著者

坂本 真史

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.76, no.3, pp.127-130, 2016 (Released:2016-11-01)

参考文献数

3

著者

山﨑 健

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.66, no.5, pp.323-325, 2006 (Released:2019-04-13)

参考文献数

1

著者

大谷 道輝 山岡 由紗 松元 美香 並木 路広 山村 喜一 江藤 隆史

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.69, no.6, pp.470-476, 2009 (Released:2019-03-31)

参考文献数

14

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Topical retinoids are very important in acne treatments. Clinical experience has shown that adapalene, a new topical retinoid, has a superior cutaneous safety profile. In the guidelines of care for acne vulgaris management of our country, the combinations with adapalene gel and topical antibiotics (e.g., clindamycin nadifloxacin) are an effective acne treatment, and these combination treatments are ranked as a recommendation A. For the purpose of improvement of compliance, the mixing of ointments and/or creams is common practice. However, many of the admixtures of ointments and/or creams may lack pharmaceutical stability.To assess the pharmaceutical stability of these mixtures after mixing, we attempted to investigate the change in the appearance and contents of adapalene, clindamycin and nadifloxacin in admixtures. As a result, no lowering of the content of adapalene was noted in any admixtute. After admixtures of adapalene and clindamycin or nadifloxacin, the contents of clindamycin or nadifloxacin were constant.

著者

花輪 剛久 藤井 まき子 近藤 直樹 国忠 聡 花輪 正明

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.80, no.1, pp.24-35, 2020 (Released:2020-01-01)

著者

山本 信夫

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.71, no.2, pp.78-81, 2011 (Released:2019-03-02)

著者

郡 修徳 小澤 武史 高崎 雅彦 江口 久恵 三輪 興三 沼 潤幸 阿部 信

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.61, no.1, pp.34-45, 2001 (Released:2019-05-18)

参考文献数

19

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We prepared a troche containing camostat mesilate for the prevention of the mucositis in the mouth induced by cancer chemotherapy. The troche was formed by the direct compression of a powder mixture of camostat mesilate, a flavoring agent, hydroxypropylcellulose, and magnesium stearate. A troche containing 10% or 20% hydroxypropylcellulose and a flavoring agent of coffee or green apple diminished the bitterness of camostat mesilate. It was found that the metabolising rate of camostat in saliva was much slower than that in blood, although metabolites in saliva were the same kinds as those in blood. The amounts of camostat retained in the mouth after administration of the troche to healthy subjects were much larger than those after applying a gargle which had a bitter taste. Moreover, the troche containing the flavoring agent of green apple showed smaller amounts of camostat and its metabolites retained in the mouth compared to the troche containing the flavoring agent of coffee. It is considered that the increase in the secreting volume of saliva after administration of the troche containing the flavoring agent of green apple would prevent the retaining of camostat and its metabolites in the mouth. Moreover, the administration of a troche is more convenient than that of a gargle for patients. The troche prepared in this study would be a substitute dosage form for the gargle and promote the quality of life in patients.

著者

石田 誠

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.77, no.5, pp.253-257, 2017-09-01 (Released:2017-09-01)

参考文献数

5

著者

合田 幸広

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.75, no.3, pp.170-176, 2015 (Released:2015-11-01)

参考文献数

5

被引用文献数

2

著者

福居 篤子

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.75, no.1, pp.42-47, 2015 (Released:2015-07-01)

参考文献数

11

被引用文献数

1

著者

野中 稔

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.77, no.1, pp.25-28, 2017 (Released:2017-01-01)

参考文献数

4

著者

矢花 直幸

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.76, no.3, pp.167-171, 2016 (Released:2016-11-01)

参考文献数

7

著者

渡部 一宏 戸田 潤

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.74, no.3, pp.172-175, 2014 (Released:2014-11-01)

参考文献数

4

著者

田中 克平

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.64, no.6, pp.326-331, 2004 (Released:2019-05-10)

参考文献数

1

被引用文献数

2

著者

落合 明子 飯田 桂 髙部 浩行 川村 恵里 佐藤 康彦 加藤 保富 大熊 盛之 檀上 和美

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.70, no.6, pp.324-331, 2010 (Released:2019-03-08)

参考文献数

18

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Latanoprost tends to degrade in an aqueous solution, and also adsorbs to the plastic containers. Moreover, the latanoprost content of the formulation can easily degrade, depending on the storage temperature, because of the very low drug concentration in the eye drops. Therefore, Xalatan® Eye Drops should be stored at 2-8°C (in the refrigerator)for the reasons described above.In this study, we investigated ways to improve the stability of latanoprost in aqueous solution in order to develop a formulation of latanoprost eye drops that can be stored at room temperature (1-30°C). Excipients used for opthalmological preparations were examined. The stability at 60°C was evaluated after 4 weeks in model formulations that included the excipient, which enables sterile filtration. As a result, the latanoprost content was not decreased in formulations that included polyoxyl 40 stearate and polyethylene glycol monostearate 25 at suitable concentrations. Then, we established a formulation of latanoprost eye drops that could be stored at room temperature. It was assumed that both the degradation of latanoprost and adsorption to the plastic containers were depressed by these excipients.The formulation developed in this study would not need to be stored in the refrigerator either during the medication period of the patient or during distribution and storage at medical sites. It was also predicted that instructions on the use of these drugs would be simplified. Therefore, the latanoprost eye drops developed in this study would be very useful for patients and health care professionals.

著者

河原 昌美

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.80, no.4, pp.198-202, 2020 (Released:2020-07-01)

参考文献数

4

著者

高田 龍平 鈴木 洋史

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.65, no.6, pp.375-380, 2005 (Released:2019-04-20)

参考文献数

16

被引用文献数

1

著者

野口 修治

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.81, no.3, pp.227-230, 2021-07-01 (Released:2021-07-01)

参考文献数

4

著者

小木曽 太郎

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.63, no.1, pp.34-45, 2003 (Released:2019-05-12)

参考文献数

31

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Recent studies have focused on the hair follicle as a potential pathway for both localized and systemic drug delivery. When drug penetration through human scalp skin was investigated using liquid formulations containing lipophilic and hydrophilic drugs in vitro, lipophilic melatonin (MT) and ketoprofen (KP) showed high permeabilities through scalp skin. Absorption enhancers, N-methyl-2-pyrrolidone and isopropylmyristate, only slightly increased the fluxes. Hydrophilic fluorouracil (5FU) and acyclovir (ACV) also penetrated across the skin with relatively large fluxes. However, there was large variability in the fluxes of drugs across scalp skins. There was a correlation between the flux and hair follicle density (r=0.651 for MT and r=0.666 for ACV). Fluorescent probes, nile red and sodium fluorescein, permeated into the junction of the internal and external root sheath of follicles and diffused into the dermis via the outer root sheath at the initial times. The penetration of MT and 5FU through scalp skin was much higher (37 and 48 times, respectively) than that via human abdominal skin. It has been demonstrated that topically-applied liposomes and microspheres are efficient in specifically targeting the delivery of a wide variety of compounds into the hair follicles. Additionally, hair follicles were a significant pathway for electroosmotic solution flow during iontophoresis. This review indicates a basis that drug delivery through human scalp skin will offer an available delivery means for many lipophilic and hydrophilic drugs.

著者

薬剤学編集委員会

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.74, no.1, pp.63-65, 2014 (Released:2014-07-01)

著者

伊藤 清美

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.64, no.1, pp.36-39, 2004 (Released:2019-05-10)

参考文献数

5