著者

村井 章悟

出版者

一般社団法人 日本結核病学会

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.35, no.8, pp.537-542, 1960-08-15 (Released:2011-05-24)

著者

高橋 了造

出版者

JAPANESE SOCIETY FOR TUBERCULOSIS

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.8, no.3, pp.330-339, 1930-03-24 (Released:2011-05-24)

参考文献数

9

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Verfasser untersuchte das Verhältnis der Alt-tuberkulinintrakutane Reaktion zur Tuberkulose der Meerschweinchen, welche sich verschieden entwickelt und gewägt hatten, und hieraus ergab sich folgendes:Häufigerer negativer oder geringgradi ger Ausfall der Reaktion findet sich bei den unter 200 g. gewägten jungeren Tieren, obgleich sie deutliche tuberculöse Affektion bei der Obduktion zeigen; dagegen beobachtet man ausnahmslos positives Ausfall bei den vollgereif ten.Somit ist es unzweckmässig, dass jungere, unter 200 g. gewägte Meerschweinchen zur Alt-tuberkulin-intracutane Reaktion, urn damit derren tuberculöse Affektion zu diagnostieren, angewandt werden.

著者

奥村 吉文

出版者

JAPANESE SOCIETY FOR TUBERCULOSIS

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.14, no.6, pp.511-525, 1936 (Released:2011-05-24)

参考文献数

3

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Wir haben BCG aus einer 1, 5 Monate alten Bouillonkultur möglichst homogen in 0, 85 proz. NaCl-Losung suspendiert und 5 verschiedene Aufschwemmungen hergestellt: und zwar so, dass 1.0 ccm Medium 0.5, 3.0, 5.0, 10.0 und 20.0 Präzipitometeilstriche Erreger enthalt.

著者

阿児 博文 三上 理一郎 坂口 泰弘 堅田 均 沢木 政好 前川 純子 米田 三平 成田 亘啓

出版者

JAPANESE SOCIETY FOR TUBERCULOSIS

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.60, no.12, pp.609-616, 1985-12-15 (Released:2011-05-24)

参考文献数

20

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Alcoholics are known to have a high frequency of pulmonary tuberculosis. There have been no report concerning to the relationship between tuberculosis and alcoholism in Japan.147 male patients with active pulmonary tuberculosis were studied for alcohol consumption. Patients were classified into three groups: “habitual” drinkers, “heavy” drinkers, and “non-habitual” drinkers on the basis of the extent of alcohol consumption. Habitual drinkers were defined by those who drink 540 ml or more of sake daily over five years or an equivalent amount of alcohl in other beverages. Heavy drinkers were defined by those who drink 900ml or more of sake daily over ten years. The remainder were defined as non habitual drinkers.Of 147 patients, 16 patients were habitual drinkers, 19 were heavy drinkers, 112 were non habitual drinkers. No statistically significant differences were observed in chest Xray findings and response to therapy. Heavy drinkers were found to smoke much more than non habitual drinkers. In heavy drinkers there was high incidence of negative reaction of immunological skin tests than that on non habitual drinkers. The incidence of both diabetes mellitus and chronic liver disease in heavy drinkers was significantly higher than that in non habitual drinkers.Humoral and/ or cellular immunity were known to be depressed in diabetes mellitus and liver cirrhosis. Many investigators have tried to determine why tuberculosis is common among alcoholics. However, no predisposing factors were demonstrated conclusively. Our data suggest that complications such as diabetes mellitus and/or liver cirrhosis may play a role in the pathogenesis of pulmonary tuberculosis in alcoholics.

著者

重藤 えり子

出版者

JAPANESE SOCIETY FOR TUBERCULOSIS

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.65, no.11, pp.701-709, 1990-11-15 (Released:2011-05-24)

