著者

玉城 敦子 中山 良朗 益崎 裕章 久高 将太 照屋 理子 本間 健一郎 屋比久 賢光 照屋 太輝 吉村 蘭 上原 盛幸 山城 清人

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.97, pp.56-58, 2021

著者

森 昭裕 梶田 和男 山北 宜由 森田 浩之 村井 敏博 安田 圭吾 杉浦 正彦 三浦 清

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.67, no.10, pp.1147-1161, 1991-10-20 (Released:2012-09-24)

参考文献数

23

被引用文献数

1 1

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Recently several types of anti-pituitary-antibodies (APA) have been found in patients with pituitary disorders including hypopituitarism and diabetes incipidus, and in postpartum women. However, the pathophysiological role(s) of APA still remains unknown. In order to elucidate the clinical significance of APA, longitudinal follow-up and family study of APA in patients with hypopituitarism were performed.APA in serum was examined in a total of 11 patients with various types of hypopituitarism (7 of isolated ACTH deficiency, 1 of partial hypopituitarism, 3 of Sheehan's syndrome, 6 males and 5 females). Chronic thyroiditis was associated in 3 out of 7 patients with isolated ACTH deficiency, and empty sella was found in each one patient with isolated ACTH deficiency and partial hypopituitarism, and in 3 patients with Sheehan's syndrome. APA was examined on 2 or 3 occasions at more than a 6 month interval (longitudinal study). In 5 patients, their 16 family members were examined for the presence of APA, and pituitary functions were evaluated in 3 out of 7 family members with positive APA (family study). For pituitary function tests, arginine infusion test, TRH, LH-RH or CRH test and insulin tolerance test were performed. APA reacting to rat pituitary cytoplasmic antigens (pituitary cell antibodies: PCA) and APA reacting to rat GH3 cells and/or mouse AtT20 cells surface antigens (pituitary cell surface antibodies: PCSA) were assayed with indirect immunofluorescence method.At the initial examination, 6 out of 11 patients (55%) showed positive APA. Thepatients were divided into 3 subgroups according to the longitudinal study: the group with disappearance of initially positive APA (3 patients), the group with altered titers or types of initially positive APA (3 patients), and the group with sustained initially negative APA (4 patients). No effects of replacement therapy on the alterations of APA were observed.In 16 family members of 5 patients (each 1 with partial hypopituitarism and isolated ACTH deficiency syndrome, and 3 with Sheehan's syndrome), APA in their sera were investigated. Seven out of 16 members (44%) showed positive APA. Among 6 first-degree relatives of 16 family members, both or either one of APA and PCSA were positive in 4 (67%). Out of 10 of their second- or third-degree relatives, 3 (30%) were positive for PCA or PCSA. All of 3 relatives with positive APA studied showed mild pituitary hypofunction without any clinical manifestations.These results suggest the possibility that autoimmune mechanism-induced hypofunction as well as hereditary background might participate in the pathogenesis of some hypopituitarism, and that APA might have a causative role in such disorders.

著者

森 崇英 福岡 正恒

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.68, no.11, pp.1151-1157, 1992-11-20 (Released:2012-09-24)

参考文献数

20

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Although it is well established that the pituitary gonadotropins and prolactin are the primary regulators of ovarian function, steroidal and nonsteroidal molecules produced locally in the ovary have been implicated in the modulation of gonadotropin action as autocrine or paracrine regulators. Recent studies suggest that the cells of the immune system play important roles in regulating ovarian function, and the immune regulation of ovarian function has become one of the topics in the field of ovarian physiology. Since it has become clear that the immune factors, cytokines, show a wide range of biological functions, not only on immune cells but also on nonimmune cells, the physiological significance of the resident immune cells, the widespread distribution of which in mammalian ovaries has been known for a long time, has reattracted attention as a third kind of regulator of ovarian function. In this article, current knowledge of the regulatory roles of immune cells as well as the cytokines in ovarian physiology is reviewed.

