著者

尾形 和夫 小泉 文明 堀野 豊

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.40, no.12, 1977-01-20

著者

和田 直人 中村 保幸 蔦本 尚慶 杉本 喜久 堀江 元 伊藤 誠 三ッ浪 健一 木之下 正彦

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.61, 1997-08-20

著者

浜 是幸 外畑 巌 竹内 省三 久永 光造 永田 和彦 市江 良康

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.46, 1982-06-01

著者

粟野 孝次郎 大西 正孝 五十川 芳明 末松 正邦 森 紀夫 井尻 靖治 土屋 五郎

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.46, 1982-11-01

著者

水谷 和郎 坂本 丞 鈴木 俊示 小出 昌伸 藤田 英樹 櫻本 博也 金高 大悟 松尾 武文

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.60, 1996-02-20

著者

青井 渉 植山 千秋 山下 俊一 古賀 英俊 阿部 康治 土井 豊 奥 保彦 倉持 衛夫 橋場 邦武

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.46, 1982-06-01

著者

藤井 善蔵 奥田 史雄 高橋 徹郎 伊達 敏明 藤井 英雄 楠川 禮造 神代 昭 馬場 洋明

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.54, 1990-12-20

著者

小林 茂樹 永田 正毅 朴 永大 榊原 博 別府 慎太郎 仁村 泰治 川副 浩平 藤田 毅

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.48, 1984-09-10

著者

Minako Yamaoka Seiji Yamaguchi Masaki Okuyama Hitonobu Tomoike

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.63, no.12, pp.951-956, 1999 (Released:2001-08-25)

参考文献数

41

被引用文献数

45 46

---

Proinflammatory cytokines, ie, tumor necrosis factor-alpha (TNFα), participate in the development and the progression of congestive heart failure (CHF). On the other hand, an anti-inflammatory cytokine may neutralize the proinflammatory cytokines of CHF. Interleukin-10 (IL-10) is known to suppress the synthesis of proinflammatory cytokines. IL-10 and the IL-10 receptor system was investigated in comparison with the behavior of TNF α in 68 patients with various causes of CHF (mean age: 61 years) and in 31 normal subjects (61 years). The circulating IL-10 level was higher in CHF patients than in normal subjects (p<0.05). The TNFα level was higher in CHF patients than in control subjects (p<0.005). The ratio of IL-10 to TNFα tended to be higher in control subjects than in patients with CHF (p=0.09). With lipopolysaccharide treatment, the release of IL-10 was more enhanced from mononuclear leukocyte of patients with CHF than from control subjects (p<0.05). The expression of the IL-10 receptor estimated by flow cytometry of mononuclear leukocytes was higher in the CHF patients than in the normal subjects. The IL-10/IL-10 receptor system was activated, at least partly, to downregulate an excess of TNF α in patients with advanced CHF. IL-10 may be an important inherent component of the cytokine network of CHF. (Jpn Circ J 1999; 63: 951 - 956)

著者

上田 三四二

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.25, no.1, pp.106-119, 1961-01-15 (Released:2008-04-14)

参考文献数

44

---

The causal relations between various neuroses and the distribution of subclinical adhesive arachnoiditis cerebrospinalis have been extensively studied by Maekawa and his students. The neurocirculatory asthenia (N.C.A.), a type of neurosis, is frequently associated with abnormal electrocardiograms. It is also known that the stimulation of the peripheral sympathetic nerve produces electrocardiograms of "coronary insufficiency" pattern. In this paper the author tried to elucidate the possible role of the spinal sympathetic nervous system supplying the heart in the pathogenesis of N.C.A. by studying the effect of the electrical stimulation of the spinal cord in dogs on the electrocardiograms. Methods After adult dogs were laminectomized under anesthesia, a pair of concentric electrodes was inserted into the spinal cord, and the electrical stimulation was applied at 4 to 15 volts for about 5 to 15 seconds. Electrocardiograms were recorded before, during and after the electrical stimulation. Results and Discussion In 30 of 36 tested animals the electrical stimulation of the spinal cord produced electrocardiographic changes in ST and T waves. Although changes could be produced either with the upper thoracic cord or lower thoracic cord stimulation, electrocardiographic changes were more frequent in incidence and severe in degree with the former mode of the stimulation than with the latter. A still stronger effect could be produced when the two areas were stimulated simultaneously. The maximum effect was obtained at 2.5 mm depth of the insertion of the stimulating electrode; in this case the tip of the electrode was located near the lateral horn of the spinal cord. Although the electrical stimulation of the spinal cord produced an elevation of the blood pressure concomitantly with the electrocardiographic changes, the observed electrocardiographic changes were not possibly reactions secondary to the elevation of the blood pressure. Altered electrocardiograms and elevated blood pressure are probably two distinct manifestations of a single reaction process of the organism to the stimulation, i.e., the coronary vasoconstriction on the one hand, and generallized peripheral vasoconstriction on the other.