参考文献数

23

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To reveal the possibility of differentiating diseases caused by M. tuberculosis and M. intracellulare, simultaneous tuberculin testing by PPDs and PPD-B was carried outamong X-ray suspects of tuberculosis and healthy persons.PPD-B was prepared by Dr. Tasaka (Department of Bacteriology, Hiroshima University) from M. intracellulare (ATCC13950).For tuberculin testing, 0.05μg of PPDs from M. tuberculosis (Nihon BCGCo.) and 0.1, μg of PPD-B were used.The study included61patients with disease caused by M. tuberculosis (TB), 23 patients with that of M. avium complex (MAC) and 40 healthy persons with no roentgenologicalabnormality (H).Forty healthy persons had been vaccinated with BCG. Statisticalanalysis of the diameter of reaction (redness) in each antigen in each group has been doneby Boxplotting method.The results were as follows: 75% upper quartile point, median, 25%lower quartile point/mean S. D.: PPDs in TB (41.8, 30.0, 19.0/32.0-17.7) PPDB in TB (15.0, 10.5, 5.0/10.9 8.1) PPDs in MAC (26.0, 10.0, 7.0/16.4-13.9) PPDB in MAC (20.5, 17.5, 12.5/19.1-11.4) PPDs in H (18.0, 12.0, 6.0/13.5-10.9) PPDB in H (7.0, 2.8, 0.0/4.4-5.4).Mean of PPDs in TB patients and PPD-B in MAC patients were significantly (P<0.01) larger than those in other groups. Significant differences of reaction by age distribution, previous history of mycobacteriosis or other diseaseswere not observed.In each patient, larger skin test reaction correlated with the infected organism in 71 (85%) of the 84 cases.In 61 patients with M. tuberculosis infection, reaction to PPDs waslarger than that of PPD-B in 58, and the reaction to PPD-B was larger than that of PPDs in only one subject, and the reaction to PPDs and PPD-B were smaller than 5mm in 2. In 23 patients with MAC infection, the reaction to PPD-B was larger than that of PPDs in 13, the reaction to PPDs was larger than that of PPD-B in8and the reaction to PPDs and PPD-B were smaller than 5mm in 2.It is concluded that simultaneous skin test with PPDs and PPD-B is useful in thedifferential diagnosis of mycobacterial disease due to M. tuberculosis and M. aviumcomplex prior to bacteriologic confirmation by culture.

著者

東 市郎

出版者

一般社団法人 日本結核病学会

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.67, no.9, pp.625-646, 1992-09-15 (Released:2011-05-24)

参考文献数

91

著者

黒丸 五郎

出版者

JAPANESE SOCIETY FOR TUBERCULOSIS

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.10, no.4, pp.196-211, 1932-04-24 (Released:2011-05-24)

参考文献数

3

被引用文献数

1

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Der Verfasser stellte eine eingehende Untersuchung der tuberkulösen Veränderungen des Darmes an 208 Sektionsfällen von Lungentuberkulösen an. Darunter wurden tuberkulöse Veränderungen insgesamt makroskopisch bei 184 Fällen (88.5%) und tuberkulöse Geschwüre bei 168 Fällen (80.8%) festgestellt.Es ist schwer, die Darmtuberkulöse vom Standpunkt der pathologischen Anatomie in bestimmten Krankheitsformen schematisch einzuteilen, da bei jedem einzelnen Fall die Veränderungen in Darmabschnitten, ja selbst in einem Darmabschnitte, vielfältig waren und keine Einheitlichkeit zeigten. Die Herde lässt sich doch nach ihrem Gestalt und Grösse in gewissen Gruppen oder Typen anordnen.

著者

橋本 達一郎

出版者

JAPANESE SOCIETY FOR TUBERCULOSIS

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.72, no.11, pp.629-637, 1997-11-15 (Released:2011-05-24)

