史夏 毛利 貴子 岡田 定規 髙橋 裕

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.99, no.S.Update, pp.48-50, 2023-05-31 (Released:2023-05-31)

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.91, no.Suppl.September, pp.33-58, 2015-09-20 (Released:2016-02-16)

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.95, no.S.May, pp.1-60, 2019 (Released:2019-05-30)

被引用文献数

7

著者

石原 理

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.81, no.2, 2005-09-20

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.91, no.Suppl.September, pp.1-4, 2015-09-20 (Released:2016-02-16)

被引用文献数

5

著者

伊藤 正雄 石川 信雄

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.19, no.4, pp.271-298, 1943-07-20 (Released:2012-09-24)

参考文献数

139

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.91, no.Suppl.September, pp.73-78, 2015-09-20 (Released:2016-02-16)

被引用文献数

1 1

著者

丸田 浩 熊本 悦明

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.59, no.6, pp.888-897, 1983-06-20 (Released:2012-09-24)

参考文献数

20

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The effects of prepubertal castration on circulating levels of LH and FSH were examined longitudinally in 3 male pseudohermaphrodites (1 yr., 6 yrs., 9 yrs.) and one Lt. monorchid (7 yrs.), and gonadotropin levels of prepubertal anorchism (9 yrs.) were also studied longitudinally.After castration, plasma LH and FSH concentration in the patient 1 yr. of age elevated significantly and progressively, but in two other patients 6 and 7 yrs. of age, a significant elevation of plasma LH and FSH was not observed from 90 to 450 days after the castration.Plasma LH and FSH concentration of one patient 9 yrs. of age, castrated at 1 yr., showed prepubertal values from 9 to 11 yrs. of age, and the abrupt elevation of LH and FSH occurred at 11-2/12 yrs. of age.From these observations we concluded that although castration in early childhood resulted in an immediate elevation of gonadotropin levels, a significant elevation of gonadotropin did not occur in midchildhood castration. These findings have also confirmed the evidence that the hypothalamic-pituitary-gonadal negative feedback mechanism is operative in early childhood, and supported the action of a CNS inhibitory mechanism which restrains the gonadotropin synthesis and secretion and inhibits puberty during the interval of midchildhood.

著者

石突 吉持 広岡 良文 村田 善晴 富樫 和美

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.67, no.5, pp.622-629, 1991-05-20 (Released:2012-09-24)

参考文献数

12

被引用文献数

1 1

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To elucidate whether soybeans would suppress the thyroid function in healthy adults, we selected 37 subjects who had never had goiters or serum antithyroid antibodies. They were given 30g of soybeans everyday and were divided into 3 groups subject to age and duration of soybean administration.In group 1, 20 subjects were given soybeans for 1 month. Groups 2 and 3 were composed of 7 younger subjects (mean 29 y. o.) and 10 elder subjects (mean 61 y. o.) respectively, and the subjects belonging to these groups received soybeans for 3 months. The Wilcoxon-test and t-test were used in the statistical analyses. In all groups, the various parameters of serum thyroid hormones remained unchanged by taking soybeans, however TSH levels rose significantly although they stayed within normal ranges. The TSH response after TRH stimulation in group 3 revealed a more significant increase than that ingroup 2, although inorganic iodide levels were lowered during the administration of the soybeans. We have not obtained any significant correlation between serum inorganic iodide and TSH.Hypometabolic symptoms (malaise, constipation, sleepiness) and goiters appeared in half the subjects in groups 2 and 3 after taking soybeans for 3 months, but they disappeared 1 month after the cessation of soybean ingestion.These findings suggested that excessive soybean ingestion for a certain duration might suppress thyroid function and cause goiters in healthy people, especially elderly subjects.