著者

DADGAR S.K. TYAGI S.P. SINGH R.P. HAMEED S.

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.43, no.2, pp.77-82, 1979-03-20 (Released:2008-04-14)

参考文献数

17

被引用文献数

22 25

---

Weight of the heart and its various components (muscular and non muscular portions) was measured in 138 specimens. Average heart weight for Indians was comparatively less then that of western population. Difference between the average heart weights for males and females was found to be statistically significant. The heart weight was not influenced by age and body length but by the body built. A statistically significant difference was noticed in emaciated persons. Ventricular weight constituted 50 to 80 percent of the total heart weight. A close correlation between the heart weight and ventricular weight was seen. Ventricular wall thickness did not correlate well with the heart weight.

著者

KOH GOTOH

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.40, no.7, pp.753-768, 1976-08-20 (Released:2008-04-14)

参考文献数

20

被引用文献数

35 40

---

The conduction system of seven cases died of the so-called "Pokkuri disease", was histopathologically studied with serial sectioning method. Fibrosis with a significant reduction of conduction fibers was observed in the sinoatrial node and unction between the node and atrial muscle fibers in 6 cases. Abnormal course and branching of the sinus node artery was seen in 6 cases of which 3 had no penetration o fits main branch into the node. Some pathological lesions exsisted in the atrioventricular conduction system in 4 cases: 2 had fibrotic lesion in the distal bundle of His and proximal left and right bundle branches which were sandwiched between the abnormal conal muscle and the summit of ventricular septum. Remaining 2 had lipomatous partial interruption in the mid- and distal bundle of His. Simultaneous involvement of sinoatrial node and the atrioventricular conduction system was observed in 4 cases. One of such cases showed abnormal ECG consisted of a left axis deviation and right bundle branch block. As a conclusion, pathological lesions in the conduction system are revealed in more than half of cases of "Pokkuri disease". The pathgenesis seems to be related to minor anomalies such as abnormal sinus node artery, abnormal conal muscle situation.

著者

加藤 裕久 広瀬 瑞夫 山口 昌之 吉沢 催章 福田 宏志 小田 積一 永山 徳郎

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.31, no.12, pp.1857-1863, 1968-01-15 (Released:2008-04-14)