参考文献数

11

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The BCG vaccines will celebrate the 100th anniversary of their discovery in a decade at the beginning of the next century since Albert Calmette and Camille Guebrin had presented it before the Academie des Sciences in 1908. At present tuberculosis kills more people than any other infectious disease about 3 million people a year, including almost 300, 000 children under 15, and is producing over 7, 000 deaths and over 24, 000 new cases every day. Therefore, WHO declared a global ealth emergency in 1993. More worse, recently multi-drug resistant tubercle bacilli are emerging rapidly making TB patients incurable.Under these situations we need a potent anti-tuberculosis vaccine. So first of all, we must check the century-old BCG before proceeding further.At moment, the BCG vaccines are being used worldwide in the largest quantities in the world, but still most controvercial vaccines anywhere.I would like to describe here their success and failure in the combat against the white plague.1. The Expanded Programme on Immunization (EPI).In 1974, when the EPI was launched by WHO, less than 5% of the world children were immunized against six infectious deseases including tuberculosis. In 1995 statistics, BCG gave the highest vaccination coverage, 87% higher than any other 5 vaccines of EPI for children. The BCG in EPI must have saved a lot of infants as the vaccine, has been proved to be most effective against the blood-born tuberculosis of child type.2. The efficacy of BCG vaccination against tuberculosis.Results of each 10 of randomized controlled trials (RCT) and Case-control studies (CCS) showed the protective efficacy against tuberculosis as uncertain, unpredictable, as protective efficacy varied from 80% to 0%.More recently, a Meta-analysis of selected papers on BCG field trials which were so far collected. They recalculated vaccine protective effect separately for pulmonary TB and for meningeal/miliary TB in the trials.As the result, it was found that protective effect against pulmonary TB could not be calculated, but protective effect against meningeal and miliary TB was calculated as 86%, 75% respectively, in RCT and CCS, being higher than against pulmonary TB.3. The duration of BCG efficacy against tuberculosis was confirmed to continue for 15 years after vaccination. The incidence of every form of tuberculosis decreased steeply during the 15 years following vaccination.4. BCG revaccination.A WHO statement was issued in 1995 mentioning that there is no definitive evidence that repeated BCG vaccination confers additional protection against tuberculosis.Therefore WHO has not recommended to repeat BCG vaccination because of no scientific evidence to support this practice. Multiple BCG revaccinations are not indicated in any persons.5. Complications with BCGSecond IUATLD study (1988) on complications induced by BCG was reviewed, especially following two points:1-2) Regional suppurative lymphadenitis3) Generalized lesions: fatal cases 1-2 Several Afirican regions had experienced that the risk of outbreak of suppurative BCG lymphadenitis was low for vaccines with Glaxo and Japanese strains, but much higher for vaccines with Pasteur. This experience in nineteen eighties has led EPI to replace the Pasteur BCG vaccine with less reactogenic BCG, Japanese or Glaxo BCG to solve the outbreak of suppurative adenitis complication.3 At moment, the only contra-indication of EPI BCG vaccination is symptomatic HIV infection (AIDS), but in the future asymptomatic HIV infection should be placed on alert, because fatal BCG generalized disseminations have already been experienced by HIV positive vaccinees although in a few cases in USA.

著者

辻村 邦夫 小出 幸夫

出版者

日本結核病学会

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.85, no.6, pp.509-514, 2010-06-15

参考文献数

41

著者

露口 泉夫

出版者

JAPANESE SOCIETY FOR TUBERCULOSIS

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.70, no.5, pp.335-346, 1995-05-15 (Released:2011-05-24)

参考文献数

28

被引用文献数

1

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One of the unique features characterizing human tuberculosis (TB) is its pathogenesis. The pathogenesis of TB involves cell-mediated immune responses against Mycobacterium tuberculosis. Concisely, macrophages activated by various soluble mediators or cytokines released through the cellular interactions after infection with M. tuberculosis play a pivotal role in the pathogenesis of human TB. In fact, very complex cellular interactions are going on within the host after infection with or endogenous reactivation of M. tuberculosis. Cells communicate by cell-cell contact and by the release of mediators which may originate locally, called cytokines.In TB infection, macrophages can be activated by two ways directly with mycobac terial organisms or lipid fractions of their cell walls at the earlier phase of infection, and indirectly with cytokines produced by CD4+ T cells specifically activated by mycobacterial peptide antigens at the later phase of infection. The various clinical features of TB are the summarized outcome of cell to cell interactions mediated by diverse cytokines produced by various immune cells which are initially triggered by M. tuberculosis infection.CD4+ T cells can be classified into two subsets according to the patterns of cytokines they produce Thl cells give rise to cell-mediated immunity and are characterized by the production of IL-2 and IFN-γ, whereas Th2 cells are more efficient in mediating antibody production and secrete IL-4, IL-5, IL-6 and IL-10. Th2 cells can control Thl cells and vice versa. Th2 cells therefore inhibit the production of cytokines by Thl cells by releasing IL-4 and IL-10.Infection with mycobacteria stimulates macrophage IL-12 production which appears to act directly on naive CD4+ T cells to induce Thl development and initiation of cell-mediated immunity. IL-12 is a critical component in the development of cell-mediated immunity. In addition, IL-12 also activates NK cells and γ/δ T cells, both of which secrete various macrophage-activating factors to kill M. tuberculosis.One of the structural characteristics of M. tuberculosis is the cell wall rich in lipid components. Of importance among various biological activities of the cell wall lipids is the stimulation of mononuclear phagocytes to produce a certain number of cytokines or monokines including IL-12 and IL-10, both of.which play important roles in regulation of immune responses in mycobacterial infection and in pathogenesis of TB. Considering the biological characteristics of mycobacterial lipid components, we need take these lipids into consideration in the future research of TB immunology, particularly in the strategy for development of a potent TB vaccine