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.93, no.S.Update, pp.57-69, 2017-06-20 (Released:2017-07-06)

著者

伊澤 正一郎 桑原 一宏 村部 浩之 村上 典彦 横田 敏彦 日下 昌平

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.83, no.4, 2008-03-20

著者

新美 仁男 佐々木 望 松本 生 中村 陽子

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.52, no.6, pp.626-629, 1976-06-20 (Released:2012-09-24)

参考文献数

5

被引用文献数

1

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The incidence of antithyroid antibodies in normal children were studied by thyroglobulin and microsomal-coated red blood cell hemagglutination techniques. (Fuji-Zoki Co.) The sera of 785 normal children were tested by these antithyroid antibody tests.Of 785 normal children, the sera of 7 (0.89%) showed a positive reaction for thyroglobulin antibodies, and eleven (1.40%) showed a positive reaction for microsomal antibodies.The thyroglobulin and microsomal antibodies were not detected in males. In females the incidence of these antibodies was 2.34 %, and was progressively greater with age.

著者

家城 恭彦 宮腰 久嗣 永井 幸広 番度 行弘 臼田 里香 宮本 市郎 大沢 謙三 小林 健一

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.67, no.7, pp.755-763, 1991-07-20 (Released:2012-09-24)

参考文献数

16

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It is generally accepted that acromegaly is often associated with hypercalciuria, but there are few reports on the frequency and the mechanisms of urolithiasis. Recently we consecutively experienced 2 cases of acromegaly with urolithiasis, and these experiences made us investigate the association between urolithiasis and acromegaly.Among 18 acromegalies from 1977 to March 1990 (10 males, 8 females, 24-64 years old), 13 cases (72%) fulfilled the criteria of hypercalciuria (urinary calcium (u-Ca) ?200mg/day or u-Ca/urinary creatinine (u-Ca/u-Cr)?0.15), and 7 cases (39%) suffered from urolithiasis that was diagnosed by KUB (4 cases) or X- ray computed tomography (CT)(3 cases). Especially in the last 2 years, 5 out of 7 cases (71%) were complicated with urolithiasis and all 7 cases were associated with hypercalciuria. These results suggest that hypercalciuria and urolithiasis are both much more frequent than previously reported.In 6 cases who were treated by pituitary adenomectomy from 1988-1989 (4 males, 2 females, 24-59 years old), we examined Ca metabolism before and after operation. Before operation, the levels of serum growth hormone (GH), u-Ca (mg/day), u-Ca/u-Cr (in all cases) and plasma somatomedin -C (Sm-C) (in 4 cases) were increased above the normal range. To determine the etiology of hypercalciuria, we performed the oral Ca load test under restriction of Ca (400mg/day) and P (650mg/day) intake. The results suggested that the hypercalciuria might be mainly due to the increased absorption of Ca from the intestine (so-called ”Absorptive hypercalciuria”). However, the levels of serum vitamin D (Vit. D) metabolites were all within the normal range before operation. After operation, GH and u-Ca/u-Cr (in 5 cases) and u-Ca (mg/day) (in all cases) decreased significantly compared with before operation, and the levels of Sm- C (in all cases), serum 25-(OH) D3, 1α,25-(OH)2D3 (in 4 cases) and 24,25-(OH)2D3 (in 3 cases) were also reduced after operation. Surprisingly, u-Ca and u-Ca/u-Cr normalized only in 4 cases who showed a reduction in 1α,25- (OH)2D3 levels after operation, although there were no correlations between u-Ca (mg/day) or u-Ca/u-Cr and 1α, 25-(OH)2D3. Significant correlations were found between u-Ca (mg/day) or u-Ca/u-Cr and Sm-C. The parathyroid function evaluated by the rapid Ca infusion test or nephrogenous cyclic adenosine monophosphate (NcAMP) was normal before and after operation.In conclusion, the high frequency of urolithiasis in acromegaly observed in this study may be strongly ascribed to hypercalciuria, and the facts that (1) in the general population, the frequency of urolithiasis has increased and (2) our methods of confirming urolithiasis were more sensitive than those described in previous reports. The cause of hypercalciuria might be partly due to increased Ca absorption from the intestine mediated by 1α,25-(OH)2D3. Now we emphasize that urolithiasis in acromegaly is more common than previously considered, so it is important to prevent severe complications of urolithiasis by early diagnosis and treatment.

著者

片上 秀喜 石川 恵美 日高 博之 後田 義彦 山口 秀樹 米川 忠杜 栗林 忠信 松倉 茂

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.84, pp.123-125, 2008-06-20