著者

須田 立雄

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.63, no.12, pp.1418-1428, 1987-12-20 (Released:2012-09-24)

参考文献数

28

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.92, no.Suppl.Update, pp.24-43, 2016-07-20 (Released:2016-08-25)

著者

原 禎造

出版者

The Japan Endocrine Society

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.4, no.3, pp.401-432,17, 1928

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Mittelst des Tissotschen Spirometers und des gasanalytischen Apparates nach Haldane bestimmte der Verfasser bei den Hyperthyreosen zuerst den Grundumsatz und beobachtete dann den Einfluss des Nebennierenpr&auml;parats darauf.<BR>Die Resultate sind die folgenden<BR>Bei Darreichung von Nebennierenpulver (0, 6-0, 8 gpro die, &ldquo;Parke Davis.&rdquo;) sank in 7 F&auml;llen (Basedowiker und Strumiker mit Hyperthyreose) der gesteigerte Grundumsatz, in 3 F&auml;llen zeigte sich Neigung zur Herabsetzung und in 5 F&auml;llen keine Veranderung.<BR>2. Die Grundumsatzerniedrigung durch Nebennierenpulver ist im allgemeinen nicht so stark und steil wie bei der Lugoitherapie, sondern langsam, und der Einfluss tritt erst nach einer Medikation von ca. 20 Tagen auf und erreicht nach 40-60 Tagen den H&ouml;hepunkt.<BR>3. Bei einem Fall n&auml;herte sich zwei Monate nach 'der Einstellung der Nebennierendarreichung der Gi undumsa tz den Du-Boisschen Standardzahlen.<BR>4. Selbst bei lang fortgesetzter Medikation hat Nehennierenpulver keine Nebenerscheinungen im Gefolge und ist nicht wie die Lugoltherapie giftig.<BR>5. Bei den 7 F&auml;llen, die einen sicheren Einfluss des Nebennierenpulvers aufwiesen, stieg in 4 F&auml;llen der unternormale respiratorische Quotient, w&auml;hrend er bei den anderen 3 F&auml;llen unver&auml;ndert blieb. Die Atmungsgr&ouml;sse nahm bei alien F&auml;llen ab.<BR>6. Von den 7 F&auml;llen, die einen sicheren Einfluss des Nebennierenpulvers zeigten, nahm in 3 F&auml;llen das K&ouml;rpergewicht zu und in 1 Fall ab. Bei 2 F&auml;llen blieb er unver&auml;ndert, und bei 1 Fall war die K&ouml;rpergewichtsveranderung undeutlich. Die Pulszahl war in 4 von 7 F&auml;llen etwas vermindert. Die subjektiven Beschwerden wurden in alien F&auml;llen gebessert, Schwitzen und Tremor bei 6 F&auml;llen erleichtert, und die Struma zeigte sich bei 5 F&auml;llen wcicher und kleincr als vor derTherapie.

著者

及川 眞一

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.76, pp.62-63, 2000-02-20

著者

伊藤 貞嘉

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.72, no.2, 1996-03-20

著者

西塚 泰美

出版者

日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.52, no.11, pp.1126-1140, 1976

著者

大山 建司

出版者

日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.55, no.5, pp.657-677, 1979