参考文献数

9

被引用文献数

1

---

The mechanism of the anoxic spells in the patient with tetralogy of Fallot is still uncertain, but beta adrenergic stimulation has been shown to accentuate cyanosis and occasionally to precipitate an anoxic spell. The purpose of the present study is to investigate the hemodynamic responses to isoproterenol (adrenergic beta stimulant) and propranolol (adrenergic beta blockade). Materials and Methods: Eleven children ranging in age from 3 to 14 years have been studied at cardiac catheterization (tetralogy of Fallot 7 cases, pulmonary stenosis with intact ventricular septum 2 cases, ventricular septal defect 1 case, patent ductus arteriosus 1 cases). All patients were sedated with hydroxyzine hydrochloride, secobarbital and pethidine HCl. The pressure pulses of pulmonary artery, right ventricle and femoral artery were obtained by the Siemens electro manometer. Determinations of oxygen satura-tions were obtained with the gas analyser (In-strumentation Laboratory) on arterial, pulmo- nary and mixed venous blood. Oxygen consumptions were measured by Fukuda Irika's respirometer. The phonocardiogram and the first derivative of right ventricular pressure pulse (dp/dt) were simultaneously recorded. Isoproterenol (0.1mg/20cc in 5% dextrose in water)was infused intravenously until the heart rate increased by 50 per cent. Then blood samples were obtained and pressure pulses were recorded. Thereafter, while the action of isoproterenol persisted, the infusion of propranolol in a dose of 5γ/kg (2mg/20cc in 5% dextrose in water) was administered, and the parameters were restudied. The angiocardiogram was obtained in one case before and after isoproterenol infusion. Results and Discussion: In tetralogy of Fallot the isoproterenol in-fusion resulted in an increase of right ventricular systolic pressure and a decrease of pulmonary systolic pressure. Pulmonary blood flow was decreased and systemic blood flow and right to left shunt were increased, so arterial oxygen saturation was markedly decreased. In angio-cardiogram the marked narrowing of the right ventricular outflow tract was demonstrated after isoproterenol infusion. In simultaneously recorded phonocardiogram the ejective systolic murmur due to pulmonary stenosis was decreased by isoproterenol infusion. In pulmonary stenosis with intact ventricular septum the pressure gradient of pulmonary artery and right ventricle was markedly increased, but arterial oxygen saturation was unchanged after isoproterenol infusion. Thereafter, while the action of isoproterenol persisted, a infusion of propranolol was administered. In tetralogy of Fallot the propranolol infusion resulted in an increase of arterial oxygen saturation. And the systolic pressure gradient of pulmonary artery and right ventricle was decreased. Pulmonary blood flow was increased and systemic blood flow and right to left shunt were decreased. So the patients were recovered from anoxic state. The mechanism of the anoxic spells in tetralogy of Fallot is still uncertain, but our study suggests that the increase of the contraction in the outflow tract of right ventricle makes the hypoxic condition. Relaxation of the outflow tract of right ventricle is seen after propranolol, and the patient is recovered from anoxic condition. In one case with tetralogy of Fallot in age of 9 months who had frequent cyanotic at-tacks we used propranolol orally 5 mg a day. After propranolol there has been no anoxic spell in this patient. So it may have been some practical usefulness in prevention and treatment of anoxic spells in tetralogy of Fallot.

著者

KANJI IGA KENJIRO HORI TADASHI MATSUMURA HIROMITSU GEN YUTAKA OKITA SHIGEHITO MIKI

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.56, no.10, pp.1032-1034, 1992-10-20 (Released:2008-04-14)

参考文献数

6

被引用文献数

1 1

---

Emergency aortic valve replacement with double aorto-coronary bypass surgery was performed to treat severe intractable congestive heart failure in an 82-year-old man. Mild circumflex and left anterior descending artery lesions were present and the pressure gradient across the aortic valve was 80 mmHg despite a low cardiac output. The preoperative anteroseptal akinesia seen by two-dimensional echocardiography was normalized after surgery. Thus, even in patients with segmental left ventricular dyfunction, tight aortic stenosis might be present when concomitant mild ischemic heart disease is present.

著者

ZHANG AN YOSHIHIRO HIMURA TOSHIAKI KUMADA WATARU HAYASHIDA NOBORU ISHIKAWA MICHIYO NODA FUJIMASA KOHNO MASASHI KAMBAYASHI CHUICHI KAWAI

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.56, no.4, pp.317-324, 1992-04-20 (Released:2008-04-14)

参考文献数

17

被引用文献数

15 22

---

To determine the characteristic change in the Doppler hepatic venous flow velocity pattern in patients with pulmonary hypertension (PH), 21 patients with PH in sinus rhythm were examined with pulsed Doppler echocardiography. The control group included 13 subjects with chest pain syndrome and normal pulmonary arterial pressure. The hepatic vein Doppler signal was biphasic with one peak during ventricular systole (S wave) and the other in diastole (D wave). A reversed signal was recorded after contraction (A wave). The peak velocity of the A wave (Va), S wave (Vs), and D wave (Vd), the time velocity integral of these waves (Vla, Vls, and Vld), the acceleration time (t-AC), and the slope of acceleration (s-AC) in the S wave were measured. Compared with controls the PH group had a higher value of Va (26.88±10.30 vs 13.41±3.69 cm/sec; p<0.01), Vla (2.55±1.18 vs 1.20±0.34cm; p<0.01). Vla/(Vls+Vld) (0.34±0.22 vs 0.14±0.06; p<0.01), and s-AC (372±156 vs 203±103 cm/sec2. p<0.01). They also had a shorter t-AC (101±32 vs 136±27 msec; p<0.01). There was a weak correlation between the reversed atrial flow and the right heart pressures (r=0.43 to 0.66). Thus, the hepatic venous flow velocity pat-tern by Doppler echocardiography is clinically useful in evaluating pulmonary hypertension.