著者

原田 泰子

出版者

JAPANESE SOCIETY FOR TUBERCULOSIS

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.52, no.10, pp.515-522, 1977-10-15 (Released:2011-05-24)

参考文献数

26

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The mice (CF1) were used for the experiment. The immunopotentiating action of BCG wasestimated by the immunologic response to the sheep red blood cells. The delayed hypersensitivitywas evaluated by the foot pad reaction and a hemagglutination test and a hemolytic plaque testwere used to assay the humoral immune response.Results obtained were as follows.1) BCG exerted its potentiating effect upon the immune response to SRBC only if BCG and SRBC were introduced into the same areas that drain to a common lymph node. The optimal intervalbetween BCG priming and the subsequent SRBC injection to produce the highest level of thedelayed hypersensitivity was about 5 to 7 weeks. The antibody formation reached its maximumabout 9 to 11 weeks when the delayed hypersensitivity was decreasing. It could reasonably beconcluded that the immunopotentiating action of BCG was biphasic following BCG injection.2) The plaque forming cells of the draining lymph node of BCG site developed in pallalelwith the resulting level of the delayed hypersensitivity. The plaque forming cells of the spleenreflected the antibody titer.

出版者

一般社団法人 日本結核病学会

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.25, no.9-11, pp.420-523, 1950 (Released:2011-05-24)

著者

谷口 浩和 泉 三郎

出版者

一般社団法人 日本結核病学会

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.80, no.10, pp.643-646, 2005-10-15

参考文献数

19

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症例は66歳女性で,悪露が大量に出たため,産婦人科を受診。子宮MRIや腹部超音波検査にて子宮留水腫が認められた。子宮内膜組織生検より類上皮肉芽腫が証明され,膣分泌物と子宮内膜組織の抗酸菌培養は陽性,ナイアシン陽性であり,子宮内膜結核と診断した。INH,RFP,EBで9カ月間治療し,子宮内貯留物の消失を認めた。

著者

室橋 豊穂 関 叉蔵 吉田 幸之助

出版者

JAPANESE SOCIETY FOR TUBERCULOSIS

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.29, no.7, pp.248-252, 1954-07-15 (Released:2011-05-24)

参考文献数

6

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Comparative studies were made on the cultural and immunobiological characteristics between Scandinavian and Japanese BCG strains.Each of them grew very nice on the potato-media and their growths were good on the bilepotato medium even from the first transplantation. Their growths were also good on the Sauton medium, but the pellicles were rather thick compared with that of Japanese strain. The growth speed on this medium was slightly more rapid in Swedish and Norwegian strains than that of Danish and Japanese. but the viable units per mg of pellicle were the greatest in Japanese, strain.The bacillary size was compared on the smears prepared from Sauton-potato cultures and it was found that the three strains, Danish, Swedish and Japanese had almost the same average size with similar distribution curves, whereas, Norwegian strain only had rather big size like French strain reported in the foregoing paper.Virulence test as well as challenge test on guinea pigs did not show any difference among those four strains except the difference due to the different amount of viable units inoculated.From these results it is considered that for the maintenance of the original characteristics of BCG strain, it is best at present to maintain it only by the successive transplantation on bilepotato medium.

著者

原 宏紀 副島 林造 松島 敏春

出版者

JAPANESE SOCIETY FOR TUBERCULOSIS

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.65, no.11, pp.711-717, 1990-11-15 (Released:2011-05-24)

参考文献数

20

被引用文献数

2

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A study to obtain information on the relation between tuberculosis and carcinoma ofthe lung was carried out in 24 hospitals in Chugoku and Shikoku areas during the period from January 1979 to December 1988 using a questionnaire.As a result of. this survey, 142 cases of coexisting active pulmonary tuberculosis and bronchogenic carcinoma were reported during the period.The incidence of coexisting caseswas 2.32% of patients with pulmonary tublrculosis and 2.22% of patients with bronchogeniccarcinoma.The foci of tuberculosis and carcinoma were found more often in the same lobe than indifferent lobes.The proportions of histological types of bronchogenic carcinoma were asfollows; squamous cell carcinoma 43.9%, adenocarcinoma 36.0%, small cell carcinoma 16.5% and large cell carcinoma 3.6%.These findings were not singnificantly different from thosein the general population. No significant difference in the proportions of histologicaltypes was found by coexisting lobe.Some cases indicated that coexisting tuberculosis gave a favorable influence to theprognosis of lung cancer.