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The subjects were 36 neonates who had had no abnormalities at gestation or at birth. In 9 of the 36 neonates, exchange transfusions were performed by umbilical vein catheterization. The others had no abnormalities during the neonatal period. They consisted of 17 male and 19 female infants who were from 39-42 weeks of gestation and weighed 2870-3900g at birth. Serum GH, TSH, LH and FSH were measured by radioimmunoassay during the exchange transfusions, and after the administration of TRH or LH-RH in the early neonatal period. Furthermore, serum GH was measured after glucose administration. The following results were obtained.<BR>1) Serum GH increased in 7 out of 8 neonates, corresponding to continuous hyperglycemia during the exchange transfusion. It also increased in one out of 4 neonates, corresponding to transient hyperglycemia after the glucose administration.<BR>2) Serum GH after the TRH administration decreased in all of six neonates during the first 120 hours after birth but increased in 3 of four neonates during 7 to 10 days after birth.<BR>3) Serum GH after the LH-RH administration increased in 4 out of six neonates.<BR>4) Serum TSH showed no significant changes by either the exchange transfusion or the administration of LH-RH in the early neonatal period.<BR>5) When TRH was given to 5 neonates during 96 hours after birth, the serum TSH response was exaggerated and prolonged. In 6 neonates of 96 hours to 15 days after birth, serum TSH response to TRH was the same as that in normal infants.<BR>6) Serum T<SUB>3</SUB> increased 60 to 90 minutes after the TRH administration in all 5 neonates.<BR>7) During the exchange transfusion, serum LH definitely increased in 3 out of five male neonates, but serum FSH remained unchanged at a low level in all the male neonates. Serum LH did not increase in all the 3 female neonates, but in 2 of them serum FSH increased.<BR>8) Serum LH after the TRH administration increased in 3 out of four males and 4 out of six neonates. On the other hand, serum FSH remained unchanged in both male and female neonates.<BR>9) Serum LH response to LH-RH was higher in male (especially in more than 6-day-old neonates) than in female neonates. Serum FSH after the LH-RH administration increased in female neonates but did not increase in male neonates.<BR>The results mentioned above suggest the immaturity of the secretory controlling mechanism of GH, LH and FSH in the hypothalamo-pituitary system. However, the secretory mechanism of TSH appears to function independently of the other secretory systems, because serum TSH levels were not influenced by the exchange transfusion and LH-RH administration. In the hypothalamo-pituitary-gonadal system, secretion of LH appears to be predominant in males while that of FSH appears to be predominant in females even in the early neonatal period.

著者

大山 建司

出版者

日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.55, no.5, pp.639-656, 1979

被引用文献数

1

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Eighty-two normal full-term neonates who had no abnormalities at gestation or at birth, and 32 of their mothers were selected to measure GH, TSH, LH, FSH, T<SUB>3</SUB>, HCG, HPL, IRI, Glucose and NEFA in the umbilical arterial and venous blood, neonatal blood and maternal blood. Hormones were measured by radioimmunoassay. The following results were obtained.<BR>1) GH levels were significantly higher in the umbilical blood than in the maternal blood (P<0.01) but were almost the same between the umbilical arterial and venous blood.<BR>2) GH levels reached a peak 24 hours after birth in the group A infants in which feeding started 12 hours after birth, and reached a peak 48 hours after birth in the group B infants in which feeding started 24 hours after birth. GH levels which were measured at 72 and 96 hours after birth were significantly higher in the group B infants than in the group A (PC 0.01).<BR>3) Differences of GH secretory patterns between groups A and B, depending on the time of initial feeding, were strongly related to those changes in NEFA and glucose levels between both groups at birth. The secretion of GH was inhibited by the increase of NEFA and was stimulated by the decrease of NEFA and the increase of glucose.<BR>4) TSH levels were significantly higher in the umbilical blood than in the maternal blood (P<0.001). T<SUB>3</SUB> levels were significantly lower in the umbilical blood than in the maternal blood (P<0.01).<BR>5) TSH levels increased rapidly with a peak immediately after birth and then showed a decreasing tendency, but they remained significantly higher during the first 24 hours than they did thereafter. T<SUB>3</SUB> levels remained at a low level during the first 12 hours and then showed a rapid increase with a peak 24 hours after birth.<BR>6) There were no differences in LH-HCG levels in the umbilical blood between male and female infants. In the early neonatal period, LH levels were higher in the males than in the females and were statistically higher in the males 96 and 168 hours after birth (P<0.01).<BR>7) FSH levels in the maternal blood, umbilical blood and neonatal blood during 96 hours after birth remained less than 2.0 mIU/ml. There were no differences in FSH levels between male and female infants.<BR>8) About 1/300 of the amounts of HCG and HPL in the maternal blood was observed in the umbilical venous blood. The amounts of HCG and HPL in the umbilical arterial blood were about half of those in the umbilical venous blood. HCG and HPL levels were undetectable in the blood of almost all the infants during the first 24 hours after birth.<BR>9) The effects of HCG and HPL on the measurement of GH and TSH by radioimmunoassay seemed to be negligible. Although LH measurement in the umbilical blood appeared to be influenced by HCG, it could be almost free from the influence of HCG 12 hours after birth.<BR>10) Change in IRI was not related to that in GH in the early neonatal period.