著者

KANJI IGA KENJIRO HORI KATUJI KITAGUCHI TADASHI MATSUMURA HIROMITU GEN GO TOMONAGA TOSHITAKE TAMAMURA

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.55, no.11, pp.1061-1067, 1991-11-20 (Released:2008-04-14)

参考文献数

12

被引用文献数

23 26

---

Eight cases of transient reversible segmental asynergy of the left ventricle thought not to be related to coronary artery lesions are reported. Three cases were associated with inflammatory reactions of unknown origin, and one each with lactic acidosis, abdominal surgery, hypoglycemia, tetanus and pneumonia. None of the patients had symptoms suggestive of ischemic heart disease before or after these episodes. Electrocardiograms before these episodes were all normal. Two-dimensional echocardiography was performed to evaluate abnormal electrocardiograms. Coronary angiography was performed in 4 of 8 cases and was normal in all 4 cases; 2 done as emergencies and 2 non-emergencies. Two ergonovine tests were negative. Left ventricular wall motion abnormalities. present mainly at the apex of the left ventricle, returned to normal in I to 4 weeks. Giant negative T waves in the chest leads during this recovery period were characteristic electrocardiographic features and normalized in 6 weeks on average . We believe that these episodes were not related to ischemia due to coronary artery disease, but to some metabolic humoral factors. An excellent prognosis can be expected if these abnormal metabolic circumstances can be resolved.

著者

KANJI IGA HIROMITSU GEN GO TOMONAGA TADASHI MATSUMURA KENJIRO HORI

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.53, no.7, pp.813-818, 1989-07-20 (Released:2008-04-14)

参考文献数

15

被引用文献数

35 41

---

Excessive catecholamine levels can cause myocardial damage in experimental animals. Similar observations have been made in humans following autopsy for pheochromocytoma. However, whether catecholamine crises are reversible or not remains uncertain. We report here a case in which pheochromocytoma manifested as acute pulmonary edema during an operation. Serial echocardiograms revealed that the depressed motion of the left ventricular wall was reversed after tumor removal. The plasma catecholamine level was extraordinarily high during the episode of acute pulmonary edema, and it seems that catecholamines in high concentration can directly damage the myocardium.

著者

上杉 道伯 曽根 孝仁 坪井 英之 近藤 潤一郎 武川 博昭 香曽我部 泰 山本 剛 若原 恵子 吉田 朋寛

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.65, 2001-10-20

著者

Akira Matsumori

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.61, no.4, pp.275-291, 1997 (Released:2001-12-25)

参考文献数

104

被引用文献数

54 68

---

Myocarditis is thought to be commonly caused by various viruses, and accumulating evidence links viral myocarditis with the eventual development of dilated cardiomyopathy. Recently, the importance of hepatitis C virus infection was noted in patients with dilated and hypertrophic cardiomyopathy. Cytokines are being increasingly recognized as an important factor in the pathogenesis and pathophysiology of myocarditis and cardiomyopathy. Elevated levels of circulating cytokines have been reported in patients with heart failure, and various cytokines have been shown to depress myocardial contractility in vitro and in vivo. A number of reports have shown that cytokines generated by activated immune cells cause an increase in nitric oxide (NO) via induction of NO synthase. Increased generation of NO may induce negative inotropism and myocardial damage. This review discusses the etiology and pathogenesis of myocarditis and cardiomyopathy from this point of view. (Jpn Circ J 1997; 61: 275 - 291)

著者

村上 弘則 櫻井 正之 中川 俊昭 土橋 和文 西村 光弘 浦澤 一史 五十嵐 慶一 佐藤 元彦

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.65, 2001-10-20