著者

倉根 修二 工藤 翔二

出版者

一般社団法人 日本結核病学会

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.78, no.9, pp.573-580, 2003-09-15

参考文献数

8

被引用文献数

2

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2002年1月, 全国80の大学医学部付属病院に対し, 結核の診療・教育・感染対策に関するアンケート調査を実施した.最終回答率は内科75%, 感染症科65%であった。回答医師の施設の結核病床保有率は27%であった。結核病床を持たない (無床) 施設における年間の診療結核患者数は, 概ね20人以下で, 診療に占める結核患者の割合は高くはないが, 回答医師の90%以上が結核患者の収容施設の必要性を認めており, 大学付属病院で診療すべき患者として "基礎疾患を有する患者" を挙げていた。結核教育に関しては系統講義のみならず, 無床施設の31.8%で結核専門病院での研修が実施されており, また60.8%の施設において, 結核感染対策に関する教育が実施されていた。一方学生に二段階ツベルクリン反応検査 (ツ反) を実施している施設は47.1%で, このうちの54.9%の施設ではツ反陰性者に対しBCG接種が実施されていた。結核緊急事態宣言以後, 大学付属病院における結核への対応は, 以前の調査と比較して若干の改善がみられるが, 結核 (感染症) 患者用病床の確保や結核専門施設との連携等, より一層の積極的な取り組みの重要性が示唆された。

著者

武野 周一

出版者

JAPANESE SOCIETY FOR TUBERCULOSIS

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.11, no.11, pp.972-982, 1933-11-24 (Released:2011-05-24)

参考文献数

14

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Urn die immunogene Wirkung verschiedene r Tuberkelbazillen-Prpärate unter sonst gleichen Bedingungen Gegeneinander vergleichen zu ktinnen, haben wir ihre in der beliebigen lokalisierten Haut Opsonine erzeugende Eigenschaft benutzt. Die zum Vergleich herangezogenen Präparate waren nämlich 1) das Kochsche Alttuberkulin, das vom Institut zur Erforschung der Infektionskrankheiten der Kaiserl. Universität zu Tokio geliefert wird, 2) das AO vom Arima-Institut und 3) das Tuberkelbazillen-Koktigen, das vom Torikata-Institut für Immunitätsforschung in Osaka erhältlich ist.

著者

阿部 達也 橋本 貴尚 小林 隆夫 人見 秀昭 海老名 雅仁 藤盛 寿一 阿見 由梨 早川 幸子 藤村 茂

出版者

一般社団法人 日本結核病学会

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.90, no.9, pp.625-630, 2015 (Released:2016-09-16)

参考文献数

19

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〔目的〕病院職員に対する結核曝露のリスクを,インターフェロンγ遊離試験(IGRA)の陽性率を指標として後ろ向きに比較した。その際,「病院環境曝露」を結核曝露のリスクとして仮定した。〔対象〕2010年12月から2012年4月の間にIGRAを行った職員870人を,病院環境曝露の有無により以下の群に分けて解析した。非曝露群は雇用時に測定を行った新入職者161人,曝露群は接触者健診受診者を含む既職者709人であった。〔方法〕IGRAはクォンティフェロンTBゴールド®3Gを用い,非曝露群を対照として,曝露群における陽性オッズ比(OR)をロジスティック回帰分析で求めた。〔結果〕全体として陽性率は6.7%で,2群間の陽性率(1.9% vs 7.8%)には有意差を認めた(P=0.005)。さらに,非曝露群を対照とし,性別,勤続年数,喫煙歴,および飲酒歴で調整した曝露群の陽性OR(95%信頼区間)は4.1(1.4-17.6)(P=0.007)であった。〔結論〕病院の職場環境ヘの曝露はその年数にかかわらず結核感染の潜在的なリスクとなっている可能性が示唆された。