著者

本庶 佑

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.76, no.1, 2000-04-20

著者

福嶋 恒彦

出版者

日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.45, no.2, pp.254-268,153, 1969

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臨床的応用の比較的簡易なFSH測定法を開発する目的で, 入手容易なCF#1系均一系マウスを用い, 飼育温度環境, FSHとHCGの協力作用, 他のゴナドトロピンの干渉および生物学的統計を検討した結果, 垂摘を要せず特殊な純系動物や大量のHCGを用いず, しかも特異性, 感度, 精度に優れたFSH低単位定量法を確立した.ついで本法を用いて成年男子, 性成熟婦人, 閉経婦人また従来報告のない小児および去勢婦人の尿中FSH排泄動態を明らかにした.

著者

鎮目 和夫

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.60, no.12, pp.1492-1502, 1984-12-20 (Released:2012-09-24)

参考文献数

19

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成長ホルモンに依る小人症の治療の対象は, 現在我が国では、所謂下垂体性小人症のみに限られており, ヒト成長ホルモンの大量入手が困難な為, もっとも適応の有る下垂体性小人症に対してすらすべての患者を治療する事が出来ない状態である。しかし, 遺伝子工学によって作製されたヒト成長ホルモンの製剤化も進み, 1~2年の後にはその実用化が可能になる状態となってきた。そこで米国では, 他の原因による小人症の治療に対しても本剤の効果が検討され始めており, 又我が国でも下垂体性小人症に対し, 遺伝子工学で作製されたヒト成長ホルモン剤の臨床治験が行われている。そこで本講演では1) ヒトの下垂体より抽出した成長ホルモンによる下垂体性小人症治療の現況, 2) 遺伝子工学によるヒト成長ホルモン剤の治験の現況, 3) 他の小人症に対するヒト成長ホルモン使用の展望について述べる。第2と第3の問題は, まだ実用面では一寸早いが, 他の分野を専門とする会員へ, 現状を紹介する意味で述べる。

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.93, no.S.September, pp.pre1-pre3, 2017 (Released:2017-10-19)

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.88, no.Supplement-2, pp.42-48, 2012-08-20 (Released:2013-11-13)

著者

西井 修 竹内 亨 高橋 稔 岡村 隆 柳沼 〓 小林 拓郎

出版者

日内分泌会誌

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.62, no.2, pp.108-116, 1986

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Eight women with normal term pregnancy were i.v. administered 10 mg Metoclopramide (M), dopamine antagonist, before and during labor. Serum prolactin (PRL), TSH, GH and cortisol levels were measured at -30, 0, 30 and 60 minutes after M administration by specific radioimmunoassay. Basal serum PRL levels before labor, 287.5&plusmn;28.6 ng/ml (mean&plusmn;S.E.), significantly declined during labor to 237.0&plusmn;22.4 and 216.4&plusmn;22.9 ng/ml (p<0.05 at both) at 0 and 30 minutes before M administration, respectively. The increments in serum PRL at 30 and 60 minutes after M administration during labor (209.5&plusmn;33.9 and 120.0&plusmn;27.1 ng/ml, respectively) were not significantly different from those before labor (202.1&plusmn;48.7 and 89.9&plusmn;30.1 ng/ml, respectively), suggesting that the decline in serum PRL levels during labor is not due to the dopaminergic control. Basal serum TSH and GH levels were not significantly changed by labor and M administration either before or during labor. Serum cortisol levels tended to increase during labor, but these changes were not significant. The data suggest that the PRL releases from the pituitary during labor are not controlled by the dopaminergic mechanism.

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.90, no.1, pp.129-252, 2014-04-01 (Released:2014-03-25)

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.94, no.S.Update, pp.75-78, 2018-06-20 (Released:2018-07-18)

被引用文献数

2

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.91, no.Suppl.HPT, pp.46-65, 2016-02-20 (Released:2016-04-19)