著者

河本 徹夫 市山 晴子

出版者

一般社団法人 日本結核病学会

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.16, no.1, pp.1-6, 1938

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Dr. Keijiro Kogami and his coworkers had published the results of the complementfixation test with their S. T. Antigen in 1330 cases of tuberculous diseases already in this Journal No.1, 1936. Our results of the complement-fixation test with the S. T. Antigen in 600 cases were briefly as follows:<BR>(1) We have obtained in 200 cases of tu b erculous sera 89.5% of positive reactor, and at the same time we experimented about the red-cell sedimentation test in 131 cases parallelly. There were no definite relations between the results of complement-fixation and sedimentation test only without in exception of the fact that the degree of both reactions were encountered parallelly to a certain extent.<BR>(2) To say the positive percentage in 193 case s of pulmonary tuberculosis from a point of view of the form of diseases the complement-fixation tests resulted in productive forms at most highest percent and the next in mixed forms finally in exsudative forms at the lowest.<BR>(3) In 81 cases of pulmonary tuberculosis which were proved the tubercle bacilli to be positively the complement-fixation test also happened in 96% positively, and thus we can say generally that the positive percentages schall be more higher in open tuberculosis than in closed ones.<BR>(4) In the cases o f Doctors, nurses and attendants who have many oppotunities of approaching tuberculous patients, the complement-fixation test resulted in 18 out of 60 cases while, on the contrary, in the same cases the Mantoux's reaction in 93% (56cases) positively. In cases of the sera which proved the Mantoux's reaction were negatively, we found the complement-fixation test also negatively.<BR>(5) In 340 cases of the so-called healthy individu a ls in simple appearances in certain provincial factorial girls of an age from 16 to 20 years old the complement-fixation test happened in 26% positively. The facts that the factorial girls of those ages have the most highest rate of contracting some tuberculous diseases already generally known.<BR>(6) The complement-fixing ambozeptors in tuberculous sera can be perfectly absorb e d with the dried powder of S. T. Bacilli. (One of a modificated tubercle bacilli already published in this Journal No.1, 1936 by K. Kogami and his coworkers). By this method we can plainly differentiate the double infections with syphilis and tuberculosis.<BR>(7) In 25 cases of non-tuberculous diseases such as: - 2Croppy pneumonia 3, pulmonary abscess 2, heartfailure 2, nephritis 2, nephrosis 3, contracted kidney 3, Cancer of the stomach 2, gastric ulcer 1, acute Appendicitis 1, acute enteritis 1, Beri-beri 3, acute articular rheumatism 1, Parkinson's disease 1, the complement-fixation test resulted only in one of two cases of heartfailurs positively, but we could prove in this case the existence of the pure and specificial tuberculous complement-fixing ambozeptors in the sera which could be excluded by Kogami's dried powder of S. T. bacilli perfectly.

著者

結核療法研究協議会

出版者

一般社団法人 日本結核病学会

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.49, no.7, pp.207-215, 1974

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The efficacy and the side-effects of Tuberactinomycin-N (TUM-N) in the retreatment of pulmonary tuberculosis were studied and compaired with those of Viomycin (VM). The drug resistance of tubercle bacilli isolated from the patients during treatment was also studied for TUM-N and VM.<BR>TUM-N i s a new antituberculous drug isolated from the culture filtrate of Streptomyces. griseoverticillatus var. tuberacticus (N 6-130 strain). This drug shows almost the same activity as VM for tubercle bacilli and one way cross resistance for kanamycin.<BR>In this study, two following regimens were allocated ran d o mly for retreated patients.<BR>(1) TUM-N group: TUM-N was injected 1 g daily for the first three months, thereafter injected twice weekly. (45 cases)<BR>(2) VM group: VM wa s injected 1 g three times a week. (38 cases)<BR>If there are previously unused drug, they were combined with TUM-N or VM. The results were summarized as follows;<BR>(1) TUM-N group showed slmo s t the same negative conversion rate on culture as VM, group.<BR>(2) All of the cases treated with TUM-N combined with two previously unused drugs. showed 100% negative conversion rate on culture at 6 months.<BR>(3) The incidence of side-effects was lower in TU M -N group compared with VM group. The auditory disturbance was 2.2% in TUM-N group and 5.7% in VM group. The renal, disturhance defined by the raise of BUN level over 20 mg/d<I>l</I> was observed in 23.7% among -VM group while it was 10.9% in TUM-N group. The dropped-out cases due to side-effects -were 3 (6.5%) among 46 cases of TUM-N group and 8(21.2%) among 38 cases of VM group.<BR>(4) The criterion of drug resistance of TUM-N was examined and it was concluded that the growth on 1% Ogawa's media containing 100 mcg/m<I>l</I> TUM-N should be considered as resistant.